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Monkeypox in pregnancy

June 8, 2022

Original sources

Original scientific reports of monkeypox in pregnancy. Summaries, links, full texts, & citations, along the lines of our Covid-19 database (click here). No opinion, reviews, or guidelines. Just primary sources. Regularly updated by Susan Bewley, Keelin O’Donoghue, Kate Walker and me.

We’ve not listed primary sources for smallpox vaccine in pregnancy, but see reference list of study 10.

30 July 2022 – MP study 11 added

MP study 11 – a monkeypox & pregnancy registry

A group from Switzerland who run a registry for emergent infectious pathogens and pregnancy (click here) have expanded it to collect cases of monkeypox in pregnancy (cleck here or study). Citation: Pomar L, Favre G, Baud D. Monkeypox infection during pregnancy: European registry to quantify maternal and fetal risks. Ultrasound Obstet Gynecol. 2022 Jul 9. doi: 10.1002/uog.26031. Epub ahead of print. PMID: 35809242.

13 June 2022 – MP studies 7 to 10 added

MP study 10 – 376 women in smallpox vaccine in pregnancy registry

As of September 2006, pregnancy outcome data were available for 376 women enrolled in the Smallpox Vaccine in Pregnancy Registry (click here or study). Rates of pregnancy loss (11.9%), preterm birth (10.7%), or birth defects (2.8%), were judged comparable with those in healthy referent populations. No cases of fetal vaccinia were identified. Citation: Ryan MA, Seward JF; Smallpox Vaccine in Pregnancy Registry Team. Pregnancy, birth, and infant health outcomes from the National Smallpox Vaccine in Pregnancy Registry, 2003-2006. Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S221-6. doi: 10.1086/524744. PMID: 18284362.

MP study 9 – 13 pregnancies in studies of Imvanex vaccine

Thirteen pregnancies occurred during five studies of Imvanex smallpox vaccine (Live Modified Vaccinia Virus Ankara). One was terminated with an elective abortion and one ended as spontaneous abortion. All others were followed up and all women gave birth to healthy babies (click here or study p109). These cases may overlap with those in study 7. Citation: European Medicines Agency 369203/2013 Committee for Medicinal Products for Human Use (CHMP) 30 May 2013. Accessed 13 June 2022

MP study 8 – no data on tecovirimat in pregnancy

Tecovirimat SIGA is indicated for the treatment of orthopoxvirus disease (smallpox, monkeypox,
cowpox, and vaccinia complications). There are no data on its use in pregnant women (click here or study p 30). Citation: European Medicines Agency 703119/2021. Committee for Medicinal Products for Human Use (CHMP)11 November 2021. Accessed 13 June 2022

MP study 7 – 14 pregnant women in trial of live, non-replicating smallpox and monkeypox vaccine

In this Federal Drug Administration report 24 women became pregnant during controlled trials of the Live, Non-replicating Smallpox and Monkeypox Vaccine, Modified Vaccinia Ankara BN (MVA-BN). 14 had received active vaccine or placebo. Five gave birth to healthy infants, and three had elective (non-medically indicated) abortions. In the MVA-BN group one had fetal death at ~12 weeks and one had a spontaneous abortion. In the placebo group, two had spontaneous abortions. Four women were lost to follow-up and the pregnancy outcomes are unknown (click here or study p 123). Citation: JYNNEOS, also referred to as Modified Vaccinia Virus Ankara–Bavarian Nordic (MVA-BN) FDA biologics license application. Clinical Review Memorandum 9/19/2019. Accessed 13 June 2022

11 June 2022 – MP study 5 added

MP Study 6 – five cases from the Democratic Republic of Congo

This preprint includes five pregnancy cases (click here or study), of which four had been previously described in MP study 1. No details are given of the new case except that this sentence in the abstract “fetal death occurred in 4 of 5 (80%) patients who were pregnant at admission” implies that the fetus died. Citation: Phillip R. Pittman, James W. Martin, Placide Mbala Kingebeni, Jean-Jacques Muyembe Tamfum, Qingwen Wan, Mary G. Reynolds, Xiaofei Quinn, Sarah Norris, Michael B. Townsend, Panayampalli S. Satheshkumar, Bryony Soltis, Anna Honko, Fernando B. Güereña, Lawrence Korman, John W. Huggins. Clinical characterization of human monkeypox infections in the Democratic Republic of the Congo. medRxiv 2022.05.26.22273379; doi: https://doi.org/10.1101/2022.05.26.22273379

8 June 2022 – MP studies 1-5 added

MP study 5 – No cases in pregnant women in present outbreak

As of 4 June 2022 no cases of monkeypox in pregnant women have been reported by WHO, either in endemic or non endemic areas (click here). Note the report does not explicitly state that no cases in pregnancy have ocurred. Citation: The World Health Organisation. Multi-country monkeypox outbreak: situation update. 4 June 2022. Accessed 8 June 2022

MP study 4 – no pregnant women in the 2003 USA outbreak

No infected pregnant women were reported in any of the CDC reports of the 2003 United States outbreak of monkeypox (click here for the latest update). Citation: Update: multistate outbreak of monkeypox—Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep 2003;52:589–90.

MP study 3 – secondary source for a case report from Zaire

“One case of probable congenital monkeypox in Zaire has been described. At approximately 24 weeks of
gestation, a pregnant woman developed a febrile illness with a rash; monkeypox virus was subsequently isolated from a vesicular lesion. Six weeks later she delivered a 1,500-g female infant with a generalized skin rash resembling monkeypox. The child died of malnutrition at 6 weeks of age.” The source is given as Jezek Z, Fenner F. Human monkeypox. New York (NY): Karger; 1988. [Not accessed]. Citation: Jamieson DJ, Cono J, Richards CL, Treadwell TA. The role of the obstetrician-gynecologist in emerging infectious diseases: monkeypox and pregnancy. Obstet Gynecol. 2004 Apr;103(4):754-6. doi: 10.1097/01.AOG.0000114987.76424.6d. PMID: 15051569.

MP study 2 – one case from Nigeria in 2017-18

One woman who was pregnant during her illness had a spontaneous abortion at 26 weeks (click here or study). Citation: Yinka-Ogunleye A, Aruna O, Dalhat M, Ogoina D, McCollum A, Disu Y, Mamadu I, Akinpelu A, Ahmad A, Burga J, Ndoreraho A, Nkunzimana E, Manneh L, Mohammed A, Adeoye O, Tom-Aba D, Silenou B, Ipadeola O, Saleh M, Adeyemo A, Nwadiutor I, Aworabhi N, Uke P, John D, Wakama P, Reynolds M, Mauldin MR, Doty J, Wilkins K, Musa J, Khalakdina A, Adedeji A, Mba N, Ojo O, Krause G, Ihekweazu C; CDC Monkeypox Outbreak Team. Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. Lancet Infect Dis. 2019 Aug;19(8):872-879. doi: 10.1016/S1473-3099(19)30294-4. Epub 2019 Jul 5. PMID: 31285143.

MP study 1 – four cases from the Democratic Republic of Congo

Four pregnant women treated in the General Hospital of Kole, in Sankuru District, Kasai Orientale Province, from March 2007 to July 2011. One was infected at six weeks (miscarriage at 9 weeks), one at 6-7 weeks (miscarriage at 8-9 weeks), one at 14 weeks (livebirth at term), and one at 18 weeks (fetal death at 21 weeks) (click here or study). Citation: Mbala PK, Huggins JW, Riu-Rovira T, Ahuka SM, Mulembakani P, Rimoin AW, Martin JW, Muyembe JT. Maternal and Fetal Outcomes Among Pregnant Women With Human Monkeypox Infection in the Democratic Republic of Congo. J Infect Dis. 2017 Oct 17;216(7):824-828. doi: 10.1093/infdis/jix260. PMID: 29029147.

Заповіт Тараса Шевченка

May 30, 2022

The tenth translation of Testament by Taras Shevchenko

The New Yorker’s May 9th issue includes two factual reports from the town of Bucha, outside Kyiv; James Nachtwey’s photo portfolio, “A Harrowed Land” (click here), and Luke Mogelson’s “The Wound Dressers” (click here).

A shell-shocked widow retrieves a book of poetry from a box under the bed in her ruined home. Nina and Lyudmyla, sisters in their seventies, lie dead in a different house. Their shelves contain the same collection.

Mogelson writes:

Widely considered the progenitor of modern Ukrainian literature, Shevchenko had contributed as much as anyone to the development of modern Ukrainian identity, distinct from Russia’s. “My Testament”, one of the poems in the book, had become a kind of anthem for protestors during the Revolution of Dignity.”

There are at least ten English translations; eight here, a ninth here. But the latest, included in The Complete Kobzar, The Poetry of Taras Shevchenko by Peter Fedynsky (click here), is not on the internet. In contrast to the rhyming original, it’s in free verse. Fedensky claims to have followed only two rules, “strict adherence to the meaning of the original, and a constant rhythm, […] facilitated by the rich vocabulary of English.” Here it is.

Testament by Taras Shevchenko
When I die, then bury me
Atop a mound
Amid the steppe's expanse.
So I may see
The great broad fields
The Dnipro and the cliffs,
So I may hear the river roar.
When it carries hostile blood  
From Ukraine into the azure sea...
I’ll then forsake
The fields and hills -
I'll leave it all  
Taking wing to pray 
To God himself... till
Then, I know not God.
Bury me, rise up,
And break your chains
Then sprinkle liberty   
With hostile wicked blood.
And in a great new family, 
A family of the free,  
Forget not to remember me
With a kind and gentle word.

Cocktails for Ukraine

March 7, 2022

And poems

Soon after the first lockfown, inspired by Stanley Tucci (click here), I started filming drinks recipes (click here) for friends who missed our usual walking and canoe trips. Sometimes I added a poem. At the end of each week we zoomed, grumbled and had a cocktail.

One (click here) managed a hundred views, mainly because The Philip Larkin Society noticed it. The first verse of Sympathy in White Major is the best poem ever written about a gin & tonic. It may be the only poem written about a gin & tonic! The rest sank without trace.

Only one, the alcohol-free Nogroni (click here), deserves to be watched again, and that because my grand-daughter stole the show.

Last week, when Ukraine was invaded, I tried my hand at a Volodymyr Zelensky (click here) in honour of their brave president. Intending to be humorous, I ended on a serious note and choked up. Too lazy for a retake, it’s already had over a thousand views. A lot for me.

Yesterday The Dirty Ukranian (click here). The 5:1 ratio reminds us of Ukraine’s numeric disadvantage, and the salty pickle how bravery, morale and leadership will more than make up for it. The crocuses & daffodils supported, Tania filmed and Susie toasted. I forgot to read Auden’s poem on the 1968 Soviet invasion of Czechoslovakia.

Za nas, za vas, i za Donbas!

August 1968

The Ogre does what ogres can,
Deeds quite impossible for Man,
But one prize is beyond his reach:
The Ogre cannot master Speech.

About a subjugated plain,
Among its desperate and slain,
The Ogre stalks with hands on hips,
While drivel gushes from his lips.

W.H.Auden

The last specialty using racist charts

January 11, 2022

Deriving normal ranges from abnormal patients

Doctors do millions of different tests on patients – bloods, imaging, exercise tolerance – and always define the range of normal values on healthy people. The normal haemoglobin concentration is based on healthy participants. Even in countries where malaria is common, and many people anaemic, the same normal ranges are used.

With two exceptions, renal function and fetal biometry. Until recently some kidney doctors used different estimated glomerular filtration rate (eGFR) ranges for people with black skins, who tend to have lower values, i.e. slightly worse renal function. And some obstetricians still use special “customised” fetal size charts, for short, underweight, or ethnic minority mothers, who tend to have smaller babies.

However the lower black eGFR values are not “normal”, they reflect more pathology, raised blood pressure etc. In 2021 NICE recognised that using different normal ranges for black people was racist. It deprived them of effective treatment, and NICE revised its guidelines to a single set of normal ranges for all adults (click here).

Most obstetricians also know that being short, under or over-weight, or having dark skin, is also associated with adverse outcomes, so using special charts for such women tends to normalise pathology. Their use is heightist, weightist and racist. The WHO, and the Intergrowth-21 group, have produced unified charts based on healthy pregnancies, which most obstetricians worldwide now use.

But the UK has been slow to adjust. About half of UK maternity units still use customised charts and the RCOG, in its Green Top guidelines, still endorses them (click here).

In the 1970s Archie Cochrane awarded obstetrics the “wooden spoon” as the last specialty to implement evidence-based medicine. We’ve done better in that department since.

But right now we are the last specialty using racist charts. Fortunately the Green Top guidelines are due for revision. It’s time to put this right.

Jim Thornton

Two maternal deaths from surgical herpes

January 6, 2022

Avoidable with blunt needles

Last year a BBC investigation suggested that two young women in Kent had died from generalised surgical herpes infection, contracted from an infected surgeon, due to a needlestick injury at Caesarean section (click here).

The evidence was compelling. Herpes contracted this way is rare, but often fatal. Neither woman had a previous history of herpes, so would likely not have had prior immunity. Both were operated on in the same trust, albeit different hospitals, by the same unnamed surgeon. Kim Sampson gave birth on 3 May 2018, and Samantha Mulcahy on June 26 the same year. Both developed overwhelming herpes infections shortly after birth and died soon after.

According to emails seen by the BBC, the partial viral genome from both infections was not only identical, but also “rare”, compared with the previous 10 years of herpes samples collected by Public Health England’s North London lab. Although the surgeon was questioned, and denied having a herpetic lesion (a whitlow) on his finger, such lesions can be small and missed.

Needlestick injuries at Caesarean are common – the BBC quotes a 50 percent glove perforation rate. It was not reported whether the surgeon used a sharp or blunt needle, but the former is likely. If so, an easy opportunity to prevent the deaths of two young women was missed.

There is overwhelming evidence that blunt needles reduce needlestick injuries. It not only accords with common sense, but there have been ten randomised trials, two involving Caesarean section, and 2,961 operations included in the latest Cochrane review in 2011 (click here).

The use of blunt needles reduced the risk of glove perforations (RR 0.46; 95% CI, 0.38 to 0.54) compared to sharp needles, and self‐reported needle stick injuries (RR of 0.31; 0.14 to 0.68). It is unlikely that future research will change this conclusion.

This was followed by a Cochrane editorial (click here) in which the review was cited as an example of one “that can and should change practice”. The authors wrote “where they can be used they should be used”. They are recommended by the US Centers for Disease Control, the US Food and Drug Administration (click here), and the National Institute for Occupational Safety and Health (click here)”.

However, for some reason, NICE (click here for the March 2021 guidance), still doesn’t recommend them, and in my experience, few UK obstetricians use them. Despite the FDA and CDC recommendations things are not much better in the US. In a recent survey only 17% of fetal medicine trainees used them, and many were not even aware such needles existed (click here).

The reason for such reluctance to implement a simple safety step is unclear. They need a little more pressure to penetrate tissue, and some surgeons argue, mistakenly, that needlestick injuries matter less when everyone is screened for Hep B, Hep C and HIV. Nothing could be further from the truth. Each of these viruses caused many surgical infections until screening caught up, and if the last two years have taught us anything, new viruses are appearing all the time!

The inquest opened this week (click here) and has been adjourned to February 21. Let’s hope the coroner, Ms Katrina Hepburn, asks if the surgeon used blunt needles, and if not, why not.

This is an avoidable harm. If NICE’s recommenation had been evidence-based, maybe two young women would be alive today.

Jim Thornton

Sharp tender shock

December 20, 2021

An Arundel Tomb

Coming across it in Chichester cathedral recently, was a shock. My friends had misled me. “It’s not here” they had said. “It’s in Arundel.”

Afterwards, walking outside, a young couple asked for a photo. I told them about the tomb and poem – they didn’t know either – so I recited the final line. They promised to check it out. I started to explain how people misread it, or maybe don’t, but got “a bit o’ grit in me eye”, so had to turn away instead.

An Arundel Tomb

Side by side, their faces blurred,   
The earl and countess lie in stone,   
Their proper habits vaguely shown   
As jointed armour, stiffened pleat,   
And that faint hint of the absurd—   
The little dogs under their feet.

Such plainness of the pre-baroque    
Hardly involves the eye, until
It meets his left-hand gauntlet, still   
Clasped empty in the other; and   
One sees, with a sharp tender shock,   
His hand withdrawn, holding her hand.

They would not think to lie so long.   
Such faithfulness in effigy
Was just a detail friends would see:
A sculptor’s sweet commissioned grace   
Thrown off in helping to prolong   
The Latin names around the base.

They would not guess how early in
Their supine stationary voyage
The air would change to soundless damage,   
Turn the old tenantry away;
How soon succeeding eyes begin
To look, not read. Rigidly they

Persisted, linked, through lengths and breadths   
Of time. Snow fell, undated. Light
Each summer thronged the glass. A bright   
Litter of birdcalls strewed the same
Bone-riddled ground. And up the paths   
The endless altered people came,

Washing at their identity.   
Now, helpless in the hollow of   
An unarmorial age, a trough
Of smoke in slow suspended skeins   
Above their scrap of history,   
Only an attitude remains:

Time has transfigured them into   
Untruth. The stone fidelity
They hardly meant has come to be   
Their final blazon, and to prove   
Our almost-instinct almost true:   
What will survive of us is love.

Philip Larkin

Evie Toombes’ Wrongful Birth

December 14, 2021

Spina bifida and folic acid

Many were startled last week to learn that Evie Toombes, who has a type of occult spinal lesion, a lipomyelomeningocele, which would not have been prevented by her mother taking folic acid, will be awarded damages against Dr Mitchell, her mother’s GP, who had failed to advise her correctly about taking folic acid. Evie is “an occasional wheelchair/Zimmer frame user”, and needs to self catheterise, but is also “a para-horse rider, a campaigner for hidden disabilities and together with her mother, the author of a book”. Click here for the news story, and here or here for the full judgment.

An earlier court had already ruled on the principle; if, with correct advice, Evie’s mother would have delayed conception, Evie would never have been born and another healthy child replaced her, Evie would be entitled to damages.

There are parallels here with abortion for fetal abnormality. In the 1970’s the Oxford philosopher, Richard Hare, argued that parents considering abortion should decide in the interests of all their potential future children. A mother carrying a fetus with spina bifida should abort in the interests of her, unconceived, but likely to be healthy, replacement child (click here). In my experience this is how many parents think, and I guess the legal arguments follow this sort of logic too. I find the earlier court’s decision rather congenial.

But the judge’s ruling that the doctor’s advice was so bad that no responsible body of GPs would have advised Evie’s mother that way, does seem harsh.

Imagine Dr Mitchell, back when the claim started, getting a lawyer’s letter presumably alleging that he’d failed to advise Evie’s mum to take folic acid. Imagine him pulling his 27 February 2001 note to read “Preconception counselling. adv. Folate if desired discussed” (judgment para 31). He must have felt out of the frame.

But here’s para 61. Both sides agree that Mrs Toombes had attended for preconception counselling at her own instigation.

“I find that Dr Mitchell’s note is completely inadequate. As I have found, Mrs Toombes’ main concern was with regard to stopping the pill and that is not referred to in the note at all. I find that Dr Mitchell’s assumption that “Folate if desired,” means that he gave his usual standard advice, but that Mrs Toombes raised an issue as to whether or not the supplement was necessary and he explored details of her diet, informed her of the risks and then left it to her to choose, is nothing but speculation after the event. The note gives the impression without more discussion that Mrs Toombes was told that she should take folic acid if she wanted to. I accept Mrs Toombes’ evidence that she came away from the consultation under the impression that if she had a healthy diet, folic acid supplements were not necessary. In the circumstances, I prefer the evidence of Mrs Toombes and find that she was not told about the recommended dose or the reason why folic acid supplementation was recommended or that it should be taken before conception and for the first 12 weeks of pregnancy.”

Nothing wrong with the judge making findings of fact. But we can now see the aspects of Dr Mitchell’s advice, that were so bad that apparently no responsible body of GPs would follow them. Here they are.

  1. Qualifying his advice with a comment that folic acid was not necessary if her diet was good
  2. Not telling her the exact dose
  3. Not saying that the reason was to prevent spina bifida
  4. Not saying that it should be given pre-conception

To a woman who was knowledgable enough to arrange preconception counselling! We used to think obstetricians had it tough.

Jim Thornton

Gynaecological effects of Covid

November 1, 2021

Scientific papers reporting short and long-term effects of Covid-19 on menstruation, menarche and menopause, fertility, genital tumours, uterovaginal prolapse, female sexual function, urinary and vulval disorders, endometriosis and other miscellaneous gynaecological problems. Primary sources only. Updated regularly. Most recent first. Curated by Jim Thornton, Keelin O’Donoghue & Kate Walker.

For Covid-19 in pregnancy (click here), indirect effects on pregnancy (click here), news reports (click here) and effects of Covid-19 vaccines (click here).

8 March – GP 25 added

Gynae paper 25 – no effect of vaccination in Israel

From the IVF units, Shamir, Sheba, and Herzliya Medical Centres, Tel Aviv (click here or paper). COVID-19 mRNA vaccine did not affect the ovarian response or pregnancy rates. Citation: Avraham S, Kedem A, Zur H, Youngster M, Yaakov O, Yerushalmi GM, Gat I, Gidoni Y, Hochberg A, Baum M, Hourvitz A, Maman E, COVID-19 Vaccination and Infertility Treatment Outcomes, Fertility and Sterility (2022), doi: https://doi.org/10.1016/j.fertnstert.2022.02.025.

20 February – GP 24 added

Gynae paper 24 – case of ovarian vein thrombosis in USA

From Reading Hospital Tower Health, Reading (click here or study). Citation: DeBoer RE, Oladunjoye OO, Herb R. Right Ovarian Vein Thrombosis in the Setting of COVID-19 Infection. Cureus. 2021 Jan 20;13(1):e12796. doi: 10.7759/cureus.12796. PMID: 33628665; PMCID: PMC7893676.

6 February – GP 23 added

Gynae paper 23 – indirect effect of the pandemic on menstruation

1159 women from Andorra, Australia, Canada, Colombia, Estonia, Germany, Israel, Latvia, Netherlands, Romania, Spain, Sweden, Switzerland, UK, and USA, using the Daysy fertility device from 1 January to 30 June, in both 2019 and 2020 (click here or paper). Citation: Haile L, van de Roemer N, Gemzell-Danielsson K, Perelló Capó J, Lete Lasa I, Vannuccini S, Koch MC, Hildebrandt T, Calaf J. The global pandemic and changes in women’s reproductive health: an observational study. Eur J Contracept Reprod Health Care. 2022 Jan 18:1-5. doi: 10.1080/13625187.2021.2024161. Epub ahead of print. PMID: 35040737.

26 January 2022 – GP 16 to 22 added. GP 13 transferred to vaccines & fertility (click here)

Gynae paper 22 – vaccine response in 36 women with ovarian cancer

Centres not reported, but approved by the research ethics committee of Alexandra Hospital, Athens, Greece (click here or paper). Citation: Liontos, M.; Terpos, E.; Markellos, C.; Zagouri, F.; Briasoulis, A.; Katsiana, I.; Skafida, E.; Fiste, O.; Kunadis, E.; Andrikopoulou, A.; Kaparelou, M.; Koutsoukos, K.; Gavriatopoulou, M.; Kastritis, E.; Trougakos, I.P.; Dimopoulos, M.-A. Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP Inhibitors. Vaccines 2021, 9, 1148. https://doi.org/10.3390/vaccines9101148

Gynae paper 21 – 46 cases from Argentina

Women, aged 21–41, undergoing assisted reproductive technology procedures between November 2020 and April 2021 at the following clinics; PREGNA Medicina Reproductiva, IVI Buenos Aires, Fertilis, and InVitro, all in Buenos Aires (click here or paper). Citation: Herrero Y, Pascuali N, Velázquez C, Oubiña G, Hauk V, de Zúñiga I, Peña MG, Martínez G, Lavolpe M, Veiga F, Neuspiller F, Abramovich D, Scotti L, Parborell F. SARS-CoV-2 infection negatively affects ovarian function in ART patients. Biochim Biophys Acta Mol Basis Dis. 2022 Jan 1;1868(1):166295. doi: 10.1016/j.bbadis.2021.166295. Epub 2021 Oct 27. PMID: 34718118; PMCID: PMC8550892. – Control study

Gynae paper 20 – 9 couples from Israel

Seven with female partner covid, and two with male partner, teated at Chaim Sheba Medical Center, Ramat Gan, both before the pandemic and after infection (click here or paper). Citation: Orvieto R, Segev-Zahav A, Aizer A. Does COVID-19 infection influence patients’ performance during IVF-ET cycle?: an observational study. Gynecol Endocrinol. 2021 Oct;37(10):895-897. doi: 10.1080/09513590.2021.1918080. Epub 2021 May 11. PMID: 33974475.

Gynae paper 19 – case report from Turkey

From author affiliations the Atasehir Memorial IVF Center, Istanbul (click here or paper). Citation: Demirel C, Tulek F, Celik HG, Donmez E, Tuysuz G, Gökcan B. Failure to Detect Viral RNA in Follicular Fluid Aspirates from a SARS-CoV-2-Positive Woman. Reprod Sci. 2021 Aug;28(8):2144-2146. doi: 10.1007/s43032-021-00502-9. Epub 2021 Feb 22. PMID: 33616884; PMCID: PMC7899067.

Gynae paper 18 – 2 case reports from Spain

From author affiliations the Clinica EUGIN, Carrer de Balmes 236, Barcelona (click here or paper). Citation: Barragan M, Guillén JJ, Martin-Palomino N, Rodriguez A, Vassena R. Undetectable viral RNA in oocytes from SARS-CoV-2 positive women. Hum Reprod. 2021 Jan 25;36(2):390-394. doi: 10.1093/humrep/deaa284. PMID: 32998162; PMCID: PMC7543480.

Gynae paper 18 – 9 cases from Israel

See vaccination source 23 here.

Gynae paper 17 – 14 cases from France

From the ART unit of Tenon Hospital, Paris, between June and December 2020 (click here or paper). Citation: Kolanska K, Hours A, Jonquière L, Mathieu d’Argent E, Dabi Y, Dupont C, Touboul C, Antoine JM, Chabbert-Buffet N, Daraï E. Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART. Reprod Biomed Online. 2021 Dec;43(6):1117-1121. doi: 10.1016/j.rbmo.2021.09.001. Epub 2021 Sep 10. PMID: 34711516; PMCID: PMC8432972.

Gynae paper 16 – 70 cases from China

From the Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology between May 2020 and February 2021 (click here or paper). Citation: Wang M, Yang Q, Ren X, Hu J, Li Z, Long R, Xi Q, Zhu L, Jin L. Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study. EClinicalMedicine. 2021 Aug;38:101013. doi: 10.1016/j.eclinm.2021.101013. Epub 2021 Jul 6. PMID: 34250457; PMCID: PMC8259363.

25 January 2022 – GP 15 added

Gynae paper 15 – 78 cases from China

Women of reproductive age with Covid between January 28 and March 8, 2020 from Tongji Hospital in Wuhan (click here or paper). Citation: Ding T, Wang T, Zhang J, Cui P, Chen Z, Zhou S, Yuan S, Ma W, Zhang M, Rong Y, Chang J, Miao X, Ma X, Wang S. Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study. Front Med (Lausanne). 2021 Mar 19;8:635255. doi: 10.3389/fmed.2021.635255. PMID: 33816526; PMCID: PMC8017139.

7 January 2022 – GP 14 added

Gynae paper 14 – vaccination & menstrual cycle length

US resident participants enrolled in the fertility-awareness application “Natural Cycles”, who recorded menstrual cycle data from October 2020 to September 2021, and were vaccinated between December 2020 and July 2021, and an unvaccinated control group (click here or paper). Citation: Edelman, Alison MD, MPH; Boniface, Emily R. MPH; Benhar, Eleonora PhD; Han, Leo MD, MPH; Matteson, Kristen A. MD, MPH; Favaro, Carlotta PhD; Pearson, Jack T. PhD; Darney, Blair G. PhD, MPH Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination, Obstetrics & Gynecology: January 5, 2022 – Volume – Issue – 10.1097/AOG.0000000000004695 doi: 10.1097/AOG.0000000000004695

23 December – GP 13 added

Gynae paper 13 – no effect of mRNA vaccine on AMH levels

129 women given two doses of the Pfizer-BioNTech vaccine (click here or paper). Citation: Mohr-Sasson A, Haas J, Abuhasira S, Sivan M, Amdurski HD, Dadon T, Blumenfeld S, Derazne E, Hemi R, Orvieto R, Afek A, Rabinovici J. The effect of Covid-19 mRNA vaccine on serum anti-Müllerian hormone levels. Hum Reprod. 2021 Dec 22:deab282. doi: 10.1093/humrep/deab282. Epub ahead of print. PMID: 34935913. 26 January update – transferred to Covid-19 vaccines, pregnancy & fertility, source 95 (click here).

13 December – GP 12 added

Gynae paper 12 – 8,538 vaccinated women

Volunteers participating in The Covid-19 Pandemic and Women’s Reproductive Health registry (click here or paper). Citation: Alexandra Alvergne, Gabriella Kountourides, Austin Argentieri, Lisa Agyen, Natalie Rogers, Dawn Knight, Gemma C Sharp, Jacqueline A Maybin , Zuzanna Olszewska. COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study. MedRxiv posted December 6, 2021

30 November – GP 10 and 11 added

Gynae paper 11 – RCT of estadiol Rx in post menopausal women with Covid in India

Recruited at the Government Institute of Medical Sciences, Greater Noida, from September 10 to December 31, 2020 (click here or paper). Citation: Seth S, Sharma R, Mishra P, Solanki HK, Singh M, Singh M. Role of Short-Term Estradiol Supplementation in Symptomatic Postmenopausal COVID-19 Females: A Randomized Controlled Trial. J Midlife Health. 2021 Jul-Sep;12(3):211-218. doi: 10.4103/jmh.JMH_57_21. Epub 2021 Oct 16. PMID: 34759703; PMCID: PMC8569453.

Gynae paper 10 – 14 cases undergoing ART in France

From Tenon Hospital, Paris (click here or paper). Citation: Kolanska K, Hours A, Jonquière L, Mathieu d’Argent E, Dabi Y, Dupont C, Touboul C, Antoine JM, Chabbert-Buffet N, Daraï E. Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART. Reprod Biomed Online. 2021 Sep 10:S1472-6483(21)00431-4. doi: 10.1016/j.rbmo.2021.09.001. Epub ahead of print. PMID: 34711516; PMCID: PMC8432972.

18 November – GP 8 and 9 added

Gynae paper 9 – case report (ectopic & Covid) from USA

From University of Miami, Health Systems, Jackson Memorial Hospital, Miami, Florida (click here or paper). Citation: Millan NM, Morano J, Florez L, Carugno J, Medina CA. Management of tubal ectopic pregnancy with methotrexate in the setting of symptomatic Coronavirus disease 2019 (COVID-19): A case report. Facts Views Vis Obgyn. 2021 Sep;13(3):277-281. doi: 10.52054/FVVO.13.3.030. PMID: 34555882.

Gynae paper 8 – Case report (ectopic & Covid) from Japan

From Gifu Prefectural Tajimi Hospital (click here or paper). Citation: Hayashi S, Takeda A. Gasless laparoendoscopic single-site surgery for management of unruptured tubal pregnancy in a woman with moderate COVID-19 pneumonia after administration of remdesivir and casirivimab-imdevimab: A case report. Case Rep Womens Health. 2022 Jan;33:e00368. doi: 10.1016/j.crwh.2021.e00368. Epub 2021 Nov 11. PMID: 34786352; PMCID: PMC8580554.

9 November – GP 7 added

Gynae paper 7 – Endometriosis survey from Italy

468 women diagnosed with endometriosis at Dipartimento di Scienze Mediche e Chirurgiche, Sant’Orsola-Malpighi Hospital, University of Bologna, and surveyed in May 2020 (click here or paper). Citation: Arena A, Orsini B, Degli Esposti E, Raimondo D, Lenzi J, Verrelli L, Iodice R, Casadio P, Seracchioli R. Effects of the SARS-CoV-2 pandemic on women affected by endometriosis: a large cross-sectional online survey. Ann Med. 2021 Dec;53(1):1924-1934. doi: 10.1080/07853890.2021.1991589. PMID: 34714186; PMCID: PMC8567944.

1 November 2021

Gynae paper 6 – 507 women with, & 520 without, endometriosis in Iran

No difference in rates or severity of Covid (click here or paper). A case–control study at Pars general hospital, Tehran, from May 21st to July 3rd, 2020. Citation: Moazzami B, Chaichian S, Samie S, Zolbin MM, Jesmi F, Akhlaghdoust M, Pishkuhi MA, Mirshafiei ZS, Khalilzadeh F, Safari D. Does endometriosis increase susceptibility to COVID-19 infections? A case-control study in women of reproductive age. BMC Womens Health. 2021 Mar 22;21(1):119. doi: 10.1186/s12905-021-01270-z. PMID: 33752656; PMCID: PMC7983080.

Gynae paper 5 – Haemothorax after IVF & Covid

From Conceber Centro de Medicina Reprodutiva, Curitiba, Paraná, Brazil (click here or paper). Citation: Rahal D, Kozlowski IF, Rosa VBD, Schuffner A. Hemothorax after oocyte retrieval in a patient with a history of COVID-19: a case report. JBRA Assist Reprod. 2021 Oct 4;25(4):647-649. doi: 10.5935/1518-0557.20210043. PMID: 34415132; PMCID: PMC8489828.

Gynae paper 4 – Covid, menopause & hormone therapy

Covid was more common among postmenopausal women and, within the latter group, more common among those taking menopausal hormone therapy (click here or paper). Women using the “Zoe” Covid Symptom Study app. Citation: Costeira R, Lee KA, Murray B, Christiansen C, Castillo-Fernandez J, Ni Lochlainn M, et al. (2021) Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study. PLoS ONE 16(9): e0257051. https://doi.org/10.1371/journal.pone.0257051

Gynae paper 3 – 237 women with Covid from China

Women aged 18 to 45 with confirmed COVID-19 who were hospitalized in Tongji Hospital, Wuhan, from 19 January to 1 April 2020 (click here or paper). Citation: Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, Lee S, Wang C, Li H, Cheng L, Ai J. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 2021 Jan;42(1):260-267. doi: 10.1016/j.rbmo.2020.09.020. Epub 2020 Sep 29. PMID: 33288478; PMCID: PMC7522626.

Gynae paper 2 – Mobile app ovulation & menstruation

No overall changes before and during pandemic in 214,426 cycles from 18,076 app users, primarily from Great Britain (29.3%) and the United States (22.6%) (click here or paper). Women using the “Natural Cycles” mobile app. Citation: Nguyen BT, Pang RD, Nelson AL, Pearson JT, Benhar Noccioli E, Reissner HR, Kraker von Schwarzenfeld A, Acuna J. Detecting variations in ovulation and menstruation during the COVID-19 pandemic, using real-world mobile app data. PLoS One. 2021 Oct 20;16(10):e0258314. doi: 10.1371/journal.pone.0258314. PMID: 34669726; PMCID: PMC8528316.

Gynae paper 1 – Menstrual symptoms in 127 self-selected women with Covid

From the Arizona CoVHORT study (click here or paper). Citation: Khan SM, Shilen A, Heslin KM, Ishimwe P, Allen AM, Jacobs ET, Farland LV. SARS-CoV-2 infection and subsequent changes in the menstrual cycle among participants in the Arizona CoVHORT Study. Am J Obstet Gynecol. 2021 Sep 20:S0002-9378(21)01044-9. doi: 10.1016/j.ajog.2021.09.016. Epub ahead of print. PMID: 34555320; PMCID: PMC8452349.

Jim Thornton, Keelin O’Donoghue & Kate Walker

Identical FSH & LH values at baseline in two different trials

August 1, 2021

My first PubPeer comment

As anyone who’s tried to expose fraudulent research by writing a “letter to the editor” will know, it can be fustrating. Editors prevaricate, authors obfuscate, and time ticks by.

PubPeer (click here) is an alternative. Publish the facts, let the author reply, and readers, editors, regulators and employers can judge for themselves. If you enter the author’s email when you submit, PubPeer automatically notifies them that one of their papers has been commented on.

It has been a powerful way to expose fabricated laboratory research, where authors have manipulated images. It can also be used for fabricated clinical studies.

To protect whistleblowers, comments can be anonymous – they just need to stick to verifiable facts – but I’ll be signing mine. Here’s my first. To read it on PubPeer (click here).

It refers to this paper:

Rezk M, Shaheen AE, Saif El-Nasr I. Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial. Gynecol Endocrinol. 2018 Apr;34(4):298-300. doi: 10.1080/09513590.2017.1395838. Epub 2017 Oct 27. PMID: 29076376.

Table 1 has identical values for FSH and LH as Table 1 in a different paper in the same journal from 2016.

Rezk M, Sayyed T, Saleh S. Impact of unilateral versus bilateral laparoscopic ovarian drilling on ovarian reserve and pregnancy rate: a randomized clinical trial. Gynecol Endocrinol. 2016;32(5):399-402. doi: 10.3109/09513590.2015.1124262. Epub 2015 Dec 15. PMID: 26670076.

Present paper
file

Rezk et al 2016
file
The earlier paper reported a trial comparing two surgical treatments with 105 participants, and the present paper a trial of two medical treatments with 202 participants. The earlier paper recruited “from October 2014 to July 2015”. The present paper recruited “between the middle of October 2016 and the beginning of May 2017”. The later paper does not reference the earlier one.

Both have the same first author, and originate from Menoufia university, Egypt.

Jim Thornton

Why use ripe-tomato as a Covid in pregnancy source?

July 30, 2021

People often ask us “What’s different about ripe-tomato? Why not use WHO (click here), Cochrane (click here), or PubMed (click here) Covid-19 databases instead?”

Serious systematic reviewers, or guideline authors, should indeed use all those. But it will be a lot of work, searching, accessing, reading and deduplicating.

Ripe-tomato has done it for you, for primary sources in pregnancy. It isn’t perfect, but we’ve not missed much. Friends and colleagues soon tell us if we have!

But haven’t the WHO/Cochrane Living Systematic Review (LSR) team and Johns Hopkins each done the work too? Yes and no.

Shakila Thangiratinam and her WHO/Cochrane LSR team (click here) have a more complete, and better indexed, database. Dozens of people update it full time – and check ripe-tomato. But it’s not publicly accessible. The reference lists and appendices of their publications reveal the sources they used, but they keep the master database to themselves.

Johns Hopkins Center for Humanitarian Health has two related repositories. COVID-19, Maternal and Child Health, and Nutrition (click here) and COVID-19, Breastfeeding, Infant Feeding, and Breast Milk (click here). Both broader in topic than ripe-tomato and not limited to primary sources. Update 1 May 2021. The two John Hopkins repositories ceased updates from 30 April. They remain publicly available but are no longer updated.

Ripe-tomato’s unique features

Primary sources only. Anyone whose ever studied Covid-19 realises that secondary sources, reviews, editorials, comments and opinion pieces outnumber the primary sources many times. Not on ripe-tomato.org

Duplicate publications noted. Another major problem for all Covid evidence synthesisers. If you’re writing a review, creating a reference list for an article, or refereeing a paper on Covid-19 in pregnancy, ripe-tomato is your friend. We’ve caught and recorded most of the obvious duplicates. Use us.

Easy access. Some sources are behind paywalls, and some difficult to access. Don’t ask how we do it. But where possible, beside a link to the source website, we also provide a direct link to our own uploaded copy.

Newspaper reports (click here). A deduplicated list of primary newspaper stories about people with Covid-19 in pregnancy. From Italy’s “patient one”, the partner of Juventus footballer, Daniele Rugani, and the wife of the British Prime Minster, to a transgender man who caught Covid during his pregnancy. The list of nearly 700 heartbeaking and heartwarming stories is unique. It’s not complete – English language reports are over represented – but there’s nothing else like it in the world.

Click here for Ripe-tomato.org’s Covid-19 in pregnancy navigation page.

Jim Thornton

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