Primary clinical sources

In roughly reverse order. Updated regularly. Click here for ripe-tomato.org’s Covid-19 in pregnancy navigation page.  Curated by Jim Thornton, Keelin O’Donoghue & Kate Walker.

Ongoing update rules. Studies added in the order in which we find them. Study numbers never change (but see below). Inadvertent duplicates deleted. Each study report contains a link to original report, pdf, and full citation. Country, state and city recorded only once for ease of counting.  From February 1st 2021 we will selectively report laboratory studies of stored specimens such as sera and placentae. Such studies are important, but unless they also purport to report original clinical data, there is less need to note duplicate reporting.

Occasional [important] studies include early series, reliable registries, high-quality therapeutic trials in pregnancy (none yet), or basic science.

4 April 2022 – From today we are no longer attempting completeness. We will continue to add papers which seem important. Prior to 4 April we will add all primary sources of which we are aware.

Update 31 July – study 1052 added

Study 1052 – 2,058 cases from India

From BYL Nair Charitable Hospital, Mumbai, and including 318 cases from 18th December 2021 to 24th February 2022, the Omicron wave (click here or study). Citation: Mahajan NN, Kesarwani S, Salunke C, Kumbhar P, Yenkure P, Shaikh J, Shikhare S, Mahale SD, Sachdeva G, Gajbhiye RK. Clinical presentation, pregnancy complications and outcomes of pregnant women with COVID-19 during the Omicron dominant third wave in Mumbai, India. Int J Gynaecol Obstet. 2022 Jul 21. doi: 10.1002/ijgo.14348. Epub ahead of print. PMID: 35861246.

Update 5 June – study 1051 added.

Study 1051 – Infected placentae in the Omicron era in USA

From Northwestern Prentice Women’s Hospital, Chicago, Illinois (click here or study). Citation: Shanes ED, Miller ES, Otero S, Ebbott R, Aggarwal R, Willnow AS, Ozer EA, Mithal LB, Goldstein JA. Placental Pathology After SARS-CoV-2 Infection in the Pre-Variant of Concern, Alpha / Gamma, Delta, or Omicron Eras. Int J Surg Pathol. 2022 May 29:10668969221102534. doi: 10.1177/10668969221102534. Epub ahead of print. PMID: 35645148; PMCID: PMC9152633.

Update 4 May – studies 1049 and 1050 added

Study 1050 – 59 cases of placentitis from UK

From ten centres between March 2020 and March 2021 (click here or study). Citation: Stenton S, McPartland J, Shukla R, Turner K, Marton T, Hargitai B, Bamber A, Pryce J, Peres CL, Burguess N, Wagner B, Ciolka B, Simmons W, Hurrell D, Sekar T, Moldovan C, Trayers C, Bryant V, Palm L, Cohen MC. SARS-COV2 placentitis and pregnancy outcome: A multicentre experience during the Alpha and early Delta waves of coronavirus pandemic in England. EClinicalMedicine. 2022 May;47:101389. doi: 10.1016/j.eclinm.2022.101389. Epub 2022 Apr 15. PMID: 35465646; PMCID: PMC9012107.[important]

Study 1049 – 6,012 cases from Canada

From the CANCOVID-Preg observational surveillance program between March 2020 and October 2021 (click here or study). Citation: McClymont E, Albert AY, Alton GD, Boucoiran I, Castillo E, Fell DB, Kuret V, Poliquin V, Reeve T, Scott H, Sprague AE, Carson G, Cassell K, Crane J, Elwood C, Joynt C, Murphy P, Murphy-Kaulbeck L, Saunders S, Shah P, Snelgrove JW, van Schalkwyk J, Yudin MH, Money D; CANCOVID-Preg Team. Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes. JAMA. 2022 May 2. doi: 10.1001/jama.2022.5906. Epub ahead of print. PMID: 35499852.[important, control group]

Update 10 April – study 1048 added

Study 1048 – 77 self-reported cases from UK

From the COVID-19 Contraception and Pregnancy Study (CAP-COVID) an on-line survey study collecting longitudinal data from pregnant women in the UK between 21st May and 31st December, 2020 (click here or study). Citation: Neerujah Balachandren, Melanie C Davies, Jennifer A Hall, Judith M Stephenson, Anna L David, Geraldine Barrett, Helen C O’Neill, George B Ploubidis, Ephia Yasmin, Dimitrios Mavrelos, SARS-CoV-2 infection in the first trimester and the risk of early miscarriage: a UK population-based prospective cohort study of 3041 pregnancies conceived during the pandemic, Human Reproduction, 2022;, deac062, https://doi.org/10.1093/humrep/deac062

Update 7 April – study 1047 added

Study 1047 – Maternal death from Iran

From Hamadan University of medical sciences (click here or study). Citation: Ghelichkhani, S, Masoumi, SZ, Jalili, E, Parsapour, H, Ali Shirzadeh, A. Maternal death due to COVID-19 and high BMI: A case report from Hamadan, Iran. Clin Case Rep. 2022; 10:e05704. doi:10.1002/ccr3.5704

Update 4 April – studies 1041 to 1046 added

Study 1046 – case report from Japan

From Ibaraki Prefectural Central Hospital, Kasama (click here or study). Citation: Akine D, Sasahara T, Koido A, Abe K, Abe K, Oki A, Takeyasu N, Hashimoto I. Case of a pregnant woman with probable prolonged SARS-CoV-2 viral shedding 221 days after diagnosis. J Infect Chemother. 2022 Mar 28:S1341-321X(22)00091-5. doi: 10.1016/j.jiac.2022.03.012. Epub ahead of print. PMID: 35367149.

Study 1045 – 165 cases from Greece

From various centres (click here or study). Citation: Konstantinidou, A.E., Angelidou, S., Havaki, S., Paparizou, K., Spanakis, N., Chatzakis, C., Sotiriadis, A., Theodora, M., Donoudis, C., Daponte, A., Skaltsounis, P., Gorgoulis, V., Papaevangelou, V., Kalantaridou, S. and Tsakris, A. (2022), Stillbirth due to SARS-CoV-2 placentitis without evidence of intrauterine transmission to fetus: association with maternal risk factors. Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.24906

Study 1044 – 19 cases from Spain

Collected between March 15 and May 31, 2020, from Barcelona (click here or study). Citation: PALOMO M, YOUSSEF L, RAMOS A, TORRAMADE-MOIX S, Belen MORENO-CASTAÑO A, MARTINEZ-SANCHEZ J, BONASTRE L, PINO M, GOMEZ-RAMIREZ P, MARTIN L, MATEOS EG, SANCHEZ P, FERNANDEZ S, CROVETTO F, ESCOLAR G, CARRERAS E, CASTRO P, GRATACOS E, CRISPI F, DIAZ-RICART M, Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy, American Journal of Obstetrics and Gynecology (2022), doi: https://doi.org/10.1016/j.ajog.2022.03.048.

Study 1043 – 10 cases of ECMO from Kuwait

From Al-Jahra ECMO center (click here or study). Citation: Mohammed Bamasood O, Shamsah M, Alfoudri H, Bitar Z, Al Shammari FR, Jagadeesan J, Raj Pandian V, Elkenany Y, Alsarraf AH, Almutawa A, Kh Abdullah T, Mahmoud Ibrahim Mahmoud M. Extracorporeal Membrane Oxygenation in Pregnant Women With COVID-19. ASAIO J. 2022 Apr 1;68(4):471-477. doi: 10.1097/MAT.0000000000001646. PMID: 35349521.

Study 1042 – 155 cases from UK

Underuse of corticosteroids in pregnancy (click here or study). Citation: Närhi F, Moonesinghe SR, Shenkin SD, Drake TM, Mulholland RH, Donegan C, Dunning J, Fairfield CJ, Girvan M, Hardwick HE, Ho A, Leeming G, Nguyen-Van-Tam JS, Pius R, Russell CD, Shaw CA, Spencer RG, Turtle L, Openshaw PJM, Baillie JK, Harrison EM, Semple MG, Docherty AB; ISARIC4C investigators. Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. Lancet Digit Health. 2022 Apr;4(4):e220-e234. doi: 10.1016/S2589-7500(22)00018-8. PMID: 35337642; PMCID: PMC8940185.

Study 1041 – Omicron variant in USA

From Parkland Health, Dallas, Texas (click here or study). Citation: Adhikari EH, MacDonald L, SoRelle JA, Morse J, Pruszynski J, Spong CY. COVID-19 Cases and Disease Severity in Pregnancy and Neonatal Positivity Associated With Delta (B.1.617.2) and Omicron (B.1.1.529) Variant Predominance. JAMA. 2022 Mar 24. doi: 10.1001/jama.2022.4356. Epub ahead of print. PMID: 35325015.

Update 11 March – studies 1038 to 1040 added

Study 1040 – 34 cases from USA

From John H. Stroger, Jr. Hospital, Cook County, and AMITA Health Saints Mary and Elizabeth Medical Center, Chicago, between April 1 and August 15, 2020 (click here or study). Possible overlap with study 391, and may include the case reported in study 979. Citation: Peter B, Ree N, Ferrer K, Younes L, Lepe B, Manhal K, Mydam J. Risk Factors Associated With COVID-19 Symptoms and Potential Vertical Transmission During Pregnancy: A Retrospective Cohort Study. Cureus. 2022 Mar 6;14(3):e22900. doi: 10.7759/cureus.22900. PMID: 35265437; PMCID: PMC8898701.

Study 1039 – 208 cases from Ukraine

From Maternity Hospital №1 in Lviv, and Danylo Halytsky Lviv National Medical University, neither of which have previously reported cases (abstract only click here or here, or study). Citation: Markin L, Fartushok T, Mrochko Y, Pidhirnyj Y. MANAGEMENT OF PREGNANT WOMEN WITH COVID-19 – OWN EXPERIENCE. Georgian Med News. 2022 Feb;(323):38-47. PMID: 35271469.

Study 1038 – 2,252 cases from Canada

Pregnant women from Ontario with test dates between March 16, 2020, and January 4, 2022 (click here or study). Citation: Kiera R. Murison, Alicia A. Grima, Alison E. Simmons, Ashleigh R. Tuite, David N. Fisman. Severity of SARS-CoV-2 Infection in Pregnancy in Ontario: A Matched Cohort Analysis. medRxiv 2022.03.04.22271915; doi: https://doi.org/10.1101/2022.03.04.22271915

Update 10 March – study 1037 added

Study 1037 – 1,561 cases from UK

Pregnant women admitted to hospital with covid-19 between 15th December 2021 and 14th January 2022, the period when the omicron variant was dominant (click here or study). These cases have not been included in previous UKOSS reports. Citation: Hilde Marie Engjom, Rema Ramakrishnan, Nicola Vousden, Kathryn Bunch, Edvard P Morris, Nigel Simpson, Christopher Gale, Pat OBrien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk, Marian Knight. Severity of maternal SARS-CoV-2 infection and perinatal outcomes during the Omicron variant dominant period: UK Obstetric Surveillance System national cohort study. medRxiv 2022.03.07.22271699; doi: https://doi.org/10.1101/2022.03.07.22271699 [important]

Update 4 March – studies 1035 and 1036 added. These two studies report the identical cohort (personal communication Marian Knight).

Study 1036 – 4,436 cases from UK

From UKOSS, pregnant women admitted to hospital with covid-19 related symptoms (click here or study). Citation: Vousden, NP, Ramakrishnan, R, Bunch, K, et al. Management and implications of severe COVID-19 in pregnancy in the UK: data from the UK Obstetric Surveillance System national cohort. Acta Obstet Gynecol Scand. 2022; 00: 1– 10. doi: 10.1111/aogs.14329

Study 1035 – 4,436 cases from UK

From UKOSS, pregnant women admitted to hospital with covid-19 related symptoms (click here or study). Overlap with previous UKOSS publications. Citation: Vousden N, Ramakrishnan R, Bunch K, et al. Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study BMJ Medicine 2022;1:e000053. doi: 10.1136/bmjmed-2021-000053

Update 3 March – study 1034 added

Study 1034 – 135 omicron wave cases from Turkey & UK

From Sancaktepe Training and Research Hospital, and Koc University Hospital, Istanbul, and St. George’s University Hospital, London, between December 27, 2021 and 01 February 2022 (click here or study). Citation: Birol Ilter, P., Prasad, S., Berkkan, M., Mutlu, M.A., Tekin, A.B., Celik, E., Ata, B., Turgal, M., Yildiz, S., Turkgeldi, E., O’Brien, P., Dadelszen, P.v., Magee, L.A., Kalafat, E., Tug, N. and Khalil, A. (2022), Clinical severity of SARS-CoV-2 infection among vaccinated and unvaccinated pregnancies during the Omicron wave. Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.24893

Update 23 February – study 1033 added

Study 1033 – 30 cases from France

From Nord Franche-Comté Hospital, Trevenans, which has not previously reported cases (click here or study). Zayet S, Gendrin V, Gay C, Selles P, Klopfenstein T. Increased COVID-19 Severity among Pregnant Patients Infected with SARS-CoV-2 Delta Variant, France. Emerg Infect Dis. 2022 Feb 18;28(5). doi: 10.3201/eid2805.212080. Epub ahead of print. PMID: 35180376.

Update 22 February – studies 1029 to 1032 added

Study 1032 – case from USA

From Northwell Health, Great Neck, New York (click here or study). Citation: Wang KY, Shah P, Pierce M. Convalescent plasma for COVID-19 complicated by ARDS due to TRALI. BMJ Case Rep. 2021 Jan 28;14(1):e239762. doi: 10.1136/bcr-2020-239762. PMID: 33509890; PMCID: PMC7844928.

Study 1031 – case from Saudi Arabia

From Al-Imam Abdulrahman Al-Faisal Hospital, Riyadh (click here or study). Citation: Alhamoud AH, Matary F, Bukhari S, Kelantan M, Bajahzer M. Outcomes of an In Vitro Fertilization Pregnancy With COVID-19 and the Perinatal Outcome in Riyadh, Saudi Arabia. Cureus. 2020 Dec 26;12(12):e12296. doi: 10.7759/cureus.12296. PMID: 33510990; PMCID: PMC7831387.

Study 1030 – case from Italy

From Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan (click here or study). Citation: Giavoli C, Iurlaro E, Morelli V, Rodari G, Ronchi A, Pietrasanta C, Pugni L, Tubiolo D, Properzi P, Pesenti A, Mantovani G, Ferrazzi E, Arosio M. Case Report: Late-Onset Congenital Adrenal Hyperplasia and Acute Covid-19 Infection in a Pregnant Woman: Multidisciplinary Management. Front Endocrinol (Lausanne). 2021 Jan 15;11:602535. doi: 10.3389/fendo.2020.602535. PMID: 33519712; PMCID: PMC7845779.

Study 1029 – case from Italy

From University of Campania “Luigi Vanvitelli”, Naples (click here or study). Citation: Sisti G, Schiattarella A, Sisti A. Treatment of COVID-19 in Pregnancy with Hydroxychloroquine and Azithromycin: a case report. Acta Biomed. 2020 Jul 16;91(4):e2020123. doi: 10.23750/abm.v91i4.10216. PMID: 33525254; PMCID: PMC7927503.

Update 21 February – studies 1026 to 1028 added

Study 1028 – case from USA

From Greater Baltimore Medical Center, Towson, Maryland (click here or study). Citation: Dande R, Qureshi A, Persaud K, Puri C, Zulfiqar S, Awasthi S. Remdesivir in a pregnant patient with COVID-19 pneumonia. J Community Hosp Intern Med Perspect. 2021 Jan 26;11(1):103-106. doi: 10.1080/20009666.2020.1857510. PMID: 33552429; PMCID: PMC7850401.

Study 1027 – case from Spain

From Hospital 12 de Octubre, Madrid (click here or study). Citation: Carbayo-Jiménez T, Carrasco-Colom J, Epalza C, Folgueira D, Pérez-Rivilla A, Barbero-Casado P, Blázquez-Gamero D, Galindo-Izquierdo A, Pallás-Alonso C, Moral-Pumarega MT. Severe Acute Respiratory Syndrome Coronavirus 2 Vertical Transmission from an Asymptomatic Mother. Pediatr Infect Dis J. 2021 Mar 1;40(3):e115-e117. doi: 10.1097/INF.0000000000003028. PMID: 33565817.

Study 1026 – case from Denmark

From Landssygehuset, Tórshavn (click here or study). Citation: Ravn A, Eysturoy A, Reynstind D, Nielsen CM, Walther-Larsen S. [Preterm delivery by cesarean section in a woman with severe COVID-19 pneumonia]. Ugeskr Laeger. 2021 Feb 1;183(5):V10200779. Danish. PMID: 33570033.

Update 20 February – studies 1016 to 1025 added

Study 1025 – miscarriage in Morocco

From Centre Hospitalier Universitaire Hassan II, Fès, (click here or study). Citation: Saoud MK, Lamsyah S, Mamouni N, Errarhay S, Bouchikhi C, Banani A. Fausse couche de 8 semaines d´aménorrhée chez une patiente positive au virus SARS-CoV-2 [8 amenorrhea week miscarriage in a patient positive for the SARS-CoV-2 virus]. Pan Afr Med J. 2020 Oct 22;37(Suppl 1):26. French. doi: 10.11604/pamj.supp.2020.37.26.23445. PMID: 33456650; PMCID: PMC7796836.

Study 1024 – case from China

From Zhongshan City People’s Hospital, Zhongshan, (click here or study). Likely also reported in studies 3, 57, 81, 192, 433, 493 and 974. Citation: Liao X, Cheng Z, Wen J, Li B. A Case Report of Sedation Strategy for a Patient With Coronavirus Disease 2019 Supported by Extracorporeal Membrane Oxygenation After Cesarean Section. Heart Surg Forum. 2021 Jan 14;24(1):E019-E021. doi: 10.1532/hsf.3459. PMID: 33635242.

Study 1023 – case from USA

From Tampa General Hospital, Florida (click here or study). Citation: Clough BM. Triple Threat: Postpartum, Coronavirus Disease 2019 Positive, and Requiring Extracorporeal Membrane Oxygenation. Air Med J. 2021 Mar-Apr;40(2):124-126. doi: 10.1016/j.amj.2020.12.009. Epub 2021 Jan 2. PMID: 33637276; PMCID: PMC7834374.

Study 1022 – case from UK

From Blackpool Victoria Hospital (click here or study). Citation: George H, Mutema E. A COVID 19 positive preterm mother and infant: a case report. J Obstet Gynaecol. 2021 Nov;41(8):1262-1264. doi: 10.1080/01443615.2020.1863343. Epub 2021 Mar 1. PMID: 33645405.

Study 1021 – case from Iran

From RobatKarim Hospital, Tehran, (click here or study). Citation: Aminimoghaddam S, Afrooz N, Nasiri S, Motaghi Nejad O, Mahmoudzadeh F. A COVID-19 pregnant patient with thrombotic thrombocytopenic purpura: a case report. J Med Case Rep. 2021 Mar 1;15(1):104. doi: 10.1186/s13256-020-02577-5. PMID: 33648584; PMCID: PMC7919244.

Study 1020 – case from India

DFrom Dr TMA Pai Hospital, Udupi, Karnataka (click here or study). Citation: Kumar V, Narayanan P, Shetty S, Mohammed AP. Lower motor neuron facial palsy in a postnatal mother with COVID-19. BMJ Case Rep. 2021 Mar 1;14(3):e240267. doi: 10.1136/bcr-2020-240267. PMID: 33649026; PMCID: PMC7929834.

Study 1019 – two cases from Mexico

From Mexico city (click here or study). Can’t guess the hospital. Citation: Lima-Rogel V, Villegas-Silva R, Coronado-Zarco A, Estrada-Ruelas I, Vega ARS, Muro-Flores RH, Villa-Guillén M. Perinatal COVID-19: a case report, literature review, and proposal of a national system for case record. Bol Med Hosp Infant Mex. 2021;78(1):34-40. English. doi: 10.24875/BMHIM.20000230. PMID: 33661873.

Study 1018 – case from India

From Amrita Institute of Medical Sciences and Research Centre, Kochi, which has not previously reported cases (click here or study). Citation: Kappanayil M, Balan S, Alawani S, Mohanty S, Leeladharan SP, Gangadharan S, Jayashankar JP, Jagadeesan S, Kumar A, Gupta A, Kumar RK. Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-CoV-2: a case report. Lancet Child Adolesc Health. 2021 Apr;5(4):304-308. doi: 10.1016/S2352-4642(21)00055-9. Epub 2021 Mar 4. PMID: 33675696; PMCID: PMC7929789.

Study 1017 – four cases from Gabon

From Libreville Mother and Child University Hospital, which has not previously reported cases (click here or study). Citation: Minkobame U, Mveang Nzoghe A, Maloupazoa Siawaya AC, Alame-Emane AK, Ndong Sima CAA, Mvoundza Ndjindji O, Zang Eyi C, Ndong Mintsa A, Padzys GS, Meye JF, Djoba Siawaya JF. Case series of SARS-COV-2 infection in pregnant African women: focus on biological features. J Med Virol. 2021 Jul;93(7):4147-4151. doi: 10.1002/jmv.26927. Epub 2021 Mar 26. PMID: 33710650; PMCID: PMC8251219.

Study 1016 – two cases from the Netherlands

From Reiner de Graaf Gasthuis, Delft, and Erasmus University Medical Center, Rotterdam (click here or study). Citation: Smeele HT, Perez-Garcia LF, Grimminck K, Schoenmakers S, Mulders AG, Dolhain RJ. Systemic lupus erythematosus and COVID-19 during pregnancy. Lupus. 2021 Jun;30(7):1188-1191. doi: 10.1177/09612033211002270. Epub 2021 Mar 14. PMID: 33715506; PMCID: PMC8120627.

Update 19 February – studies 1006 to 1015 added

Study 1015 – case from Mexico

From UMARE Reproduction Clinic, Mexico City (click here or study). Citation: Oropeza Chávez L, Sánchez Tinajero Á, Martínez Orozco JA, Becerril Vargas E, Dolores De la Merced A, Ruíz Santillán DP, Delgado Cueva AI, Alvarado Peña N. A 34-Year-Old Woman with a Diamniotic Dichorionic Twin Pregnancy Presenting with an Erythematous and Papular Skin Rash Associated with SARS-CoV-2 Infection. Am J Case Rep. 2021 Mar 20;22:e929489. doi: 10.12659/AJCR.929489. PMID: 33743006; PMCID: PMC7990122.

Study 1014 – case from Spain

From University and Polytechnic La Fe Hospital, Valencia (click here or study). Citation: Martínez-Varea A, Desco-Blay J, Monfort S, Hueso-Villanueva M, Perales-Marín A, Diago-Almela VJ. Transitory Fetal Skin Edema in a Pregnant Patient with a Mild SARS-CoV-2 Infection. Case Rep Obstet Gynecol. 2021 Mar 16;2021:5552877. doi: 10.1155/2021/5552877. PMID: 33763271; PMCID: PMC7962876.

Study 1013 – case from Mexico

From Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City (click here or study). Citation: Valdespino-Vázquez MY, Helguera-Repetto CA, León-Juárez M, Villavicencio-Carrisoza O, Flores-Pliego A, Moreno-Verduzco ER, Díaz-Pérez DL, Villegas-Mota I, Carrasco-Ramírez E, López-Martínez IE, Giraldo-Gómez DM, Lira R, Yocupicio-Monroy M, Rodríguez-Bosch M, Sevilla-Reyes EE, Cortés-Bonilla M, Acevedo-Gallegos S, Merchant-Larios H, Cardona-Pérez JA, Irles C. Fetal and placental infection with SARS-CoV-2 in early pregnancy. J Med Virol. 2021 Jul;93(7):4480-4487. doi: 10.1002/jmv.26965. Epub 2021 Apr 6. PMID: 33764543; PMCID: PMC8250563.

Study 1012 – case from Turkey

From Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul (click here or study). Citation: Tekin AB, Zanapalioglu U, Gulmez S, Akarsu I, Yassa M, Tug N. Guillain Barre Syndrome following delivery in a pregnant woman infected with SARS-CoV-2. J Clin Neurosci. 2021 Apr;86:190-192. doi: 10.1016/j.jocn.2021.01.028. Epub 2021 Feb 2. PMID: 33775326; PMCID: PMC7993757.

Study 1011 – case from Morocco

From Cheikh Khalifa International University Hospital, Casablanca (click here or study). Citation: Aasfara J, Hajjij A, Bensouda H, Ouhabi H, Benariba F. A unique association of bifacial weakness, paresthesia and vestibulocochlear neuritis as post-COVID-19 manifestation in pregnant women: a case report. Pan Afr Med J. 2021 Jan 13;38:30. doi: 10.11604/pamj.2021.38.30.27646. PMID: 33777298; PMCID: PMC7955605.

Study 1010 – case from Russia

From First Moscow State Medical University Named after I.M. Sechenov, Moscow (click here or study). Citation: Sukhikh G, Petrova U, Prikhodko A, Starodubtseva N, Chingin K, Chen H, Bugrova A, Kononikhin A, Bourmenskaya O, Brzhozovskiy A, Polushkina E, Kulikova G, Shchegolev A, Trofimov D, Frankevich V, Nikolaev E, Shmakov RG. Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology. Viruses. 2021 Mar 10;13(3):447. doi: 10.3390/v13030447. PMID: 33801923; PMCID: PMC7999228.

Study 1009 – four cases from India

From Vardhaman Mahavir Medical College & Safdarjung Hospital, New Delhi (click here or study). Citation: Marwah S, Kanwar R, Naghma S, Dabral A, Gupta N. A Clinical Study on Initial Experience of COVID-19 ARDS in Obstetric Patients at a Tertiary Care Centre in India. Case Rep Obstet Gynecol. 2021 Mar 29;2021:5591041. doi: 10.1155/2021/5591041. PMID: 33815855; PMCID: PMC8010524.

Study 1008 – case from Iran

From Mazandaran University of Medical Sciences, Sari (click here or study). Citation: Farhadi R, Mehrpisheh S, Ghaffari V, Haghshenas M, Ebadi A. Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report. J Med Case Rep. 2021 Apr 23;15(1):213. doi: 10.1186/s13256-021-02835-0. PMID: 33892788; PMCID: PMC8063577.

Study 1007 – case from Nepal

From KIST Medical College, and Teaching Hospital, Lalitpur, which has not previously reported cases (click here or study). Citation: Thapa B, Acharya S, Karki S. Vertical Transmission of COVID-19: A Case Report and Review of Literature. J Nepal Health Res Counc. 2021 Apr 23;19(1):203-205. doi: 10.33314/jnhrc.v19i1.3312. PMID: 33934161.

Study 1006 – case from USA

Abstract only (click here or study). Authors affiliated with Fort Worth, Texas and Denver, Colorado. Citation:Harenberg JL, Church R, Tubog TD. Anesthesia Considerations of a Pregnant Woman With COVID-19 Undergoing Cesarean Delivery: A Case Report. AANA J. 2020 Aug;88(4):47-53. PMID: 33944772.

Update 18 February – studies 1001 to 1005 added

Study 1005 – case report from Mexico

From Hospital “Dalinde”, Mexico City (click here or study). Citation: Mendoza-Hernández M, Huerta-Niño de Rivera I, Yoldi-Negrete M, Saviñon-Tejeda P, Franco-Cendejas R, López-Jácome LE, Navarro-Castellanos I. Probable Case of Vertical Transmission of SARS-CoV-2 in a Newborn in Mexico. Neonatology. 2021;118(3):364-367. doi: 10.1159/000514710. Epub 2021 May 6. PMID: 33957638; PMCID: PMC8247818.

Study 1004 – case report from China

From Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, (click here or study). Citation: He JR, Xiao YH, Ding W, Shi YL, He X, Liu XD, Zhang GZ, Li SS, Su JQ, Liang L, Zeng L, Li F, Qiu X. Maternal, placental and neonatal outcomes after asymptomatic SARS-CoV-2 infection in the first trimester of pregnancy: A case report. Case Rep Womens Health. 2021 Jul;31:e00321. doi: 10.1016/j.crwh.2021.e00321. Epub 2021 May 4. PMID: 33968612; PMCID: PMC8095019.

Study 1003 – case report from the Philippines

From Philippine General Hospital, Manila (click here or study). Citation: Garcia JJ, Turalde CW, Bagnas MA, Anlacan VM. Intravenous immunoglobulin in COVID-19 associated Guillain-Barré syndrome in pregnancy. BMJ Case Rep. 2021 May 11;14(5):e242365. doi: 10.1136/bcr-2021-242365. PMID: 33975846; PMCID: PMC8118003.

Study 1003 – two cases from USA

From Danbury Hospital, Connecticut (click here or study). Citation: Ogamba I, Chuang L, Panarelli E, Zilberman D. A case report of COVID-19 infection and management during pregnancy. SAGE Open Med Case Rep. 2021 May 16;9:2050313X211015899. doi: 10.1177/2050313X211015899. PMID: 34035922; PMCID: PMC8132078.

Study 1002 – twin pregnancy from Italy

From University of Bari “Aldo Moro” (click here or study). Citation: Resta L, Vimercati A, Sablone S, Marzullo A, Cazzato G, Ingravallo G, Mazzia G, Arezzo F, Colagrande A, Rossi R. Is the First of the Two Born Saved? A Rare and Dramatic Case of Double Placental Damage from SARS-CoV-2. Viruses. 2021 May 26;13(6):995. doi: 10.3390/v13060995. PMID: 34073492; PMCID: PMC8230224.

Study 1001 – case report from Iran

From Shahid Beheshti University of Medical Sciences, Tehran (click here or study). Citation: Mehrpour M, Arab M, Hadavand F, Khalafi M, Khalafi M. A case report of Guillain-Barré syndrome in a pregnant woman infected by COVID-19. Acta Neurol Belg. 2021 Aug;121(4):1079-1080. doi: 10.1007/s13760-021-01696-0. Epub 2021 Jun 3. PMID: 34080170; PMCID: PMC8172359.

Update 14 February – studies 992 to 1000 added

Study 1000 – one infected mother in South Africa

From University of Botswana, Gaborone (click here or study). Citation: Nakstad B, Kaang T, Gezmu AM, Strysko J. Nosocomial SARS-CoV-2 transmission in a neonatal unit in Botswana: chronic overcrowding meets a novel pathogen. BMJ Case Rep. 2021 Jun 7;14(6):e242421. doi: 10.1136/bcr-2021-242421. PMID: 34099450; PMCID: PMC8186748.

Study 999 – case report from Hong Kong (China)

From Queen Elizabeth hospital (click here or study). Citation: Yeung KSK, Kwok CY, Chow YF. Anaesthesia in a patient with COVID-19 undergoing elective lower segment caesarean section: a case report. Hong Kong Med J. 2021 Jun;27(1):210-212. doi: 10.12809/hkmj208944. Epub 2021 Jun 11. PMID: 34127562.

Study 998 – two cases from India

From Tata Main Hospital, Jamshedpur (click here or study). Possible overlap with studies 650, 950 and 978. Citation: Singh V, Choudhary A. Treatment With Remdesivir in Two Pregnant Patients With COVID-19 Pneumonia. Cureus. 2021 May 12;13(5):e14986. doi: 10.7759/cureus.14986. PMID: 34131531; PMCID: PMC8195547.

Study 997 – two cases from UK

From St Mary’s Hospital, London (click here or study). Citation: Pikovsky M, Tan MY, Ahmed A, Sykes L, Agha-Jaffar R, Yu CKH. Euglycaemic ketoacidosis in pregnant women with COVID-19: two case reports. BMC Pregnancy Childbirth. 2021 Jun 16;21(1):427. doi: 10.1186/s12884-021-03928-w. PMID: 34134652; PMCID: PMC8207493.

Study 996 – case report from UK

From Shrewsbury & Telford hospital (click here or study). Citation: Sanders-Davis LJ, Ritchie J. Appendicitis with concurrent COVID-19 infection in a patient during the third trimester of pregnancy. BMJ Case Rep. 2021 Jun 23;14(6):e242651. doi: 10.1136/bcr-2021-242651. PMID: 34162616; PMCID: PMC8230971.

Study 995 – case report frm USA

From Piedmont Medical Center, Atlanta, Georgia (click here or study). Citation: Roberts J, Cheng JD, Moore E, Ransom C, Ma M, Rogers BB. Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling. Pediatr Dev Pathol. 2021 Nov-Dec;24(6):581-584. doi: 10.1177/10935266211025122. Epub 2021 Jun 28. PMID: 34176361.

Study 994 – case report from China

From Renmin Hospital of Wuhan University (click here or study). Citation: Peng L, Khan S, Ali A, Ahmed S, Ali L, Han G, Jing Y. Vertical transmission potential of SARS-CoV-2 from infected mother to twin neonates. Future Virol. 2021 May:10.2217/fvl-2020-0324. doi: 10.2217/fvl-2020-0324. PMID: 34181703; PMCID: PMC8221022.

Study 993 – case report from Iran

From the Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran,(click here or study). Citation: Shahidi Dadras M, Rakhshan A, Diab R, Abdollahimajd F. SARS-CoV-2 infection as a potential triggering factor for urticarial vasculitis during pregnancy: A case report. Clin Case Rep. 2021 Jun 24;9(6):e04323. doi: 10.1002/ccr3.4323. PMID: 34194805; PMCID: PMC8223884.

Study 992 – 8 cases from Iran

From Besat Hospital, Sanandaj from March to May 2020 (click here or study). Citation: Sheikhahmadi S, Behzadi S, Karimi A, Zakaryaei F. Evaluating Vertical Transmission of COVID-19 from Mothers to Neonates: An Iranian Case Series of 8 Patients. Arch Iran Med. 2021 May 1;24(5):405-408. doi: 10.34172/aim.2021.58. PMID: 34196206.

Update 13 February – studies 953 to 991 added

Study 991 – case report from USA

From University of Texas Health, San Antonio (click here or study). Citation: Pfeiffer AF, James R, Neuhoff BK, Pfeiffer WB, Lowery DR, Rizvi SAA. The Deleterious Effects of COVID-19 in the Peripartum Period: A Case Report. Pediatr Rep. 2021 Jun 16;13(2):334-339. doi: 10.3390/pediatric13020041. PMID: 34208425; PMCID: PMC8293368.

Study 990 – case report from Romania

From “Bucur” Maternity, Saint John Hospital, Bucharest (click here or study). Citation: Lesnic A, Haj Hamoud B, Poenaru MO, Moldovan VT, Chicea R, Sima RM, Popescu M, Ples L. Can SARS-CoV-2 Induce Uterine Vascular Anomalies and Poor Contractile Response?-A Case Report. Medicina (Kaunas). 2021 Jun 29;57(7):670. doi: 10.3390/medicina57070670. PMID: 34209533; PMCID: PMC8303955.

Study 989 – case report from India

From Indraprastha Apollo Hospital, New Delhi (click here or study). Citation: Shankar V, Dhar P, George J, Sharma A, Raj A. Eclampsia and posterior reversible encephalopathy syndrome in a parturient complicated by SARS COVID-19 pneumonia. Braz J Anesthesiol. 2021 Sep-Oct;71(5):576-578. doi: 10.1016/j.bjane.2021.06.008. Epub 2021 Jun 29. PMID: 34214521; PMCID: PMC8239311.

Study 988 – case report from USA

From Rush University Medical Center, Chicago (click here or study). Citation: Testani E, Twiehaus S, Waters T, Pombar X. Conscious prone positioning in a pregnant patient with COVID-19 respiratory distress: A case report and review. Case Rep Womens Health. 2021 Jul;31:e00339. doi: 10.1016/j.crwh.2021.e00339. Epub 2021 Jun 29. PMID: 34221902; PMCID: PMC8239207.

Study 987 – case report from India

Abstract only available on PubMed (click here or study). Citation: Bedi N, Aggarwal P, Dang A, Nigam A. Transplacental COVID Antibodies and Cytokine Storm in Newborn: Presence of Antibodies does not Indicate Protection Always! J Assoc Physicians India. 2021 Jan;69(1):76-77. PMID: 34227782.

Study 986 – case report from Germany

Hospital not named (click here or study). Citation: Ackermann M, Jonigk DD. Microvascular placental alterations in maternal COVID-19. Am J Obstet Gynecol. 2022 Jan;226(1):135-136. doi: 10.1016/j.ajog.2021.06.098. Epub 2021 Jul 3. PMID: 34228972; PMCID: PMC8254388.

Study 985 – 4 maternal deaths in Turkey

From Diyarbakir Gazi Yasargil Research and Training Hospital, Diyarbakır (click here or study). Citation: Bağlı İ, Öcal E, Yavuz M, Uzundere O, Bozkurt F. Maternal deaths due to COVID-19 disease: The cases in a single center pandemic hospital in the south east of Turkey. J Obstet Gynaecol Res. 2021 Nov;47(11):4067-4076. doi: 10.1111/jog.14928. Epub 2021 Jul 12. PMID: 34254718; PMCID: PMC8447164.

Study 984 – case report from Iran

From Ghaem Hospital, Mashhad (click here or study). Citation: Alirezaei S, Vatanchi A, Pourali L, Aminzadeh B, Latifnejad Roudsari R. Mortality of a postpartum woman presented with massive vulvar edema in association with Covid-19: a case report with clinical and radiological findings. BMC Infect Dis. 2021 Jul 13;21(1):678. doi: 10.1186/s12879-021-06175-8. PMID: 34256733; PMCID: PMC8276204.

Study 983 – case report from Turkey

From Zonguldak Bulent Ecevit University, Zonguldak (click here or study). Citation: Akdemir Y, Haciseyitoglu D, Celebi G, Aydemir C, Bahadır B, Cakir AT, Barut A, Ozmen U. Probable viremia and positive placental swabs for SARS-CoV-2 in a preterm pregnant woman with mild COVID-19. J Med Virol. 2021 Dec;93(12):6788-6793. doi: 10.1002/jmv.27202. Epub 2021 Jul 28. PMID: 34260081; PMCID: PMC8426688.

Study 982 – case report from Spain

From Hospital Universitari Vall d’Hebron, Barcelona (click here or study). Citation: Piñana M, Abril JF, Andrés C, Silgado A, Navarro A, Suy A, Sulleiro E, Pumarola T, Quer J, Antón A. Viral populations of SARS-CoV-2 in upper respiratory tract, placenta, amniotic fluid and umbilical cord blood support viral replication in placenta. Clin Microbiol Infect. 2021 Oct;27(10):1542-1544. doi: 10.1016/j.cmi.2021.07.008. Epub 2021 Jul 11. PMID: 34260951; PMCID: PMC8272946.

Study 981 – case report from Qatar

From Hamad Medical Corporation, Doha (click here or study). May be included in studies 364 and 407, but the clinical details differ from studies 577 and 605. Citation: Hailan YMA, Sayed G, Yassin MA. COVID-19 in a pregnant patient with beta-thalassemia major: A case report. Clin Case Rep. 2021 Jul 11;9(7):e04331. doi: 10.1002/ccr3.4331. PMID: 34267898; PMCID: PMC8272935.

Study 980 – two cases from USA

From NYU Langone Hospital, New York (click here or study). Citation: Hanna N, Lin X, Thomas K, Vintzileos A, Chavez M, Palaia T, Ragolia L, Verma S, Khullar P, Hanna I. Underestimation of SARS-CoV-2 infection in placental samples. Am J Obstet Gynecol. 2021 Nov;225(5):572-575.e1. doi: 10.1016/j.ajog.2021.07.010. Epub 2021 Jul 21. PMID: 34297970; PMCID: PMC8294065.

Study 979 – case report from USA

Cared for at AMITA Health, Saints Mary and Elizabeth Medical Center, Chicago (click here or study). Citation: Mydam J, Younes L, Siddiqui M, Tarsha T. Death from COVID-19 in a Hispanic postpartum woman and review of the literature. BMJ Case Rep. 2021 Jul 23;14(7):e242819. doi: 10.1136/bcr-2021-242819. PMID: 34301683; PMCID: PMC8311310.

Study 978 – case report from India

From Tata Main Hospital, Jamshedpur, so possibly also included in studies 650 and 950 (click here or study). Citation: Choudhary A, Singh V, Bharadwaj M, Barik A. Pregnancy With SARS-CoV-2 Infection Complicated by Preeclampsia and Acute Fatty Liver of Pregnancy. Cureus. 2021 Jun 14;13(6):e15645. doi: 10.7759/cureus.15645. PMID: 34306855; PMCID: PMC8279907.

Study 977 – case report from Germany

From Hannover Medical School, Hannover, which has not previously reported cases (click here or study). Citation: Düppers AL, Bohnhorst B, Bültmann E, Schulz T, Higgins-Wood L, von Kaisenberg CS. Severe fetal brain damage subsequent to acute maternal hypoxemic deterioration in COVID-19. Ultrasound Obstet Gynecol. 2021 Sep;58(3):490-491. doi: 10.1002/uog.23744. PMID: 34319630; PMCID: PMC8441859.

Study 976 – case report from India

From Military Hospital Kirkee, Pune, which has not previously reported cases (click here or study). Citation: Karade S, Vishal AK, Sen S, Bewal N, Gupta RM. Probable vertical transmission of severe acute respiratory syndrome coronavirus 2 infection from mother to neonate. Med J Armed Forces India. 2021 Jul;77(Suppl 2):S490-S493. doi: 10.1016/j.mjafi.2020.11.026. Epub 2021 Jul 26. PMID: 34334918; PMCID: PMC8313057.

Study 975 – case report from USA

It is not possible to identify the hospital from author affiliations (click here or study). Citation: Shields AD, Byrne JJ, Munisteri M, Wood M. Survival from Maternal Cardiac Arrest Complicating Coronavirus Disease 2019. Case Rep Obstet Gynecol. 2021 Jul 19;2021:3762198. doi: 10.1155/2021/3762198. PMID: 34336319; PMCID: PMC8292066.

Study 974 – case report from China

From Zhongshan People’s Hospital (Zhongshan Hospital of Sun Yat-Sen University) (click here or study). The clinical features suggest this is the same patient previously reported in studies 3, 57, 81, 192, 433, and 493. Citation: Huang W, Cheng Z, Liao X, Wang L, Wen J, Li J, Jiang H, Yuan Y, Li B. Postpartum extracorporeal membrane oxygenation of a woman with COVID-19-related acute respiratory distress syndrome: A case report. Medicine (Baltimore). 2021 Jul 30;100(30):e26798. doi: 10.1097/MD.0000000000026798. PMID: 34397736; PMCID: PMC8322481.

Study 973 – case report from the Philippines

From Philippine General Hospital, Manila (click here or study). Citation: Cuaño PMGM, Pilapil JCA, Larrazabal RJB, Villalobos RE. Acquired tracheoesophageal fistula in a pregnant patient with COVID-19 pneumonia on prolonged invasive ventilation. BMJ Case Rep. 2021 Aug 20;14(8):e244016. doi: 10.1136/bcr-2021-244016. PMID: 34417243; PMCID: PMC8381298.

Study 972 – case report from UK

From Chelsea and Westminster Hospital, London (click here or study). Citation: Agbontaen KO, Somasundram K, Baker M. Critical COVID-19 in a 24-week pregnant woman with 32 days of invasive mechanical ventilation before delivery of fetus: a case of successful collaborative multidisciplinary care. BMJ Case Rep. 2021 Sep 8;14(9):e243516. doi: 10.1136/bcr-2021-243516. PMID: 34497055; PMCID: PMC8438726.

Study 971 – two cases from Sweden

From Örebro University Hospital, which has not previously reported cases (click here or study). Citation: Östling H, Ugarph-Edfeldt M, Hildén K. Two cases of severe COVID-19 in gestational week 27 and 28 respectively, after which both pregnancies proceeded to term. Int J Obstet Anesth. 2021 Nov;48:103212. doi: 10.1016/j.ijoa.2021.103212. Epub 2021 Aug 18. PMID: 34500190; PMCID: PMC8372455.

Study 970 – two cases from Taiwan

From Mackay Memorial Hospital, Taipei, which has not previously reported cases (click here or study). Citation: Chang WH. COVID-19 pandemic’s effects on the quality of pregnant women’s emergency treatment: Review of two cases from a medical center in northern Taiwan. Taiwan J Obstet Gynecol. 2020 Nov;59(6):795-800. doi: 10.1016/j.tjog.2020.09.003. Epub 2020 Sep 10. PMID: 33218391; PMCID: PMC7832363.

Study 969 – case report from Taiwan

From Taipei Veterans General Hospital (click here or study). The clinical details differ from those of study 968. Citation: Wang LM, Lai SP, Liang SJ, Yang ST, Liu CH, Wang PH. Maternal and fetal outcomes of the pregnant woman with COVID-19: The first case report in Taiwan. Taiwan J Obstet Gynecol. 2021 Sep;60(5):942-944. doi: 10.1016/j.tjog.2021.07.045. Epub 2021 Aug 2. PMID: 34507681; PMCID: PMC8326015.

Study 968 – case report from Taiwan

From Taipei Veterans General Hospital, which has not previously reported cases (click here or study). Citation: Yang ST, Yeh CC, Lee WL, Lee FK, Chang CC, Wang PH. A symptomatic near-term pregnant woman recovered from SARS-CoV-2 infection. Taiwan J Obstet Gynecol. 2021 Sep;60(5):945-948. doi: 10.1016/j.tjog.2021.07.046. Epub 2021 Aug 3. PMID: 34507682; PMCID: PMC8328571.

Study 967 – case report from Indonesia

Cared for at Cipto Mangunkusumo General Hospital, which has not previously reported cases (click here or study). Citation: Irwinda R, Wibowo N, Prameswari N. Cytokines storm in COVID-19 with dengue co-infection in pregnancy: Fatal maternal and fetal outcome. IDCases. 2021;26:e01284. doi: 10.1016/j.idcr.2021.e01284. Epub 2021 Sep 6. PMID: 34513593; PMCID: PMC8420090.

Study 966 – case report from Poland

From the Regional Specialist Hospital Megrez in Tychy, which has not previously reported cases (click here or study). Citation: Urban A, Dyrda M. Mother and neonate suffering from COVID-19 infection. Is there any risk of vertical transmission? A case report. Ginekol Pol. 2021;92(10):701-703. doi: 10.5603/GP.a2021.0033. Epub 2021 Sep 20. PMID: 34541649.

Study 965 – case report from Mexico

From Ángeles del Pedregal Hospital, Mexico City, which has not previously reported cases (click here or study). Citation: Morales HSG, Cortés DV, Hernández HS, Guiot ML, Torres GCR, Camacho FMR, Montoya GA, Maldonado BF, Bárcenas JG, López GGP. Vertical transmission: evidence of COVID-19 in a twin pregnancy. JBRA Assist Reprod. 2022 Jan 17;26(1):153-157. doi: 10.5935/1518-0557.20210058. PMID: 34542252; PMCID: PMC8769174.

Study 964 – case report from Turkey

From Manisa City Hospital, which has nt previously reported cases (click here or study). Citation: Yangin Ergon E, Akbay S, Aytemiz G, Avcı Çelik EC, Çalıskan Polat A, Umit Z, Paytoncu S. A novel case of neonatal acute respiratory distress syndrome with SARS-CoV-2 infection: potential perinatal transmission. Arch Argent Pediatr. 2021 Oct;119(5):e531-e535. English, Spanish. doi: 10.5546/aap.2021.eng.e531. PMID: 34569757.

Study 963 – case report from Japan

From Okayama (click here or study). The hospital is not named, and the authors give only their university affiliations. However, there have been no previous cases reported from this city. Citation: Yamamoto K, Hagiya H, Maki J, Okahara S, Hasegawa K, Otsuka F. High-Dose Corticosteroids for a Pregnant Woman Critically Ill With Coronavirus Disease 2019. Cureus. 2021 Aug 23;13(8):e17398. doi: 10.7759/cureus.17398. PMID: 34584807; PMCID: PMC8457894.

Study 962 – 5 cases from Italy

From the University Hospital of Parma (click here or study). Four of the cases appear to have been reported in study 109, reference not cited. Citation: Giordano G, Petrolini C, Corradini E, Campanini N, Esposito S, Perrone S. COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome in five cases. Diagn Pathol. 2021 Oct 3;16(1):88. doi: 10.1186/s13000-021-01148-6. PMID: 34602071; PMCID: PMC8487453.

Study 961 – case report from Canada

From St. Michael’s Hospital, Toronto, Ontario, which has not previously reported cases (click here or study). Citation: Naeh A, Berezowsky A, Yudin MH, Dhalla IA, Berger H. Preeclampsia-Like Syndrome in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19). J Obstet Gynaecol Can. 2021 Oct 12:S1701-2163(21)00752-0. doi: 10.1016/j.jogc.2021.09.015. Epub ahead of print. PMID: 34648956; PMCID: PMC8505022.

Study 960 – case report from USA

[Currently neither abstract nor full text available] (click here or study). Citation: Dalla S, Rausch M, Kellerman R. Case Report: Second-Trimester Maternal COVID-19 Infection and Tetralogy of Fallot. Am Fam Physician. 2021 Oct 1;104(4):331. PMID: 34652122.

Study 959 – case report from Spain

From Hospital San Pedro de Alcántara, Cáceres, which has not previously reported cases (click here or study). Citation: Márquez Isidro EM, García García MJ, Solo de Zaldívar Tristancho M, Romero Peguero R. SARS-CoV-2 and prematurity. Any evidence of vertical transmission? An Pediatr (Engl Ed). 2021 Nov;95(5):375-377. doi: 10.1016/j.anpede.2021.05.005. Epub 2021 Oct 8. PMID: 34670719; PMCID: PMC8498649.

Study 958 – 26 cases from China

Cared for at Tongji Hopital, Wuhan, from January 23, to March 23, 2020, and presumably reported many times (click here or study). Citation: Ding L, Xiong X, Yu G, Li C, Wang H, Yang Y, Wu S, Cai X. Nursing Care of 26 Infants Born to Mothers With COVID-19. Adv Neonatal Care. 2022 Feb 1;22(1):15-21. doi: 10.1097/ANC.0000000000000958. PMID: 34670953; PMCID: PMC8815632.

Study 957 – case report from Romania

From the National Institute of Mother and Child Care, Alessandrescu-Rusescu, Bucharest, which has not previously reported cases (click here or study). Citation: Radoi V, Pop LG, Bacalbasa N, Panaitescu AM, Ciobanu AM, Cretoiu D, Toader OD. Fatal Association of Mirror and Eisenmenger Syndrome during the COVID-19 Pandemic. Medicina (Kaunas). 2021 Sep 28;57(10):1031. doi: 10.3390/medicina57101031. PMID: 34684068; PMCID: PMC8537604.

Study 956 – case report from India

From Goa Medical College, Bambolim, which has not previously reported cases (click here or study). Citation: Bakhle A, Sreekumar K, Baracho B, Sardessai S, Silveira MP. Cavitary lung lesions in a neonate: Potential manifestation of COVID-19 related multisystem inflammatory syndrome. Pediatr Pulmonol. 2022 Jan;57(1):311-314. doi: 10.1002/ppul.25732. Epub 2021 Oct 29. PMID: 34714960; PMCID: PMC8661966.

Study 955 – case report from Ireland

From Our Lady of Lourdes Hospital, Drogheda, which has not previously reported cases (click here or study). Citation: Brady A, Aglan A. Critical COVID-19 in a pregnant patient who presented in starvation ketoacidosis with a background history of acrorenal syndrome. BMJ Case Rep. 2021 Nov 2;14(11):e244117. doi: 10.1136/bcr-2021-244117. PMID: 34728503; PMCID: PMC8565554.

Study 954 – case report from Brazil

Cared for at the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, which has not previously reported cases (click here or study). Citation: Avila WS, Kirschbaum M, Devido MS, Demarchi LMMF. COVID-19, congenital heart disease, and pregnancy: dramatic conjunction-case report. Eur Heart J Case Rep. 2021 Jul 24;5(10):ytab291. doi: 10.1093/ehjcr/ytab291. PMID: 34729452; PMCID: PMC8557342.

Study 953 – case report from Spain

From Hospital Universitari Germans Trias i Pujol, Badalona (click here or study). May have been included in study 177. Citation: Velasco I, Soldevila B, Julián T, García-Riaño N, Puig-Domingo M. Euglycemic diabetic ketoacidosis and COVID-19: A combination to foresee in pregnancy. J Diabetes. 2022 Jan;14(1):88-89. doi: 10.1111/1753-0407.13237. Epub 2021 Nov 19. PMID: 34729932.

Update 12 February – studies 928 to 952 added

Study 952 – case report from Poland

Cared for at the Tertiary University Hospital in Wroclaw (click here or study). The dates suggest not included in study 908. Citation: Rosner-Tenerowicz A, Fuchs T, Zimmer-Stelmach A, Pomorski M, Trzeszcz M, Zwierzchowski J, Zimmer M. Placental pathology in a pregnant woman with severe COVID-19 and successful ECMO treatment: a case report. BMC Pregnancy Childbirth. 2021 Nov 10;21(1):760. doi: 10.1186/s12884-021-04228-z. PMID: 34758757; PMCID: PMC8579174.

Study 951 – case report from Spain

From Hospital Universitario Puerta de Hierro Majadahonda (click here or study). Possibly included in studies 125, 151, 177, 196 and 443. Citation: González Rockmore D, Tung-Chen Y, Gómez Nicolás C, Díaz de Santiago A. Importance of point-of-care ultrasound in early diagnosis of COVID-19 complications. BMJ Case Rep. 2021 Nov 11;14(11):e246311. doi: 10.1136/bcr-2021-246311. PMID: 34764124; PMCID: PMC8587469.

Study 950 – 4 cases from India

From Tata Main Hospital, Jamshedpur, which has not previously reported cases (click here or study). Citation: Kumar S, Choudhary A, Shukla R, Singh V, Ranjan R. Moderate to Severe Thrombocytopenia in Four Pregnant Women With Asymptomatic COVID-19 Infection. Cureus. 2021 Oct 6;13(10):e18531. doi: 10.7759/cureus.18531. PMID: 34765332; PMCID: PMC8575279.

Study 949 – case report from Poland

From PCK Marine Hospital in Gdynia, which has not previously reported cases (click here or study). Citation: Brzezinski M, Brzezinska N, Rusek U, Broniecki K. Acute respiratory distress syndrome in pregnant women infected with SARS-CoV-2 – a case report. Pol Merkur Lekarski. 2021 Oct 22;49(293):356-360. PMID: 34800023.

Study 948 – case report from USA

From The Brooklyn Hospital Center, New York, which has not previously reported cases (click here or study). Citation: Kahlon GK, Zylak A, Leblanc P, Kondamudi N. Fetal Gallstones in a Newborn after Maternal COVID-19 Infection. Case Rep Pediatr. 2021 Nov 18;2021:3688173. doi: 10.1155/2021/3688173. PMID: 34804624; PMCID: PMC8601857.

Study 947 – case report from Romania

From the Emergency Clinical County Hospital, Cluj-Napoca, which has not previously reported cases (click here or study). Citation: Trancǎ SD, Antal O, Farcaş AD. Case Report: Acute Splenic Artery Thrombosis in a COVID 19, Postpartum Patient. Front Med (Lausanne). 2021 Nov 5;8:698627. doi: 10.3389/fmed.2021.698627. PMID: 34805195; PMCID: PMC8604041.

Study 946 – case report from Iran

Cared for at Imam Ali Hospital, Alborz (click here or study). The clinical features differ from those in studies 584 and 887. Citation: Nagdi Dorabati P, Khoshnam Rad M, Hedayat Yaghoobi M, Mahmoodi Z. A Pregnant Mother Infected With Severe Acute Respiratory Syndrome Coronavirus 2 With Substance Dependence: A Case Report. J Addict Nurs. 2021 Oct-Dec 01;32(4):260-262. doi: 10.1097/JAN.0000000000000437. PMID: 34855325.

Study 945 – 4 cases from India

From King George’s Medical University, Lucknow, which has not previously reported cases (click here or study). Citation: Singh R, Agrawal A, Asnani M. Remdesivir in Pregnant Patients with Novel Coronavirus Disease 2019: Case Series. J Obstet Gynaecol India. 2021 Dec 2:1-3. doi: 10.1007/s13224-021-01589-5. Epub ahead of print. PMID: 34873384; PMCID: PMC8637515.

Study 944 – 29 cases from Turkey

Pregnant women with covid, treated with favipavir, and reported to the Clinical Pharmacology and Toxicology Unit, Ataturk Research Hospital, Izmir, from 1 September to 31 December 2020 (click here or study). Possible overlap with other reports from Turkey. Citation: Tırmıkçıoğlu Z. Favipiravir exposure and pregnancy outcome of COVID-19 patients. Eur J Obstet Gynecol Reprod Biol. 2022 Jan;268:110-115. doi: 10.1016/j.ejogrb.2021.12.001. Epub 2021 Dec 6. PMID: 34902747; PMCID: PMC8647391.

Study 943 – case report from Indonesia

From Dr. Kariadi General Hospital, Semarang, which has not previously reported cases (click here or study). Citation: Santosa D, Sofro MAU, Farida, Nindita N, Pangarsa EA, Setiawan B, Rizky D, Suharti C. A full-term pregnant woman with secondary Evans syndrome caused by severe coronavirus disease 2019: a case report. J Med Case Rep. 2021 Dec 13;15(1):606. doi: 10.1186/s13256-021-03205-6. PMID: 34903274; PMCID: PMC8667974.

Study 942 – case report from Iran

From Mashhad University of Medical Science, Mashhad, which has not previously reported cases (click here or study). Citation: Moeindarbary S, Dadgar S, Layegh P, Shahriari Z, Fayyaz F, Danesteh S, Rafiee M, Bahrami M. Extensive bilateral diffuse infiltrates and deterioration of lung following infection with severe acute respiratory syndrome coronavirus 2 in a pregnant woman: a case report. J Med Case Rep. 2021 Dec 13;15(1):588. doi: 10.1186/s13256-021-03156-y. PMID: 34903276; PMCID: PMC8667013.

Study 941 – 2 cases from Switzerland

Probably cared for at Lausanne University Hospital (click here or study). May be included in study 922. Citation: Favre G, Mazzetti S, Gengler C, Bertelli C, Schneider J, Laubscher B, Capoccia R, Pakniyat F, Ben Jazia I, Eggel-Hort B, de Leval L, Pomar L, Greub G, Baud D, Giannoni E. Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury. Viruses. 2021 Dec 15;13(12):2517. doi: 10.3390/v13122517. PMID: 34960786; PMCID: PMC8706116.

Study 940 – case report from USA

From Bethesda Hospital East, Boynton Beach, Florida, which has not previously reported cases (click here or study). Citation: Campbell M, Palati S, Sanchez A, Castaneda M. A Case of Recovery From COVID-19 Pneumonia in Pregnancy After Vaginal Delivery in ICU. Cureus. 2021 Nov 24;13(11):e19862. doi: 10.7759/cureus.19862. PMID: 34976489; PMCID: PMC8712199.

Study 939 – case report from Iran

From Firoozgar Hospital, Iran University of Medical Sciences, Tehran (click here or study). Possibly included in study 345, but the clical features differ from the case reported in study 664. Citation: Dini P, Aminimoghaddam S, Mirzaasgari Z, Rahimian N, Khotbehsara ST, Abolmaali M. Spontaneous Intracerebral Hemorrhage (ICH) associated with pregnancy and SARS-CoV-2 infection: a case report. BMC Pregnancy Childbirth. 2022 Jan 6;22(1):14. doi: 10.1186/s12884-021-04345-9. PMID: 34986833; PMCID: PMC8731675.

Study 938 – case report from Sri Lanka

From De Soysa Hospital for Women, Kynsey Road, Colombo, which has not previously reported cases (click here or study). Citation: Rishard M, Perera S, Jayasinghe K, Rubasinghe A, Athapaththu S, Edirisinghe M, Ranaweera P, Ranawaka T, Kaluarachchi A, Jayawardana P, Haniffa Z. An Unusual Presentation of COVID-19 Associated Multisystem Inflammatory Syndrome in Adults (MIS-A) in a Pregnant Woman. Case Rep Obstet Gynecol. 2022 Jan 7;2022:4186846. doi: 10.1155/2022/4186846. PMID: 35013694; PMCID: PMC8742152.

Study 937 – case report from USA

From Overland Park Regional Medical Center, Kansas City, which has not previously reported cases (click here or study). Citation: Wang G, Stapley E, Peterson S, Parrott J, Clark-Ganheart C. Persistent Fetal SVT in a COVID-19 Positive Pregnancy. Case Rep Obstet Gynecol. 2022 Jan 7;2022:9933520. doi: 10.1155/2022/9933520. PMID: 35013695; PMCID: PMC8742150.

Study 936 – 292 cases from India

Out of 292 pregnant women with Covid, cared for at Gandhi Medical College, Hyderabad, six developed AKI and are reported in detail (click here or study). This centre has not previously reported cases. Citation: Vadakkeveetil AK, Yadla M, Cherian A, Rahul, Goli M, Chada R, Nazneen S. Coronavirus disease 2019 and pregnancy-related acute kidney injury: Our initial experience of six cases. Saudi J Kidney Dis Transpl. 2021 Mar-Apr;32(2):559-563. doi: 10.4103/1319-2442.335471. PMID: 35017353.

Study 935 – case report from Romania

From Bucharest (click here or study). It is not possible to idetify the hospital from author affiliations. Citation: Bohîlțea RE, Margareta Mihai B, Munteanu O, Ducu I, Adrian Dumitru V, Gheorghe CM, Augustin Georgescu T, Varlas V, Vlădăreanu R. Early prenatal diagnosis of an atypical phenotype of sacral spina bifida. J Med Life. 2021 Sep-Oct;14(5):716-721. doi: 10.25122/jml-2021-0292. PMID: 35027976; PMCID: PMC8742886.

Study 934 – case report from India

Cared for at Mahatma Gandhi Memorial Medical College, Indore, which has not previously reported cases (click here or study). Citation: Dave A, Joshi P, Jaiswal S, Kapdeo P. Successful outcome of severe COVID-19 in pregnancy: individualised approach. BMJ Case Rep. 2022 Jan 17;15(1):e246648. doi: 10.1136/bcr-2021-246648. PMID: 35039364; PMCID: PMC8768493.

Study 933 – case report from France

From either Bordeaux or Clermont-Ferrand. It is not possible to determine the hospital from author affiliations (click here or study). Citation: Zalle I, Barthelemy Y, Piperata A, Galvaing G, Camilleri L, d’Ostrevy N. Low fetal age is not a contraindication for extracorporeal membranous oxygenation in COVID-19-related ARDS. J Card Surg. 2022 Jan 20. doi: 10.1111/jocs.16251. Epub ahead of print. PMID: 35060195.

Study 932 – 15 cases from USA

Treated with monoclonal antibody at Ronald Reagan UCLA Medical Center, which has not previously reported cases (click here or study). Citation: Richley M, Rao RR, Afshar Y, Mei J, Mok T, Vijayan T, Weinstein S, Pham CU, Madamba J, Shin CS, Suda D, Han CS. Neutralizing Monoclonal Antibodies for Coronavirus Disease 2019 (COVID-19) in Pregnancy: A Case Series. Obstet Gynecol. 2022 Feb 3. doi: 10.1097/AOG.0000000000004689. Epub ahead of print. PMID: 35115451.

Study 931 – case report from USA

A 31-year-old woman pregnant with twins contracted COVID-19 at 16 weeks’ gestation (click here or study). The babies were delivered by Caesarean at 26 weeks. From author affiliations cared for at California Pacific Medical Center, San Francisco, which has not previously reported cases. Citation: Retajczyk CT, Jaffee IM, McKim KJ, Retajczyk PJ, Mueller CM. Premature twin neonates with a Coronavirus-19 positive mother present with an unusual pattern of intestinal ischemia. J Pediatr Surg Case Rep. 2022 Mar;78:102173. doi: 10.1016/j.epsc.2021.102173. Epub 2022 Jan 29. PMID: 35127444; PMCID: PMC8800498.

Study 930 – case report from Canada

A 27-year-old woman with Covid and an in-utero fetal death, delivered at 24+5 (click here or study). From author affiliations cared for at Vernon Jubilee Hospital in British Columbia, which has not previously reported cases. Citation: Bewley DJ, Lee J, Popescu O, Oviedo A. SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise. Cureus. 2021 Dec 30;13(12):e20833. doi: 10.7759/cureus.20833. PMID: 35141086; PMCID: PMC8800441.

Study 929 – 63 cases from Italy

From the “Guglielmo da Saliceto” Hospital in Piacenza (click here or study). Possible overlap with studies 117, 252 and 356. Citation: Ghiselli S, Laborai A, Biasucci G, Carvelli M, Salsi D, Cuda D. Auditory evaluation of infants born to COVID19 positive mothers. Am J Otolaryngol. 2022 Feb 5;43(2):103379. doi: 10.1016/j.amjoto.2022.103379. Epub ahead of print. PMID: 35144104; PMCID: PMC8816906.

Study 928 – 3,042 cases from USA

De-identified electronic medical record data in the Cerner HealtheDataLab platform, including 82 healthcare facilities, from December 2019 to September 2020 (click here or study). Likely overlap with study 677, and other US series. Citation: Hsu AL, Ohler AM, Goldstein A, Truong S, Tang CY, Wan XF, McElroy JA. Coronavirus Disease 2019 (COVID-19) Disease Severity: Pregnant vs Nonpregnant Women at 82 Facilities. Clin Infect Dis. 2022 Feb 11;74(3):467-471. doi: 10.1093/cid/ciab441. PMID: 35148386.

Update 11 February – studies 922 to 927 added

Study 927 – 68 cases from 12 countries

The centres can be inferred from author affiliations (click here or study). Likely inclusion in many other series. Citation: Schwartz DA, Avvad-Portari E, Babál P, Baldewijns M, Blomberg M, Bouachba A, Camacho J, Collardeau-Frachon S, Colson A, Dehaene I, Ferreres JC, Fitzgerald B, Garrido-Pontnou M, Gerges H, Hargitai B, Helguera-Repetto AC, Holmström S, Irles CL, Leijonhfvud Å, Libbrecht S, Marton T, McEntagart N, Molina JT, Morotti R, Nadal A, Navarro A, Nelander M, Oviedo A, Oyamada Otani AR, Papadogiannakis N, Petersen AC, Roberts DJ, Saad AG, Sand A, Schoenmakers S, Sehn JK, Simpson PR, Thomas K, Valdespino-Vázquez MY, van der Meeren LE, Van Dorpe J, Verdijk RM, Watkins JC, Zaigham M. Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries. Arch Pathol Lab Med. 2022 Feb 10. doi: 10.5858/arpa.2022-0029-SA. Epub ahead of print. PMID: 35142798.

Study 926 – case report from USA

A 34-year-old woman with 3 prior live births, BMI 47.5 and chronic hypertension and a history of preeclampsia was hospitalized at 25 weeks of gestation for preeclampsia management (click here or study). She was asymptomatic but tested positive. Delivered at 25w+5d by Caesarean. It is not possible to identify the centre from author affiliations. Citation: Reagan-Steiner S, Bhatnagar J, Martines RB, Milligan NS, Gisondo C, Williams FB, Lee E, Estetter L, Bullock H, Goldsmith CS, Fair P, Hand J, Richardson G, Woodworth KR, Oduyebo T, Galang RR, Phillips R, Belyaeva E, Yin XM, Meaney-Delman D, Uyeki TM, Roberts DJ, Zaki SR. Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta. Emerg Infect Dis. 2022 Feb 9;28(3). doi: 10.3201/eid2803.211735. Epub ahead of print. PMID: 35138244.

Study 925 – 26 cases from Iraq

Cared for at Al Yarmouk teaching hospital, Baghdad from June to August 2020 (click here or study) [abstract only]. Likely overlap with study 837. Citation: Hameed BH, Thamir AR, Jassim H, Hassan Ali MA. Maternal and perinatal outcome of pregnant women with COVID 19, a tertiary centre experience in Iraq – A Case Series. J Pak Med Assoc. 2021 Dec;71(Suppl 8)(12):S174-S178. PMID: 35130244.

Study 924 – case report from Italy

A 35-year-old woman pregnant with twins following IVF, and following cerclage at 16 weeks, ruptured her membranes at 20 weeks. She was asymptomatic but tested positive for SARS-Cov-2. The babies were stillborn at 21.4 weeks (click here or study). From author affiliations cared for at Papa Giovanni XXIII – Bergamo. The date of delivery is not reported so previous inclusion in the various Lombardy series is possible. Citation: L Patane , M Cadamuro , G Massazza , S Pirola , V Stagnati, C Comerio , M Carnelli , M Arosio , AP Callegaro , P Tebaldi , E Rigoli , A Gianatti , D Morotti, Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second trimester twin stillbirth in asymptomatic woman. Case report and review of the literature, American Journal of Obstetrics & Gynecology MFM (2022), doi: https://doi.org/10.1016/j.ajogmf.2022.100589

Study 923 – 41 cases treated with remdesivir from USA

From author affiliations cared for at Ohio State University, Columbus, Ohio, from April 2020 through October 2021 (click here or study). This hospital does not appear to have previously reported cases. Citation: Eid J, Abdelwahab M, Colburn N, Day S, Cackovic M, Rood KM, Costantine MM. Early Administration of Remdesivir and Intensive Care Unit Admission in Hospitalized Pregnant Individuals With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2022 Feb 8. doi: 10.1097/AOG.0000000000004734. Epub ahead of print. PMID: 35134032.

Study 922 – 153 cases from Switzerland

Cared for in University Hospital of Bern, Lausanne University Hospital, and Ente Ospedaliero Cantonale Lugano, between May 2020 and July 2021 (click here or study). Possible overlap with studies 72, 310, 526 and 752. Citation: Radan A-P, Baud D, Favre G, Papadia A, Surbek D, Baumann M, Raio L, Low placental weight and altered metabolic scaling after severe acute respiratory syndrome coronavirus type 2 infection during pregnancy: a prospective multicentric study, Clinical Microbiology and Infection, https://doi.org/10.1016/j.cmi.2022.02.003.

Update 8 February – study 921 added

Study 921 – 2,352 cases from USA

From 17 hospitals participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development’s Gestational Research Assessments of COVID-19 (GRAVID) Study and delivered between March 1 and December 31, 2020 (click here or study). Likely overlap with studies 609 and 903 as well as other US studies. Citation: Metz TD, Clifton RG, Hughes BL, Sandoval GJ, Grobman WA, Saade GR, Manuck TA, Longo M, Sowles A, Clark K, Simhan HN, Rouse DJ, Mendez-Figueroa H, Gyamfi-Bannerman C, Bailit JL, Costantine MM, Sehdev HM, Tita ATN, Macones GA; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications. JAMA. 2022 Feb 7. doi: 10.1001/jama.2022.1190. Epub ahead of print. PMID: 35129581. [control group]

Update 7 February – study 920 added

Study 920 – 8 cases from Northern Ireland

Collected during the Delta era of the pandemic from July to October 2021 (click here or study). Hospitals not reported. Citation: Graham, M., Sproule, C., Sharma, M., Likinyo, H., Glackin, K., Hurrell, D., Khalil, A. and Mone, F. (2022), Spontaneous maternal coagulopathy in COVID-19. Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.24859

Update 6 February – studies 915 to 919 added

Study 919 – 31 cases from China

Cared for at Zhongnan Hospital of Wuhan University, between January 2020 and Jnauary 2021 (click here or study). Likely overlap with many previous reports. Citation: Liu HY, Guo J, Zeng C, Cao Y, Ran R, Wu T, Yang G, Zhao D, Yang P, Yu X, Zhang W, Liu SM, Zhang Y. Transient Early Fine Motor Abnormalities in Infants Born to COVID-19 Mothers Are Associated With Placental Hypoxia and Ischemia. Front Pediatr. 2022 Jan 6;9:793561. doi: 10.3389/fped.2021.793561. PMID: 35071136; PMCID: PMC8772397.

Study 918 – 16 cases from Iran

Cared for at Imam Reza Hospital, Mashhad, from March 20 to August 5, 2020 (click here or study). Possible overlap with studies 101 and 250. Citation: Dadgar S, Mahmoudinia M, Akbari A, Zandieh E, Attaranzadeh A, Hoseinpour S, Jahanpak N, Tavanaee Sani A, Mohammadi SA. Placental infection with SARS-CoV-2, analysis of 16 cases and literature review. Arch Gynecol Obstet. 2022 Jan 28:1–9. doi: 10.1007/s00404-021-06372-5. Epub ahead of print. PMID: 35088195; PMCID: PMC8794612.

Study 917 – 16 cases from USA

Mother-infant dyads enrolled at Boston Medical Center between July 2020 and April 2021 (click here or study). Likely overlap with studies 292, 490, 681 and 684. Citation: Taglauer ES, Wachman EM, Juttukonda L, Klouda T, Kim J, Wang Q, Ishiyama A, Hackam DJ, Yuan K, Jia H. Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding. Am J Pathol. 2022 Jan 26:S0002-9440(22)00011-6. doi: 10.1016/j.ajpath.2021.12.011. Epub ahead of print. PMID: 35090860; PMCID: PMC8789383.

Study 916 – 9 cases from Mexico

Cared for in Bíte Médica Hospital, Mexico City, which has not previously reported cases, in 2020 (click here or study). Citation: Vargas-Hernández VM, Luján-Irastorza JE, Durand-Montaño C. Placental pathology and perinatal risk during the COVID-19 pandemic. Gac Med Mex. 2021;157(5):494-501. English. doi: 10.24875/GMM.M21000604. PMID: 35104270.

Study 915 – 5 cases from Brazil

From Julio Muller University Hospital, Cuiabá, Mato Grosso, from June to July 2020 (click here or study). This hospital has not previously reported cases. Citation: Ferreira MFC, Pavon JAR, Napoleão ACB, Figueiredo GMDP, Florêncio PCB, Arantes RBDS, Rizzo PS, Carmo MAMV, Nakazato L, Dutra V, Hahn RC, Slhessarenko RD. Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in brazil. Microbes Infect. 2022 Feb 2:104949. doi: 10.1016/j.micinf.2022.104949. Epub ahead of print. PMID: 35123044.

Update 2 February – studies 911 to 914 added

Study 914 – 786 cases from Italy

From ITOSS between February 25 and August 31, 2020 (click here or study). Likely overlap with studies 246, 536, 674 and 862, as well as other Italian series. Citation: Donati S, Corsi E, Maraschini A, Salvatore MA; ItOSS COVID-19 Working Group; ItOSS COVID-19 WORKING GROUP. The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study. Ann Ist Super Sanita. 2021 Oct-Dec;57(4):272-285. doi: 10.4415/ANN_21_04_02. PMID: 35076417.

Study 913 – case report from Jordan

Born by cesarean at 35 weeks to a SARS-CoV-2-positive mother (click here or study). Authors affiliated with the University of Jordan, Amman. Citation: El-Isa HZ, Khader OA, Khader M, Ashour BA, Azzam MI, Badran EF. Secondary Hemophagocytic Lymphohistiocytosis in a Neonate with SARS-CoV-2 Infection. Am J Case Rep. 2022 Jan 28;23:e934839. doi: 10.12659/AJCR.934839. PMID: 35087017.

Study 912 – 82 cases from France

From Tenon hospital, Paris, which appears to have not previously reported cases (click here or study). Citation: Kolanska K, Vasileva R, Lionnet F, Santin A, Jaudi S, Dabi Y, Chabbert-Buffet N, Daraï E, Bornes M. Sickle cell disease and COVID-19 in pregnant women. J Gynecol Obstet Hum Reprod. 2022 Jan 28:102328. doi: 10.1016/j.jogoh.2022.102328. Epub ahead of print. PMID: 35093595; PMCID: PMC8800150.

Study 911 – 116 cases from Austria

From the Clinic Ottakring, Vienna, which has not previously reported cases (click here or study). One mother died and one required ECMO. No babies died. Citation: Hall M, Hölbfer S, Endress D, Aicher G, Drechsel-Burkhard G, Maier B. One year into the SARS-CoV-2 pandemic: perinatal outcome and data on the transmission of 116 pregnant women. J Perinat Med. 2022 Feb 1. doi: 10.1515/jpm-2021-0271. Epub ahead of print. PMID: 35107227.

Update 28 January – studies 906 to 910 added

Study 910 – 30 cases treated with monoclonals from USA

From author affiliations treated with bamlanivimab, bamlanivimab/etesevimab, or casirivimab/imdevimab between December 2020 and October 2021 at Montefiore Medical Center, Albert Einstein College of Medicine, New York (click here or study). This hospital has not previously reported cases from this time period. Citation: CHANG MH, COWMAN K, GUO Y, BAO H, BERNSTEIN PS, GENDLINA I, NORI P, A real-world assessment of tolerability and treatment outcomes of COVID-19 monoclonal antibodies administered in pregnancy, American Journal of Obstetrics and Gynecology (2022), doi: https://doi.org/10.1016/j.ajog.2022.01.018.

Study 909 – poor correlation between testing and diagnostic coding in USA

In the OptumLabs® Data Warehouse (OLDW), 78,283 individuals had a pregnancy ending between 11 March 2020 and 31 January 2021. Of the 5,644 with information on COVID-19 testing, 736 had a record of COVID-19. Of these 380 (51.6%) had only a COVID-19 diagnosis, 140 (19.0%) had only a positive laboratory test, and 216 (29.3%) had both a positive test and a COVID-19 diagnosis (click here or study). Likely overlap with study 896. Citation: Regan AK, Arah OA, Sullivan SG. Performance of diagnostic coding and laboratory testing results to measure COVID-19 during pregnancy and associations with pregnancy outcomes. Paediatr Perinat Epidemiol. 2022 Jan 25. doi: 10.1111/ppe.12863. Epub ahead of print. PMID: 35077581.

Study 908 – 83 cases from Poland

Cared for between 15 February and 01 May 2021 at Wroclaw Medical University Teaching Hospital (click here or study). This hospital has not previously reported cases. Citation: Szczygiol P, Baranska K, Korczak I, Zimmer-Stelmach A, Rosner-Tenerowicz A, Zimmer M, Krolak-Olejnik B. COVID-19 in pregnancy, management and outcomes among pregnant women and neonates – results from tertiary care center in Wroclaw. Ginekol Pol. 2022 Jan 24. doi: 10.5603/GP.a2021.0201. Epub ahead of print. PMID: 35072251.

Study 907 – 122 cases from Turkey

Pregnant patients with confirmed COVID-19 from April 1 to May 31, 2020, at Kanuni Sultan Süleyman Training and Research Hospital, Istanbul (click here or study). This hospital has not previously reported cases. Citation Can E, Oğlak SC, Ölmez F. Abnormal liver function tests in pregnant patients with COVID-19 – a retrospective cohort study in a tertiary center. Ginekol Pol. 2022 Jan 24. doi: 10.5603/GP.a2021.0182. Epub ahead of print. PMID: 35072238.

Study 906 – vaccine status of 318 severe cases in Europe

Although labelled as a comment, the authors report the vaccination status of 318 pregnant women admitted to critical care with covid fromMay-December 2021, and collected by the UKOSS, NethOSS registries and from Denmark, Finland, Norway and the Lombardy region of Italy (click here or study). The cases will likely overlap with many previous reports, but the vaccine status is original. Citation: Engjom, Hilde et al. Severe COVID-19 in pregnancy is almost exclusively limited to unvaccinated women – time for policies to change The Lancet Regional Health – Europe, Volume 13, 100313 [important]

Update 22 January – study 905 added belatedly

Study 905 – 4,203 cases from India

Collected by the PregCovid registry from 19 medical colleges across the State of Maharashtra during the first wave (March 2020-January 2021) (click here or study). Likely overlap with studies 225, 283, 369, 501, 520, 547, 746, 777, 778, 839 and 840. Citation: Gajbhiye RK, Mahajan NN, Waghmare RB, Zala S, Chaaithanya IK, Kuppusamy P, Bhurke AV, Pious M, Surve S, Modi DN, Mahale SD; PregCovid Registry Network. Clinical characteristics, outcomes, & mortality in pregnant women with COVID-19 in Maharashtra, India: Results from PregCovid registry. Indian J Med Res. 2021 May;153(5&6):629-636. doi: 10.4103/ijmr.ijmr_1938_21. PMID: 34596595; PMCID: PMC8555584.

Update 20 January – study 904 added

Study 904 – 882 cases from USA

882 pregnant women who tested positive (1st trimester 85; 2nd 226; 3rd 571) out of 73,666 who delivered at Providence St Joseph Health sites in Alaska, California, Montana, Oregon, or Washington between March 5, 2020, and July 4, 2021 (click here or study). Citation: Samantha N Piekos, Ryan T Roper, Yeon Mi Hwang, Tanya Sorensen, Nathan D Price, Leroy Hood, Jennifer J Hadlock. The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study. Lancet Digit Health 2021 Published Online January 13, 2022 https://doi.org/10.1016/S2589-7500(21)00250-8

Update 19 January – study 903 added

Study 903 – 12 cases from USA

Lab studies on stored samples from the Eunice Kennedy Shriver NICHHD from Bethesda, Maryland, and Detroit, Michigan (click here or study) Clinical data reported in Supplementary table 1 (click here or suppl table). Likely overlap with previous US reports. Citation: Garcia-Flores, V., Romero, R., Xu, Y. et al. Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2. Nat Commun 13, 320 (2022). https://doi.org/10.1038/s41467-021-27745-z

Update 13 January – Studies 901 and 902 added. Study 884 updated.

Study 902 – 3 cases from USA

From the COVID-19 in Pregnancy Biorepository, approved by the Mass General Brigham Institutional Review Board, and cared for in August 2021 at Massachusetts General Hospital (click here or study). Overlap with study 856, and other reports from this biorepository, is unlikely, due to birth timing and clinical features. Citation: Lydia L Shook, MD, Sara Brigida, BA, James Regan, BS, James P Flynn, BS, Abbas Mohammadi, MD, Behzad Etemad, PhD, Molly R Siegel, MD, Mark A Clapp, MD, MPH, Jonathan Z Li, MD, Drucilla J Roberts, MD, Andrea G Edlow, MD MSc, SARS-CoV-2 placentitis associated with B.1.617.2 (Delta) variant and fetal distress or demise, The Journal of Infectious Diseases, 2022;, jiac008, https://doi.org/10.1093/infdis/jiac008

Study 901 – 7 cases from Ireland

Seven women with Covid who experienced second trimester miscarriage, stillbirth or neonatal death during the first three months of 2021 (click here or study). Citation: Fitzgerald B, O’Donoghue K, McEntagart N, Gillan JE, Kelehan P, O’Leary J, Downey P, Dean J, De Gascun CF, Bermingham J, Armstrong F, Al Fathil A, Maher N, Murphy C, Burke L. Fetal deaths in Ireland due to SARS-CoV-2 placentitis caused by SARS-CoV-2 Alpha. Arch Pathol Lab Med. 2022 Jan 12. doi: 10.5858/arpa.2021-0586-SA. Epub ahead of print. PMID: 35020786.

Update 12 January – study 900 added

Study 900 – 306 cases from USA

From the Ochsner Health System between June 15 and August 20, 2021 (click here or study). Citation: Morgan JA, Biggio JR Jr, Martin JK, Mussarat N, Chawla HK, Puri P, Williams FB. Maternal Outcomes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Compared With Unvaccinated Pregnant Patients. Obstet Gynecol. 2022 Jan 1;139(1):107-109. doi: 10.1097/AOG.0000000000004621. PMID: 34644272.

Update 11 January – studies 898 and 899 added

Study 899 – case report from Italy

From Universitario Agostino Gemelli IRCCS, Rome (click here or study). Possibly included in study 76 and may be the same case as study 78. Likely also included in some other series from Italy. Citation: Costa S, Delogu AB, Bottoni A, Purcaro V, D’Andrea V, Paladini A, Muto S, Marano R, Savino G, Secinaro A, De Benedetti F, Carsetti R, Piano Mortari E, Spanu T, Vento G. COVID-19 associated multisystem inflammatory syndrome in a neonate with atypical coronary artery involvement. Am J Perinatol. 2022 Jan 7. doi: 10.1055/a-1733-4163. Epub ahead of print. PMID: 34996119.

Study 898 – Affected mother with triplets in Germany

From the Women’s Hospital, Weiden which has not previously reported cases (click here or study). Citation: Disse SC, Manuylova T, Adam K, Lechler A, Zant R, Klingel K, Aepinus C, Finkenzeller T, Wellmann S, Schneble F. COVID-19 in 28-Week Triplets Caused by Intrauterine Transmission of SARS-CoV-2-Case Report. Front Pediatr. 2021 Dec 24;9:812057. doi: 10.3389/fped.2021.812057. PMID: 35004553; PMCID: PMC8740284.

Update 7 January – studies 896 & 897 added. Inadvertent study number duplication of studies 847 to 863 corrected, with later duplicates renumbered as 847b to 863b

Study 897 – 33 cases from Pakistan

Cared for in the HDU or ITU at Sir Sadiq Abbasi Hospital, Bahawalpur from 15th August to 15th September, 2021 (click here or study). Eight mothers died. This hospital has not previously reported cases. Citation: Aslam J, Masroor M, Mehmood QUA, Arshad M, Jabeen S, Mushtaq MA. Maternal Mortality with SARS-COV-2 during its 4th Wave in Pakistan: The Vaccine Paradox and Pregnancy. J Coll Physicians Surg Pak 2022; 32(01):119-121.

Study 896 – 25 pregnant women in ICU in Ireland

Admitted to ICU during wave four, 27 June to 25 December 2021 (click here or study). Overlap with study 858. Citation: Intensive Care Society of Ireland. Epidemiology of intensive care admissions in cases (aged 15 years and older) of COVID-19 in Ireland Report prepared by HPSC on 29.12.2021 https://www.hpsc.ie/a-z/respiratory/coronavirus/novelcoronavirus/surveillance/covid-19intensivecareadmissions/COVID-19_ICU_Report_Adults_29_12_2021_v0.1_website.pdf Accessed 7 January 2022

Update 2 January – studies 892 to 895 added

Study 895 – 725 cases from the Intercovid registry

(click here or study). Previously reported in studies 683 and 737 Citation: Eskenazi B, Rauch S, Iurlaro E, Gunier RB, Rego A, Gravett MG, Cavoretto PI, Deruelle P, García-May PK, Mhatre M, Usman MA, Elbahnasawy M, Etuk Fwacs S, Napolitano R, Deantoni S, Liu B, Prefumo F, Savasi V, Marques PF, Baafi E, Zainab G, Nieto R, Serrano B, Aminu MB, Cardona-Perez JA, Craik R, Winsey A, Tavchioska G, Bako B, Oros D, Benski C, Galadanci H, Savorani M, Oberto M, Sentilhes L, Risso M, Takahashi K, Vecciarelli C, Ikenoue S, Pandey AK, Soto Conti CP, Cetin I, Nachinab VB, Ernawati E, Duro EA, Kholin A, Firlit ML, Easter SR, Sichitiu J, John-Akinola Y, Casale R, Cena H, Agyeman-Duah J, Roggero P, Langer A, Bhutta ZA, Kennedy SH, Villar J, Papageorghiou AT. Diabetes mellitus, maternal adiposity, and insulin-dependent gestational diabetes are associated with Covid-19 in pregnancy: The INTERCOVID Study. Am J Obstet Gynecol. 2021 Dec 20:S0002-9378(21)02696-X. doi: 10.1016/j.ajog.2021.12.032. Epub ahead of print. PMID: 34942154; PMCID: PMC8686449.

Study 894 – 100 cases from South Africa

Cared for at Tygerberg Hospital, Cape Town, from 1 May to 31 July 2020 (click here or study). This hospital has not previously reported cases. Citation: De Waard L, Langenegger E, Erasmus K, Van der Merwe T, Olivier SE, Du Toit N, Paulsen C, Nkangana N, Van Niekerk M, Moodley A, Schell S, Taljaard J, Botha MH, Dramowski A, Cluver CA, Bekker A. Maternal and neonatal outcomes of COVID-19 in a high-risk pregnant cohort with and without HIV. S Afr Med J. 2021 Dec 2;111(12):1174-1180. doi: 10.7196/SAMJ.2021.v111i12.15683. PMID: 34949304.

Study 893 – Two pregnancy cases treated with monoclonal antibody from USA

From Cedars-Sinai Medical Center, Los Angeles, California (click here or study). Citation: Mayer C, VanHise K, Caskey R, Naqvi M, Burwick RM. Monoclonal Antibodies Casirivimab and Imdevimab in Pregnancy for Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021 Dec 1;138(6):937-939. doi: 10.1097/AOG.0000000000004603. PMID: 34583385.

Study 892 – 51 pregnancy cases treated with monoclonal antibody from USA

Collected by the Mayo Clinic Monoclonal Antibody Treatment (MATRx) Program and treated between November 19, 2020 and September 23, 2021 (click here or study). Citation: Bright P. Thilagar, Aditya K. Ghosh, Jerome Nguyen, Regan N. Theiler, Myra J. Wick, Ryan T. Hurt, Raymund R. Razonable, Ravindra Ganesh. Outcomes of Anti-Spike Monoclonal Antibody Therapy in Pregnant Women with Mild to Moderate COVID-19. medRxiv 2021.11.27.21266942; doi: https://doi.org/10.1101/2021.11.27.21266942

Update 1 Jan 2022 – study 891 added

Study 891 – 4 cases from Turkey

From Etlik Zübeyde Hanım Women’s Health Care, Training and Research Hospital, Ankara, which has not previously reported cases (click here or study). Citation: Yucel Celik O, Çelen Ş, Engin Üstün Y. Did the SARS-CoV-2 effect pregnancy complications? Ginekol Pol. 2021 Jul 15. doi: 10.5603/GP.a2021.0134. Epub ahead of print. PMID: 34263916.

Update 31 December – study 890 added

Study 890 – Ten cases from USA

From Saint Francis Hospital and Medical Center, of Trinity Health of New England, Hartford, Connecticut from April 24 to May 21, 2020 (click here or study). This hospital has not previously reported cases. Citation: Pimentel VM, Jackson FI, Ferrante AD, Figueroa R. Ethnic Disparities in Coronavirus Disease 2019 after the Implementation of Universal Screening in Hartford, Connecticut. AJP Rep. 2021 Dec 22;11(4):e147-e153. doi: 10.1055/s-0041-1740562. PMID: 34966566; PMCID: PMC8695059.

Update 29 December – studies 894 to 899 added, and study 882 updated

Study 899 – 8 cases from USA

From the MotherToBaby prospective cohort collected by the OTIS Research Center at University California, San Diego (click here or study). This appears to be the first Covid report from this cohort, but overlap with other cases from California is possible. Citation: Hsieh LE, Grifoni A, Dave H, Wang J, Johnson D, Zellner J, Sidney J, Chambers C, Franco A. SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women. J Reprod Immunol. 2021 Dec 11;149:103464. doi: 10.1016/j.jri.2021.103464. Epub ahead of print. PMID: 34953325; PMCID: PMC8665650.

Study 898 – 87 cases from Oman, Iraq & Jordan

Abstract only available (click here or study). Citation: Al Hashmi I, Khalaf A, Seshan V, Alsabti H, Al Omari O, Yehia D, Baqer M, Al Khadhuri J. Maternal and Neonatal Outcomes of Healthy Pregnant Women With COVID-19 Versus High-risk Pregnant Women: A Multi-Center Case-Control Comparison Study. Clin Nurs Res. 2021 Dec 26:10547738211064027. doi: 10.1177/10547738211064027. Epub ahead of print. PMID: 34955040.

Study 897 – case report from Oman

From Sultan Qaboos University Hospital, Al Khod, Muscat, which has not previously reported cases (click here or study). Citation: Burad J, Kodange S. Neuroleptic Malignant Syndrome due to Atypical Antipsychotics in a COVID-19-positive Pregnant Woman. Indian J Crit Care Med. 2021 Sep;25(9):1073-1074. doi: 10.5005/jp-journals-10071-23959. PMID: 34963731; PMCID: PMC8664039.

Study 896 – 2,655 cases from USA

Using claims data from the OptumLabs Data Warehouse (click here or study). This stores deidentified patient data from all over the US. Likely overlap with many other series. Citation: Regan AK, Arah O, Fell DB, Sullivan SG. SARS-CoV-2 infection during pregnancy and associated perinatal health outcomes: a national US cohort study. J Infect Dis. 2021 Dec 27:jiab626. doi: 10.1093/infdis/jiab626. Epub ahead of print. PMID: 34958090.

Study 895 – 57 cases from Italy

From author affiliations cared for between April 2020 to October 2021 at San Gerardo Hospital, Monza, so likely overlap with studies 64, 117, 252, and 709 as well as the various Lombary series (click here or study). Citation: Giardini V, Ornaghi S, Acampora E, Vasarri MV, Arienti F, Gambacorti-Passerini C, Casati M, Carrer A, Vergani P. Letter to the Editor: SFlt-1 and PlGF Levels in Pregnancies Complicated by SARS-CoV-2 Infection. Viruses. 2021 Nov 27;13(12):2377. doi: 10.3390/v13122377. PMID: 34960646.

Study 894 – case report from Slovakia

From author affiliations cared for at University Hospital, Trnava, which has not previously reported cases (click here or study). Citation: Babal P, Krivosikova L, Sarvaicova L, Deckov I, Szemes T, Sedlackova T, Palkovic M, Kalinakova A, Janega P. Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case? Viruses. 2021 Dec 19;13(12):2545. doi: 10.3390/v13122545. PMID: 34960815.

Update 24 December – study 893 added

Study 893 – 427 cases from USA

From six Northwell Health hospitals and Maimonides Medical Center, New York between April 10th and June 4th 2020 (click here or study). Probable overlap with studies 113, 134, 162, 179, 289, 315, 331, 561 & 854. Citation: London V, Blitz MJ, Solmonovich R, Silver M, Minkoff H. Temporal Trend in SARS-CoV-2 Symptoms in Pregnant Women. Am J Perinatol. 2021 Dec 16. doi: 10.1055/s-0041-1739490. Epub ahead of print. PMID: 34918329.

Update 23 December – studies 887 to 892 added

Study 892 – 7 cases from Nigeria

Cared for at University of Port Harcourt Teaching Hospital, Rivers State, from March to August 2020 (abstract click here or study). This centre has not previously reported cases. Citation: Alasia D, Maduka O, Oputa VO, Orazulike N, Otokwala J, Osemwegie N, Ozah C, Inya JN, Omietimi S, Ogan S, Ugboma H, Stanley P. COVID-19 and Pregnancy: A Prospective Descriptive Study from a Tertiary Hospital in Nigeria. West Afr J Med. 2021 Nov 30;Vol. 38(11):1036-1041. PMID: 34919179.

Study 891 – 856 cases from India

Cared for at the Government Medical College, Kannur, Kerala, from 1 August 2020 to 31 July 2021 (click here or study). Likely overlap with study 618 (not cited). Citation: Kurian S, Mathews M, Reshmi VP, Divakaran B, Ajith S. Impact of diabetes on the severity of COVID-19 infection in pregnant women – A single-center descriptive study. Diabetes Metab Syndr. 2021 Dec 9;16(1):102362. doi: 10.1016/j.dsx.2021.102362. Epub ahead of print. PMID: 34922215; PMCID: PMC8654463.

Study 890 – 5 cases treated with ECMO in USA

Cared for at University of California, Los Angeles from March 2020 to August 2021 (click here or study). Two cases previously included in study 323. Citation: Yin O, Richley M, Hadaya J, Mei J, Mok T, Fahim M, Pluym ID, Rao R, Martin C, Han CS, Benharesh P, Afshar Y, Extracorporeal membrane oxygenation in pregnancy: a bridge to delivery and pulmonary recovery for COVID-19-related severe respiratory failure, American Journal of Obstetrics and Gynecology (2022), doi: https://doi.org/10.1016/j.ajog.2021.12.024.

Study 889 – 9 cases from China

Cared for in Wuhan Maternal and Child Health Hospital from January 24 to March 14, 2020 (click here or study). Likely reported many times. Citation: Cheng Y, Teng H, Xiao Y, Yao M, Yin J, Sun G. Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study. Front Pediatr. 2021 Dec 2;9:762684. doi: 10.3389/fped.2021.762684. PMID: 34926345; PMCID: PMC8678601.

Study 888 – 6,073 cases from Brazil

Data from SIVEP-Gripe (Sistema de Informação de Vigilância Epidemiológica da Gripe), a nationwide database severe acute respiratory syndrome (SARS), from February 2020 until May 1, 2021 (click here or study). Likely overlap with many other series from Brazil. Citation: Gonçalves BMM, Franco RPV, Rodrigues AS. Maternal mortality associated with COVID-19 in Brazil in 2020 and 2021: Comparison with non-pregnant women and men. PLoS One. 2021 Dec 21;16(12):e0261492. doi: 10.1371/journal.pone.0261492. PMID: 34932589.

Study 887 – case report from Iran

From Alborz University of Medical Sciences, Karaj (click here or study). The clinical details differ from those reported in study 584. Citation: Farahani M, Azadi K, Hashemnejad M, Agoushi A, Nirouei M. Ruled out of preeclampsia-like syndrome due to COVID-19: A case study. Clin Case Rep. 2021 Dec 7;9(12):e05195. doi: 10.1002/ccr3.5195. PMID: 34934502; PMCID: PMC8650748.

Update 17 December – studies 884 to 886 added

Study 886 – 151,354 cases from USA

13 December update of CDC surveillance includes 249 maternal deaths (click here or data). Citation: Centres for Disease Control. Weekly COVID-19 Pregnancy Data updated 13 December 2021, Accessed 17 December 2021.

Study 885 – 1,436 cases from UK

This infographic from the UKOSS team reports cases admitted to hospital for the delta predominant period, 16th May to 31st October 2021 (click here or study). It also shows that from the start of the pandemic up to 31 October, 34 pregnant or postnatal women had died with Covid in UK. Note different denominator periods. Overlap with previous UKOSS reports, especially study 846. Citation: Knight M. UKOSS infographic. 16 December 2021. Accessed 17 December 2021

Study 884 – 4,274 cases from Scotland

National data up to to September 30, 2021 (click here or study). No maternal deaths. Perinatal mortality 9/567 births within 28 days of diagnosis (PMR 15.9/1000; 95% CI 7.8 to 31.0). All perinatal deaths in unvaccinated women. Citation: Sarah Stock, Jade Carruthers, Clara Calvert et al. COVID-19 vaccination rates and SARS-CoV-2 infection in pregnant women in Scotland, 09 November 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1051010/v1] Update 13 Jan 2022 Peer reviewed version (click here or study). Citation: Stock, S.J., Carruthers, J., Calvert, C. et al. SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nat Med (2022). https://doi.org/10.1038/s41591-021-01666-2

Update 13 December – studies 882 and 883 added

Study 883 – 9,620 cases from The Netherlands

We’ve not reported on the NETHOSS registry recently. On 7 December it included 9,620 pregnant women with a proven COVID-19 infection, between 1 March 2020 to 1 May 2021 (click here or study). Citation: NETHOSS registry. https://www-nvog-nl.translate.goog/actueel/registratie-van-covid-19-positieve-zwangeren-in-nethoss/?_x_tr_sl=nl&_x_tr_tl=en&_x_tr_hl=en-GB&_x_tr_pto=op,sc Accessed 13 Dec 2021.

Study 882 – 112 cases from USA

Cared for at at Thomas Jefferson University Hospital from April 2020-February 2021 (click here or study). Possible overlap with studies 65, 86 and 359. Citation: Rupsa C. Boelig, Sidhartha Chaudhury, Zubair H. Aghai, Emily Oliver, Francesca Manusco, Vincenzo Berghella, Elke Bergmann-Leitner. Comprehensive Serological Profile and Specificity of Maternal and Neonatal Cord Blood SARS CoV-2 Antibodies. medRxiv 2021.12.06.21267328; doi: https://doi.org/10.1101/2021.12.06.21267328 Update 29 December Peer review publication (click here or study). Citation: Boelig RC, Chaudhury S, Aghai ZH, Oliver E, Manusco F, Berghella V, Bergmann-Leitner E. Comprehensive Serological Profile and Specificity of Maternal and Neonatal Cord Blood SARS CoV-2 Antibodies. AJOG Glob Rep. 2021 Dec 23:100046. doi: 10.1016/j.xagr.2021.100046. Epub ahead of print. PMID: 34961853; PMCID: PMC8697419.

Update 10 December – studies 877 to 881 added

Study 881 – 4 cases treated with monoclonal antibodies from USA

From author affiliations probably treated in Barnes-Jewish Hospital, in St. Louis, Missouri, between November 2020 and July 2021 (click here or study). They may have been included in studies 259, 290, 579 and 638. Citation: Hirshberg JS, Cooke E, Oakes MC, Odibo AO, Raghuraman N, Kelly JC. Monoclonal antibody treatment of symptomatic COVID-19 in pregnancy: initial report. Am J Obstet Gynecol. 2021 Dec;225(6):688-689. doi: 10.1016/j.ajog.2021.08.025. Epub 2021 Aug 25. PMID: 34453934; PMCID: PMC8386136.

Study 880 – 70 cases from Bangladesh

From Dhaka, Sir Salimullah, and Mugdha, Medical College & Hospitals, all three in Dhaka, between March and August 2020 (click here or study). Citation: Binte Masud S, Zebeen F, Alam DW, Hossian M, Zaman S, Begum RA, Nabi MH, Hawlader MDH. Adverse Birth Outcomes Among Pregnant Women With and Without COVID-19: A Comparative Study From Bangladesh. J Prev Med Public Health. 2021 Nov;54(6):422-430. doi: 10.3961/jpmph.21.432. Epub 2021 Oct 21. PMID: 34875825.

Study 879 – 60 cases from India

From the All India Institute of Medical Sciences, Rishikesh, which has not previously reported cases, from July to December 2020 (click here or study). Citation: Khoiwal K, Agarwal A, Gaurav A, Kumari R, Mittal A, Sabnani S, Mundhra R, Chawla L, Bahadur A, Chaturvedi J. Obstetric and perinatal outcomes in pregnant women with COVID-19: an interim analysis. Women Health. 2021 Dec 7:1-9. doi: 10.1080/03630242.2021.2007199. Epub ahead of print. PMID: 34875976.

Study 878 – 193 cases from Slovenia

From University Medical Center, Ljubljana between October 27th 2020 and January 31st 2021 (click here or study). Probably a different hospital as study 393, and certainly a later time period. Citation: Lucovnik M, Druskovic M, Vidmar Simic M, Verdenik I, Mesaric V, Kosir R, Kornhauser Cerar L, Tojner Bregar A, Steblovnik L, Kavsek G, Premru Srsen T. Perinatal outcomes in women with severe acute respiratory syndrome coronavirus 2 infection: comparison with contemporary and matched pre-COVID-19 controls. J Perinat Med. 2021 Dec 9. doi: 10.1515/jpm-2021-0313. Epub ahead of print. PMID: 34881547.

Study 877 – 33 cases from USA

From Prentice Women’s Hospital and Erie Family Health Center in Illinois between 3 April and 26 July 2020 (click here or study). Neither centre has previously reported cases. Citation: Schuh TL, Mithal LB, Naureckas S, Miller ES, Garfield CF, Shah MD. Outcomes from birth to 6 months of publicly insured infants born to mothers with severe acute respiratory syndrome coronavirus 2 infection in the United States. J Perinat Med. 2021 Dec 10. doi: 10.1515/jpm-2021-0251. Epub ahead of print. PMID: 34882359.

Update 1 December – study 876 added

Study 876 – 874 cases from France

From the French national hospitalization database (PMSI) between January and June 202 (click here or study). Likely includes cases from many previous French series. Citation: Epelboin S, Labrosse J, De Mouzon J, Fauque P, Gervoise-Boyer MJ, Levy R, Sermondade N, Hesters L, Bergère M, Devienne C, Jonveaux P, Ghosn J, Pessione F. Obstetrical outcomes and maternal morbidities associated with COVID-19 in pregnant women in France: A national retrospective cohort study. PLoS Med. 2021 Nov 30;18(11):e1003857. doi: 10.1371/journal.pmed.1003857. PMID: 34847147.

Update 30 November – studies 872 to 875 added

Study 875 – some cases from Israel

Neither full text nor abstract available yet (click here or study). Citation: Ganor Paz Y, Shiloh S, Brosh-Nissimov T, Grupel D, Sorek N, Kustin T, Stern A, Maklakovsky M, Polak M, Sharvit M, Neeman O, Ben Valid T, Tovbin J, Barzilay E. The association between SARS-CoV-2 infection and late pregnancy loss. Int J Gynaecol Obstet. 2021 Nov 14. doi: 10.1002/ijgo.14025. Epub ahead of print. PMID: 34778964.

Study 874 – 52 cases from Poland

From the Central Clinical Hospital of the Ministry of the Interior and Administration, in Warsaw, which has not previously reported cases (click here or study). Citation: Januszewski M, Ziuzia-Januszewska L, Jakimiuk AA, Wierzba W, Gluszko A, Zytynska-Daniluk J, Jakimiuk AJ. Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study. Int J Environ Res Public Health. 2021 Nov 16;18(22):12011. doi: 10.3390/ijerph182212011. PMID: 34831766; PMCID: PMC8620897.

Study 873 – 1,704 cases from Spain

From the 79 hospitals of the Spanish Obstetric Emergency Group between 26 February and 5 November 2020 (click here or study). Likely overlap with studies 264b, 712, 727, 740 and 849 and perhaps others. Citation: Morán Antolín E, Broullón Molanes JR, de la Cruz Conty ML, Encinas Pardilla MB, Guadix Martín MDP, Sainz Bueno JA, Forcén Acebal L, Pintado Recarte P, Álvarez Bartolomé A, Martínez Cendán JP, Martínez-Pérez Ó, On Behalf Of The Spanish Obstetric Emergency Group. SARS-CoV-2 Infection and C-Section: A Prospective Observational Study. Viruses. 2021 Nov 22;13(11):2330. doi: 10.3390/v13112330. PMID: 34835136; PMCID: PMC8622813.

Study 872 – 110 cases from Turkey

From Adana City Education and Research Hospital, which has not previously reported cases (click here or study). Citation: Arslan B, Bicer IG, Sahin T, Vay M, Dilek O, Destegul E. Clinical characteristics and hematological parameters associated with disease severity in COVID-19 positive pregnant women undergoing cesarean section: A single-center experience. J Obstet Gynaecol Res. 2021 Nov 27. doi: 10.1111/jog.15108. Epub ahead of print. PMID: 34837446.

Update 29 November – studies 868 to 871 added

Study 871 – 76 cases from Romania

From Timisoara Municipal Emergency Hospital between 1 July 2020 and 1 July 2021 (click here or study). This hospital has not previously reported cases. Citation: Citu C, Neamtu R, Sorop VB, Horhat DI, Gorun F, Tudorache E, Gorun OM, Boarta A, Tuta-Sas I, Citu IM. Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications. J Clin Med. 2021 Nov 11;10(22):5253. doi: 10.3390/jcm10225253. PMID: 34830532; PMCID: PMC8617726.

Study 870 – 13 cases from Angola

From Lucrécia Paim maternity hospital in Luanda, which has not previously reported cases (click here or study). Citation: Sebastião CS, Parimbelli P, Mendes M, Sacomboio E, Morais J, de Vasconcelos JN, Brito M. Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola. Pathogens. 2021 Nov 16;10(11):1494. doi: 10.3390/pathogens10111494. PMID: 34832649; PMCID: PMC8624220.

Study 869 – case report from Romania

From “Elena Doamna” Hospital, Iasi (click here or study). Citation: Socolov R, Akad M, Păvăleanu M, Popovici D, Ciuhodaru M, Covali R, Akad F, Păvăleanu I. The Rare Case of a COVID-19 Pregnant Patient with Quadruplets and Postpartum Severe Pneumonia. Case Report and Review of the Literature. Medicina (Kaunas). 2021 Nov 1;57(11):1186. doi: 10.3390/medicina57111186. PMID: 34833404; PMCID: PMC8624501.

Study 868 – 20 cases from Turkey

From Basaksehir Cam and Sakura City Hospital, Istanbul (click here or study). Likely overlap with study 770. Citation: Yasa B, Memur S, Ozturk DY, Bagci O, Uslu SI, Cetinkaya M. Neonatal Outcomes of Premature Infants Born to Women with the Novel Coronavirus (SARS-CoV-2) Infection: A Case Control Study. Am J Perinatol. 2021 Nov 28. doi: 10.1055/s-0041-1740177. Epub ahead of print. PMID: 34839474.

Update 26 November – studies 864 to 867 added

Study 867 – 458 cases from Turkey

From Ankara City Hospital (click here or study). No harmful effect on newborn hearing noted. Probable overlap with previous cases from that hospital. Citation: Oskovi-Kaplan ZA, Ozgu-Erdinc AS, Buyuk GN, Sert-Dinc UY, Ali-Algan C, Demir B, Sahin D, Keskin HL, Tayman C, Moraloglu-Tekin Ö. Newborn Hearing Screening Results of Infants Born To Mothers Who Had COVID-19 Disease During Pregnancy: A Retrospective Cohort Study. Ear Hear. 2021 Nov 19. doi: 10.1097/AUD.0000000000001167. Epub ahead of print. PMID: 34812792.

Study 866 – ten cases treated with ECMO from USA

Five pregnant and five postpartum women with Covid, treated at Baylor University Medical Center Dallas, Texas, and at Baylor Scott & White The Heart Hospital, Plano, Texas (click here or study). Six survived to discharge, two died, and two remain inpatients. Citation: Shih E, DiMaio JM, Squiers JJ, Krueger AR, Schwartz GS, Herd J, Bleich AT. Treatment of Acute Respiratory Distress Syndrome from COVID-19 with Extracorporeal Membrane Oxygenation in Obstetric Patients. Am J Obstet Gynecol MFM. 2021 Nov 20:100537. doi: 10.1016/j.ajogmf.2021.100537. Epub ahead of print. PMID: 34813975; PMCID: PMC8605810.

Study 865 – Seventeen 1st trimester cases from Italy

Cared for at an unnamed hospital in Turin between 16 April and 22 June 2020 (click here or study). Possible overlap with studies 167, 195, 247, 615, 644, and 775. Citation: Cosma S, Carosso AR, Cusato J, Borella F, Bertero L, Bovetti M, Bevilacqua F, Mengozzi G, Mazzone R, Ghisetti V, Di Perri G, Benedetto C. Obstetric and neonatal outcomes after SARS-CoV-2 infection in the first trimester of pregnancy: A prospective comparative study. J Obstet Gynaecol Res. 2021 Nov 23. doi: 10.1111/jog.15105. Epub ahead of print. PMID: 34814234.

Study 864 – 1,637 cases from USA

Collected by Mississippi State Department of Health between March 1, 2020 & October 6, 2021 (click here or study). Maternal mortality in the pre-delta period (5/1000 cases) rose to 25/1000 during the delta predominant period. Likely overlap with study 597. Citation: Kasehagen L, Byers P, Taylor K, et al. COVID-19–Associated Deaths After SARS-CoV-2 Infection During Pregnancy — Mississippi, March 1, 2020–October 6, 2021. MMWR Morb Mortal Wkly Rep 2021;70:1646–1648. DOI: http://dx.doi.org/10.15585/mmwr.mm7047e2

Update 23 November – study 863 added

Study 863b – follow up of 298 cases from Kuwait

Infants born between April 1 and August 30, 2020, to mothers with SARS-CoV-2 infection during various trimesters of pregnancy, identified from the Kuwait National COVID-19 registry (click here or study). Of 840 pregnant women with COVID-19, 445 gave birth, and 298 infants were followed up at one year. Likely overlap with study 189. Citation: Mariam Ayed, Alia Embaireeg, Mais Kartam, Kiran More, Mafaza Alqallaf, Abdullah AlNafisi, Zainab Alsaffar, Zainab Bahzad, Yasmeen Buhamad, Haneen Alsayegh, Wadha Al-Fouzan, Hessa Alkandari. Neurodevelopmental outcomes of infants secondary to in utero exposure to maternal SARS-CoV-2 infection: A national prospective study in Kuwait. medRxiv 2021.11.12.21266291; doi: https://doi.org/10.1101/2021.11.12.21266291Update 22 November – study 862 added

Study 862b – Delta variant stillbirths in USA

From the Premier Healthcare Database Special COVID-19 Release (PHD-SR) before and during the
period of Delta variant predominance in the United States (March 2020–June 2021 and July–September 2021, respectively) (click here or study). COVID-19 documented at delivery was associated with increased risk for stillbirth (aRR = 1.90; 95% CI = 1.69–2.15), with a stronger association during the period of Delta variant predominance (aRR = 4.04; 95% CI = 3.28–4.97). Citation: DeSisto CL, Wallace B, Simeone RM, et al. Risk for Stillbirth Among Women With and Without COVID-19 at Delivery Hospitalization — United States, March 2020–September 2021. MMWR Morb Mortal Wkly Rep. ePub: 19 November 2021. DOI: http://dx.doi.org/10.15585/mmwr.mm7047e1 [Important]

Update 18 November – studies 858 to 861 added

Study 861b – seven cases from USA

From the University of Arkansas for the Medical Sciences, Little Rock, Arkansas, which has not previously reported cases (click here or study). Citation: Pagan ME, Ramseyer AM, Whitcombe DD, Doiron TE, Magann EF, Sandlin AT, Hughes DS. Management of Critically Ill Pregnant Patients with COVID-19 Infection in a Rural State. Am J Perinatol. 2021 Nov 14. doi: 10.1055/s-0041-1739292. Epub ahead of print. PMID: 34775583.

Study 860b – case report from Russia

From S.P. Botkin Infectious Hospital, Saint-Petersburg, which has not previously reported cases (click here or study). Citation: Zinserling VA, Bornstein SR, Narkevich TA, Sukhanova YV, Semenova NY, Vashukova MA, Steenblock C. Stillborn child with diffuse SARS-CoV-2 viral infection of multiple organs. IDCases. 2021;26:e01328. doi: 10.1016/j.idcr.2021.e01328. Epub 2021 Nov 5. PMID: 34777995; PMCID: PMC8570448.

Study 859b – 19 cases from Turkey

From Sakarya University Hospital, (click here or paper). The clinical features differ from those reported in study 474. Citation: Eman A, Balaban O, Kocayiğit H, Süner KÖ, Cırdı Y, Erdem AF. Maternal and Neonatal Outcomes of Critically Ill Pregnant and Puerperal Patients Diagnosed with COVID-19 Disease: Retrospective Comparative Study. J Korean Med Sci. 2021 Nov 15;36(44):e309. doi: 10.3346/jkms.2021.36.e309. PMID: 34783218.

Study 858b – 137 cases from French Guiana

Pregnant women who tested positive and admitted to the maternity of the West French Guiana Hospital Center (Centre Hospitalier de l’Ouest Guyanais, CHOG) from the 16 of June to the 16 of August 2020 (click here or study). This hospital has not previously reported cases. Citation: Hcini, N., Maamri, F., Picone, O., Carod, J.F., Lambert, V., Mathieu, M., et al. (2021) Maternal, Fetal and Neonatal Outcomes of Large Series of SARS-CoV-2 Positive Pregnancies in Peripartum Period: A Single-Center Prospective Comparative Study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 257, 11-18. https://doi.org/10.1016/j.ejogrb.2020.11.068

Update 8 November – study 857 added

Study 857b – 157 cases from Israel

Update of study 714 (click here or study). See also vaccine source 75 (click here). Citation: Romina Plitman Mayo, Tal Raz, Bar Ben David, Gila Meir, Haim Barr, Leonardo J. Solmesky, Rony Chen, Ana Idelson, Lucilla Zorzetti, Rinat Gabbay-Benziv, Yuval Jaffe Moshkovich, Tal Biron-Shental, Gil Shechter-Maor, Hen Yitzhak Sela, Itamar Glick, Hedi Benyamini Raischer, Raed Salim, Yariv Yogev, Ofer Beharier, Debra Goldman-Wohl, Ariel Many, Michal Kovo, Simcha Yagel, Michal Neeman. Waning of the Humoral Response to SARS-CoV-2 in Pregnancy is Variant-Dependent. medRxiv 2021.11.03.21265478; doi: https://doi.org/10.1101/2021.11.03.21265478

Update 7 November – studies 850 to 856 added. Study 732 updated.

Study 856b – 64 cases from Egypt

From an unspecified number “some” of unnamed hospitals (click here or study). From author affliliations they likely include hospitals affiliated with Al-Azhar University, Cairo, Cairo University, Ain Shams University, Cairo, Tanta University, Menoufia University, and Al Zahraa University Hospital, Cairo. Citation: Zaky S, Hosny H, Elassal G, Asem N, Baki AA, Kamal E, Abdelbary A, Said A, Ibrahim H, Taema K, Amin W, Abd-Elsalam S, Soliman S, Abdelmenam HS, Mohamed AS, Elnady M, Hassany M, Zaid H. Clinical evaluation of pregnant women with SARS-COV2 pneumonia: a real-life study from Egypt. J Egypt Public Health Assoc. 2021 Nov 4;96(1):29. doi: 10.1186/s42506-021-00092-z. PMID: 34735655; PMCID: PMC8567119.

Study 855b – 56 cases from Iran

Cared for at Shahid Beheshti Hospital, Kashan, which has not previously reported cases (click here or study). Citation: Abedzadeh-Kalahroudi M, Sehat M, Vahedpour Z, Talebian P. Maternal and neonatal outcomes of pregnant patients with COVID-19: A prospective cohort study. Int J Gynaecol Obstet. 2021 Jun;153(3):449-456. doi: 10.1002/ijgo.13661. Epub 2021 Mar 28. PMID: 33638200.

Study 854b – case report from Iran

From author affiliations likely cared for at Urmia University of Medical Sciences, Urmia (Click here or study). The clinical features differ from study 564. Citation: Nejadrahim R, Khademolhosseini S, Kavandi H, Hajizadeh R. Severe acute respiratory syndrome coronavirus-2- or pregnancy-related cardiomyopathy, a differential to be considered in the current pandemic: a case report. J Med Case Rep. 2021 Mar 19;15(1):143. doi: 10.1186/s13256-021-02751-3. PMID: 33741059; PMCID: PMC7978166.

Study 853b – 106 cases from USA

Cared for by the Maternal Fetal Medicine Division of the University of Texas McGovern Medical School, between
1st May and 31st August 2020. This covers seven hospitals in the Memorial Hermann system in Houston (click here or study). Probable overlap with studies 265b, 643 and 783. Citation: Soto-Torres E, Hernandez-Andrade E, Huntley E, Mendez-Figueroa H, Blackwell SC. Ultrasound and Doppler findings in pregnant women with SARS-CoV-2 infection. Ultrasound Obstet Gynecol. 2021 Jul;58(1):111-120. doi: 10.1002/uog.23642. PMID: 33794060; PMCID: PMC8251118.

Study 852b – 24 cases from Iran

Cared for at Al-Zahra hospital, Tabriz (click here or study). This hospital has not previousy reported cases. Citation: Vaezi M, Mirghafourvand M, Hemmatzadeh S. Characteristics, clinical and laboratory data and outcomes of pregnant women with confirmed SARS-CoV-2 infection admitted to Al-Zahra tertiary referral maternity center in Iran: a case series of 24 patients. BMC Pregnancy Childbirth. 2021 May 17;21(1):378. doi: 10.1186/s12884-021-03764-y. PMID: 34001013; PMCID: PMC8127208.

Study 851b – case report from Spain

From Hospital Clínico Universitario Lozano Blesa, Zaragoza (click here or study). Citation: Abadía-Cuchí N, Ruiz-Martínez S, Fabre M, Mateo P, Remacha Sienes M, Ventura Faci P, Bueno Sancho J, Benito R, Paules C. SARS-CoV-2 congenital infection and pre-eclampsia-like syndrome in dichorionic twins: A case report and review of the literature. Int J Gynaecol Obstet. 2021 Aug;154(2):370-372. doi: 10.1002/ijgo.13749. Epub 2021 Jun 9. PMID: 34009656.

Study 850b – 43 cases from Peru

Cared for at the Instituto Nacional Materno Perinatal (INMP) of Peru, between April 1 and June 30, 2020 (click here or study). Likely overlap with study 114. Citation: Dávila-Aliaga C, Hinojosa-Pérez R, Espinola-Sánchez M, Torres-Marcos E, Guevara-Ríos E, Espinoza-Vivas Y, Mendoza-Ibañez E, Saldaña-Díaz C. Maternal-perinatal outcomes in pregnant women with covid-19 in a level III hospital in Peru. Rev Peru Med Exp Salud Publica. 2021 Jan-Mar;38(1):58-63. Spanish, English. doi: 10.17843/rpmesp.2021.381.6358. Epub 2021 Jun 25. PMID: 34190925.

Update 6 November – studies 846 to 849 added. Study 717 updated.

Study 849b – 1,278 cases from Spain

From the Spanish Obstetric Emergency Group (click here or study). Overlap with studies 246b, 548, 589, 661 and 712. Citation: Sainz Bueno JA, Cerrillos González L, Abascal-Saiz A, Rodríguez Gallego MV, López Pérez R, Fernández Alonso AM, de la Cruz Conty ML, Alonso Saiz R, Molina Oller M, Santamaría Ortiz A, Martínez-Pérez Ó; Spanish Obstetric Emergency Group. Association of ABO and Rh blood groups with obstetric outcomes in SARS-CoV-2 infected pregnancies: A prospective study with a multivariate analysis. Eur J Obstet Gynecol Reprod Biol. 2021 Sep;264:41-48. doi: 10.1016/j.ejogrb.2021.07.008. Epub 2021 Jul 7. PMID: 34271364; PMCID: PMC8260552.

Study 848b – case report from USA

From the University of Texas Health Science Center, Houston (click here or study). May be included in studies 265b or 783. Citation: Mai B, Alrais M, Tchakarov A. A Case Report of Fetal Thrombotic Vasculopathy in a COVID Placenta. Ann Clin Lab Sci. 2021 Jul;51(4):570-572. PMID: 34452898.

Study 847b – case report from Indonesia

From Universitas Airlangga, Surabaya, (click here or study). Possibly included in study 732. Citation: Aldika Akbar MI, Gumilar KE, Tjokroprawiro BA, Ulhaq RA. Successful management of a pregnant woman with COVID-19 and multiple severe complications. BMJ Case Rep. 2021 Sep 16;14(9):e243594. doi: 10.1136/bcr-2021-243594. PMID: 34531234; PMCID: PMC8449948.

Study 846b – 35 cases from Ireland

Twenty three pregnant, and twelve recently pregnant women with Covid admitted to ICU between Dec 2020 & 1 August 2021. There were no such cases prior to that date (click here or study). Overlap with study 858. Citation: National Office of Clinical Audit. NOCA Report on Intensive Care Unit (ICU) Activity during the Covid-19 pandemic. https://www.noca.ie/documents/noca-report-on-icu-activity-during-covid-19-pandemic. Accessed 6 November 2021

Update 30 October – study 863 added

Study 863 – seven pregnant cases from UK

Randomly selected from the routine laboratory reporting system in England from all those who requested a test on 26-27 November 2020 (click here or study). Citation: Frank Sandmann, Elise Tessier, Joanne Lacy, Meaghan Kall, Edwin Van Leeuwen, Andre Charlett, Rosalind M Eggo, Gavin Dabrera, W. John Edmunds, Mary Ramsay, Helen Campbell, Gayatri Amirthalingam, Mark Jit. Long-term health-related quality of life in non-hospitalised COVID-19 cases with confirmed SARS-CoV-2 infection in England: Longitudinal analysis and cross-sectional comparison with controls medRxiv 2021.10.22.21264701; doi: https://doi.org/10.1101/2021.10.22.21264701

Update 29 October – studies 859 to 862 added

Study 862 – 3,306 cases from Italy

From ITOSS (click here or study). Overlap with studies 246, 536, and 674 plus other Italian series. Citation: Donati S, Corsi E, Maraschini A, Salvatore MA; ItOSS- COVID-19 working group. SARS-CoV-2 infection among hospitalized pregnant women and impact of different viral strains on COVID-19 severity in Italy: a national prospective population-based cohort study. BJOG. 2021 Oct 23. doi: 10.1111/1471-0528.16980. Epub ahead of print. PMID: 34687585.

Study 861 – Seven cases from Italy

Identified in a case control study of miscarriage between March 3 and May 25, 2020 at IRCCS Foundation Policlinico San Matteo, Pavia (click here or study). Citation: Zelini P, Dominoni M, Lilleri D, Gardella B, Arossa A, Perotti F, Arrigo A, Spinillo A. Asymptomatic SARS-CoV-2 infection is not associated with miscarriage in early pregnancy: a retrospective analysis. New Microbiol. 2021 Oct 25;44(3). Epub ahead of print. PMID: 34694414.

Study 860 – 197 placentas from USA

From Columbia University – Irving Medical Center, New York (click here or study). The series overlaps with studies 209 and 673, as well as probably also studies 41, 136, 261, 317, 598, 689 and 751. Citation: Thomas J, Sun Y, Debelenko L. Infrequent Placental and Fetal Involvement in SARS-CoV-2 Infection: Pathology Data from a Large Medical Center. J Dev Biol. 2021 Oct 16;9(4):45. doi: 10.3390/jdb9040045. PMID: 34698210; PMCID: PMC8544396.

Study 859 – 2,196 cases from Sweden

Women admitted for delivery between March 11, 2020, and January 31, 2021, as captured from the Swedish Pregnancy Register (click here or study). This appears almost the same cohort as study 688, not cited. It likely also includes cases from studies 20, 88, 259b, 282, 298, 523, 588, 610 & 636. Citation: Stephansson O, Pasternak B, Ahlberg M, Hervius Askling H, Aronsson B, Appelqvist E, Jonsson J, Sengpiel V, Söderling J, Norman M, Ludvigsson JF, Neovius M. SARS-CoV-2 and pregnancy outcomes under universal and non-universal testing in Sweden: register-based nationwide cohort study. BJOG. 2021 Oct 27. doi: 10.1111/1471-0528.16990. Epub ahead of print. PMID: 34706148.

Update 23 October – studies 855 to 858 added

Study 858 – 12 pregnant women in ICU in Ireland in wave 4

Pregnancy was reported in 12 cases of COVID-19 admitted to ICU between 27.06.2021 and 02.10.2021. This is compared to one case in Wave 1 (16.02.2020-01.08.2020), no cases in Wave 2 (02.08.2020-21.11.2020) and 19 cases in Wave 3 (22.11.2020-26.06.2021) (click here or study). Citation: Health Protection Surveillance Centre. Epidemiology of intensive care admissions in cases of COVID-19 in Ireland (among those aged 15 years and older). Report prepared on 05.10.2021 (data from 27.06.2021 to midnight 02.10.2021). https://www.hpsc.ie/a-z/respiratory/coronavirus/novelcoronavirus/surveillance/covid-19intensivecareadmissions/ Accessed 23 October 2021

Study 857 – Case control study from Norway

708 pregnant women aged between 15 and 45 in the Norwegian National Population Registry between March 1st, 2020 and February 28th, 2021, testing positive for SARS-Cov-2, and non pregnant controls (click here or study). Citation: Magnus MC, Oakley L, Gjessing HK, Stephansson O, Engjom HM, Macsali F, Juliusson PB, Andersen AN, Håberg SE. Pregnancy and risk of COVID-19: a Norwegian registry-linkage study. BJOG. 2021 Oct 17. doi: 10.1111/1471-0528.16969. Epub ahead of print. PMID: 34657368.

Study 856 – Placental studies from USA

Placentas from pregnant women cared for at Massachusetts General or Brigham & Women’s Hospital, Boston, Massachussetts, and enrolled in a COVID-19 pregnancy biorepository starting April 2, 2020 (click here or study). Citation: Bordt EA, Shook LL, Atyeo C, Pullen KM, De Guzman RM, Meinsohn MC, Chauvin M, Fischinger S, Yockey LJ, James K, Lima R, Yonker LM, Fasano A, Brigida S, Bebell LM, Roberts DJ, Pépin D, Huh JR, Bilbo SD, Li JZ, Kaimal A, Schust D, Gray KJ, Lauffenburger D, Alter G, Edlow AG. Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. Sci Transl Med. 2021 Oct 19:eabi7428. doi: 10.1126/scitranslmed.abi7428. Epub ahead of print. PMID: 34664987.

Study 855 – 13,062 cases from Mexico

Data from the Mexican National Registry of Coronavirus April 1st, 2020 to July 31st, 2021 (click here or study). The 3rd overlapping analysis from this source, see studies 513 and 518. Likely also overlap with studies 340, 475, 632, 685, 722, 726, 739, and 768, plus other smaller series from this country. Citation: Torres-Torres, J., Martinez-Portilla, R.J., Espino-y-Sosa, S., Estrada-Gutierrez, G., Solis-Paredes, J.M., Villafan-Bernal, J.R., Medina-Jimenez, V., Rodriguez-Morales, A.J., Rojas-Zepeda, L. and Poon, L.C. (2021), Comorbidities, poverty and social vulnerability as risk factors for mortality in pregnant women with confirmed SARS-CoV-2 infection: analysis of 13 062 positive pregnancies including 176 maternal deaths in Mexico. Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.24797

Update 18 October – study 854 added

Study 854 – seropositivity in USA

From Hofstra/Northwell in New York between May 2020 and June 2020 (click here or study). Citation: Staszewski C, Rochelson B, Krantz DA, Gerber R, Juhel H, Reddy S, Blitz MJ, Persistence of infection-induced SARS-CoV-2 seropositivity throughout gestation, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.09.037.

Update 13 October – studies 847 to 853 added

Study 853 – 871 cases from India

Cared for at Postgraduate Institute and YCM Hospital Pimpri Pune (Maharashtra) from May 1st, 2020, to April 30th, 2021 (click here or study). Nine mothers died. This hospital has not previously reported cases. Citation: Asalkar M, Thakkarwad S, Rumani I, Sharma N. Prevalence of Maternal Mortality and Clinical Course of Maternal Deaths in COVID-19 Pneumonia-A Cross-Sectional Study. J Obstet Gynaecol India. 2021 Oct 6:1-10. doi: 10.1007/s13224-021-01545-3. Epub ahead of print. PMID: 34629786; PMCID: PMC8492816.

Study 852 – 18 social media self-selected cases

The survey was conducted during May to September 2020 using advertisements on social media from
Canada, USA, UK, India and other countries (click here or study). Citation: Papadopoulos A, Nichols ES, Mohsenzadeh Y, Giroux I, Mottola MF, Van Lieshout RJ, Duerden EG. Depression in pregnant women with and without COVID-19. BJPsych Open. 2021 Sep 21;7(5):e173. doi: 10.1192/bjo.2021.1010. PMID: 34635872; PMCID: PMC8485035.

Study 851 – 101 cases from Poland

Cared for in the Gynecological-Obstetrical Hospital of Poznan University of Medical Sciences, from May to December 2020 (click here or study). This hospital has not previously reported cases. Citation: Wróblewska-Seniuk, K.; Basiukajć, A.; Wojciechowska, D.; Telge, M.; Miechowicz, I.; Mazela, J. Clinical Characteristics of Newborns Born to Mothers with COVID-19. J. Clin. Med. 2021, 10, 4383. https://doi.org/10.3390/jcm10194383

Study 850 – 172 cases from Israel

Cared for at Mayanei Hayeshua Medical Center, in Bnei Brak, between 26 March and 30 September 2020 (click here or study). Likely overlap with study 360. Citation: Linda Harel, Elior Eliasi, Shirlee Jaffe Lifshitz, Yehudit Schindler, Doron Rosen, Ioana Olteanu, Amichai Rottenstreich & Avinoam Tzabari (2021) Does the presence of symptoms affect pregnancy outcomes in third trimester in women with SARS-CoV-2, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2021.1956895

Study 849 – 98 cases from Iran

Collected from hospitals of the Hamadan province from March 2020 until April 2021 (click here or study). The time period and hospital raise the possibility of overlap with studies 375 and 515. Citation: Ghelichkhani S, Jenabi E, Jalili E, Alishirzad A, Shahbazi F. Pregnancy outcomes among SARS-CoV-2-infected pregnant women with and without underlying diseases: a case-control study. J Med Life. 2021 Jul-Aug;14(4):518-522. doi: 10.25122/jml-2021-0157. PMID: 34621376; PMCID: PMC8485375.

Study 848 – 32 seropositive cases from Ecuador

Identified from 100 pregnant women tested in Cgora Women Clinic, Babahoyo from September 3, 2020 to January 31, 2021 (click here or study). The first report from this centre. Citation: Zambrano H, Anchundia K, Aviles D, Andaluz R, Calderon N, Torres E, Gonzalez-Granda N, Maxwell A, Chen K, Gonik B, Mor G. Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region. Placenta. 2021 Oct 6;115:146-150. doi: 10.1016/j.placenta.2021.10.001. Epub ahead of print. PMID: 34626893; PMCID: PMC8492380.

Study 847 – 390 cases from UK

From 1 May, 218 currently pregnant, and 172 recently pregnant women have been admitted to critical care in UK (click here or study). Overlap with previous ICNARC reports Citation: Intensive Care National Audit & Research Centre. ICNARC report on COVID-19 in critical care: England, Wales and Northern Ireland 8 October 2021 Accessed 13 October 2021. https://www.icnarc.org/Our-Audit/Audits/Cmp/Reports

Update 11 October – study 846 added [personal communication Marian Knight]

Study 846 – 1714 cases from UK

This infographic from UKOSS reports that 235/1714 (14%) of UK women admitted with Covid between 1 Feb and 30 September 2021 were also admitted to intensive care (98.7% of them unvaccinated). 13 women (85% known to be unvaccinated) died in the 3rd delta wave (July to September) in UK (click here or source). Although not a peer reviewed report, it comes from an impeccable source, Marian Knight from UKOSS, and the data are important. These numbers includes cases from previous UKOSS reports studies 92, 533, 667 and 764. Citation: Knight M. UKOSS infographic 11 October 2021. Accessed 10 October 2021

Update 26 September – sources 61 to 63 added

4 October 2021 – study 845 added

Study 845 – 66 cases from Canada, UK & France

From the Centre Hospitalier Universitaire Sainte Justine, Montreal, the Childrens Hospital of Eastern Ontario, Ottawa, Centre Hospitalier Universitaire, Nancy, and St-Mary’s Hospital, Manchester (click here or study). Likely included in various national cohorts. Citation: Brien ME, Bouron-Dal Soglio D, Dal Soglio S, Couture C, Boucoiran I, Nasr Y, Widdows K, Sharps MC, El Demellawy D, Ep Heazell A, Menzies D, Girard S. Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface. Placenta. 2021 Sep 11;115:37-44. doi: 10.1016/j.placenta.2021.09.007. Epub ahead of print. PMID: 34537470; PMCID: PMC8433096.

1 October 2021 – studies 842 to 844 added

Study 844 – 293 cases from USA

Cared for at at the University of Alabama at Birmingham from March 22, 2020, to August 18, 2021 (click here or study). Likely to include cases in studies 480 and 813. Citation: Seasely AR, Blanchard CT, Arora N, Battarbee AN, Casey BM, Dionne-Odom J, Sinkey RG, Szychowski JM, Tita AT, Subramaniam A; CWRH COVID-19 Working Group. Maternal and Perinatal Outcomes Associated With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta (B.1.617.2) Variant. Obstet Gynecol. 2021 Sep 30. doi: 10.1097/AOG.0000000000004607. Epub ahead of print. PMID: 34592747.

Study 843 – 152 cases from USA

Two cohorts of pregnant women testing positive for SARS-CoV-2 infection between March to July 2020, and July to August 2021 and cared for at the University of Texas Medical Branch at Galveston, Texas (click here or study). The earlier cohort of 91 cases were reported in study 616. Citation: Wang AM, Berry M, Moutos CP, Omere C, Clark SM, Harirah HM, Jain S, Olson GL, Pacheco LD, Saade GR, Saad AF. Association of the Delta (B.1.617.2) Variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) With Pregnancy Outcomes. Obstet Gynecol. 2021 Sep 30. doi: 10.1097/AOG.0000000000004595. Epub ahead of print. PMID: 34592748.

Study 842 – 100 pregnant women treated with ECMO

Collected by the Extracorporeal Life Support Organization (ELSO) registry from 349 centres in 41 countries (click here or study). Includes cases from study 535. Citation: Barbaro R, MacLaren G, Boonstra PS et al. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the International Extracorporeal Life Support Organization Registry. Lancet. 2021; (published online Sept 29.) https://doi.org/10.1016/S0140-6736(21)01960-7

30 September 2021 – study 840 added

Study 841 – 167 cases from Turkey

Cared for at Bursa City Hospital, Bursa, which has not previously reported cases, between April 1, and December 1, 2020 (click here or study). Citation: Aydın GA, Ünal S, Özsoy HGT. The effect of gestational age at the time of diagnosis on adverse pregnancy outcomes in women with COVID-19. J Obstet Gynaecol Res. 2021 Sep 28. doi: 10.1111/jog.15051. Epub ahead of print. PMID: 34585464.

Study 840 – 1,645 cases from India

Cared for at Nair hospital, Mumbai from 1st April 2020 to 12th July 2021 (click here or study). Likely overlap with studies 225, 283, 369, 501, 520, 547, 746, 777, 778 and 839. Citation: N.N. Mahajan, C. Gaikwad, R. Tayshete, C. Saldanha, R. Pednekar, S.D. Mahale, R.K.Gajbhiye, Increased stillbirth rate during the second wave of COVID-19 pandemic in India, European Journal of Obstetrics & Gynecology and Reproductive Biology (2021), doi: https://doi.org/10.1016/j.ejogrb.2021.09.030

29 September 2021 – study 839 added

Study 839 – 1,630 cases from India

Cared for at Nair hospital, Mumbai from 1st April 2020 to 4th July 2021 (click here or study). Likely overlap with studies 225, 283, 369, 501, 520, 547, 746, 777 and 778. Citation: Gajbhiye, R.K., Tilve, A., Kesarwani, S., Srivastava, S., Kore, S.J., Patil, K., Mahale, S.D. and Mahajan, N.N. (2021), Increased spontaneous abortions during the second wave of COVID-19 pandemic in India. Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.24784

28 September 2021 – country and hospital of study 838 updated. HT @joallotey

27 September 2021 – studies 836 and 838 added

Study 838 – case report from India

The patient gave birth at Mal Superspeciality Hospital, West Bengal, which has not previously reported cases, on 11th June 2021 (click here or study). Citation: Kalsar P, Datta S, Kalsar A, Kipkoech Kirui B, Kanyike AM. Severe Postpartum Hemorrhage in an Asymptomatic COVID-19 Patient: A Call to Be on Guard. Int Med Case Rep J. 2021;14:683-687 https://doi.org/10.2147/IMCRJ.S334249

Study 837 – 51 cases from Iraq

From Al Yarmouk Teaching Hospital, in Baghdad (click here or study). One woman, excluded from the main study, died. Citation: Nori W, Hameed BH, Thamir AR, Fadhil A. COVID-19 in Pregnancy: Implication on Platelets and Blood Indices. Rev Bras Ginecol Obstet. 2021 Aug;43(8):595-599. English. doi: 10.1055/s-0041-1733912. Epub 2021 Sep 21. PMID: 34547793.

Study 836 – 72 cases from Japan

A survey of 1,418 maternity institutions identified 72 pregnant women with COVID-19 between 16 January and 30 June 2020 (click here or study). One woman, a tourist, needed ventilation and later died. Citation: Arakaki, T., Hasegawa, J., Sekizawa, A. et al. Clinical characteristics of pregnant women with COVID-19 in Japan: a nationwide questionnaire survey. BMC Pregnancy Childbirth 21, 636 (2021). https://doi.org/10.1186/s12884-021-04113-9

26 September 2021 – studies 828 to 835 added

Study 835 – two cases from USA

Cared for by Zucker School of Medicine at Hofstra/Northwell and Northwell Health between June 26th and September 4th 2020 (click here or study). None of 96 women undergoing Caesrean section, who were negative on admision, got infected. Citation: Nizam A, Nimaroff ML, Menzin AW, Goldberg GL, Miyara SJ, Molmenti E. Nosocomial Covid-19 Infection in Women Undergoing Elective Cesarean Sections: A prospective cohort study. Am J Obstet Gynecol MFM. 2021 Sep 17:100490. doi: 10.1016/j.ajogmf.2021.100490. Epub ahead of print. PMID: 34543753; PMCID: PMC8447544.

Study 834 – 45 cases from UK

Cared for in five unnamed NHS hospitals within London, and three outside, between 16 November 2020 and 10 January 2021 (click here or study). Citation: Stirrup O, Boshier F, Venturini C, Guerra-Assunção JA, Alcolea-Medina A, Beckett A, Charalampous T, da Silva Filipe A, Glaysher S, Khan T, Kulasegaran Shylini R, Kele B, Monahan I, Mollett G, Parker M, Pelosi E, Randell P, Roy S, Taylor J, Weller S, Wilson-Davies E, Wade P, Williams R; COG-UK-HOCI Variant substudy consortium; COVID-19 Genomics UK (COG-UK) consortium, Copas A, Cutino-Moguel MT, Freemantle N, Hayward AC, Holmes A, Hughes J, Mahungu T, Nebbia G, Partridge D, Pope C, Price J, Robson S, Saeed K, de Silva T, Snell L, Thomson E, Witney AA, Breuer J. SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study. BMJ Open Respir Res. 2021 Sep;8(1):e001029. doi: 10.1136/bmjresp-2021-001029. PMID: 34544733; PMCID: PMC8453594.

Study 833 – 1,515 cases from the USA

Cared for at the Parkland Health & Hospital System, Dallas, from May 17, 2020 through September 4, 2021 (click here or study). Likely overlap with studies 186 and 361. Citation: Adhikari EH, SoRelle JA, McIntire DD, Spong CY. Increasing severity of COVID-19 in pregnancy with Delta (B.1.617.2) variant surge. Am J Obstet Gynecol. 2021 Sep 13:S0002-9378(21)01005-X. doi: 10.1016/j.ajog.2021.09.008. Epub ahead of print. PMID: 34529957; PMCID: PMC8437765.

Study 832 – 15 cases from Ireland

Cared for at the Rotunda Hospital, Dublin and delivered between January and March 2021 (click here or study). This hospital has previously reported cases (studies 300, 596 & 676) but the dates suggest no overlap. Nor do the dates overlap with the Republic of Ireland’s Covid-19 register report, study 284. Citation: C.A. Murphy, D.P. O’reilly, O. Edebiri, L. Weiss, S. Cullivan, A. EL-Khuffash, E. Doyle, J.C. Donnelly, F.D. Malone, W. Ferguson, R.J. Drew, J. O’loughlin, E. Neary, P.B. Maguire, B. Kevane, F. Níainle, n. Mccallion, Haematological parameters and coagulation in umbilical cord blood following COVID-19 infection in pregnancy, European Journal of Obstetrics & Gynecology and Reproductive Biology (2021), doi: https://doi.org/10.1016/j.ejogrb.2021.09.019

Study 831 – 381 cases from India

Cared for at the Government Rajaji Hospital (GRH) & Medical College, Madurai, neither of which have previously reported cases, between March 22 and August 31, 2020 (click here or study). Citation: Priyadharshini CB, Priya S, Selvameena M, Waseemsha S, Muthurajesh E, Shalini M. Demographic profile of COVID-19 positive mothers & their outcome in government Rajaji hospital, Madurai, Tamilnadu – A cross sectional Study. Clin Epidemiol Glob Health. 2021 Oct-Dec;12:100864. doi: 10.1016/j.cegh.2021.100864. Epub 2021 Sep 10. PMID: 34541381; PMCID: PMC8432978.

Study 830 – 19 cases from Nigeria

Cared for at the University of Benin Teaching Hospital, Benin City, which has not previously reported cases, from April to September 2020 (click here or study). Citation: James Osaikhuwuomwan et al. Clinical characteristics and outcomes for pregnant women diagnosed with COVID-19 disease at the University of Benin Teaching Hospital, Benin City, Nigeria. Pan African Medical Journal. 2021;39(134). 10.11604/pamj.2021.39.134.27627

Study 829 – ICNARC update

This consortium collects cases from critical care in England, Wales and Northern Ireland (click here or study). See fig 28, p 40 (and others) for pregnancy. Citation: Intensive Care National Audit & Research Centre. ICNARC report on COVID-19 in critical care: England, Wales and Northern Ireland 17 September 2021 Accessed 26 September 2021. https://www.icnarc.org/Our-Audit/Audits/Cmp/Reports

Study 828 – 8,555 cases from ISARIC

This MedRxiv preprint reports that after adjusting for age, and stratifying by country, pregnancy was associated with a lower risk of death (HR 0.44 [0.38, 0.50] for females aged 15 to 45 (click here or study). The pregnancy cases are in supplementary table 5 (click here). The ISARIC consortium covers 720 sites across 49 countries. Citation: ISARIC Clinical Characterisation Group, Christiana Kartsonaki. Characteristics and outcomes of an international cohort of 400,000 hospitalised patients with Covid-19. medRxiv 2021.09.11.21263419; doi: https://doi.org/10.1101/2021.09.11.21263419 [Important, control group]

11 September 2021 – study 827 added

Study 827 – 36 cases from the Netherlands

Cared for at Erasmus Medical Center, Ikazia hospital, and Franciscus Gasthuis & Vlietland hospitals, all in Rotterdam, and at Leiden University Medical Center in Leiden, between April 2020 and March 2021 (click here or study). Citation: Husen, M.F.; van der Meeren, L.E.; Verdijk, R.M.; Fraaij, P.L.A.; van der Eijk, A.A.; Koopmans, M.P.G.; Freeman, L.; Bogers, H.; Trietsch, M.D.; Reiss, I.K.M.; DeKoninck, P.L.J.; Schoenmakers, S. Unique Severe COVID-19 Placental Signature Independent of Severity of Clinical Maternal Symptoms. Viruses 2021, 13, 1670. https://doi.org/10.3390/v13081670

9 September 2021 – study 826 added. Study 141 updated.

Study 826 – 376 cases from the Netherlands

From the NethOSS registry between March 1st, and August 31st, 2020 (click here or study). Likely overlap with studies 262, 373 and 528 as well as study 545 and other reports from the NethOSS registry. No maternal deaths, although one had been reported in the 22 May update of the NethOSS website (study 141). See study 141, 9 September update. Citation: Overtoom, E.M., Rosman, A.N., Zwart, J.J., Vogelvang, T.E., Schaap, T.P., van den Akker, T. and Bloemenkamp, K.W. (2021), SARS-CoV-2 infection in pregnancy during the first wave of COVID-19 in the Netherlands: a prospective nationwide population-based cohort study (NethOSS). BJOG: An International Journal of Obstetrics & Gynaecology. Accepted Author Manuscript. https://doi.org/10.1111/1471-0528.16903 [Important, control group]

8 September 2021 – studies 814 to 825 added. Study 716 updated.

Study 825 – 5,614 cases from Colombia

Collected by Colombia’s Instituto Nacional de Salud, Sivigila surveillace system from 6 March to 12 December 2020 (click here or study). Likely overlap with study 420. Citation: Rozo N, Valencia D, Newton SM, Avila G, Gonzalez MA, Sancken CL, Burkel VK, Ellington SR, Gilboa SM, Rao CY, Azziz-Baumgartner E, Ospina ML, Prieto FE, Tong VT. Severity of illness by pregnancy status among laboratory-confirmed SARS-CoV-2 infections occurring in reproductive-aged women in Colombia. Paediatr Perinat Epidemiol. 2021 Sep 1. doi: 10.1111/ppe.12808. Epub ahead of print. PMID: 34467554.

Study 824 – 233 cases from USA

Cared for at NYU Langone Health-Tisch, NYU Langone Health-Brooklyn, or Bellevue Hospital Center, New York from 1 March to 1 July 2020 (click here or study). Likely overlap with many studies. Citation: Limaye MA, Roman AS, Trostle ME, Venkatesh P, Lantigua Martinez M, Brubaker SG, Chervenak J, Wei LS, Sahani P, Grossman TB, Meyer JA, Penfield CA. Predictors of severe and critical disease in pregnant women with SARS-CoV-2. J Matern Fetal Neonatal Med. 2021 Sep 1:1-5. doi: 10.1080/14767058.2021.1951216. Epub ahead of print. PMID: 34470122.

Study 823 – 39 cases with rheumatic disease

Collected by the COVID-19 Global Rheumatology Alliance (click here or study). Citation: Bermas BL, Gianfrancesco M, Tanner HL, Seet AM, Aguiar MC, Al Adhoubi NK, Emadi SA, Cunha BM, Flood R, Kusevich DA, McCarthy EM, Patel NJ, Ruderman E, Sattui SE, Sciascia S, Siddique F, Valenzuela-Almada MO, Wise LM, Worthing AB, Zell J, Bhana S, Costello W, Duarte-Garcia A, Grainger R, Gossec L, Hausmann JS, Hyrich K, Lawson-Tovey S, Liew JW, Sirotich E, Sparks J, Sufka P, Wallace Z, Machado PM, Strangfeld A, Clowse MEB, Yazdany J, Robinson PC. COVID-19 in women with rheumatic disease who are pregnant: Data from the COVID-19 Global Rheumatology Alliance. J Rheumatol. 2021 Sep 1:jrheum.210480. doi: 10.3899/jrheum.210480. Epub ahead of print. PMID: 34470798.

Study 822 – 312 cases from Iran

Cared for at Nekouei-Hedayati-Forghani Hospital in Qom, from 15 March to 15 November 2020 (click here or study). Details of only 133 cases are reported. Likely overlap with studies 555 and 567. Citation: Alipour Z, Samadi P, Eskandari N, Ghaedrahmati M, Vahedian M, Khalajinia Z, Mastanijahroodi A. Relationship between coronavirus disease 2019 in pregnancy and maternal and fetal outcomes: Retrospective analytical cohort study. Midwifery. 2021 Aug 25;102:103128. doi: 10.1016/j.midw.2021.103128. Epub ahead of print. PMID: 34474247; PMCID: PMC8384487. PubPeer comment click here

Study 821 – 494 cases from USA

Survey conducted by Kaiser Permanente Northern California of women who were pregnant between January 1, 2020 and April 28, 2021 (click here or study). Likely overlap with study 414. Citation: Ames JL, Ferrara A, Avalos LA, Badon SE, Greenberg MB, Hedderson MM, Kuzniewicz MW, Qian Y, Young-Wolff KC, Zerbo O, Zhu Y, Croen LA. COVID-19 prevalence, symptoms, and sociodemographic disparities in infection among insured pregnant women in Northern California. PLoS One. 2021 Sep 3;16(9):e0256891. doi: 10.1371/journal.pone.0256891. PMID: 34478463; PMCID: PMC8415576.

Study 820 – 163 cases from USA

Collected by Cuyahoga County Board of Health, Cleveland, Ohio, with illness onset dates from March 13 through August 21, 2020 (click here or study). Possible overlap with study 198. Citation: Miracle JE, Ganesh PR, Rose J, Terebuh P, Stange KC, Wolfe HM, Szabo A, Gullett H, Pope R. COVID-19 in Pregnancy: Occupations with Higher Density of Population Exposure Associated with More Severe Disease. J Occup Environ Med. 2021 Sep 2. doi: 10.1097/JOM.0000000000002374. Epub ahead of print. PMID: 34483305.

Study 819 – 989 cases from india

956 were pregnant and 33 postpartum, collected from 53 hospitals participating in the Federation of Obstetric and Gynaecological Societies of India (FOGSI) COVID registry from 28 April to 28 August 2020 (click here or study). The hospitals are not named. Citation: Gandhi AM, Ganatra AM, Tank P. Preliminary Results from the FOGSI’s National Registry on Pregnancy with COVID-19. J Obstet Gynaecol India. 2021 Aug 31:1-8. doi: 10.1007/s13224-021-01537-3. Epub ahead of print. PMID: 34483513; PMCID: PMC8405343.

Study 818 – case report from Brazil

From author affiliations cared for at Maternity School, Federal University of Rio de Janeiro, which has not previously reported cases (click here or study). Citation: Marinho PS, da Cunha AJLA, Chimelli L, Avvad-Portari E, Andreiuolo FDM, de Oliveira-Szejnfeld PS, Mendes MA, Gomes IC, Souza LRQ, Guimarães MZ, Goldman SM, de Oliveira MBG, Rehen S, Amim J Jr, Tovar-Moll F, Prata-Barbosa A. Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism. Front Med (Lausanne). 2021 Aug 16;8:677001. doi: 10.3389/fmed.2021.677001. PMID: 34485327; PMCID: PMC8415358.

Study 817 – 24 cases from Bosnia & Herzegovina

From the Cantonal Hospital Zenica which has not previously reported cases (click here or study). Citation: Hodžić J, Muračević B, Štimjanin H, Iriškić R, Husika M. Pregnancy outcomes of COVID-19 positive pregnant women at the Cantonal Hospital Zenica, Bosnia and Herzegovina. Med Glas (Zenica). 2022 Feb 1;19(1). doi: 10.17392/1407-21. Epub ahead of print. PMID: 34486362.

Study 816 – 127 cases from India

From author affiliations likely cared for at Kalinga Institute of Medical Sciences, Bhubaneswar, which has not previously reported cases (click here or study). Citation: Mohini Ahmed S, Kasarla. V, Rath SK, Worse Outcomes of Pregnancy in COVID-19 Infection during Parturition may be due to Referral Bias: Analysis in a Prospective Cohort of 963 pregnancies, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/
j.ajog.2021.08.058.

Study 815 – two cases from the Czech Republic

Country assumed from journal title. Full text and journal source not found (click here or study). Citation: Čivrná J, Skanderová D, Ehrmann J, Pilka R. HELLP syndrome and HELLP-like syndrome in pregnancies with covid-19 – case reports. Ceska Gynekol. 2021 Summer;86(4):236-241. English. doi: 10.48095/cccg2021236. PMID: 34493047.

Study 814 – 22 cases from Brazil

From author affiliations the unnamed hospital is likely in Campinas, Sao Paolo (click here or study). Citation: Freitas-Jesus JV, Sánchez ODR, Rodrigues L, Faria-Schützer DB, Serapilha AAA, Surita FG. Stigma, guilt and motherhood: Experiences of pregnant women with COVID-19 in Brazil. Women Birth. 2021 Aug 27:S1871-5192(21)00151-7. doi: 10.1016/j.wombi.2021.08.009. Epub ahead of print. PMID: 34493479.

2 September 2021 – Studies 809 to 813 added

Study 813 – 99 cases from USA

Of 1,413 pregnant women, less than 28 weeks gestation, prospectively enrolled during August 2020–February 2021, who self-swabbed weekly, 99 tested positive (click here or study). They were cared for at three U.S. medical centers in Salt Lake City, Utah, New York City, and Birmingham, Alabama. It is not possible to identify the treating centres from author affliations. Citation: Fatimah S Dawood, Michael Varner, Alan Tita, Gabriella Newes-Adeyi, Cynthia Gyamfi-Bannerman, Ashley Battarbee, Ann Bruno, Michael Daugherty, Lawrence Reichle, Kelly Vorwaller, Celibell Vargas, Mickey Parks, Emily Powers, Miriam Lucca-Susana, Marie Gibson, Akila Subramaniam, Yiling J Cheng, Pei-Jean Feng, Sascha Ellington, Romeo R Galang, Jennifer Meece, Chris Flygare, Melissa S Stockwell, Incidence, Clinical Characteristics, and Risk Factors of SARS-CoV-2 Infection among Pregnant Individuals in the United States, Clinical Infectious Diseases, 2021;, ciab713, https://doi.org/10.1093/cid/ciab713

Study 812 – case report from Brazil

From Hospital Universitário Oswaldo Cruz, Recife, Pernambuco, which has not previously reported cases (click here or study). However she might be included in study 761. Citation: Gama MDP, Angelo Júnior JRL, Cunha-Correia CD. Stroke in COVID-19 and Pregnancy: A Case Report. Rev Soc Bras Med Trop. 2021 Aug 20;54:e03012021. doi: 10.1590/0037-8682-0301-2021. PMID: 34431948.

Study 811 – 267 cases from USA

Clinical nasopharyngeal or lateral mid-turbinate nasal swabs obtained during inpatient and outpatient encounters across the five acute hospitals in Johns Hopkins Medical System, as well as several long-term care facilities in the State of Maryland (click here or study). Citation: Chun Huai Luo, C. Paul Morris, Jaiprasath Sachithanandham, Adannaya Amadi, David Gaston, Maggie Li, Nicholas J. Swanson, Matthew Schwartz, Eili Y. Klein, Andrew Pekosz, Heba H. Mostafa. Infection with the SARS-CoV-2 Delta Variant is Associated with Higher Infectious Virus Loads Compared to the Alpha Variant in both Unvaccinated and Vaccinated Individuals. medRxiv 2021.08.15.21262077; doi: https://doi.org/10.1101/2021.08.15.21262077

Study 810 – 2,604 cases from USA

Taken from electronic medical record data from 182 Hospital Corporation of America (HCA) hospitals across the US between March 1, and August 23, 2020 (click here or study). 2,604 out of 84,624 patients with Covid were pregnant. Six died. Likely overlap with many previous US series. Citation: Adam V. Delora, Ashlynn Mills, David Jacobson, Brendon Cornett, W. Frank Peacock, Anita Datta, Shane Jenks. Socioeconomic and comorbid factors affecting mortality and length of stay in COVID-19. medRxiv 2021.08.26.21262693; doi: https://doi.org/10.1101/2021.08.26.21262693

Study 809 – two cases from Sri Lanka

Two pregnant health care workers tested positive for SARS CoV-2 in this series from Base Hospital, Wathupitiwala, which has not previously reported cases (click here or study). Citation: W.A.M.P. Samaranayake, G.P.C. Jayawardena, A.L.L. Roshan, M.A.M. Wijewardene, M.I. Siraj. COVID-19 infection among health care workers: Experience in Base Hospital Wathupitiwala, Sri Lanka. medRxiv 2021.08.28.21262733; doi: https://doi.org/10.1101/2021.08.28.21262733

31 August 2021 – studies 803 to 808 (Recovery trials with pregnant participants) added, some belatedly

Study 808 – 25 pregnant women in UK Recovery casirivimab & imdevimab trial

Their group allocation was not reported in this MedRxiv preprint of this trial of Regeneron’s monoclonal antibody combination, casirivimab and imdevimab, “REGEN-COV” (click here or study). Citation: RECOVERY Collaborative Group, Peter W Horby, Marion Mafham, Leon Peto, Mark Campbell, Guilherme Pessoa-Amorim, Enti Spata, Natalie Staplin, Jonathan R Emberson, Benjamin Prudon, Paul Hine, Thomas Brown, Christopher A Green, Rahuldeb Sarkar, Purav Desai, Bryan Yates, Tom Bewick, Simon Tiberi, Tim Felton, J Kenneth Baillie, Maya H Buch, Lucy C Chappell, Jeremy N Day, Saul N Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, David M Weinreich, Richard Haynes, Martin J Landray. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. medRxiv 2021.06.15.21258542; doi: https://doi.org/10.1101/2021.06.15.21258542

Study 807 – 10 pregnant women in UK Recovery tocilizumab trial

Group allocation not reported (click here or study). Citation: RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021 May 1;397(10285):1637-1645. doi: 10.1016/S0140-6736(21)00676-0. PMID: 33933206; PMCID: PMC8084355.

Study 806 – 58 pregnant women in UK Recovery aspirin trial

Their group allocation was not reported in this MedRxiv preprint (click here or study). Citation: RECOVERY Collaborative Group, Peter W Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J Kenneth Baillie, Buddha Basnyat, Maya H Buch, Lucy C Chappell, Jeremy Day, Saul N Faust, Raph L Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J Landray. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. medRxiv 2021.06.08.21258132; doi: https://doi.org/10.1101/2021.06.08.21258132

Study 805 – 25 pregnant women in UK Recovery azithromycin trial

Group allocation not reported (click here or study). Citation: RECOVERY Collaborative Group. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021 Feb 13;397(10274):605-612. doi: 10.1016/S0140-6736(21)00149-5. Epub 2021 Feb 2. PMID: 33545096; PMCID: PMC7884931.

Study 804 – Six pregnant women in UK Recovery Lopinavir–ritonavir trial

Group allocation not reported (click here or study). Citation: RECOVERY Collaborative Group. Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2020 Oct 24;396(10259):1345-1352. doi: 10.1016/S0140-6736(20)32013-4. Epub 2020 Oct 5. PMID: 33031764; PMCID: PMC7535623.

Study 803 – Four pregnant women in UK Recovery dexamethasone trial

One in treatment group and three in usual care (click here or study). Citation: RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. PMID: 32678530; PMCID: PMC7383595.

28 August 2021 – studies 801 and 802 added

Study 802 – case report from Italy

The hospital and date of delivery are not stated, but from ethics approval the former was in Brescia (click here or study). The case is likely included in the various Lombardy series. Citation: Schwartz DA, Bugatti M, Santoro A, Facchetti F. Molecular Pathology Demonstration of SARS-CoV-2 in Cytotrophoblast from Placental Tissue with Chronic Histiocytic Intervillositis, Trophoblast Necrosis and COVID-19. J Dev Biol. 2021 Aug 25;9(3):33. doi: 10.3390/jdb9030033. PMID: 34449643.

Study 801 – case report from Austria

From author affiliations cared for at the Medical University of Vienna, which has not previously reported cases, in October 2020 (click here or study). Citation: Palmrich P, Roessler B, Wisgrill L, Kampf S, Gattinger P, Valenta R, Fleischmann E, Berger A, Kiss H, Farr A. Multiprofessional perinatal care in a pregnant patient with acute respiratory distress syndrome due to COVID-19. BMC Pregnancy Childbirth. 2021 Aug 26;21(1):587. doi: 10.1186/s12884-021-04059-y. PMID: 34445988.

22 August 2021 – studies 797 to 800 added

Study 800 – 234 cases from Spain

Cared for in the 14 Neo-COVID-19 Research Group hospitals so likely included in many previous series (click here or study). Citation: Neo-COVID-19 Research Group:, Marín Gabriel MA, Domingo Goneche L, Cuadrado Pérez I, Reyne Vergeli M, Forti Buratti A, Royuela Vicente A, Olabarrieta Arnal I, Sánchez L, Alonso Díaz C, Criado E, Carrizosa Molina T, Caserío Carbonero S, Casas Satre C, Fernández-Cañadas Morillo A; Authoring Group (Neo-COVID-19 Research Group). Baby Friendly Hospital Initiative Breastfeeding Outcomes in Mothers with COVID-19 Infection During the First Weeks of the Pandemic in Spain. J Hum Lact. 2021 Aug 10:8903344211039182. doi: 10.1177/08903344211039182. Epub ahead of print. PMID: 34374323.

Study 799 – 512 cases from India

Cared for at Employees State Insurance Corporation Medical College and Hospital, Faridabad, Haryana, between April–December 2020 (click here or study). This hospital has not previously reported cases. Citation: Gupta P, Khatana VP, Prabha R, Jha I, Singh M, Pandey AK, Kesri A. An observational study for appraisal of clinical outcome and risk of mother-to-child SARS-CoV-2 transmission in neonates provided the benefits of mothers’ own milk. Eur J Pediatr. 2021 Aug 11:1–15. doi: 10.1007/s00431-021-04206-9. Epub ahead of print. PMID: 34379196; PMCID: PMC8355567.

Study 798 – 50 cases from Russia

From Samara Regional Clinical Hospital named after V.D. Seredavin, which has not previously reported cases (click here or study [full text not available]). Citation: Borodina IA, Gil’miyarova FN, Gusyakova OA, Selezneva IA, Borisova OV, Potyakina EE, Kolot’eva NA, Kozlov AV, Gorbacheva IV, Kuznecova OY, Baldina OA, Vinogradova LN, Emel’yanova NG, Koroteeva YA. Newborns from women infected with COVID-19: somatic and metabolic status. Klin Lab Diagn. 2021 Aug 13;66(8):453-458. English. doi: 10.51620/0869-2084-2021-66-8-453-458. PMID: 34388314.

Study 797 – two cases from South Korea

Both cared for at the National Health Insurance Service Ilsan Hospital which has not previously reported cases (click here or study). Citation: Jin JH, Kim Y, Yoo J, Kim EH, Yoon SW. Two Cases of SARS-CoV-2-Positive Mothers and Their Newborns in Korea. Infect Chemother. 2021 Jul 28. doi: 10.3947/ic.2021.0027. Epub ahead of print. PMID: 34405595.

21 August 2021 – studies 795 and 796 added

Study 796 – 224 cases from Turkey

Pregnant women with covid over 32 weeks, cared for between August and October 2020 at Ankara City Hospital (click here or study). Likely overlap with studies 203, 223, 399, 512, 569, 604 and 640. Citation: Sinaci S, Ocal DF, Ozden Tokalioglu E, Halici Ozturk F, Aydin Senel S, Keskin LH, Moraloglu Tekin O, Sahin D. Cardiotocographic features in COVID-19 infected pregnant women. J Perinat Med. 2021 Aug 19. doi: 10.1515/jpm-2021-0132. Epub ahead of print. PMID: 34411469.

Study 795 – 8,957 cases from USA

These were live births between July 2020 and January 2021 documented by California Vital Statistics birth certificates, using data received by the California Preterm Birth Initiative by March 1, 2021, with a COVID-19 diagnosis in pregnancy (click here or study). Likely overlap with studies 222, 226, 228, 323, 388, 414, 600, 680, 696, and 697. Citation: D. Karasek, R.J. Baer, M.R. McLemore et al., The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California, The Lancet Regional Health – Americas, https://doi.org/10.1016/j.lana.2021.100027

19 August 2021 – studies 792 to 794 added

Study 794 – 7,432 cases from USA

Data from Epic’s Cosmos research platform which covers one third of the hospitals in the United States (click here or paper). There was no difference in adverse pregnancy outcomes between 7,432 patients with a SARS-CoV-2 positive test and 100,635 SARS-CoV-2 negative controls. See also paper 91 here. Citation: Moeun Son, Kieran Gallagher, Justin Y. Lo, Eric Lindgren, Heather H. Burris, Kevin Dysart, Jay Greenspan, Jennifer F. Culhane, and Sara C. Handley. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population Obstet Gynecol 2021;00:1–10) DOI: 10.1097/AOG.0000000000004547

Study 793 – 175 cases from USA

Cared for at Northwestern Memorial Hospital, in Chicago, Illinois, between March and October 2020 (click here or study). Likely overlap with studies 116, 124 and 251, although none of these studies were cited. Citation: Stephanie A. FISHER, Jeffery A. GOLDSTEIN, Leena B. MITHAL, Alexandra L. ISAIA, Elisheva D. SHANES, Sebastian OTERO, Emily S. MILLER. Laboratory Analysis of Symptomatic and Asymptomatic Pregnant Patients with SARS-CoV-2 Infection, American Journal of Obstetrics & Gynecology MFM (2021), doi: https://doi.org/10.1016/j.ajogmf.2021.100458

Study 792 – Case report from Iran

Cared for in April 2020 at Shariati Hospital, Tehran University of Medical Sciences, North-Kargar Avenue, Tehran (click here or study). The only previous report from this hospital, study 287, describes two patients with different clinical features. The first author Amir Hossein Norooznezhad has the same name as the last author on study 43 which was retracted due to the case having been included in an earlier series (study 67). However study 67‘s last author was affiliated with a different university, namely, Kermanshah University of Medical Sciences, Kermanshah. Citation: Norooznezhad, A.H., Nurzadeh, M., Darabi, M.H. et al. Coronavirus disease 2019 (COVID-19) in a pregnant women with treatment resistance thrombocytopenic purpura with and suspicion to HELLP syndrome: a case report. BMC Pregnancy Childbirth 21, 567 (2021). https://doi.org/10.1186/s12884-021-04030-x

18 August 2021 – study 791 added

Study 791 – 1,582 cases from India

Among 1,582 pregnant and post-partum women with COVID-19, admitted to six COVID-19 hospitals participating in the PregCovid registry from April 2020 to January 2021, 31 had sickle cell disease or were carriers (click here or study). The unnamed hospitals were in Nagpur, Chandrapur, Akola, Yavatmal, and Mumbai but cannot be precisely identified from author affiliations. Likely overlap with studies 283 and 514. Citation: Waghmare, R., Chaaithanya, I.K., Zala, S. et al. Outcomes of COVID-19 in Pregnant Women with Sickle Cell Disease in India: A Case Series. Indian J Hematol Blood Transfus (2021). https://doi.org/10.1007/s12288-021-01482-1

15 August 2021 – studies 789 and 790 added

Study 790 – 10 cases from Argentina

Cared for in four hospitals in the San Isidro district of Buenos Aires, from March 1, to October 31 2020 (click here or study). The hospitals were San Isidro, Las Lomas, San Lucas, and Trinidad, none of which have previously reported cases. Citation: Maria Ana Barra, Nelson Adolfo Carlos Medinacelli, Camilo Andres Meza Padilla, Lucrecia Di Rocco, Ramiro Manuel Larrea, Giuliano Gaudenzi, Veronica Vanesa Mastrovincenzo, Ines Moreno, Elisa Rana, Dagmar Ana Sorvik, Andrea Sarlingo, Florencia Dadomo, Miguel Torrilla. COVID-19 in hospitalized patients in 4 hospitals in San Isidro, Buenos Aires, Argentina. medRxiv 2021.07.30.21261220; doi: https://doi.org/10.1101/2021.07.30.21261220

Study 789 – 218 cases from USA

Cared for at four medical centers in New Jersey between 10 April and 15 June 2020 (click here or study). The centres were the Robert Wood Johnson University Hospital, New Brunswick (overlap with studies 86, 285 & 392), Saint Barnabas Medical Center, Livingston (86 & 111), Monmouth Medical Center, Long Branch (no previous reports), and Clara Maass Medical Center, Belleville (no previous reports). Citation: Hill J, Patrick HS, Ananth CV, O’Brien D, Spernal S, Horgan R, Brandt JS, Schwebel M, Miller RC, Straker MJ, Graebe RA, Rosen T. Obstetrical outcomes and follow-up for patients with asymptomatic COVID-19 at delivery: A multicenter prospective cohort study. Am J Obstet Gynecol MFM. 2021 Aug 7:100454. doi: 10.1016/j.ajogmf.2021.100454. Epub ahead of print. PMID: 34375750; PMCID: PMC8349406.

14 August 2021 – studies 781 to 788 added

Study 788 – seven cases from Italy

From Fondazione IRCCS Policlinico San Matteo, Pavia (click here or study). Listed also as Source 60 here. Citation: Cassaniti I, Percivalle E, Zelini P, Nanhorngue KN, Parolo A, Bernardi V, Jorizzo G, Santer P, Perotti F, Spinillo A, Lilleri D, Baldanti F. Both SARS-CoV-2 infection and vaccination in pregnancy elicited neutralizing antibodies in pregnant women and newborns. Clin Microbiol Infect. 2021 Aug 6:S1198-743X(21)00442-0. doi: 10.1016/j.cmi.2021.08.004. Epub ahead of print. PMID: 34371204; PMCID: PMC8349424.

Study 787 – 18,715 cases from USA

Data collected by the Vizient Clinical Data Base/Resource Manager, an administrative, clinical, and financial database of more than 650 academic centers and their community affiliates, which claims to cover 97% of US academic medical centers (click here or study). 24 women died. Presumably overlap with other US series and especially those of the CDC and SET-NET consortium. Citation: Chinn J, Sedighim S, Kirby KA, Hohmann S, Hameed AB, Jolley J, Nguyen NT. Characteristics and Outcomes of Women With COVID-19 Giving Birth at US Academic Centers During the COVID-19 Pandemic. JAMA Netw Open. 2021 Aug 2;4(8):e2120456. doi: 10.1001/jamanetworkopen.2021.20456. PMID: 34379123; PMCID: PMC8358731.

Study 786 – 46 cases from Spain

Cared for at La Paz University, 12 de Octubre, Quironsalud Madrid, and Quironsalud San José hospitals, all in Madrid between April and July 2020 (click here or study). Likelylincluded in many previous Madrid series. Citation: Sánchez García L, Gómez-Torres N, Cabañas F, González-Sánchez R, López-Azorín M, Moral-Pumarega MT, Escuder-Vieco D, Cabañes-Alonso E, Castro I, Alba C, Rodríguez Gómez JM, Pellicer A. Immediate Pre-Partum SARS-CoV-2 Status and Immune Profiling of Breastmilk: A Case-Control Study. Front Immunol. 2021 Jul 26;12:720716. doi: 10.3389/fimmu.2021.720716. PMID: 34381462; PMCID: PMC8350512.

Study 785 – 16 cases from Morocco

From the Moroccan Military Hospital in Benslimane, from July 21 to October 21, 2020 (click here [english] or study [in French]). This hospital has not previously reported cases. Citation: Benlghazi A, Benali S, Bouhtouri Y, Belouad M, Massoudi H, Kouach J. Infection SARS-CoV-2 chez la femme enceinte; profil épidémiologique, clinique, biologique et évolutifs, à propos de 16 cas: expérience de l’Hôpital Militaire Marocain COVID-19 de Benslimane [SARS-CoV-2 infection in pregnant women; epidemiological, clinical, biological and evolutionary profile in 16 cases: the COVID-19 experience in the Moroccan Military Hospital in Benslimane]. Pan Afr Med J. 2021 Apr 20;38:384. French. doi: 10.11604/pamj.2021.38.384.28695. PMID: 34381528; PMCID: PMC8325444.

Study 784 – 4 cases from UK

From Chelsea & Westminster and West Middlesex Hospitals, London (click here or study). Likely included in many other UK series. Citation: Thorne I, Steele S, Martineau M, Girling J. Case series of COVID-19 infection in pregnancy complicated by ketoacidosis and symptomatic breathlessness. Obstetric Medicine. July 2021. doi:10.1177/1753495X211024511

Study 783 – 61 cases from USA

Patients admitted to one of four unnamed hospitals affiliated with the University of Texas Health Science Center at Houston between May 4, and July 26, 2020 (click here or study). Possible overlap with studies 265b, 576 and 643. Citation: Pineles BL, Stephens A, Narendran LM, Tigner A, Leidlein C, Pedroza C, Mendez-Figueroa H, Sibai BM. The Relationship Between Delivery and the PaO2/FiO2 ratio in COVID-19: A Cohort Study. BJOG. 2021 Aug 10. doi: 10.1111/1471-0528.16858. Epub ahead of print. PMID: 34375031.

Study 782 – case report from India

From Holy Family Hospital Bandra, Mumbai, which has not previously reported cases (click here or study). Citation: Kripalani Y, Parulekar L. Pulmonary Embolism in a COVID-19-Positive Primigravida After Caesarean Section Despite Prophylaxis. Eur J Case Rep Intern Med. 2021 Jul 16;8(7):002684. doi: 10.12890/2021_002684. PMID: 34377695; PMCID: PMC8336743.

Study 781 – case report from India

From All India Institute of Medical Sciences (AIIMS), Patna, which has not previously reported cases (click here or study). Citation: Agarwal M, Singh S, Sinha U, Bhushan D. Extrahepatic portal vein thrombosis in a pregnant patient with COVID-19: a rare thrombotic event survivor. BMJ Case Rep. 2021 Aug 12;14(8):e243697. doi: 10.1136/bcr-2021-243697. PMID: 34385221.

9 August 2021 – studies 779 and 780 added

Study 780 – some cases from India

Seven cases are described, but the abstract mentions 109, and the tables are ambiguous. Patients were cared for at Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha (click here or study). This hospital has not previously reported cases. Citation: Panda A, Das S, Satapathy GC. Perioperative Obstetric Care in Coronavirus Infectious Disease 2019: Anesthetic Perspective. Anesth Essays Res. 2020 Oct-Dec;14(4):584-588. doi: 10.4103/aer.AER_4_21. Epub 2021 May 27. PMID: 34349324; PMCID: PMC8294413. Comment. Although listed on PubMed, and not by Beall, this journal has some predatory features; submission as well as processing charges, and no institutional contact emails. It is published by the “Pan Arab Federation of Societies of Anesthesiologists”, which elsewhere on the internet is called the “Pan Arab Federation of Societies of Anaesthesia, Intensive Care and Pain Management”. Administrative functions are conducted by, and fees directed to, Wolters Kluwer India Pvt. Ltd. (Medknow), A-202, 2nd Floor The Qube, C.T.S. No.1498A/2, Village Marol, Andheri (East), Mumbai, Maharashtra 400059.

Study 779 – two cases from United Arab Emirates

Treated at Sheikh Khalifa Medical City, Abu Dhabi, in May and June 2020 (click here or study). This hospital has not previously reported cases. Citation: Abdullah S, Bashir N, Mahmood N. Use of intravenous tocilizumab in pregnancy for severe coronavirus disease 2019 pneumonia: two case reports. J Med Case Rep. 2021 Aug 7;15(1):426. doi: 10.1186/s13256-021-03010-1. PMID: 34364393.

8 August 2021 – studies 772 to 778 added

Study 778 – 18 cases from India

Six with concurrent pulmonary tuberculosis, and 12 with previously cured TB, and Covid in pregnancy (click here or study). Selected from 879 pregnant or postpartum women with COVID-19 cared for at Nair Hospital, Mumbai from April to September 2020. Citation: Gajbhiye RK, Mahajan NN, Kamath N, Bahirat S, Patokar G, Bhurke AV, Modi DN, Mahale SD. Clinical presentations, pregnancy complications, and maternal outcomes in pregnant women with COVID-19 and tuberculosis: A retrospective cohort study. Int J Gynaecol Obstet. 2021 Apr;153(1):176-179. doi: 10.1002/ijgo.13588. Epub 2021 Feb 11. PMID: 33421126; PMCID: PMC7611277.

Study 777 – case report from India

A woman contracted Covid in pregnancy at 12 weeks, miscarried at 13 and developed Guillain-Barré syndrome (click here or study). From Nair hospital, Mumbai, so likely included in previous series. Citation: Mahajan NN, Srivastava S, Chakor R, More P, Mahale SD, Gajbhiye RK. Neurological complications of COVID-19 and spontaneous abortion in a pregnant woman – A case report. Eur J Obstet Gynecol Reprod Biol. 2021 Aug;263:278-279. doi: 10.1016/j.ejogrb.2021.06.010. Epub 2021 Jun 16. PMID: 34175157; PMCID: PMC8206547.

Study 776 – 115 cases from India

All delivered by elective cesarean under spinal from July 2020 to December 2020 at Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, which has not previously reported cases (click here or study). Citation: Jan M, Bhat WM, Rashid M, Ahad B. Elective Cesarean Section in Obstetric COVID-19 Patients under Spinal Anesthesia: A Prospective Study. Anesth Essays Res. 2020 Oct-Dec;14(4):611-614. doi: 10.4103/aer.AER_29_21. Epub 2021 May 27. PMID: 34349329; PMCID: PMC8294416.

Study 775 – Case control study from Italy

From Sant Anna Hospital, Turin, for delivery between 20 September 2020 and 9 January 2021 (click here or study). Likely overlap with studies 79, 167, 195, 247, 615, and possibly 644. Citation: Cosma S, Carosso AR, Cusato J, Borella F, Carosso M, Gervasoni F, Stura I, Preti M, Ghisetti V, Di Perri G, Benedetto C. Preterm birth is not associated with asymptomatic/mild SARS-CoV-2 infection per se: Pre-pregnancy state is what matters. PLoS One. 2021 Aug 5;16(8):e0254875. doi: 10.1371/journal.pone.0254875. PMID: 34351922; PMCID: PMC8341509.

Study 774 – 393 cases from Europe

Collected by the PregOuTCOV group from 4 university hospitals in Europe (click here or study. Also appendix). From author affiliations University Hospital Brugmann, Brussels, Belgium, Louis Mourier Hospital, Colombes, France, Gemelli University Polyclinic Foundation, Rome, Italy and Antoine Béclère Hospital, Clamart, France, which have all previously reported cases. Citation: Badr DA, Picone O, Bevilacqua E, Carlin A, Meli F, Sibiude J, Mattern J, Fils JF, Mandelbrot L, Lanzone A, De Luca D, Jani JC, Vivanti AJ. Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection. Emerg Infect Dis. 2021 Aug 5;27(10). doi: 10.3201/eid2710.211394. Epub ahead of print. PMID: 34352196.

Study 773 – 9 cases from Germany

One baby, exposed at weeks 5 and 6, had unilateral microphthalmia, optic nerve hypoplasia, and congenital retinopathy (click here or study). From University of Erlangen-Nürnberg, Erlangen, which has not previously reported cases. Citation: Morhart P, Mardin C, Rauh M, Jüngert J, Hammersen J, Kehl S, Schuh W, Maier-Wohlfart S, Hermes K, Neubert A, Schneider M, Hein A, Woelfle J, Schneider H. Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant. Eur J Pediatr. 2021 Aug 5:1–6. doi: 10.1007/s00431-021-04221-w. Epub ahead of print. PMID: 34355278; PMCID: PMC8341836.

Study 772 – 18 cases from India

Twenty babies with features of neonatal multisystem inflammatory syndrome in children (MIS-C) were born to eighteen mothers with a history of COVID-19 disease or exposure during pregnancy (click here or study). The babies were cared for in seven NICUs in Kolhapur, Maharashtra, a city from which previous maternal cases have not been reported. Citation: Pawar R, Gavade V, Patil N, Mali V, Girwalkar A, Tarkasband V, Loya S, Chavan A, Nanivadekar N, Shinde R, Patil U, Lakshminrusimha S. Neonatal Multisystem Inflammatory Syndrome (MIS-N) Associated with Prenatal Maternal SARS-CoV-2: A Case Series. Children (Basel). 2021 Jul 2;8(7):572. doi: 10.3390/children8070572. PMID: 34356552.

2 August 2021 – studies 765 to 771 added

Study 771 – 97 cases from USA

Cared for at Weill Cornell Medicine, New York (click here or study). Likely overlap with studies 99, 118, 216, 230, 234, 276, 578, 669, and 758. Citation: Glynn SM, Yang YJ, Thomas C, Friedlander RL, Cagino KA, Matthews KC, Riley LE, Baergen RN, Prabhu M. SARS-CoV-2 and Placental Pathology: Malperfusion Patterns Are Dependent on Timing of Infection During Pregnancy. Am J Surg Pathol. 2021 Jul 26. doi: 10.1097/PAS.0000000000001772. Epub ahead of print. PMID: 34310367.

Study 770 – 40 cases from Turkey

Cared from Basaksehir Cam and Sakura City Hospital, Istanbul, which has not previously reported cases (click here or study). Citation: Yasa B, Memur S, Ozturk DY, Bagci O, Uslu SI, Polat I, Cetinkaya M. Severity of Maternal SARS-CoV-2 Infection in Pregnancy Predicts Neonatal Outcomes. Am J Perinatol. 2021 Jul 28. doi: 10.1055/s-0041-1733783. Epub ahead of print. PMID: 34320680.

Study 769 – 85 cases from USA

Cared for at any of fourteen Advocate Aurora Health medical centers in Wisconsin and Illinois between March 23 and October 3, 2020 (click here or study). Three women required ventilation, but no mothers or babies died. This hospital network has not previously reported cases. Citation: Zlochiver V, Tilkens B, Perez Moreno AC, Aziz F, Jan MF. COVID-19 Deliveries: Maternal Features and Neonatal Outcomes. J Patient Cent Res Rev. 2021 Jul 19;8(3):286-289. doi: 10.17294/2330-0698.1848. PMID: 34322584; PMCID: PMC8297489.

Study 768 – 53 cases from Mexico

Cared for at the UMAE Hospital de Gineco Obstetricia “Luis Castelazo Ayala” Instituto Mexicano del Seguro Social, Mexico City from January to April 2021 (click here or study). This hospital has not previously reported cases, although they are likely included in the various national Mexico series. Citation: Carranza Lira S, Espinosa MG. Differences in the neutrophil/lymphocyte ratio and the platelet/lymphocyte ratio in pregnant women with and without COVID-19. Int J Gynaecol Obstet. 2021 Jul 29. doi: 10.1002/ijgo.13840. Epub ahead of print. PMID: 34322880.

Study 767 – 20 cases from China

From Tongji Hospital, Wuhan, between March 18 and May 9 2020 (click here or study). Likely reported many times before. Citation: Chen G, Zhang Y, Zhang Y, Ai J, Yang B, Cui M, Liao Q, Chen H, Bai H, Shang D, Chen J, Sun C, Liu H, Liu F, Mao B, Sun G, Chen L, Lin JW, Li K. Differential immune responses in pregnant patients recovered from COVID-19. Signal Transduct Target Ther. 2021 Jul 29;6(1):289. doi: 10.1038/s41392-021-00703-3. PMID: 34326311; PMCID: PMC8320317.

Study 766 – 14 cases from Italy

Asymptomatic or mild, but otherwise no clinical details (click here or study). Citation: De Biasi S, Tartaro DL, Gibellini L, Paolini A, Quong A, Petes C, Awong G, Douglas S, Lin D, Nieto J, Galassi FM, Borella R, Fidanza L, Mattioli M, Leone C, Neri I, Meschiari M, Cicchetti L, Iannone A, Trenti T, Sarti M, Girardis M, Guaraldi G, Mussini C, Facchinetti F, Cossarizza A. Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection. Nat Commun. 2021 Jul 29;12(1):4677. doi: 10.1038/s41467-021-24940-w. PMID: 34326336.

Study 765 – 5 cases from France

From author affiliations the patients were cared for at a l’Hopital Femme-M`ere-Enfant, Hospices Civils de Lyon, which has not previously reported cases (click here or study). Hower they may be included in study 150. Citation: Bouachba A, Allias F, Nadaud B, Massardier J, Mekki Y, Bouscambert Duchamp M, Fourniere B, Huissoud C, Trecourt A, Collardeau-Frachon S. Placental lesions and SARS-Cov-2 infection: Diffuse placenta damage associated to poor fetal outcome. Placenta. 2021 Jul 15;112:97-104. doi: 10.1016/j.placenta.2021.07.288. Epub ahead of print. PMID: 34329973; PMCID: PMC8280612.

26 July 2021 – study 764 added

Study 764 – 3,371 cases from UK

This MedRxiv preprint reports that compared with the first wave (wildtype SARS-CoV-2 predominant), pregnant women admitted to hospital during the 2nd wave (alpha variant predominant) had an increased risk of moderate or severe disease, aOR 1.75 (95% CI 1.48-2.06) (click here or study). Pregnant women admitted during the 3rd wave (delta predominant), had a further increase in risk, aOR 1.53 (1.07-2.17). No fully vaccinated pregnant women were admitted between 01/02/2021 when vaccination data collection commenced and 11/07/2021. This series includes cases from previous UKOSS reports studies 92, 533 and 667 as well as other UK series. Citation: Nicola Vousden, Rema Ramakrishnan, Kathryn Bunch, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk, Marian Knight. Impact of SARS-CoV-2 variant on the severity of maternal infection and perinatal outcomes: Data from the UK Obstetric Surveillance System national cohort. medRxiv 2021.07.22.21261000; doi: https://doi.org/10.1101/2021.07.22.21261000 [important]

24 July 2021 – studies 759 to 763 added

Study 763 – case report from Iran

From Shahid Beheshti University of Medical Sciences, Tehran (click here or study). Citation: Naseh A, Ashrafzadeh S. Possible Vertical Transmission From an Unsuspected SARS-CoV-2-Infected Mother to Her Newborn. Cureus. 2021 Jun 17;13(6):e15717. doi: 10.7759/cureus.15717. PMID: 34290917; PMCID: PMC8288625.

Study 762 – 56 cases from Italy

Cared for at “L. Sacco” University Hospital, Milan between March 7th and April 30th, 2020 (click here or study). The cases appear to overlap with study 312 and other series from Milan. Citation: Fenizia C, Saulle I, Di Giminiani M, Vanetti C, Trabattoni D, Parisi F, Biasin M, Savasi V. Unlikely SARS-CoV-2 Transmission During Vaginal Delivery. Reprod Sci. 2021 Jul 22. doi: 10.1007/s43032-021-00681-5. Epub ahead of print. PMID: 34296422.

Study 761 – 338 cases from Brazil

Collected by 16 maternity hospitals from the Brazilian network of COVID-19 during pregnancy (REde BRAsileira em estudos do COVID-19 em Obstetrícia REBRACO) up to July 2020 (click here or study). 29 mothers died. of whom 15 deaths were attributed to COVID-19. From author affiliations the hospitals were: Sao Paolo; University of Campinas, Faculdade de Medicina de Jundiaı´, Universidade Federal de São Carlos, Universidade Federal de São Paulo, Hospital Regional Jorge Rossmann Instituto So´crates Guanaes, Itanhae´m, Hospital Estadual Sumare´, Faculdade de Medicina da Universidade Estadual de São Paulo; plus Hospital das Clı´nicas de Porto Alegre, Maternidade UNIMED, Belo Horizonte, Universidade Federal do Ceara´, Fortaleza, Hospital Moinhos de Vento, Porto Alegre, Universidade Federal de Minas Gerais, Belo Horizonte, Instituto Fernandes Figueira, Rio de Janeiro, Universidade Federal de Pernambuco, Recife, Maternidade Clime´rio de Oliveira, Salvador, and Santa Casa de Miserico´rdia do Para´, Bele´m’. Likely overlap with other studies from Brazil. Citation: Costa ML, Souza RT, Pacagnella RC, Bento SF, Ribeiro-do-Valle CC, Luz AG, et al. (2021) Facing the COVID-19 pandemic inside maternities in Brazil: A mixed-method study within the REBRACO initiative. PLoS ONE 16(7): e0254977. https://doi.org/10.1371/journal.pone.0254977

Study 760 – 22 infected placentas from 7 countries

They were reviewed by a panel of pathologists (click here or study). Citation: Schwartz DA, Baldewijns M, Benachi A, Bugatti M, Bulfamante G, Cheng K, Collins RRJ, Debelenko L, De Luca D, Facchetti F, Fitzgerald B, Levitan D, Linn RL, Marcelis L, Morotti D, Morotti R, Patanè L, Prevot S, Pulinx B, Saad AG, Schoenmakers S, Strybol D, Thomas K, Tosi D, Toto V, van der Meeren LE, Verdijk RM, Vivanti AJ, Zaigham M. Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy: Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission. Arch Pathol Lab Med. 2021 Jul 23. doi: 10.5858/arpa.2021-0296-SA. Epub ahead of print. PMID: 34297794.

Study 759 – Case report from USA

From Vassar Brothers Medical Center, Poughkeepsie, New York state (click here or study), so may be included in study 371. Citation: Abdulraheem, E, Shaikhoun, M, Kung, D. Severe peripartum cardiomyopathy complicated by COVID-19 infection and small intestinal obstruction. Clin Case Rep. 2021; 9:e04505. https://doi.org/10.1002/ccr3.4505

22 July 2021 – study 758 added

Study 758 – 88 cases from USA

Maternal and cord serology (click here or study). From author affiliations delivered at Weill Cornell Medicine, New York between April 18 and May 31, 2020. Likely overlap with studies 99, 118, 216, 230, 234, 276, 578 and 669. Citation: Kubiak JM, Murphy EA, Yee J, et al. Severe acute respiratory syndrome coronavirus 2 serology levels in pregnant women and their neonates. Am J Obstet Gynecol 2021;225:73.e1-7

21 July 2021 – studies 756 and 757 added

Study 757 – case report from the Slovak Republic

From author affiliations cared for at Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, which has not previously reported cases (click here or study). Citation: Kamil Biringer, Jana Sivakova, Juraj Marcinek, Terezia Pribulova, Tomas Rokos, Erik Kozubik, Erik Kudela, Lukas Plank. Placental pathology concerning sudden foetal demise in SARS-CoV-2 positive asymptomatic pregnant female. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021; 165:XX

Study 756 – 926 cases from COVI-preg

Collected by the approximately 81 centres, from 15 countries, participating in the COVI-Preg registry between March 24 and July 26, 2020 (click here or study). Click here for centres. Likely overlap with other series. Citation: Vouga, M., Favre, G., Martinez-Perez, O. et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep 11, 13898 (2021). https://doi.org/10.1038/s41598-021-92357-y

20 July 2021 – study 755 added

Study 755 – case report from Spain

The patient had SARS-CoV-2 infection in the first trimester (click here or study). From author affiliations she was probably cared for at Hospital Clínico San Carlos de Madrid, so possibly also included in study 196. Citation: Fuentes Carrasco M, Mayoral Triana A, Cristóbal García IC, Pérez Pérez N, Izquierdo Méndez N, Soler Ruiz P, González González V. Catastrophic antiphospholipid syndrome during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2021 Jul 7;264:21-24. doi: 10.1016/j.ejogrb.2021.07.002. Epub ahead of print. PMID: 34273751; PMCID: PMC8260489.

19 July 2021 – Study 754 added

Study 754 – 8,564 cases from ISARIC

This MedRxiv ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) preprint of cases up to 25 May 2021, includes 8,564 pregnant women (click here or study). Collected by 1,651 sites across 63 countries. Citation: ISARIC Clinical Data Report issued: 14 July 2021. ISARIC Clinical Characterisation Group, Kenneth Baillie, … Laura Merson et al. medRxiv 2020.07.17.20155218; doi: https://doi.org/10.1101/2020.07.17.20155218

18 July 2021 – studies 751 to 753 added

Study 753, – 75 cases from Turkey

From Sanliurfa Training and Research Hospital between April and August 2020 (click here or study). This hospital has not previously reported cases. Citation: Damar Çakırca T, Torun A, Hamidanoğlu M, Portakal RD, Ölçen M, Çakırca G, Haksever M. COVID-19 infection in pregnancy: a single center experience with 75 cases. Ginekol Pol. 2021 Jul 15. doi: 10.5603/GP.a2021.0118. Epub ahead of print. PMID: 34263921.

Study 752 – 45 cases from Switzerland

This MedRxiv preprint reports participants of the Swiss COGEN Cohort study diagnosed between February and December 2020 at University Hospital Basel, University Hospital Zurich, University Hospital Bern, and the Cantonal Hospital Baden (click here or study). Being pregnant at the time of acute COVID-19 illness (OR 0.48 [0.23-1.01], p=0.054) was associated with lower odds of post COVID syndrome. Probable overlap with cases reported in studies 72, 310, 427 and 526. Citation: Caroline E. Gebhard, Claudia Sütsch, Susan Bengs, Manja Deforth, Karl Philipp Buehler, Nadia Hamouda, Alexander Meisel, Reto A. Schuepbach, Annelies S. Zinkernagel, Silvio D. Brugger, Claudio Acevedo, Dimitri Patriki, Benedikt Wiggli, Jürg H. Beer, Andrée Friedl, Raphael Twerenbold, Gabriela M. Kuster, Hans Pargger, Sarah Tschudin-Sutter, Joerg C. Schefold, Thibaud Spinetti, Arnaud Dussault-Cloutier, Chiara Henze, Mina Pasqualini, Dominik F. Sager, Lilian Mayrhofer, Mirjam Grieder, Janna Tontsch, Fabian Franzeck, Pedro D. Wendel Garcia, Daniel A. Hofmaenner, Thomas Scheier, Jan Bartussek, Leon Chrobok, David Stähli, Nicola Lott, Ahmed Haider, Muriel Grämer, Nidaa Mikail, Alexia Rossi, Nuria Zellweger, Petra Opic, Angela Portmann, Atanas Todorov, Aju P. Pazhenkottil, Michael Messerli, Ronny R. Buechel, Philipp A. Kaufmann, Valerie Treyer, Martin Siegemund, Ulrike Held, Vera Regitz-Zagrosek, Catherine Gebhard. Sex- and Gender-specific Risk Factors of Post-COVID-19 Syndrome: A Population-based Cohort Study in Switzerland. medRxiv 2021.06.30.21259757; doi: https://doi.org/10.1101/2021.06.30.21259757 [Long covid]

Study 751 – 107 cases from USA

From Columbia University Irving Medical Center – affiliated, New York Presbyterian (NYP), Morgan Stanley Children’s Hospital, and NYP Allen Pavilion Hospitals, New York, from 3/13/2020 (click here or study). Likely overlap with other studies from these hospitals. See also indirect effects, Paper 77 (click here). Citation: Lauren C. Shuffrey, Morgan R. Firestein, Margaret Kyle, Andrea Fields, Carmela Alcantara, Dima Amso, Judy Austin, Jennifer M. Bain, Jennifer Barbosa, Mary Bence, Catherine Bianco, Cristina Fernandez, Sylvie Goldman, Cynthia Gyamfi-Bannerman, Violet Hott, Yunzhe Hu, Maha Hussain, Pam Factor-Litvak, Maristella Lucchini, Arthur Mandel, Rachel Marsh, Danielle McBrian, Mirella Mourad, Rebecca Muhle, Kimberly Noble, Anna A. Penn, Cynthia Rodriguez, Ayesha Sania, Wendy G. Silver, Kally C. O Reilly, Melissa Stockwell, Nim Tottenham, Martha G. Welch, Noelia Zork, William P. Fifer, Catherine Monk, Dani Dumitriu. Birth during the COVID-19 pandemic, but not maternal SARS-CoV-2 infection during pregnancy, is associated with lower neurodevelopmental scores at 6-months medRxiv 2021.07.12.21260365; doi: https://doi.org/10.1101/2021.07.12.21260365

12 July 2021 – studies 747 to 750 added

Study 750 – 58 cases from India

Cared for between June and September 2020 at Bharati Vidyapeeth hospital, in Pune, which has not previously reported cases (click here or study). One mother died. Citation: Malshe N, Patnaik SK, Lalwani S, Suryawanshi P, Kulkarni R, Mhaske S, Mishra AC, Arankalle V. Perinatal transmission of SARS-CoV-2 and transfer of maternal IgG/neutralizing anti-SARS-CoV-2 antibodies from mothers with asymptomatic infection during pregnancy. Infection. 2021 Jul 7:1–7. doi: 10.1007/s15010-021-01650-5. Epub ahead of print. PMID: 34232457; PMCID: PMC8262126.

Study 749 – 42 cases from Iran

From the hospitals of Shahid Beheshti University of Medical Sciences, Tehran between 21 February and 30 November 2020, so likely overlap with study 514 (click here or study). Two mothers died. Citation: Hosseini MS, Hosseini A, Ghaffari E, Radfar M, Shirvani F, Tabatabai S, Abtahi D, Mirhadi M, Mortazavi M, Ariana S. Evaluation of clinical outcomes of neonates born to mothers with coronavirus (COVID-19) in Shahid Beheshti Hospitals. J Educ Health Promot. 2021 May 31;10(1):173. doi: 10.4103/jehp.jehp_20_21. PMID: 34250107; PMCID: PMC8249960.

Study 748 – 65 cases from India

From Sarojini Naidu Medical College, Agra, Uttar Pradesh, which has not previously reported cases, between April 15 and June 30, 2020 (click here or study). Citation: Agarwal N, Garg R, Singh S, Agrawal A. Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome. J Educ Health Promot. 2021 May 31;10(1):194. doi: 10.4103/jehp.jehp_954_20. PMID: 34250128; PMCID: PMC8249977.

Study 747 – 70 women with past SARS-CoV-2 infection undergoing assisted conception in China

Fourteen conceived, which was similar to the rate among those without past infection (click here or study). From Tongji Hospital, Wuhan between May 2020 and February 2021. Citation: Wang M, Yang Q, Ren X, Hu J, Li Z, Long R, Xi Q, Zhu L, Jin L. Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study. EClinicalMedicine. 2021 Aug;38:101013. doi: 10.1016/j.eclinm.2021.101013. Epub 2021 Jul 6. PMID: 34250457; PMCID: PMC8259363.

10 July 2021 – study 697 citation updated.

9 July 2021 – study 746 added

Study 746 – 1,530 cases from India

From Nair hospital in Mumbai between 1 April 2020 and 14 May 2021, so overlap with previous cases from that hospital (click here or study. Appendix here). 30 mothers died, with maternal mortality, ICU admission and severity significantly higher during the 2nd wave. Citation: Mahajan, Niraj N. MD; Pophalkar, Madhura MS; Patil, Sarika MPhil; Yewale, Bhagyashree MBBS; Chaaithanya, Itta Krishna PhD; Mahale, Smita D. PhD; Gajbhiye, Rahul K. MBBS, PhD Pregnancy Outcomes and Maternal Complications During the Second Wave of Coronavirus Disease 2019 (COVID-19) in India, Obstetrics & Gynecology: July 7, 2021 – Volume – Issue – 10.1097/AOG.0000000000004529
doi: 10.1097/AOG.0000000000004529

8 July 2021 – studies 743 to 745 added

Study 745 – 217 cases from Turkey

Cared for in an unnamed tertiary medical centre between 1 March and 30 November 2020 (click here or study). Citation: Bozkurt F, Çoşkun Ö, Yeleç S, Bekçibaşi M, Asena M, Bağli I. Comparison of the Clinical and Laboratory Findings in COVID-19 Positive Pregnants without Comorbidity. Turk J Med Sci. 2021 Jul 8. doi: 10.3906/sag-2105-116. Epub ahead of print. PMID: 34233388.

Study 744 – 17 maternal deaths in UK

The second MBRRACE report (July 2021) includes ten pregnant or recently pregnant women who died from Covid-19, four who died from other causes with SARS-CoV-2 infection, and three whose deaths were indirectly caused by the pandemic (click here or study). This report covers 01/06/2020 to 31/03/2021, and therefore excludes cases in the previous MBRRACE report (study 255). Citation: Knight M, Bunch K, Cairns A, Cantwell R, Cox P, Kenyon S, Kotnis R, Lucas DN, Lucas S, Nelson-Piercy C, Patel R, Rodger A, Shakespeare J, Tuffnell D, Kurinczuk JJ on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care Rapid Report 2021: Learning from SARS-CoV-2-related and associated maternal deaths in the UK June 2020-March 2021. Oxford: National Perinatal Epidemiology Unit, University of Oxford 2021. ISBN: 978-1-8383678-2-4

Study 743 – 426 cases admitted to ICU in UK

The 5 July 2021 ICNARC report (click here or study). Pregnancy p74. Thirteen pregnant or recently pregnant woman have died. Citation: Intensive Care National Audit & Research Centre. ICNARC report on COVID-19 in critical care: England, Wales and Northern Ireland 5 July 2021 Accessed 8 July 2021. https://www.icnarc.org/Our-Audit/Audits/Cmp/Reports

7 July 2021 – Studies 738 and 742 added

Study 742 – 11,247 cases from Brazil

1,031 of the mothers died (click here or study). Collected by the Obstetric Observatory, so overlap with study 724, and many other series from Brazil. Citation: Francisco RPV, Lacerda L, Rodrigues AS. Obstetric Observatory BRAZIL – COVID-19: 1031 maternal deaths because of COVID-19 and the unequal access to health care services. Clinics (Sao Paulo). 2021 Jun 28;76:e3120. doi: 10.6061/clinics/2021/e3120. PMID: 34190858; PMCID: PMC8221555.

Study 741 – 16 possible cases from Kenya

(click here or study [no pdf available]). Citation: Otieno NA, Azziz-Baumgartner E, Nyawanda BO, Oreri E, Ellington S, Onyango C, et al. SARS-CoV-2 infection among pregnant and postpartum women, Kenya, 2020–2021. Emerg Infect Dis. 2021 Sep [date cited]. https://doi.org/10.3201/eid2709.210849

Study 740 – 1,295 cases from Spain

Recruited by the Spanish Obstetrics Emergency Group between 1 March and 3 November 2020, so included in many previous studies (click here or study). Citation: Cuñarro-López Y, Pintado-Recarte P, Hernández-Martín C, Paya-Martínez P, López-Pérez R, Cueto-Hernández I, Ruiz-Labarta J, Cano-Valderrama Ó, Martínez-Pérez Ó, Bravo-Arribas C, Ortega MA, De León-Luis JA. Comparing Infection Profiles of Expectant Mothers with COVID-19 and Impacts on Maternal and Perinatal Outcomes between the First Two Waves of the Pandemic. J Pers Med. 2021 Jun 25;11(7):599. doi: 10.3390/jpm11070599. PMID: 34201923.

Study 739 – maternal mortality ratio in Mexico in 2021

The MMR increased from expected, 29.8 per 100,000, to observed 47.2 per 100,000 (click here or study). A 60% increase compared with the pre-pandemic trend. 309 deaths were directly caused by Covid. Citation: Mendez-Dominguez, N., Santos-Zaldívar, K., Gomez-Carro, S. et al. Maternal mortality during the COVID-19 pandemic in Mexico: a preliminary analysis during the first year. BMC Public Health 21, 1297 (2021). https://doi.org/10.1186/s12889-021-11325-3 important

Study 738 – 7 cases from China

Pregnant women with COVID-19 from January 28 to February 28, 2020, at Tongji and Union Hospital, Huazhong University of Science and Technology, Wuhan. (click here or study). This is grid.412793.a, so these cases have been reported many times before. Citation: Liang Dong, Shiyao Pei, Qin Ren, Shuxiang Fu, Liang Yu, Hui Chen, Xiang Chen, Mingzhu Yin, Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns, Placenta, Volume 111, 2021, Pages 91-96, ISSN 0143-4004, https://doi.org/10.1016/j.placenta.2021.06.007. (https://www.sciencedirect.com/science/article/pii/S0143400421001806)

5 July 2021 – studies 735 to 737 added

Study 737 – 725 cases and 1,459 controls collected by the Intercovid group

A slightly expanded, and different analysis, of the cases in study 683 (click here or study). Citation: Papageorghiou AT, Deruelle P, Gunier RB, et al. Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study [published online ahead of print, 2021 Jun 26]. Am J Obstet Gynecol. 2021;S0002-9378(21)00561-5. doi:10.1016/j.ajog.2021.05.014

Study 736 – 12,566 severe cases from Brazil

Pregnancy cases and non-pregnant control women with severe Covid-19 collected by the Brazilian ARDS Surveillance System (click here or study). Likely overlap with many previous reports from that registry. Citation: Scheler, C.A., Discacciati, M.G., Vale, D.B., Lajos, G.J., de Castro Surita, F. and Teixeira, J.C. (2021), Mortality in pregnancy and the postpartum period in women with severe acute respiratory distress syndrome related to COVID-19 in Brazil, 2020. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript. https://doi.org/10.1002/ijgo.13804

Study 735 – case report from Romania

From Premiere Hospital, Timişoara, which has not previously reported cases (click here or study). Citation: Popescu, D.E.; Cioca, A.; Muresan, C.; Navolan, D.; Gui, A.; Pop, O.; Marcovici, T.; Ilie, C.; Craina, M.; Boia, M. A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death. Medicina 2021, 57, 667. https://doi.org/10.3390/medicina57070667

1 July 2021 – studies 733 and 734 added

Study 734 – 16 cases from Israel

From E. Wolfson Medical Center, in Holon, which has not previously reported cases (click here or study). Citation: Barber, E.; Kovo, M.; Leytes, S.; Sagiv, R.; Weiner, E.; Schwartz, O.; Mashavi, M.; Holtzman, K.; Bar, J.; Engel, A.; Ginath, S. Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study. J. Clin. Med. 2021, 10, 2735. https://doi.org/10.3390/jcm10122735

Study 733 – 40 cases from Greece

From Alexandra Maternity Hospital, Athens, which has not previously reported cases (click here or study). No mothers required intensive care and no mothers or babies died. Citation: Antsaklis P, Tasias K, Psarris A, Theodora M, Daskalakis G, Rodolakis A. Covid-19 and pregnancy: the experience of a tertiary maternity hospital. J Perinat Med. 2021 Jun 29. doi: 10.1515/jpm-2021-0070. Epub ahead of print. PMID: 34187133.

29 June 2021 – studies 731 and 732 added

Study 732 – 62 cases from Indonesia

From Universitas Airlangga Hospital, Surabaya, between April & August 2020 (click here or study). Six mothers and five babies died. This hospital has not previously reported cases. Citation: Muhammad Ilham Aldika Akbar, Khanisyah Erza Gumilar, Rino Andriya, Manggala Pasca Wardhana, Pungky Mulawardhana, Jimmy Yanuar Anas, Ernawati, Muhammad Ardian Cahya Laksana, Gustaaf Dekker. Clinical Manifestations and Pregnancy Outcomes of Covid-19 in Indonesian Referral Hospital in Central Pandemic Area medRxiv 2021.06.20.21259219; doi: https://doi.org/10.1101/2021.06.20.21259219. 7 November update. Peer reviewed publication (click here or study). Citation:Akbar MIA, Gumilar KE, Andriya R, Wardhana MP, Mulawardhana P, Anas JY, Ernawati, Laksana MAC, Dekker PG. Clinical manifestations and pregnancy outcomes of COVID-19 in indonesian referral hospital in central pandemic area. Obstet Gynecol Sci. 2021 Nov 5. doi: 10.5468/ogs.21135. Epub ahead of print. PMID: 34736316.

Study 731 – 94 first trimester cases from USA

Selected from the PRIORITY registry (click here or study). Likely overlap with other US cases. Citation: JACOBY VL, MURTHA A, AFSHAR Y, GAW S, ASIODU I, TOLOSA J, NORTON ME, BOSCARDIN J, FLAHERMAN V, Risk of Pregnancy Loss Prior to 20 weeks Gestation with COVID-19, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.06.080.

26 June 2021 – study 730 added

Study 730 – 24 cases from Germany

From author affiliations, treated in University Medical Centre Hamburg-Eppendorf, Hamburg which has not previously reported cases (click here or study). Clinical details in supplementary material here. Citation: Tallarek AC, Urbschat C, Fonseca Brito L, Stanelle-Bertram S, Krasemann S, Frascaroli G, Thiele K, Wieczorek A, Felber N, Lütgehetmann M, Markert UR, Hecher K, Brune W, Stahl F, Gabriel G, Diemert A, Arck PC. Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy. Front Immunol. 2021 Jun 3;12:698578. doi: 10.3389/fimmu.2021.698578. PMID: 34149740; PMCID: PMC8211452.

24 June 2021 – studies 725 to 729 added

Study 729 – 195 cases from USA

From the University of Maryland health care system in Baltimore (click here or study). Probable overlap with studies 269, 418 and 669. Citation: Liviu Cojocaru, Myint Noe, Autusa Pahlavan, Alissa Werzen, Hyunuk Seung, Young Chae Jessica Yoo, Patricia Tyson, Shivakumar Narayanan, Shifa Turan, Ozhan M. Turan, Joel V. Chua. Increased Risk of Severe COVID-19 Disease in Pregnancy in a Multicenter Propensity Score-Matched Study. medRxiv 2021.06.18.21258899; doi: https://doi.org/10.1101/2021.06.18.21258899

Study 728 – 55 cases from Iran

From Shahid Mohammadi Hospital, Bandar Abbas, Hormozgan, which has not previously reported cases, between March to November 2020 (click here or study). Citation: Taghavi SA, Heidari S, Jahanfar S, Amirjani S, Aji-Ramkani A, Azizi-Kutenaee M, Bazarganipour F. Obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran: a retrospective, case-control study. Middle East Fertil Soc J. 2021;26(1):17. doi: 10.1186/s43043-021-00059-2. Epub 2021 Jun 14. PMID: 34149282; PMCID: PMC8202219.

Study 727 – 43 cases from Spain

Collected by the nine hospitals of the GESTACOVID Collaborative Group (click here or study). These are Vall d’Hebron , Barcelona; La Paz, Madrid; Hospital Virgen de la Arrixaca, Murcia; Hospital Universitario Cruces, Bizkaia; Hospital Clínico Universitario Lozano Blesa, Zaragoza; Hospital de Torrejón, Madrid; Hospital Universitario San Cecilio, Granada; Hospital Universitario La Fe, Valencia; and Hospital Universitario Príncipe de Asturias, Madrid. Likely overlap with other Spanish series. Citation: Garcia-Ruiz I, Sulleiro E, Serrano B, Fernandez-Buhigas I, Rodriguez-Gomez L, Sanchez-Nieves D, Anton-Pagarolas A, Esperalba-Esquerra J, Frick MA, Camba F, Navarro-Jimenez A, Fernandez-Hidalgo N, Maiz N, Carreras E, Suy A, GESTACOVID Collaborative Group, Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study, Clinical Microbiology and Infection, https://doi.org/10.1016/j.cmi.2021.06.016.

Study 726 – 31,253 cases from Mexico

The last of these weekly reports for 2020 from Mexico. 205 women had died (click here or study). [In Spanish] Overlap with study 722. Citation: Health Secretary General Directorate of Epidemiology Epidemiological reports of pregnant and postpartum women studied, suspected of COVID 19 February 22, 2021. Weekly publication by the Directorate of Epidemiological Surveillance of Noncommunicable Diseases. https://www.gob.mx/salud/documentos/informes-epidemiologicos-de-embarazadas-y-puerperas-estudiadas-ante-sospecha-de-covid-19. Accessed 24 June 2021

Study 725 – 104 cases from South Africa

From Ekurhuleni Heath District which includes Johannesburg and Pretoria (click here or study). Six women died. Citation: Jayati Kusari Basu, Lawrence Chauke & Terrance Magoro (2021): Maternal mortality from COVID 19 among South African pregnant women, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2021.1902501

20 June 2021 – studies 723 and 724 added

Study 724 – 10,349 cases from Brazil

The Brazilian Obstetric Observatory included 10,349 pregnant or postnatal women with Covid-19 on 20 June 2021 (click here). 2,281 (16.2%) had died. Citation: Rodrigues A, Lacerda L, Francisco, RPV. ‘Brazilian Obstetric Observatory’ arXiv preprint arXiv:2105.06534 (2021). https://observatorioobstetrico.shinyapps.io/covid_gesta_puerp_br/ Accessed 20 June 2021 Important

Study 723 – methods used by Brazilian Obstetric Observatory

This arXiv preprint includes no primary data but provides background methodology for study 724 (click here or study). Citation: Rodrigues, A. and Lacerda, L. and Francisco, RPV ‘Brazilian Obstetric Observatory’ arXiv preprint arXiv:2105.06534 (2021).

19 June update – studies 720 to 722 added

Study 722 – 220 maternal deaths in Mexico

There were 220 maternal deaths from Covid-19 in Mexico in 2020 (click here or study). Citation: General Directorate of Epidemiology. Informes Semanales para la Vigilancia Epidemiológica de Muertes Maternas 2020. https://www.gob.mx/salud/documentos/informes-semanales-parala-vigilancia-epidemiologica-de-muertes-maternas-2020. Accessed June 19 2021

Study 721 – 36 cases from UK

Collected as part of the Coagulopathy Associated with COVID-19 [CA-COVID-19] study from 12 NHS Trusts between 1st of March and 31st May 2020 (click here or study). Likely overlap with many previous UK series. Citation: Crossette-Thambiah C, Nicholson P, Rajakaruna I, Langridge A, Sayar Z, Perelta MR, Essex S, Oakes R, Mounter P, Lewis S, Dutt T, Scott I, Aung N, Shapiro S, Laffan M, Arachchillage DR. The clinical course of COVID-19 in pregnant versus non-pregnant women requiring hospitalisation: results from the multicentre UK CA-COVID-19 study. Br J Haematol. 2021 Jun 16. doi: 10.1111/bjh.17579. Epub ahead of print. PMID: 34132386.

Study 720 – case report from Germany

A woman with SARS-CoV-2 antibodies, but PCR negative, gave birth to a moderately preterm infant with intracranial bleeding and periventricular leukomalacia as a potential consequence of post-COVID-19 hyperinflammation during pregnancy (click here or study). From author affilation cared for in University Hospital of Würzburg, which has not previously reported cases. Citation: Engert V, Siauw C, Stock A, Rehn M, Wöckel A, Härtel C, Wirbelauer J. Severe Brain Damage in a Moderate Preterm Infant as Complication of Post-COVID-19 Response during Pregnancy. Neonatology. 2021 Jun 14:1-4. doi: 10.1159/000516846. Epub ahead of print. PMID: 34126613.

14 June update – study 719 added

Study 719 – Case report from UK or Ireland

From author affiliations the patient was likely cared for either in Birmingham, UK, or Limerick, Republic of Ireland (click here or study). Citation: Marton T, Hargitai B, Hunter K, Pugh M, Murray P. Massive Perivillous Fibrin Deposition and Chronic Histiocytic Intervillositis a Complication of SARS-CoV-2 Infection. Pediatr Dev Pathol. 2021 Jun 3:10935266211020723. doi: 10.1177/10935266211020723. Epub ahead of print. PMID: 34082613.

13 June update – studies 716 to 718 added

Study 718 – 19 maternal deaths in Brazil

An analysis of maternal deaths and live births in the state of Bahia, from January 1, 2011, to December 31, 2020 (click here or study). The 19 maternal deaths in 2020, which mentioned Covid, may underestimate those caused directly or indirectly by the disease. Citation: de Carvalho-Sauer RCO, Costa MDCN, Teixeira MG, do Nascimento EMR, Silva EMF, Barbosa MLA, da Silva GR, Santos TP, Paixao ES. Impact of COVID-19 pandemic on time series of maternal mortality ratio in Bahia, Brazil: analysis of period 2011-2020. BMC Pregnancy Childbirth. 2021 Jun 10;21(1):423. doi: 10.1186/s12884-021-03899-y. PMID: 34112099. Important

Study 717 – 253 cases from Panama

From the following five hospitals, Complejo Hospitalario “Dr. AAM” Social Security Fund, Santo Tomás
Hospital, José Domingo de Obaldía Hospital in Chiriquí, Luis “Chico” Fábrega Hospital in Veraguas, and San Miguel Arcángel Hospital, none of which have previously reported cases (click here or study). The first report from Panama. Citation: Jaime Sánchez, Jorge Espinosa, Luis Carlos Caballero, B Sara Campana, Arelys Quintero, Carlos Luo, C Jorge Ng, Rafael de Gracia, Paulino Vigil-De Gracia. NEW CORONAVIRUS IN PREGNANT WOMEN. Maternal and perinatal outcomes medRxiv 2021.06.03.21258328; doi: https://doi.org/10.1101/2021.06.03.21258328. Update 5 November. Peer reviewed publication (click here). Citation: Sánchez J, Espinosa J, Caballero LC, Campana BS, Quintero A, Luo C, Ng CJ, de Gracia R, Vigil-De Gracia P. COVID 19 and high pregnancy and perinatal complications in Panama. J Matern Fetal Neonatal Med. 2021 Oct 4:1-4. doi: 10.1080/14767058.2021.1967925. Epub ahead of print. PMID: 34607516.

Study 716 – 418 cases from Denmark

Collected by the Danish National Patient Register and Danish Microbiology Database between March 1 and October 31, 2020 (click here or study). Citation: Anna JM Aabakke, Lone Krebs, Tanja G Petersen, Frank S Kjeldsen, Giulia Corn, Karen Wøjdemann, Mette H Ibsen, Fjola Jonsdottir, Elisabeth Rønneberg, Charlotte S Andersen, Iben Sundtoft, Tine Clausen, Julie Milbak, Lars Burmester, Birgitte Lindved, Annette Thorsen-Meyer, Mohammed R Khalil, Birgitte Henriksen, Lisbeth Jønsson, Lise LT Andersen, Kamilla K Karlsen, Monica L Pedersen, Åse Klemmensen, Marianne Vestgaard, Dorthe Thisted, Manrinder K Tatla, Line S Andersen, Anne-Line Brülle, Arense Gulbech, Charlotte B Andersson, Richard Farlie, Lea Hansen, Lone Hvidman, Anne N Sørensen, Sidsel L Rathcke, Katrine H Rubin, Lone K Petersen, Jan S Jørgensen, Lonny Stokholm, Mette Bliddal. SARS-CoV-2 infection in pregnancy in Denmark – characteristics and outcomes after confirmed infection in pregnancy: a nationwide, prospective, population-based cohort study. medRxiv 2021.06.08.21258480; doi: https://doi.org/10.1101/2021.06.08.21258480 Important. [Control group] Update 8 Sept. Peer reviewed citation: Aabakke AJM, Krebs L, Petersen TG, Kjeldsen FS, Corn G, Wøjdemann K, Ibsen MH, Jonsdottir F, Rønneberg E, Andersen CS, Sundtoft I, Clausen T, Milbak J, Burmester L, Lindved B, Thorsen-Meyer A, Khalil MR, Henriksen B, Jønsson L, Andersen LLT, Karlsen KK, Pedersen ML, Klemmensen Å, Vestgaard M, Thisted D, Tatla MK, Andersen LS, Brülle AL, Gulbech A, Andersson CB, Farlie R, Hansen L, Hvidman L, Sørensen AN, Rathcke SL, Rubin KH, Petersen LK, Jørgensen JS, Stokholm L, Bliddal M. SARS-CoV-2 infection in pregnancy in Denmark-characteristics and outcomes after confirmed infection in pregnancy: A nationwide, prospective, population-based cohort study. Acta Obstet Gynecol Scand. 2021 Aug 31. doi: 10.1111/aogs.14252. Epub ahead of print. PMID: 34467518.

12 June update – study 715 added

Study 715 – 514 cases from India

524 livebirths from 514 mothers, including 8 twins and one triplet pregnancy, collected by the National Registry of pregnant women with COVID-19 in India (PregCovid registry) (click here or study). The hospitals are not named and cases likely overlap with other series from India. Citation: Sushma Malik, MD, Suchitra Surve, MD, Poonam Wade, MD, Santosh Kondekar, MD, Vishal Sawant, MD, Murtuja Shaikh, MD, Periyasamy Kuppusamy, PhD, Ramesh Bharmal, MD, Smita D Mahale, PhD, Deepak N Modi, PhD, Rahul K Gajbhiye, MBBS, PhD, Clinical characteristics, management, and short term outcome of neonates born to mothers with COVID-19 in a tertiary care hospital in India, Journal of Tropical Pediatrics, 2021;, fmab054, https://doi.org/10.1093/tropej/fmab054

7 June update – studies 713 and 714 added

Study 714 – 65 cases from Israel

From eight hospitals, so likely overlap with other Israeli studies (click here or study). Compared with 86 vaccinated pregnant women -see vaccine source 39. Citation: Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y, Chen R, Gomez-Tolub R, Hadar E, Gabbay-Benziv R, Jaffe Moshkovich Y, Biron-Shental T, Shechter-Maor G, Farladansky-Gershnabel S, Yitzhak Sela H, Benyamini-Raischer H, Sela ND, Goldman-Wohl D, Shulman Z, Many A, Barr H, Yagel S, Neeman M, Kovo M. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Invest. 2021 May 20:150319. doi: 10.1172/JCI150319. Epub ahead of print. PMID: 34014840.

Study 713 – 68 cases from Bangladesh

These women were treated at Dhaka Medical College Hospital from March 15, to August 15, 2020 (click here or study). Two mothers died. This hospital, which disambiguates as Dhaka Medical College and Hospital grid.413674.3, has not previously reported cases. Citation: S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, Mohammad Abdullah Yusuf, Sabrina Rahman. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. American Journal of Internal Medicine. Vol. 9, No. 1, 2021, pp. 11-16. doi: 10.11648/j.ajim.20210901.12 Cautionary note – American Journal of Internal Medicine is not on PubMed, but is listed as a predatory journal on Beall’s list. The publisher Science Publishing Group has an address in New York City but is actually based in Pakistan (click here).

6 June update – studies 710 to 712 added

Study 712 – 1,347 cases from Spain

Collected by the 78 centers of the Spanish Obstetric Emergency Group between 26 February and 5 November 2020 (click here or study). Includes both the second wave in Spain, and a control group of unaffected women. Likely overlap with many other reports from Spain. Citation: Cruz Melguizo S, de la Cruz Conty ML, Carmona Payán P, Abascal-Saiz A, Pintando Recarte P, González Rodríguez L, Cuenca Marín C, Martínez Varea A, Oreja Cuesta AB, Rodríguez PP, Fernández Buhigas I, Rodríguez Gallego MV, Fernández Alonso AM, López Pérez R, Broullón Molanes JR, Encinas Pardilla MB, Ramírez Gómez M, Gimeno Gimeno MJ, Sánchez Muñoz A, Martínez-Pérez O, On Behalf Of The Spanish Obstetric Emergency Group S O E G. Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study. Viruses. 2021 May 7;13(5):853. doi: 10.3390/v13050853. PMID: 34067086; PMCID: PMC8151603. [important]

Study 711 – five cases from Indonesia

From Cipto Mangunkusumo General Hospital, Jakarta, and treated with remdesivir (click here or study). This hospital has not previously reported cases. Citation: Saroyo YB, Rumondang A, Febriana IS, Harzif AK, Irwinda R. Remdesivir Treatment for COVID 19 in Pregnant Patients with Moderate to Severe Symptoms: Serial Case Report. Infect Dis Rep. 2021 May 17;13(2):437-443. doi: 10.3390/idr13020042. PMID: 34067822; PMCID: PMC8162322.

Study 710 – 14 cases from Turkey

From Gungoren Hospital, Istanbul, which has not previously reported cases (click here or study). Citation: Yaman A, Kandemir I, Varkal MA. Infants infected with SARS-CoV-2 and newborns born to mother diagnosed with COVID-19: clinical experience. Ir J Med Sci. 2021 Jun 1:1–6. doi: 10.1007/s11845-021-02662-8. Epub ahead of print. PMID: 34075529; PMCID: PMC8169398.

5 June update – studies 708 and 709 added

Study 709 – 64 cases from Italy

From Sacco Hospital and Buzzi Hospital in Milan, and at San Gerardo Hospital in Monza between March and August 2020 (click here or study). The cases are likely included in the various Lomabardy series. Citation: Chiara Tasca, Roberta Simona Rossi, Silvia Corti, Gaia Maria Anelli, Valeria Savasi, Federica Brunetti, Manuela Cardellicchio, Emilio Caselli, Cristina Tonello, Patrizia Vergani, Manuela Nebuloni, Irene Cetin, Placental pathology in COVID-19 affected pregnant women: A prospective case-control study. Placenta, Volume 110, 2021, Pages 9-15, ISSN 0143-4004, https://doi.org/10.1016/j.placenta.2021.04.002. (https://www.sciencedirect.com/science/article/pii/S0143400421001132)

Study 708 – 55 cases from Israel

These first and second trimester cases were treated at Sheba Medical Center, Tel-Hashomer, between March 2020 and February 2021 (click here or study). Possible overlap with studies 330 and 449. Citation: Rosen H, Bart Y, Zlatkin R, Ben-Sira L, Ben Bashat D, Amit S, Cohen C, Regev-Yochay G, Yinon Y. Fetal and Perinatal Outcome Following First and Second Trimester COVID-19 Infection: Evidence from a Prospective Cohort Study. J Clin Med. 2021 May 16;10(10):2152. doi: 10.3390/jcm10102152. PMID: 34065646; PMCID: PMC8156528.

29 May update – studies 706 and 707 added

Study 707 – 120 cases from Palestine

Collected by the Palestine Ministry of Health (click here or study). One mother died. The first reported cases from Palestine. Citation: Maraqa B, Al-Shakhra K, Alawneh M, Jallad R, Alkaila M. Demographic factors associated with COVID-19-related death in Palestine. Public Health Pract (Oxf). 2021 Nov;2:100145. doi: 10.1016/j.puhip.2021.100145. Epub 2021 May 18. PMID: 34027510; PMCID: PMC8129786.

Study 706 – 288 cases from Saudi Arabia

From King Fahad Medical City, Al-Yammamah, and Imam Abdulrahman Al-Faisal hospitals in Riyadh between March and November 2020 (click here or study). One mother and four babies died. This series likely includes cases in studies 554 and 608. Citation: Al-Matary A, Almatari F, Al-Matary M, AlDhaefi A, Alqahtani MHS, Alhulaimi EA, AlOtaiby S, Almehiny K, John LS, Alanazi FS, Azad A, Aldandan FK. Clinical outcomes of maternal and neonate with COVID-19 infection – Multicenter study in Saudi Arabia. J Infect Public Health. 2021 Apr 20;14(6):702-708. doi: 10.1016/j.jiph.2021.03.013. Epub ahead of print. PMID: 34020209; PMCID: PMC8056848.

28 May update – study 705 added

Study 705 – 28 pregnant women in Recovery immune plasma trial

Twenty eight pregnant women participated in the UK Recovery convalescent plasms trial (click here or study). Their group allocation was not reported. Citation: RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet. 2021 May 14:S0140-6736(21)00897-7. doi: 10.1016/S0140-6736(21)00897-7. Epub ahead of print. PMID: 34000257; PMCID: PMC8121538.

27 May update – study 704 added

Study 704 – 52 cases from Japan

A web-survey of 624 hospitals in Japan identified 52 newborns born to mothers with confirmed SARS-CoV-2 infection (click here or study). One newborn tested positive. Citation: Morioka I, Toishi S, Kusaka T, Wada K, Mizuno K; committee of neonatal medicine in Japan Pediatric Society. Medical care of newborns born to mothers with confirmed or suspected severe acute respiratory syndrome coronavirus 2 infections in Japan. Pediatr Int. 2021 May 27. doi: 10.1111/ped.14855. Epub ahead of print. PMID: 34041810.

24 May update – studies 702 and 703 added

Study 703 – 198 cases from Spain

From author affiliations collected by 11 pathology departments in Barcelona (click here or study). Probably overlap with studies 140, 185, 191, 235, 413, 417, 607, 635, and 695. Citation: Garrido-Pontnou, M., Navarro, A., Camacho, J. et al. Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise. Mod Pathol (2021). https://doi.org/10.1038/s41379-021-00827-5

Study 702 – 7,950 cases from USA

Collected by the SET-NET consortium (click here or study). Citation: Romeo R Galang, Suzanne M Newton, Kate R Woodworth, Isabel Griffin, Titilope Oduyebo, Christina L Sancken, Emily O’Malley Olsen, Kathryn Aveni, Heather Wingate, Hanna Shephard, Chris Fussman, Zahra S Alaali, Kristin Silcox, Samantha Siebman, Umme-Aiman Halai, Camille Delgado Lopez, Mamie Lush, Ayomide Sokale, Jerusha Barton, Ifrah Chaudhary, Paul H Patrick, Levi Schlosser, Bethany Reynolds, Nicole Gaarenstroom, Sarah Chicchelly, Jennifer S Read, Leah de Wilde, Deborah Mbotha, Eduardo Azziz-Baumgartner, Aron J Hall, Van T Tong, Sascha Ellington, Suzanne M Gilboa, CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team, Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020 -March 5, 2021, Clinical Infectious Diseases, 2021;, ciab432, https://doi.org/10.1093/cid/ciab432

21 May update – study 701 added

Study 701 – 3,527 cases from UK

3,527 women who gave birth between 29th May 2020 and 31st 29 January 2021, and had a positive SARS-Cov-2 test, were compared with 338,553 women giving birth without (click here or study). They were identified using Hospital Episode Statistics, and will therefore overlap with UKOSS and most other UK reports over this time period. Citation: Ipek GUROL-URGANCI, Jennifer E. JARDINE, Fran CARROLL, Tim DRAYCOTT, George DUNN, Alissa FREMEAUX, Tina HARRIS, Jane HAWDON, Edward MORRIS, Patrick MULLER, Lara WAITE, Kirstin WEBSTER, Jan VAN DER MEULEN, Asma KHALIL. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. American Journal of Obstetrics and Gynecology,
2021. ISSN 0002-9378, https://doi.org/10.1016/j.ajog.2021.05.016. (https://www.sciencedirect.com/science/article/pii/S0002937821005652) [important]

17 May update – study 700 added

Study 700 – 73 cases from USA

From MedStar Washington Hospital Center, Washington, District of Columbia. (click here or study). Citation: Chornock R, Iqbal SN, Wang T, Kodama S, Kawakita T, Fries M. Incidence of Hypertensive Disorders of Pregnancy in Women with COVID-19. Am J Perinatol. 2021 May 3. doi: 10.1055/s-0041-1727167. Epub ahead of print. PMID: 33940651.

16 May update – studies 697 to 699 added. Study 533 updated

Study 699 – 20 cases from China

From Tongji Hospital in Wuhan between January 19 to April 20, 2020 (click here or study). Likely previously reported many times. Citation: Chen G, Liao Q, Ai J, Yang B, Bai H, Chen J, Liu F, Cao Y, Liu H and Li K (2021) Immune Response to COVID-19 During Pregnancy. Front. Immunol. 12:675476. doi: 10.3389/fimmu.2021.675476

Study 698 – 8,248 cases from Brazil

From the Brazilian official severe acute respiratory syndrome (SARS) surveillance system (click here or study). 803 mothers died. Likely overlap with studies 66, 138, 194, 201, 203, 248, 249 and 309. Citation: Maíra L S Takemoto, Marcos Nakamura-Pereira, Mariane O Menezes, Leila Katz, Roxana Knobel, Melania M R Amorim, Carla B Andreucci. Higher case fatality rate among obstetric patients with COVID-19 in the second year of pandemic in Brazil: do new genetic variants play a role? medRxiv 2021.05.06.21256651; doi: https://doi.org/10.1101/2021.05.06.21256651

Study 697 – 145 cases from USA

Treated in a public healthcare system, in Santa Clara County, California from April 15, 2020 to March 31, 2021 (click here or study). Citation: Song D, Prahl M, Gaw SL, et al. Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study. Preprint. medRxiv. 2021;2021.05.01.21255871. Published 2021 May 3. doi:10.1101/2021.05.01.21255871 10 July update. Peer reviewed publication (click here or study). Citation: Song D, Prahl M, Gaw SL, et al. Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: prospective cohort study. BMJ Open 2021;11:e053036. doi: 10.1136/bmjopen-2021-053036

15 May update – studies 693 to 696 added

Study 696 – case report from USA

From Cedars‐Sinai Medical Center, Los Angeles, California (click here or study). Citation: Rushakoff JA, Polyak A, Caron J, et al. A case of a pregnant patient with COVID‐19 infection treated with emergency c‐section and extracorporeal membrane oxygenation. J Card Surg. 2021;1‐4. https://doi.org/10.1111/jocs.15623

Study 695 – two cases from Belgium

From author affiliations probably treated at Ghent University Hospital which has not previously reorted cases (click here or study). Citation: Libbrecht S, Van Cleemput J, Vandekerckhove L, Colman S, Padalko E, Verhasselt B, Van de Vijver K, Dendooven A, Dehaene I, Van Dorpe J. A rare but devastating cause of twin loss in a near-term pregnancy highlighting the features of severe SARS-CoV-2 placentitis. Histopathology. 2021 May 13. doi: 10.1111/his.14402. Epub ahead of print. PMID: 33982813.

Study 694 – 60 cases from Spain

This MedRxiv preprint describes lack of virus and presence of antibodies in breast milk (click here or study). Participants were recruited from 7 health centers from Valencia, Barcelona, Granada, and Zaragoza from April to December 2020 Citation: Christine Bauerl, Walter Randazzo, Gloria Sanchez, Marta Selma-Royo, Elia Garcia-Verdevio, Laura Martinez-Rodriguez, Anna Parra-Llorca, Carles Lerin, Victoria Fumado, Francesca Crovetto, Fatima Crispi, Francisco Jose Perez-Cano, Gerardo Rodriguez, Gema Ruiz-Redondo, Cristina Campoy, Cecilia Martinez-Costa, Maria Carmen Collado. SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain. medRxiv 2021.05.06.21256766; doi: https://doi.org/10.1101/2021.05.06.21256766

Study 693 – 1,062 cases from USA

Cases and controls collected from the Premier Healthcare Database, an all-payer data repository that captures 20% of U.S. hospitalizations (click here or study). Citation: Pineles BL, Goodman KE, Pineles L, O’Hara LM, Nadimpalli G, Magder LS, Baghdadi JD, Parchem JG, Harris AD. In-Hospital Mortality in a Cohort of Hospitalized Pregnant and Nonpregnant Patients With COVID-19. Ann Intern Med. 2021 May 11. doi: 10.7326/M21-0974. Epub ahead of print. PMID: 33971101.

4 May update – study 692 added

Study 692 – case report from the Netherlands

From Amsterdam Medical Centre (AMC) (click here or study). Citation: van Amesfoort JE, Werter DE, Painter RC, Hermans FJR. Severe metabolic ketoacidosis as a primary manifestation of SARS-CoV-2 infection in non-diabetic pregnancy. BMJ Case Rep. 2021 Apr 19;14(4):e241745. doi: 10.1136/bcr-2021-241745. PMID: 33875510.

3 May update – studies 690 and 691 added

Study 691 – 2,824 cases from Canada

The 3rd report from the CanCovid registry includes cases up to 31 December 2020 (click here or study). 1,880 cases reported in detail. Overlap with studies 510 and 690. Citation: Deborah Money. CANADIAN SURVEILLANCE OF COVID-19 IN PREGNANCY: EPIDEMIOLOGY, MATERNAL AND INFANT OUTCOMES Report #3: Released February 25, 2021. School of Population & Public Health, University of British Colombia

Study 690 – 1,940 cases from Canada

The 2nd report from the CanCovid registry includes cases up to 30 November 2020 (click here or study). 1,271 cases repoted in detail. Overlap with study 510. Citation: Deborah Money. CANADIAN SURVEILLANCE OF COVID-19 IN PREGNANCY: EPIDEMIOLOGY, MATERNAL AND INFANT OUTCOMES Report #2: Released January 15, 2021. School of Population & Public Health, University of British Colombia

1 May update – study 689 added

Study 689 – no hospital-acquired maternal infection in New York

Of 72 SARS-CoV-2 negative pregnant women admitted to New York Presbyterian Hospital/Columbia University Irving Medical Center between November 23, 2020 to March 3, 2021, none retested positive during their admission (click here or study). Citation: Zork NM, Markan A, Sheen J-J, AUBEY J, Saiman L, Goffman D, Serial Surveillance for SARS-CoV-2 in hospitalized antepartum women, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.04.222.

29 April update – study 688 added

Study 688 – 2,286 cases from Sweden

Collected from the National Swedish Pregnancy Register between March 11, 2020, and January 31, 2021 (click here or study). Baby outcomes compared with babies of all SARS-CoV-2 negative mothers, and with a matched control group. Probable overlap with studies 20, 88, 259b, 282, 298, 523, 588, 610 and 636. Citation: Norman M, Navér L, Söderling J, et al. Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA. Published online April 29, 2021. doi:10.1001/jama.2021.5775 [important]

28 April update – studies 686 & 687 added

Study 687 – case report from Japan

From Toho University Omori Medical Center, Tokyo, which has not previously reported cases (click here or study). Citation: Ito A, Hayata E, Nakata M, Shigeta T, Nakamura Y, Kishi K, Yoda H, Morita M. Rapid recovery achieved by intensive therapy after preterm cesarean section for worsening COVID-19-induced acute respiratory failure: A case report and literature review. Case Rep Womens Health. 2021 Apr;30:e00315. doi: 10.1016/j.crwh.2021.e00315. Epub 2021 Apr 18. PMID: 33898274; PMCID: PMC8053357.

Study 686 – 105 cases from Spain

Collected from hospitals participating in the GESNEO-COVID cohort between 15 March & 31 July 2020 (click here or study). The hospitals include General Universitario Gregorio Marañón; Hospital Universitario Infanta Sofía; Hospital La Fe; Hospital Materno Infantil de Badajoz; Complejo Hospitalario de Navarra; Hospital Universitario de Albacete; Hospital Universitario Infanta Elena; Hospital Parc Taulí ; Hospital Universitario HM Montepríncipe; Hospital General de Albace; Complejo Hospitalario de Navarra; Hospital Universitario Infanta Leonor; Hospital San Pedro de Alcántara; Complejo Hospitalario de Santiago, and Hospital 12 de Octubre. Only the last appears to have previously reported cases. However that hospital in Madrid has reported cases in studies 151, 165, 196, 205, 458, 470, 583 and 635. Citation: Carrasco I, Muñoz-Chapuli M, Vigil-Vázquez S, Aguilera-Alonso D, Hernández C, Sánchez-Sánchez C, Oliver C, Riaza M, Pareja M, Sanz O, Pérez-Seoane B, López J, Márquez E, Domínguez-Rodríguez S, Hernanz-Lobo A, De León-Luis JA, Sánchez-Luna M, Navarro ML. SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave. BMC Pregnancy Childbirth. 2021 Apr 26;21(1):326. doi: 10.1186/s12884-021-03784-8. PMID: 33902483.

24 April update – studies 684 & 685 added, 610 updated, & numbering from 650 corrected

Study 685 – 240 cases from Mexico

Cared for at Instituto Nacional de Perinatologı´a Isidro Espinosa de los Reyes, (INPer), in Mexico City, between April 22 and May 25, 2020 (click here or study). This hospital has not previously reported cases although they likely overlap with other multicentre Mexican series. Citation: Cardona-Pérez JA, Villegas-Mota I, Helguera-Repetto AC, Acevedo-Gallegos S, Rodríguez-Bosch M, Aguinaga-Ríos M, Coronado-Zarco I, León-Juárez M, Aguilar-Ayala D, Valdespino-Vázquez MY, Moreno-Verduzco ER, Rivera MA, Valencia-Contreras C, Gómez-Sousa ML, Solis-Paredes M, Frías-Madrid B, Velasco-Téllez C, Rodriguez-Aldama JC, Avila-Sosa V, Galván-Contreras R, Figueroa-Damian R, Cortés-Bonilla M, Estrada-Gutierrez G, Espino-Y-Sosa S, Irles C. Prevalence, clinical features, and outcomes of SARS-CoV-2 infection in pregnant women with or without mild/moderate symptoms: Results from universal screening in a tertiary care center in Mexico City, Mexico. PLoS One. 2021 Apr 22;16(4):e0249584. doi: 10.1371/journal.pone.0249584. PMID: 33886590.

Study 684 – 250 cases from USA

255 neonates born to 250 mothers with Covid-19 between March 1 and July 31, 2020 (click here or study). Cared for at 11 hospitals in Massachusetts (Baystate; Beth Israel Deaconess; Beverly; Brigham & Women’s; Boston Medical Center; Cambridge Health Alliance; Massachusetts General; Newton-Wellesley; Tufts Children’s; UMass Memorial; Winchester). Probable overlap with studies 142, 231, 257, 262, 387, 488, 490, 519, 531, 550, 571, 577, 589, 591 and 606. Citation: Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R, Chaudhary N, Vaidya R, Culic I, Singh R, Yanni D, Patrizi S, Hudak ML, Parker MG, Belfort MB. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021 Apr 1;4(4):e217523. doi: 10.1001/jamanetworkopen.2021.7523. PMID: 33890989.

22 April update – study 683 added

Study 683 –  706 cases & 1,424 controls from the Intergrowth-21 consortium

For each case, two control pregnancies were selected (click here or study). Collected from 43 institutions in 18 countries. Although some institutions had previously reported cases, the authors “excluded women/neonates from the final analysis if their data were already published in any comparative study with women without COVID-19 diagnosis”, and list the overlapping papers. These are studies 92, 102, 140, 144, 150, 161, 232, 246, 252 and 488. Citation: Villar J, Ariff S, Gunier RB, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr. Published online April 22, 2021. doi:10.1001/jamapediatrics.2021.1050 [important]

21 April update – study 682 added

Study 682 – case report from Germany

A pregnant woman with Covid-19 deteriorated post-partum and required ventilation and ECMO (click here or study). From author affiliations she was cared for at Vivantes Klinikum im Friedrichshain in Berlin, which has not previously reported cases. Citation: Maier JT, Zickler D, Metz M, Jebens A, Jarchau U, Fischer J, Kimmel V, Prueter E, Hellmeyer L. Peripartum Covid-19 Pneumonia with Severe ARDS – A Case Report. Z Geburtshilfe Neonatol. 2021 Apr;225(2):183-187. doi: 10.1055/a-1365-9262. Epub 2021 Apr 19. PMID: 33873231.

18 April update – studies 676 to 681 added

Study 681 – 72 cases from USA

Cared from at Boston Medical Center, Massachusetts (click here or study). Probable overlap with studies 292 and 490. Citation: Sabharwal V, Bartolome R, Hassan SA, Levesque BM, Camelo IY, Wachman EM, Figueira M, Yarrington CD, Cooper ER, Barnett ED, Parker MG. Mother-Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes. Am J Perinatol. 2021 Apr 14. doi: 10.1055/s-0041-1726429. Epub ahead of print. PMID: 33853145.

Study 680 – case report from USA

Cared for at University of California, Los Angeles (click here or study). Citation: Mok T, Contreras D, Chmait RH, Goldstein J, Pluym ID, Tabsh K, Aldrovandi G, Afshar Y. Complicated Monochorionic-Diamniotic Twins in a Pregnant Woman with COVID-19 in the Second Trimester. Am J Perinatol. 2021 Apr 14. doi: 10.1055/s-0041-1726428. Epub ahead of print. PMID: 33853148.

Study 679 – 56 cases from USA

Cared from at Kings County Hospital Center in New York, which has not previously reported cases (click here or study). Citation: Liu C, Andrusier M, Silver M, Applewhite L, Clare CA. Effect of SARS-CoV-2 Infection on Pregnancy Outcomes in an Inner-City Black Patient Population. J Community Health. 2021 Apr 15:1–7. doi: 10.1007/s10900-021-00988-z. Epub ahead of print. PMID: 33855649; PMCID: PMC8046575.

Study 678 – 34 patients from Turkey

Cared for at Kartal Training and Research Hospital, Istanbul, which has not previously reported cases (click here or study). Citation: Ozer KB, Sakin O, Koyuncu K, Cimenoglu B, Demirhan R. Comparison of Laboratory and Radiological Findings of Pregnant and Non-Pregnant Women with Covid-19. Rev Bras Ginecol Obstet. 2021 Mar;43(3):200-206. doi: 10.1055/s-0041-1726054. Epub 2021 Apr 15. PMID: 33860503.

Study 677 – 1,609 cases from USA

The Cerner COVID-19 De-Identified Data Cohort was used to compare pregnant women with Covid, with non-pregnant affected women aged 18-44 (click here or study). Although pregnant women were more likely to be hospitalised, they were no more likely to need invasive ventilation or die. They were cared for in 62 US hospitals with which Cerner had a data use agreement. Citation: Qeadan F, Mensah NA, Tingey B, Stanford JB. The risk of clinical complications and death among pregnant women with COVID-19 in the Cerner COVID-19 cohort: a retrospective analysis. BMC Pregnancy Childbirth. 2021 Apr 16;21(1):305. doi: 10.1186/s12884-021-03772-y. PMID: 33863292.

Study 676 – 18 cases from from Ireland

Cared for at Rotunda Hospital, Dublin (click here or study). Probable overlap with studies 284, 300 and 596. Citation: Alaya F, Worrall AP, O’toole F, Doyle J, Duffy RM, Geary MP. Health-related quality of life and quality of care in pregnant and postnatal women during the COVID-19 pandemic: A cohort study. Int J Gynaecol Obstet. 2021 Apr 16. doi: 10.1002/ijgo.13711. Epub ahead of print. PMID: 33864252.

16 April update – studies 674 and 675 added

Study 675 – 38 severe cases in UK

7/34 ECMO referrals of women aged 16-49 to the Royal Brompton Hospital in London in the first wave, were pregnant or post-partum, compared with 31/62 in the second wave (click here or study). This hospital has not previously reported cases, but there will be overlap with the various UKOSS and ICNARC reports. Citation: Suraj Kadiwar, Jonathan J Smith, Stephane Ledot, Mark Johnson, Paolo Bianchi, Natasha Singh, Claudia Montanaro, Michael Gatzoulis, Nishel Shah, Emem-Fong Ukor, Were pregnant women more affected by COVID-19 in the second wave of the pandemic?, The Lancet, 2021, ISSN 0140-6736, https://doi.org/10.1016/S0140-6736(21)00716-9. https://www.sciencedirect.com/science/article/pii/S0140673621007169)

Study 674 – 525 first wave cases from Italy

Collected by the Italian Obstetric Surveillance System (ITOSS) registry between 25 February and 31 July 2020 (click here or study). Likely overlap with study 536 and other Italian series. Citation: Donati, S.; Corsi, E.; Salvatore, M.A.; Maraschini, A.; Bonassisa, S.; Casucci, P.; Cataneo, I.; Cetin, I.; D’Aloja, P.; Dardanoni, G.; De Ambrosi, E.; Ferrazzi, E.; Fieni, S.; Franchi, M.P.; Gargantini, G.; Iurlaro, E.; Leo, L.; Liberati, M.; Livio, S.; Locci, M.; Marozio, L.; Martini, C.; Maso, G.; Mecacci, F.; Meloni, A.; Mignuoli, A.D.; Patanè, L.; Pellegrini, E.; Perotti, F.; Perrone, E.; Prefumo, F.; Ramenghi, L.; Rusciani, R.; Savasi, V.; Schettini, S.C.A.; Simeone, D.; Simeone, S.; Spinillo, A.; Steinkasserer, M.; Tateo, S.; Ternelli, G.; Tironi, R.; Trojano, V.; Vergani, P.; Zullino, S.; on behalf of the ItOSS COVID-19 Working Group. Childbirth Care among SARS-CoV-2 Positive Women in Italy. Int. J. Environ. Res. Public Health 2021, 18, 4244. https://doi.org/10.3390/ijerph18084244

15 April update – study 673 added

Study 673 – 75 cases from USA

The placentas were compared with those from 75 control pregnancies (click here or study). From author affiliations the patients had been cared for at Columbia University Irving Medical Center, New York. Citation: Debelenko L, Katsyv I, Chong AM, Peruyero L, Szabolcs M, Uhlemann AC. Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2. Hum Pathol. 2021 Mar;109:69-79. doi: 10.1016/j.humpath.2020.12.004. Epub 2020 Dec 13. PMID: 33321162; PMCID: PMC7733682.

14 April update – studies 671and 672 added

Study 672 – 50 cases from USA

From Loma Linda University Medical Center which has not previously reported cases (click here or study). Citation: Ruofan Yao, Courtney B Martin , Victoria S Haase , Beverly C Tse , Ms Melissa Nishino , Ciprian Gheorghe , Kevin Balli , Initial clinical characteristics of gravid SARS-CoV-2 positive patients and the risk of progression to severe COVID-19 disease, American Journal of Obstetrics & Gynecology MFM (2021), doi:https://doi.org/10.1016/j.ajogmf.2021.100365

Study 671 – 29 cases from Spain

From University Hospital La Paz, Madrid (click here or study). Probable overlap with study 196. Citation: Blasco Santana L, Miraval Wong E, Álvarez-Troncoso J, Sánchez García L, Bartha JL, Regojo-Zapata RM. Maternal and perinatal outcomes and placental pathologic examination of 29 SARS-CoV-2 infected patients in the third trimester of gestation. J Obstet Gynaecol Res. 2021 Apr 5. doi: 10.1111/jog.14784. Epub ahead of print. PMID: 33821521.

13 April update – studies 668 to 670 added

Study 670 – 110 cases from Iran

Collected between March and October 2020 from multiple hospitals in Tehran (click here or study). Five women died. Citation: Vizheh M, Muhidin S, Aghajani F, Maleki Z, Bagheri F, Hosamirudsari H, Aleyasin A, Tehranian A. Characteristics and outcomes of COVID-19 pneumonia in pregnancy compared with infected nonpregnant women. Int J Gynaecol Obstet. 2021 Apr 8. doi: 10.1002/ijgo.13697. Epub ahead of print. PMID: 33829492.

Study 669 – 1,454 cases from USA

From the Society for Obstetric Anesthesia and Perinatology (SOAP) COVID-19 Registry (click here or study). Collected from March 19-May 31, 2020 from 14 centres which, from author affiliations, probably include Brigham and Women’s Hospital, Boston; Weill Cornell, New York; Massachusetts General Hospital, Boston; University of California at San Francisco; Langone Health, New York, Stanford University School of Medicine, Emory School of Medicine, Atlanta, Icahn School of Medicine at Mount Sinai, New York; Mayo Clinic, Rochester; University of Maryland School of Medicine, Baltimore; Washington University School of Medicine, St. Louis; MGH-North Shore Medical Center, Danvers; Columbia University College of Physicians and Surgeons, New York. Citation: Katz D, Bateman BT, Kjaer K, Turner DP, Spence NZ, Habib AS, George RB, Toledano RD, Grant G, Madden HE, Butwick AJ, Lynde G, Minehart RD, Beilin Y, Houle TT, Sharpe EE, Kodali B, Bharadwaj S, Farber MK, Palanisamy A, Prabhu M, Gonzales NY, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology (SOAP) COVID-19 Registry: An analysis of outcomes among pregnant women delivering during the initial SARS-CoV-2 outbreak in the United States. Anesth Analg. 2021 Apr 8. doi: 10.1213/ANE.0000000000005592. Epub ahead of print. PMID: 33830956.

Study 668 – two cases from Chile

Two patients with severe Covid-19 were pregnant in this series of patients cared for in the Regional Hospital in Los Ríos (click here or study). Both were in the 2nd trimester. One was delivered by Caesarean at 28 weeks. This hospital has not previously reported cases. Citation: Olivares F, Muñoz D, Fica A, Delama I, Alvarez I, Navarrete M, Blackburn E, Garrido P, Wenger R, Grandjean J. Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center. Rev Med Chil. 2020 Nov;148(11):1577-1588. doi: 10.4067/S0034-98872020001101577. PMID: 33844763.

12 April update – studies 662 to 667 added

Study 667 – 5,479 cases from UK

This paper was prepared by the ISARIC4C Consortium, UK Obstetric Surveillance System (UKOSS) and COVID-19 Clinical Information Network (CO-CIN) for the UK Scientific Advisory Group for Emergencies (SAGE). It includes pregnant women with Covid from the whole of the UK. It is available as a pdf (click here or study) and as a set of powerpoint slides (click here or study). Citation: Marian Knight, Rema Ramakrishnan, Kathryn Bunch, Nicola Vousden, Jennifer J Kurinczuk, Sarah Dunn, Lisa Norman, Aisling Barry, Ewen Harrison, Annemarie Docherty, Calum Semple. Females in Hospital with SARS-CoV-2 infection, the association with pregnancy and pregnancy outcomes: A UKOSS/ISARIC/CO-CIN investigation. Report presented 25 March 2021. Published 9 April 2021 https://www.gov.uk/government/publications/ukossisaricco-cin-females-in-hospital-with-sars-cov-2-infection-the-association-with-pregnancy-and-pregnancy-outcomes-25-march-2021 Accessed 12 April 2021 [important]

Study 666 – 165 cases from Brazil

The patients were cared for in three different unnamed hospitals in São Paulo (click here or study). They may overlap with cases in studies 201, 213 and 426. Citation: Kiappe OP, Santos da Cruz NF, Rosa PAC, Arrais L, Bueno de Moraes NS. Ocular Assessments of a Series of Newborns Gestationally Exposed to Maternal COVID-19 Infection. JAMA Ophthalmol. Published online April 07, 2021. doi:10.1001/jamaophthalmol.2021.1088

Study 665 – 567 cases from Iran

Eight women died (click here or study). They were all cared for at Forghani Hospital in Qom. If this is the same as Nekouei-Hedayati-Forghani Hospital in the same city, some may have been reported in study 555. Neither hospital disambiguates on GRID.ac. Citation: Samadi, P., Alipour, Z., Ghaedrahmati, M. and Ahangari, R. (2021), The severity of COVID‐19 among pregnant women and the risk of adverse maternal outcomes. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript. https://doi.org/10.1002/ijgo.13700

Study 664 – case report from Iran

Cared for at Firoozgar Hospital, Tehran (click here or study). The patient died, so may be included in study 345. Citation: Goudarzi, S, Firouzabadi, FD, Mahmoudzadeh, F, Aminimoghaddam, S. Pulmonary embolism in pregnancy with COVID‐19 infection: A case report. Clin Case Rep. 2021; 00: 1– 5. https://doi.org/10.1002/ccr3.3709

Study 663 – 68 cases from USA

This BioRxiv preprint reports a detailed study of placental immunology (click here or study). The hospitals caring for the patients are not reported, but from the last author affiliation might be Massachusetts General Hospital in Boston. Citation: Evan A Bordt, Lydia L Shook, Caroline Atyeo, Krista M Pullen, Rose M De Guzman, Marie-Charlotte Meinsohn, Maeva Chauvin, Stephanie Fischinger, Laura J. Yockey, Kaitlyn James, Rosiane Lima, Lael M Yonker, Alessio Fasano, Sara Brigida, Lisa M Bebell, Drucilla J Roberts, David Pépin, Jun R Huh, Staci D Bilbo, Jonathan Z Li, Anjali Kaimal, Danny Schust, Kathryn J Gray, Douglas Lauffenburger, Galit Alter, Andrea G Edlow. Sexually dimorphic placental responses to maternal SARS-CoV-2 infection bioRxiv 2021.03.29.437516; doi: https://doi.org/10.1101/2021.03.29.437516

Study 662 – 13 cases from China

Collected from centres outside Wuhan (click here or study). Some or all have probably been reported previously. Citation: Yangli Liu , Haihong Chen , Weiping Tan , Yukun Kuang , Kejing Tang , Yifeng Luo , Yubiao Guo , Clinical characteristics and outcome of SARS-CoV-2 infection during pregnancy, Journal of Infection (2021), doi: https://doi.org/10.1016/j.jinf.2021.03.030

11 April update – studies 658 to 661 added

Study 661 – 246 cases from Spain

Collected from the 45 hospitals of the Spanish Obstetric Emergency group (click here or study). Likely overlap with studies 264b, 548 and 589 as well as other Spanish report. Citation: Martinez-Perez O, Prats Rodriguez P, Muner Hernandez M, Encinas Pardilla MB, Perez Perez N, Vila Hernandez MR, Villalba Yarza A, Nieto Velasco O, Del Barrio Fernandez PG, Forcen Acebal L, Orizales Lago CM, Martinez Varea A, Muñoz Abellana B, Suarez Arana M, Fuentes Ricoy L, Martinez Diago C, Janeiro Freire MJ, Alférez Alvarez-Mallo M, Casanova Pedraz C, Alomar Mateu O, Lesmes Heredia C, Wizner de Alva JC, Bernardo Vega R, Macia Badia M, Alvarez Colomo C, Sanchez Muñoz A, Pratcorona Alicart L, Alonso Saiz R, Lopez Rodriguez M, Del Carmen Barbancho Lopez M, Meca Casbas MR, Vaquerizo Ruiz O, Moran Antolin E, Nuñez Valera MJ, Fernandez Fernandez C, Tubau Navarra A, Cano Garcia AM, Baena Luque C, Soldevilla Perez S, Gastaca Abasolo I, Adanez Garcia J, Teulon Gonzalez M, Puertas Prieto A, Ostos Serna R, Del Pilar Guadix Martin M, Catalina Coello M, Ferriols Perez E, Caño Aguilar A, De la Cruz Conty ML, Sainz Bueno JA; Spanish Obstetric Emergency Group. The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy Childbirth. 2021 Apr 1;21(1):273. doi: 10.1186/s12884-021-03742-4. PMID: 33794829; PMCID: PMC8016158.

Study 660 – 22 cases from USA

From Johns Hopkins Hospital, Baltimore, which has not previously reported cases (click here or study). Citation: Sherer ML, Lei J, Creisher P, Jang M, Reddy R, Voegtline K, Olson S, Littlefield K, Park HS, Ursin RL, Ganesan A, Boyer T, Elsayed N, Brown DM, Walch SN, Antar AAR, Manabe YC, Jones-Beatty K, Christopher Golden W, Satin AJ, Sheffield JS, Pekosz A, Klein SL, Burd I. Pregnancy alters IL-1β expression and anti-viral antibody responses during SARS-CoV-2 infection. Am J Obstet Gynecol. 2021 Mar 30:S0002-9378(21)00208-8. doi: 10.1016/j.ajog.2021.03.028. Epub ahead of print. PMID: 33798476; PMCID: PMC8008823.

Study 659 – case report from Italy

A woman with Covid-19 and twins cared for at the Institute for Maternal and Child Health “IRCCS Burlo Garofolo”, Trieste (click here or study). This hospital has not previously reported cases. Citation: Trombetta A, Comar M, Tommasini A, Canton M, Campisciano G, Zanotta N, Cason C, Maso G, Risso FM. SARS-CoV-2 Infection and Inflammatory Response in a Twin Pregnancy. Int J Environ Res Public Health. 2021 Mar 17;18(6):3075. doi: 10.3390/ijerph18063075. PMID: 33802696; PMCID: PMC8002573.

Study 658 – 30 cases from Italy

From Policlinico Umberto I Hospital, Sapienza University of Rome (click here or study). This hospital appears to have only reported one previous case in study 448. Citation: Porpora MG, Merlino L, Masciullo L, D’Alisa R, Brandolino G, Galli C, De Luca C, Pecorini F, Fonsi GB, Mingoli A, Franchi C, Oliva A, Manganaro L, Mastroianni CM, Piccioni MG. Does Lung Ultrasound Have a Role in the Clinical Management of Pregnant Women with SARS COV2 Infection? Int J Environ Res Public Health. 2021 Mar 9;18(5):2762. doi: 10.3390/ijerph18052762. PMID: 33803223; PMCID: PMC7967479.

3 April update – studies 654 to 657 added

Study 657 – case report from Iran

Neurosurgical complications from Covid-19 in pregnancy are described (click here or Saberi case rep). From author affiliations the patient was cared for, and delivered by Caesarean, in Imam Khomeini hospital, Tehran, which has not previously reported cases. Citation: Saberi H, et al, Acute presentation of third ventricular cavernous malformation following COVID-19 infection in a pregnant woman: A case report, Neurochirurgie, https://doi.org/10.1016/j.neuchi.2021.03.010

Study 656 – case report from Japan

From author affiliations the patient who required ventilation, but recovered was probably cared for at University of the Ryukyus Hospital, Okinawa, which has not previously reported cases (click here or Chinen case rep). Citation: Y. Chinen, Y. Kinjyo, K. Mekaru, et al., Critical respiratory failure in pregnancy complicated with COVID-19: A case report, Case Reports in Women’s Health (2018), https://doi.org/10.1016/j.crwh.2021.e00309

Study 655 – 45 cases from Canada

From author affiliations the women were cared for at McGill University Health Centre, and Jewish General Hospital Montreal (click here or Trahan Montreal). Citation: Marie-Julie Trahan, Isabelle Malhame, Patrick O’Farrell, Cristina Mitric, Jade Desilets, Marie-Pier Bastrash, Amira El-Messidi, Haim A. Abenhaim, Obstetrical and Newborn Outcomes among Patients with SARS-CoV-2 during Pregnancy, Journal of Obstetrics and Gynaecology Canada (2021),
doi: https://doi.org/10.1016/j.jogc.2021.03.012

Study 654 – 458 cases from Chile

From Hospital San Jose, Santiago, 8 April – 30 August 2020 (click here or Haye Chile). One mother died. A different hospital Study 486, which has not previously reported cases. Citation: Maria Teresa Haye, Giorgia Cartes, Jorge Gutiérrez, Paz Ahumada, Bernardo Krause, Mario Merialdi & Rogelio Gonzalez (2021): Maternal and perinatal outcomes in pregnant women with confirmed severe and mild COVID-19 at one large maternity hospital in Chile, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2021.1902498

30 March update – studies 652 and 653 added

Study 653 – 64 cases from Egypt

This MedRxiv preprint includes 64 pregnant women, of whom three died (click here or paper). Citation: Noha Asem, Mohamed Hassany, Khaled Taema, Hossam Masoud, Gehan Elassal, Ehab Kamal, Wagdy Amin, Akram Abdelbary, Amin Abdel Baki, Samy Zaky, Ahmad Abdalmohsen, Hamdy Ibrahim, Mohamed Elnady, Ahmed Mohamed, Ehab Atteia, Hala Zaid. Demographic and clinical features associated with in-hospital mortality in Egyptian COVID-19 patients: A retrospective cohort study. medRxiv 2021.03.22.21253577; doi: https://doi.org/10.1101/2021.03.22.21253577

Study 652 – 708 cases from Norway

This MedRxiv preprint includes 708 pregnant women with a positive test from the Norwegian National Population Registry between March 1st, 2020 and February 28th, 2021 (click here or paper). Citation: Maria C. Magnus, Laura Oakley, Håkon K. Gjessing, Olof Stephansson, Hilde M. Engjom, Ferenc Macsali, Petur B. Juliusson, Anne-Marie Nybo Andersen, Siri E. Håberg. Pregnancy and risk of COVID-19. medRxiv 2021.03.22.21254090; doi: https://doi.org/10.1101/2021.03.22.21254090

21 March update – study 651 added

Study 651 – 2 cases in two US fertility clinics

Both asymptomatic (click here or PIIS0002937821001599). Six other women, out of 339 showed evidence of past infection. The clinics were Utah Fertility Center, Utah, and Boston IVF, Massachusetts. Citation: FOULK R, SAKKAS D, KAYALI R, VALBUENA D, SIMON C, CUZZI J, SARSCoV-2 immunity, infective and naïve incidence in fertility clinics after lockdown, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.03.008. 

20 March update – studies 648 to 650 added

Study 650 – 132 cases from India

Cared for between 15th May and 15th November 2020, at Tata Main Hospital, Jamshedpur, which has not previously reported cases (click here or cureus-0013-00000013184). Citation: Singh V, Choudhary A, Datta MR, Ray A. Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study. Cureus. 2021 Feb 6;13(2):e13184. doi: 10.7759/cureus.13184. PMID: 33717728; PMCID: PMC7943051.

Study 649 – Case report from USA

The authors are affiliated with the Medical College of Wisconsin, Milwaukee, Wisconsin (click here or e240385.full). The clinical details differ from the case in study 563. Citation: Roddy JT, Collier WS, Kurman JS. Prone positioning for severe ARDS in a postpartum COVID-19 patient following caesarean section. BMJ Case Rep. 2021 Mar 16;14(3):e240385. doi: 10.1136/bcr-2020-240385. PMID: 33727296.

Study 648 – one case from UK

From 7 May to 6 June 2020, 1/465 asymptomatic pregnant women from The Rosie Hospital in Cambridge tested positive (click here or s12884-021-03653-4). The Rosie has not previously reported cases. Citation: Xu R, Pauley TA, Missfelder-Lobos H, Haddon RJ, Gupta RK, Chong HP. Samba II PCR testing for COVID-19 in pregnant women: a retrospective cohort study and literature review. BMC Pregnancy Childbirth. 2021 Mar 17;21(1):212. doi: 10.1186/s12884-021-03653-4. PMID: 33731037.

16 March – study 647 added

Study 647 – 36 cases from UK

This MedRxiv preprint from ICNARC, QResearch, and the COVID-19 testing (PHE) database, reports 36 pregnant or recently pregnant women in critical care with Covid-19, between 1 November 2020 and 27 January 2021, of whom 25 were infected with the variant of concern (VOC) B.1.1.7 (click here or 2021.03.11.21253364v1.full). Citation: Martina Patone, Karen Thomas, Rob Hatch, Pui San Tan, Carol Coupland, Weiqi Liao, Paul Mouncey, David Harrison, Kathryn Rowan, Peter Horby, Peter Watkinson, Julia Hippisley-Cox Analysis of severe outcomes associated with the SARS-CoV-2 Variant of Concern 202012/01 in England using ICNARC Case Mix Programme and QResearch databases. medRxiv 2021.03.11.21253364; doi: https://doi.org/10.1101/2021.03.11.21253364

13 March update – study 646 added. Full text added to study 576

Study 646 – Case report from UK

Cared for at East and North Hertfordshire NHS Trust, Stevenage, in April 2020 (click here or e238055.full). Likely included in studies 533, 539 and perhaps others. Citation: Reindorf M, Newman J, Ingle T. Successful use of CPAP in a pregnant patient with COVID-19 pneumonia. BMJ Case Rep. 2021 Mar 8;14(3):e238055. doi: 10.1136/bcr-2020-238055. PMID: 33685910; PMCID: PMC7942271.

8 March update – studies 642 to 645 added. Study 541, English version added

Study 645 – case report from Brazil

From author affiliations she was probably cared for at the Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, which has not previously reported cases (click here or fmed-08-624166). Citation JAK B, Zanirati G, Rodrigues FVF, et al. Case Report: Placental Maternal Vascular Malperfusion Affecting Late Fetal Development and Multiorgan Infection Caused by SARS-CoV-2 in Patient With PAI-1 4G/5G Polymorphism. Front Med (Lausanne). 2021;8:624166. Published 2021 Feb 17. doi:10.3389/fmed.2021.624166

Study 644 – 17 serologically positive cases from Italy

It is not clear which Turin hospital cared for these patients (click here or diagnostics-11-00398). They may therefore overlap with those in studies 79, 167, 195, 247 and 615. Citation: Cosma S, Carosso AR, Borella F, Cusato J, Bovetti M, Bevilacqua F, Carosso M, Gervasoni F, Sciarrone A, Marozio L, Revelli A, Rolfo A, Filippini C, Ghisetti V, Di Perri G, Benedetto C. Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics (Basel). 2021 Feb 26;11(3):398. doi: 10.3390/diagnostics11030398. PMID: 33652805.

Study 643 – case report from USA

Cared for at McGovern Medical School, University of Texas Health Science Center, Houston (click here or cureus-0013-00000012990). May be included in study 267b. Citation: Moses ML, Kazzi NG, Lee L. Severe Thrombocytopenia in a Pregnant Patient with Asymptomatic COVID-19 Infection: A Case Report. Cureus. 2021 Jan 29;13(1):e12990. doi: 10.7759/cureus.12990. PMID: 33654642; PMCID: PMC7916745.

Study 642 – 142 cases from USA

Cared for at New York Presbyterian, Brooklyn Methodist Hospital between March and August 2020 (click here or Zhang JMFM Feb 28 14767058.2021). Probably included in a number of New York series. Citation: Peilin Zhang, Taryn Heyman, Marisa Greechan, Beata Dygulska, Farah Al Sayyed, Pramod Narula & Sanford Lederman (2021) Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2021.1892637

7 March update – Study 641 added

Study 641 – 50 cases from Italy

From Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, so likely included in the various series from there and Lombardy  (click here or jog.14729). Citation: D’Ambrosi F, Iurlaro E, Tassis B, Di Maso M, Erra R, Cetera GE, Cesano N, Di Martino D, Ossola MW, Ferrazzi EM. Sociodemographic characteristics of pregnant women tested positive for COVID-19 admitted to a referral center in Northern Italy during lockdown period. J Obstet Gynaecol Res. 2021 Mar 1. doi: 10.1111/jog.14729. Epub ahead of print. PMID: 33650278.

6 March update – study 640 added

Study 640 – 54 cases from Turkey

54 pregnant women with Covid-19 cared for in Ankara City Hospital between August 1 and October 1, 2020 (click here or [full text not yet available]). Likely overlap with studies 203, 223, 399, 512, 569 and 604. Citation: Ayhan SG, Tanacan A, Atalay A, Sinaci S, Tokalioglu EO, Sahin D, Tekin OM. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study. J Perinat Med. 2021 Mar 3. doi: 10.1515/jpm-2020-0512. Epub ahead of print. PMID: 33660492.

4 March update – studies 638 and 639 added

Study 639 – 5,963 cases from USA

This MedRxiv preprint includes pregnant women testing positive for SARS-CoV-2 identified though the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET) between March 29, and January 8, 2021 (click here or 2021.02.27.21252169v1.full). They likely overlap with those in study 338.  Citation: Romeo R. Galang, Suzanne M. Newton, Kate R. Woodworth, Isabel Griffin, Titilope Oduyebo, Christina L. Sancken, Emily O’Malley Olsen, Kathy Aveni, Heather Wingate, Hanna Shephard, Chris Fussman, Zahra S. Alaali, Samantha Siebman, Umme-Aiman Halai, Camille Delgado Lopez, Jerusha Barton, Mamie Lush, Paul H. Patrick, Levi Schlosser, Ayomide Sokale, Ifrah Chaudhary, Bethany Reynolds, Similoluwa Sowunmi, Nicole Gaarenstroom, Jennifer S. Read, Sarah Chicchelly, Leah de Wilde, Eduardo Azziz-Baumgartner, Aron J. Hall, Van T. Tong, Sascha Ellington, Suzanne M. Gilboa Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 20 state, local, and territorial health departments, March 29, 2020 -January 8, 2021 CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team medRxiv 2021.02.27.21252169; doi: https://doi.org/10.1101/2021.02.27.21252169

Study 638 – 83 cases from USA

From Barnes-Jewish Hospital in St. Louis, Missouri between June 1, and November 30, 2020 (click here or Rosenbloom AJOG PIIS0002937821001502). They likely overlap with cases in studies 69, 259, 290 and possibly 579. Citation: Rosenbloom JI, Raghuraman N, Carter EB, Kelly JC, COVID-19 Infection and Hypertensive Disorders of Pregnancy, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.03.001.

2 March update – studies 636 and 637 added

Study 637 – case report from USA

The hospital is not named, but the authors are affiliated with the Whole Family Health Center, Vero Beach, Florida, which has not previously reported cases (click here or 1-s2.0-S2214911221000059-main). Citation: Poisson TM, Pierone G Jr. Placental pathology and fetal demise at 35 weeks of gestation in a woman with SARS-CoV-2 infection: A case report. Case Rep Womens Health. 2021 Apr;30:e00289. doi: 10.1016/j.crwh.2021.e00289. Epub 2021 Jan 28. PMID: 33527073; PMCID: PMC7840395.

Study 636 – case report from Sweden

Probably included in study 610 (click here or Zaigham case BJOG in press). Although cared for at either Lund or Malmo hospitals clinical details differ from cases in studies 259b and 588. Citation: Zaigham M, Holmberg A, Karlberg ML, Lindsjö OK, Jokubkiene L, Sandblom J, Strand AS, Andersson O, Hansson SR, Nord DG, Tannenberg P. Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome. BJOG. 2021 Feb 27. doi: 10.1111/1471-0528.16682. Epub ahead of print. PMID: 33638908.

28 February update – study 635 added

Study 635 – 12 cases from Spain 

From author affiliations they were cared for at Vall d’Hebron Hospital, Barcelona, and Hospital Universitario “12 de Octubre”, Madrid, between 1 March and 31 April 2020 (click here or ). They probably overlap with cases in studies 151, 165, 185, 205, 413, 417, 458, 470 and 583. Citation: Jiménez-Lozano I, Caro-Teller JM, Fernández-Hidalgo N, Miarons M, Frick MA, Batllori Badia E, Serrano B, Parramon-Teixidó CJ, Camba-Longueira F, Moral-Pumarega MT, San Juan-Garrido R, Cabañas Poy MJ, Suy A, Gorgas Torner MQ. Safety of tocilizumab in COVID-19 pregnant women and their newborn: A retrospective study. J Clin Pharm Ther. 2021 Feb 26. doi: 10.1111/jcpt.13394. Epub ahead of print. PMID: 33638257.

27 February update – studies 628 to 634 added

Study 634 – 13 cases from Spain

These 13 pregnant women with Covid-19 were cared for at five public hospitals in Valencia (Hospital Universitario de La Ribera, Hospital Lluis Alcanyis, Hospital de Ontinyent, Hospital General de Valencia and Hospital Universitari i Politècnic La Fe), none of which have previously reported cases (click here or 1-s2.0-S1130862121000334-main). They may of course be included in Spanish or international registries. Spanish, with English abstract. Citation: R. Vila-Candel, D. Mena-Tudela, A. Gómez-Seguí et al., Manejo del parto, el puerperio y la lactancia en mujeres positivas para SARS-CoV-2. Estudio multicéntrico en la Comunidad Valenciana, Enfermería Clínica, https://doi.org/10.1016/j.enfcli.2021.01.006

Study 633 – 58 cases from USA

These pregnant women with Covid-19  were cared for at the University of Iowa Hospitals and Clinics, which have not previously reported cases (click here or Steffen Iowa AJP s-0041-1723938). However the woman reported in study 537 is probably also in this series. Citation: Steffen HA, Swartz SR, Jackson JB, Kenne KA, Ten Eyck PP, Merryman AS, Castaneda CN, Marsden K, Maxwell T, Merrill AE, Krasowski MD, Rysavy MB. SARS-CoV-2 Infection during Pregnancy in a Rural Midwest All-delivery Cohort and Associated Maternal and Neonatal Outcomes. Am J Perinatol. 2021 Feb 21. doi: 10.1055/s-0041-1723938. Epub ahead of print. PMID: 33611783.

Study 632 – 583 cases from Mexico

This report (click here or excli2021-3413) of 395,343 patients with COVID-19 in 688 medical units in Mexico City between February 24 and September 14, 2020, includes 583 pregnant women, of whom 10 died. See supplementary tables 3, 8 and 15 for pregnancy data excli2021-3413_supplementary_information. They likely overlap with cases reported in studies 271, 340, 425, 475, 513 and 518. Citation: Mancilla-Galindo, J., García-Méndez, J. Óscar, Marquéz-Sánchez, J., Reyes-Casarrubias, R. E. ., Aguirre-Aguilar, E., Rocha-González, H. I., & Kammar-García, A. (2021). All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A real-world observational study. EXCLI Journal, 20, 199-222. https://doi.org/10.17179/excli2021-3413

Study 631 – case report from China

Cared for in March 2020 in Peking (Beijing) University Third Hospital grid.411642.4 (click here or JCTH-9-133). This hospital has not previously reported cases and does not seem to be included in the various non-Wuhan China series. Citation: Li QY, An ZY, Li C, et al. Chronic Active Hepatitis B with COVID-19 in Pregnancy: A Case Report. J Clin Transl Hepatol. 2021;9(1):133-135. doi:10.14218/JCTH.2020.00085

Study 630 – 81 cases from Turkey

55/81 with chest X ray or CT are reported (click here or JTGGA-0-0-En). From author affiliations they were cared for in Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, and Marmara University Faculty of Medicine, both in Istanbul. The cases may therefore overlap with those in studies 146, 210, 244 and 286. Citation: Kuzan TY, Murzoğlu Altıntoprak K, Çiftçi HÖ, Kuzan BN, Yassa M, Tuğ N, Çimşit NÇ. Clinical and radiologic characteristics of symptomatic pregnant women with COVID-19 pneumonia. J Turk Ger Gynecol Assoc. 2021 Feb 26. doi: 10.4274/jtgga.galenos.2021.2020.0215. Epub ahead of print. PMID: 33631874.

Study 629 – 45 cases from USA

Of these 45 cases from Einstein Medical Center Philadelphia, three re-tested positive more than 90 days later (click here or 1-s2.0-S2589933321000264-main). Probably includes the case reported in study 320. Citation: Emily Dubelbeiss, Michael Silverberg, Chase White, David Jaspan, Christopher Haines, Jay Goldberg, Repeat positive SARS-CoV-2 (COVID-19) testing e 90 days apart in pregnant women., American Journal of Obstetrics & Gynecology MFM (2021), doi: https://doi.org/10.1016/j.ajogmf.2021.100331

Study 628 – 887 cases from WAPM

These cases collected from 76 centers in 25 countries, and diagnosed between 04 April & 28 October 2020 overlap with those in studies 278 and 415 and other studies (click here or 1-s2.0-S2589933321000240-main). The centres can be inferred from author affilations, but case numbers by centre are not reported.  Citation: Francesco D’Antonio, Cihat Sen, Daniele DI Mascio, et al. Maternal and perinatal outcomes in high vs low risk-pregnancies affected by SARS-COV-2 infection (Phase-2): The WAPM (World Association of Perinatal Medicine) working group on COVID-19, American Journal of Obstetrics & Gynecology MFM (2021), doi: https://doi.org/10.1016/j.ajogmf.2021.100329

23 February update – study 539 (UK PanCovid & US AAP SONPM registries) updated

21 February update – studies 619 to 627 added

Study 627 – 49 cases from Italy

From Università di Roma Tor Vergata, from September to November 2020 (click here or aogs.14130). Citation: Rizzo, G., Mappa, I., Maqina, P., Bitsadze, V., Khizroeva, J., Makatsarya, A. and D’Antonio, F. (2021), Effect of SARS‐CoV‐2 infection during the second half of pregnancy on fetal growth and hemodynamics: a prospective study. Acta Obstetricia et Gynecologica Scandinavica. Accepted Author Manuscript. https://doi.org/10.1111/aogs.14130 [case series & controls, 2nd wave]

Study 626 – 247 cases from Germany

Collected from 65 hospitals participating in the CRONOS registry between 3 April and 1 October 2020 (click here or CRONOS). 14 women were treated in ITU. No maternal deaths were reported, although 32 women have not yet recovered. Of 189 completed pregnancies, there were 4 terminations, 2 stillbirths and 183 livebirths. Four neonates were infected but all recovered. Although German cases were included in studies 127 and 278 this is the first substantive report from Germany. Citation: Pecks U, Kuschel B, Mense L, Oppelt P, Rüdiger M, on behalf of the CRONOS network: Pregnancy and SARS-CoV-2 infection in Germany—the CRONOS registry. Dtsch Arztebl Int 2020; 117: 841–2. DOI: 10.3238/arztebl.2020.0841 [important]

Study 625 – case report from USA

From MedStar Washington Hospital Center, Washington DC (click here or 10-1055-s-0040-1721672). The clinical details differ from those in study 21 from the same hospital. Citation: Mokhtari NB, Drassinower D, Orr LA, Cobb NK, Mims OL Jr, Landy HJ. Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons Learned. AJP Rep. 2021;11(1):e29-e33. doi:10.1055/s-0040-1721672

Study 624 – 4 cases from India

Of four pregnant women with Covid-19 in pregnancy treated in Bundelkhand Medical College Hospital, Sagar City, one died (click here or jog.14696). This hospital has not previously reported cases. Citation: Rawat, S.K., Saad, T., Jindal, A. and Vyas, A.K. (2021), Coronavirus disease 2019 in pregnancy: Case report on maternal death in Sagar City of Central India. J. Obstet. Gynaecol. Res.. https://doi.org/10.1111/jog.14696

Study 623 – Case report from Japan

From Kyoto Prefectural University of Medicine, which as not previously reported cases (click here or jog.14701). Citation: Waratani, M., Ito, F., Tanaka, Y., Mabuchi, A., Mori, T. and Kitawaki, J. (2021), Severe coronavirus disease pneumonia in a pregnant woman at 25 weeks’ gestation: A case report. J. Obstet. Gynaecol. Res.. https://doi.org/10.1111/jog.14701

Study 622 – Case report from Iran

From Arash Hospital, Tehran University of Medical Sciences, Tehran (click here or Rabiei JMCR). The clinical features and hospital suggest these are the same triplets as previously reported in studies 250 and 409. Citation: Rabiei, M., Soori, T., Abiri, A. et al. Maternal and fetal effects of COVID-19 virus on a complicated triplet pregnancy: a case report. J Med Case Reports 15, 87 (2021). https://doi.org/10.1186/s13256-020-02643-y

Study 621 –  Case report from Turkey

From Konya Education and Research Hospital, Konya, which has not previously reported cases (click here or Gunduz). Citation: GUNDUZ, Zahide Betül. Venous sinus thrombosis during COVID-19 infection in pregnancy: a case report. Sao Paulo Med. J. [online]. In press. [cited 2021-02-21], pp.-. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021005005202&lng=en&nrm=iso&gt;. Epub Feb 15, 2021. ISSN 1806-9460. https://doi.org/10.1590/1516-3180.2020.0659.r1.08122020.

Study 620 – 17 cases from Brazil

Of 360 women aged <20 with Covid-19 in Pernambuco, from March 12 to June 19, 2020, 17 were pregnant or in the puerperium (click here or [14761645 – The American Journal of Tropical Medicine and Hygiene] Clinical Characteristics and Mortality Profile of COVID-19 Patients Aged less than 20 years Old in Pernambuco – Brazil). None died. Citation: Sena GR, Lima TPF, Vidal SA, Duarte MDCMB, Bezerra PGM, Fonseca Lima EJ, Braga C, Andrade LB, Lins MM, Torres LC, Lima JTO, Mello MJG. Clinical Characteristics and Mortality Profile of COVID-19 Patients Aged less than 20 years Old in Pernambuco – Brazil. Am J Trop Med Hyg. 2021 Feb 18: tpmd201368. doi: 10.4269/ajtmh.20-1368. Epub ahead of print. PMID: 33606669.

Study 619 – 240 cases from USA

From Washington state (click here or Lokken AJOG Feb 21). These appear to be the same cases as in study 573. Citation: LOKKEN EM, TAYLOR GG, HUEBNER EM, VANDERHOEVEN J, HENDRICKSON S, COLER B, SHENG JS, WALKER CL, MCCARTNEY SA, KRETZER NM, RESNICK R, KACHIKIS A, BARNHART N, SCHULTE V, BERGAM B, K K, ALBRIGHT C, LARIOS V, KELLEY L, LARIOS V, EMHOFF S, RAH J, RETZLAFF K, THOMAS C, PAEK BW, HSU RJ, ERICKSON A, CHANG A, MITCHELL T, HWANG JK, GOURLEY R, ERICKSON S, DELANEY S, KLINE CR, ARCHABALD K, BLAIN M, LACOURSE SM, ADAMS WALDORF KM, Higher SARS-CoV-2 Infection Rate in Pregnant Patients, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.02.011.

15 February update – studies 615 to 618 added

Study 618 – 350 cases from India

From Government Medical College Kannur, Pariyaram, in Kerala, which has not previously reported cases (click here or 13224_2021_Article_1436). Two mothers were admitted to ITU, one of whom was ventilated. Of 221 babies 32 tested positive. Citation: Ajith S, Reshmi VP, Nambiar S, Naser A, Athulya B. Prevalence and Risk Factors of Neonatal Covid-19 Infection: A Single-Centre Observational Study. J Obstet Gynaecol India. 2021 Feb 4:1-4. doi: 10.1007/s13224-021-01436-7. Epub ahead of print. PMID: 33564217; PMCID: PMC7861010. [breastfeeding, rooming in]

Study 617 – Case report from Indonesia

A woman with Covid-19 delivered twins at 32 weeks by Caesarean (click here or main (3)). One twin had an ileal perforation. Mother and babies were cared for at Dr. Soetomo General Hospital, Surabaya, which has not previously reported cases. Citation: Harahap A, Harianto A, Etika R, Utomo MT, Angelika D, Handayani KD, Arif Sampurna MT. Spontaneous Ileum Perforation in a premature twin with Coronavirus-19 positive mother. J Pediatr Surg Case Rep. 2021 Feb 4:101807. doi: 10.1016/j.epsc.2021.101807. Epub ahead of print. PMID: 33564621; PMCID: PMC7860962.

Study 616 – 91 cases from USA

From the University of Texas Medical Branch Galveston, Texas which has not previously reported cases (click here or s-0041-1723761). Citation: Berry M, Wang A, Clark SM, Harirah HM, Jain S, Olson GL, Pacheco LD, Saade GR, Saad AF. Clinical Stratification of Pregnant COVID-19 Patients based on Severity: A Single Academic Center Experience. Am J Perinatol. 2021 Feb 6. doi: 10.1055/s-0041-1723761. Epub ahead of print. PMID: 33548937. [case series]

Study 615 – 17 patients with antibodies from Italy

These pregnant women were probably cared for at S. Anna Hospital, Turin (click here or 1-s2.0-S0165037821000152-main). They may therefore overlap with studies 79, 167, 195 and 247. Citation: Stefano Cosma, Andrea Roberto Carosso, Silvia Corcione, Jessica Cusato, Fulvio Borella, Miriam Antonucci, Luca Marozio, Alberto Revelli, Mario Preti, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto. Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery. Journal of Reproductive Immunology, Volume 144, 2021, 103285, ISSN 0165-0378, https://doi.org/10.1016/j.jri.2021.103285. (https://www.sciencedirect.com/science/article/pii/S0165037821000152) [neonatal antibodies]

13 February update – studies 611 to 614 added

Study 614 – serum screening in Jamaica

From University Hospital of the West Indies, in Kingston, during September-November 2020 (click here or Chisolm preprint). Citation: Te’Anne Chisolm, Jerome P Walker, Ynolde Leys, Tiffany R Butterfield, Candice Medley, Tamara K Thompson, Glendee Reynolds-Campbell, Willem H Mulder, Michelle Campbell Mitchell, Joshua J Anzinger. SARS-CoV-2 Seroprevalence Among Antenatal Clinic Attendees in Kingston, Jamaica, September-November 2020. medRxiv 2021.02.08.21251367; doi: https://doi.org/10.1101/2021.02.08.21251367 [2nd wave]

Study 613 – serum screening in Kenya

From Kenyatta National Hospital in Nairobi between 30th July and 25th August (click here or 2021.02.05.21250735v1.full). Citation: R. Lucinde, D. Mugo, C. Bottomley, R Aziza, J. Gitonga, H. Karanja, J. Nyagwange, J. Tuju, P. Wanjiku, E. Nzomo, E. Kamuri, K. Thuranira, S. Agunda, G. Nyutu, A. Etyang, I. M. O. Adetifa, E. Kagucia, S. Uyoga, M. Otiende, E. Otieno, L. Ndwiga, C. N. Agoti, R. Aman, M. Mwangangi, P. Amoth, K. Kasera, A. Nyaguara, W. Ng’ang’a, L. B. Ochola, E. Barasa, P. Bejon, B. Tsofa, L. I. Ochola-Oyier, G. M. Warimwe, A. Agweyu, J. A. G. Scott, K. E. Gallagher. Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in two Kenyan referral hospitals. medRxiv 2021.02.05.21250735; doi: https://doi.org/10.1101/2021.02.05.21250735

Study 612 – 14 cases from Spain

Interim report of a planned follow-up study (click here or MOACC-19 study 2020.08.20.20178657v2.full). Citation: Javier Llorca, Carolina Lechosa-Muñiz, Pilar Gortázar, María Fernández-Ortiz, Yolanda Jubete, María J. Cabero, the MOACC-19 group, Jéssica Alonso-Molero, Bárbara Arozamena, Laura Conde-Gil, Elsa Cornejo del Río, Rocío Cuesta-González, Trinidad Dierssen-Sotos, Pelayo Frank de Zulueta, Inés Gómez-Acebo, Coral Llano-Ruiz, Lorena Lasarte-Oria, Sonia López-Gómez, Sonia Mateo-Sota, Victoria Orallo, Rosa Pardo, Daniel Pérez González, María Sáez de Adana Herrero. Cohort profile: COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study. medRxiv 2020.08.20.20178657; doi: https://doi.org/10.1101/2020.08.20.20178657

Study 611 – ISARIC again

Among 240,149 patients admitted to hospital with covid-19 in the UK, 1,502/17,850 women of childbearing age, were reported as being pregnant (click here or 2020.07.17.20155218v6.full). Citation: Martina Escher, Matthew Hall, J Kenneth Baillie, Joaquin Baruch, Lucille Blumberg, Gail Carson, Barbara Wanjiru Citarella, Emmanuelle Dankwa, Annemarie B Docherty, Murray Dryden, Christl Donnelly, Jake Dunning, Christophe Fraser, Hayley Hardwick, Ewen M Harrison, Karl Holden, Waasila Jassat, Christiana Kartsonaki, Kalynn Kennon, James Lee, Kenneth McLean, Caroline Mudara, Peter JM Openshaw, Daniel R Plotkin, Mark Pritchard, Amanda Rojek, Clark D Russell, Malcolm Gracie Semple, Louise Sigfrid, Susan Smith, Jia Wei, Peter Horby, Piero L Olliaro, Laura Merson. ISARIC COVID-19 Clinical Data Report: 10 February 2021 medRxiv 2020.07.17.20155218; doi: https://doi.org/10.1101/2020.07.17.20155218 [2nd wave]

12 February update – study 610 added

Study 610 – 214 cases from Scandinavia

These cases were collected by the Nordic Obstetric Surveillance Study (NOSS) collaboration countries, Denmark, Finland, Iceland, Norway, Sweden, (click here or 2021.02.05.21250672v1.full). They probably include cases from studies 20, 88, 256, 259b, 278, 282, 298, 299, 341, 523 and 588. Citation: Hilde Engjom, Anna JM Aabakke, Kari Klungsøyr, Teresia Svanvik, Outi Äyräs, Eva Jonasdottir, Lars Thurn, Elin Jones, Karin Pettersson, Lill Trine Nyfløt, Iqbal Al-Zirqi, Siri Vangen, Pétur B. Júlíusson, Karin Källén, Mika Gissler, Lone Krebs. COVID-19 in pregnancy – characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries. medRxiv 2021.02.05.21250672; doi: https://doi.org/10.1101/2021.02.05.21250672 [Registry] Update 24 April. Peer reviewed publication (click here or study). Citation: Engjom H, Aabakke AJ, Klungsøyr K, Svanvik T, Äyräs O, Jonasdottir E, Thurn L, Jones E, Pettersson K, Nyfløt LT, Al-Zirqi I, Vangen S, Júlíusson PB, Källén K, Gissler M, Krebs L. COVID-19 in pregnancy – characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries. Acta Obstet Gynecol Scand. 2021 Apr 22. doi: 10.1111/aogs.14160. Epub ahead of print. PMID: 33885150.

11 February update – studies 608 and 609 added

Study 609 – 1,291 cases from USA

These pregnant women with a positive SARS-CoV-2 test result were cared for in 33 National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network hospitals between March 1 and July 31, 2020 (click here or METZ Disease_Severity_and_Perinatal_Outcomes_of.121 (1)). The hospitals, listed here, include many which have previously reported cases. Citation: Metz, Torri D. MD, MS; Clifton, Rebecca G. PhD; Hughes, Brenna L. MD; Sandoval, Grecio MA; Saade, George R. MD; Grobman, William A. MD, MBA; Manuck, Tracy A. MD, MS; Miodovnik, Menachem MD; Sowles, Amber BSN, RN; Clark, Kelly BSN, RN; Gyamfi-Bannerman, Cynthia MD, MS; Mendez-Figueroa, Hector MD; Sehdev, Harish M. MD; Rouse, Dwight J. MD; Tita, Alan T.N. MD, PhD; Bailit, Jennifer MD, MPH; Costantine, Maged M. MD; Simhan, Hyagriv N. MD; Macones, George A. MD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: February 8, 2021 – Volume Latest Articles – Issue – 10.1097/AOG.0000000000004339 doi: 10.1097/AOG.0000000000004339

Study 608 – Case report from Saudi Arabia

From King Saud Medical City, Riyadh (click here or ccr3.3913). None of the newborns reported in study 554 from the same centre tested positive. Citation: Huseynova, RA, A. Bin Mahmoud, L, Huseynov, O, et al. A neonate born to an infected COVID‐19 mother was tested positive just 24 hours after its birth. Clin Case Rep. 2021; 00: 1– 4. https://doi.org/10.1002/ccr3.3913

10th February update – studies 606 and 607 added

Study 607 – 317 cases from Spain

Pregnant women with anti SARS-CoV-2 &/or a positive RT-PCR, from three hospitals (Sant Joan de Déu, Hospital Clinic Barcelona, and Hospital de Sant Pau) in Barcelona (click here or CROVETTO ciab104 (1)). The details and hospitals suggest overlap with study 235. Citation: Francesca Crovetto, Fàtima Crispi, Elisa Llurba, Rosalia Pascal, Marta Larroya, Cristina Trilla, Marta Camacho, Carmen Medina, Carlota Dobaño, Maria Dolores Gomez-Roig, Francesc Figueras, Eduard Gratacos, KidsCorona Pregnancy COVID-19 group, Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study, Clinical Infectious Diseases, 2021;, ciab104, https://doi.org/10.1093/cid/ciab104

Study 606 – IgG & IgA in breast milk from 18 cases in USA

The hospitals from which women were recruited is not stated. but from the ethics approvals included centres in Idaho, the University of Rochester Medical Center, New York, and Brigham & Women’s Hospital, Boston, Massachusetts (click here or mBio-2021-Pace-e03192-20.full). Citation: Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CDW, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan CL, Caffé B, Sangster MY, Topham D, McGuire MA, Seppo A, McGuire MK. 2021. Characterization of SARS-CoV-2 RNA, antibodies, and neutralizing capacity in milk produced by women with COVID-19. mBio 12:e03192-20. https://doi.org/10.1128/mBio.03192-20.&nbsp;

9th February update – studies 603 to 605 added

Study 605 – Case report from Qatar

From the Women’s Wellness and Research Center, Hamad Medical Corporation, Doha, which also reported the case in study 577 (click here or ccr3.3886). However the clinical details differ. Citation: Khatib MY, Olagundoye VO, Elshafei MS, El Khatib FM, Mohamed AS, Nashwan AJ. Management considerations for a critically ill 26-gestational week patient with COVID-19: A case report. Clin Case Rep. 2021;00:1–4. https://doi.org/10.1002/ccr3.3886 [ITU, ventilation]

Study 604 – 39 cases from Turkey

Cared for at Ankara City Hospital (click here or full text not available). Likely overlap with studies 203, 227, 244, 399, 444, 512, & 569. Citation: Erol Koç, Esin Merve, Fındık, Rahime Bedir, Akkaya, Hatice, Karadağ, Işılay, Tokalıoğlu, Eda Özden and Tekin, Özlem Moraloğlu. “Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort” Journal of Perinatal Medicine, vol. 49, no. 2, 2021, pp. 141-147. https://doi.org/10.1515/jpm-2020-0403 [control group]

Study 603 – 35 cases from Austria

Cared for at Clinik Ottakring, in Vienna, which has not previously reported cases (click here or full text not available). Citation: Hall, Mirijam, Endress, David, Hölbfer, Susanne and Maier, Barbara. “SARS-CoV-2 in pregnancy: maternal and perinatal outcome data of 34 pregnant women hospitalised between May and October 2020” Journal of Perinatal Medicine, vol. 49, no. 2, 2021, pp. 138-140. https://doi.org/10.1515/jpm-2020-0499&nbsp;

7th February update – studies 599 to 602 added

Study 602 – case report from United Arab Emirates

A woman contracted Covid-19 at 26 weeks gestation and required ventilation and five days of ECMO therapy (click here or Tambawala e240823.full). She recovered and the pregnancy is continuing. Cared for at Dubai Hospital, which has not previously reported cases. Citation: Tambawala ZY, Hakim ZT, Hamza LK, et al. Successful management of severe acute respiratory distress syndrome due to COVID-19 with extracorporeal membrane oxygenation during mid-trimester of pregnancy. BMJ Case Reports CP 2021;14:e240823.

Study 601 – 34 cases from USA

Cared for at Hutzel Women’s Hospital, Detroit, Michigan, between March 11, 2020 and July 31, 2020 (click here or 10-1055-s-0040-1721673). This hospital has not previously reported cases. Citation: Jani S, Jacques SM, Qureshi F, et al. Clinical Characteristics of Mother-Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population. AJP Rep. 2021;11(1):e15-e20. doi:10.1055/s-0040-1721673

Study 600 – 171 cases from USA

Of 171 pregnant women hospitalised with Covid-19, 21 were admitted to ICU and 3 died (click here or 2021.01.29.21250788v1.full). They were cared for at the University of California affiliated hospitals of Davis, Irvine, Los Angeles, San Diego, and San Francisco, so likely overlap with study 323. Citation: Miriam Nuño, Yury García, Ganesh Rajasekar, Diego Pinheiro, Alec J. Schmidt. COVID-19 Hospitalizations in Five California Hospitals. medRxiv 2021.01.29.21250788; doi: https://doi.org/10.1101/2021.01.29.21250788

Study 599 – 116 seropositive women and 12 RT-PCR positive in USA

Of 708 pregnant women cared for at the Mount Sinai and Mount Sinai West hospitals in New York, from April 20, 2020 and delivered by 15 August, 116 were seropositive, and 12 RT-PCR positive (click here or 2021.02.01.21250943v1.full (1)). They likely overlap with studies 86, 119,131, 135, 160, 240, 412, 455, & 457. Citation: Nina M. Molenaar, Anna-Sophie Rommel, Lotje de Witte, Siobhan M. Dolan, Whitney Lieb, Erona Ibroci, Sophie Ohrn, Jezelle Lynch, Christina Capuano, Daniel Stadlbauer, Florian Krammer, Lauren B. Zapata, Rachel I. Brody, Rhoda S. Sperling, Omara Afzal, Mr Roy Missall, Amy Balbierz, Teresa Janevic, Joanne Stone, Elizabeth A. Howell, Veerle Bergink. Seroprevalence of SARS-CoV-2 during pregnancy and associated outcomes: results from an ongoing prospective cohort study, New York City. medRxiv 2021.02.01.21250943; doi: https://doi.org/10.1101/2021.02.01.21250943

3rd February update – study 598 added

Study 598 – 100 mothers, 101 babies from USA

From New York–Presbyterian’s Morgan Stanley Children’s Hospital and Allen Hospital from March 13 to April 24, 2020 (click here or jamapediatrics_dumitriu_2020_oi_200070_1611604165.97231 (1)). Both hospitals are affiliated with Columbia University Irving Medical Center. The authors note that they include 14 previously reported cases in study 27. There may also be overlap with studies 14, 41, 95, 96, 136, 160, 216, 230, 234, 261, and 276. Citation: Dumitriu D, Emeruwa UN, Hanft E, et al. Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City. JAMA Pediatr. 2021;175(2):157–167. doi:10.1001/jamapediatrics.2020.4298

1st February update – studies 592 to 597 added. Study 3 withdrawal noted.

Studies 593 to 597 – SMFM 2021 posters

Posters presented at the Society for Maternal Fetal Medicine virtual conference, 25 to 30 January, 2021 (SMFM 2021). Study 593– 52 patients from McGill University Medical Centre and the Jewish Genereal Hospital, Montreal, Quebec, Canade . Study 594 – 10 cases from University of Toledo, Ohio, USA . Study 595 – 29 cases from University of New Mexico Hospital, Albuquerque, New Mexico, USA . Study 596 – 11 cases from The Rotunda Hospital, Dublin, Ireland . Study 597 – 15 cases (two deaths) from the University of Mississippi Medical Center, Jackson, Mississippi, USA .  Citations to the AJOG abstracts to be added.

Study 592 – Case report from Italy

From Santo Stefano Hospital, Prato (click here or jmv.26609). The clinical features suggest this is case 2 in study 367. Citation: Cavaliere AF, Marchi L, Aquilini D, Brunelli T, Vasarri PL. Passive immunity in newborn from SARS-CoV-2-infected mother. J Med Virol. 2020 Oct 19. doi: 10.1002/jmv.26609. Epub ahead of print. PMID: 33073377.

31 January update – study 589 to 591 added

Study 591 – antibody transfer in 22 mother infant dyads from USA

SARS-CoV-2-specific antibody transfer is reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity is lower than in maternal plasma, in 22 maternal: cord dyads from SARS-CoV-2 positive mothers in third trimester (click here or PIIS0092867420317499). From Boston Massachusetts. Citation: Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, Slein MD, Loos C, Shook LL, Boatin AA, Yockey LJ, Pepin D, Meinsohn MC, Nguyen NMP, Chauvin M, Roberts D, Goldfarb IT, Matute JD, James KE, Yonker LM, Bebell LM, Kaimal AJ, Gray KJ, Lauffenburger D, Edlow AG, Alter G. Compromised SARS-CoV-2-specific placental antibody transfer. Cell. 2020 Dec 23:S0092-8674(20)31749-9. doi: 10.1016/j.cell.2020.12.027. Epub ahead of print. PMID: 33476549; PMCID: PMC7755577. [important]

Study 590 – antibody levels in 83 mother/infant dyads from USA

Anti-SARS-CoV-2 IgG crosses the placenta (click here or jamapediatrics_flannery_2021_oi_210002_1611680224.61476). From Pennsylvania Hospital in Philadelphia, so may overlap with studies 65, 175, 202, 221, 350, 359 and 496. Citation: Flannery DD, Gouma S, Dhudasia MB, et al. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. Published online January 29, 2021. doi:10.1001/jamapediatrics.2021.0038 [important]

Study 589 – 1,150 cases from Spain

No association between past flu & Tdap vaccination status, and severity of SARS-CoV-2 in pregnancy (click here or vaccines-09-00031). From the 78 Spanish Obstetric Emergency Group hospitals. Citation: de la Cruz Conty ML, Encinas Pardilla MB, Garcia Sanchez M, Gonzalez Rodriguez L, Muner-Hernando ML, Royuela Vicente A, Pintado Recarte P, Martinez Varea A, Martinez Diago C, Cruz Melguizo S, Martinez-Perez O, On Behalf Of The Spanish Obstetric Emergency Group. Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study. Vaccines (Basel). 2021 Jan 8;9(1):31. doi: 10.3390/vaccines9010031. PMID: 33429912; PMCID: PMC7826802.

30 January update – studies 582 to 588 added

Study 588 – Case report from Sweden

From either Lund or Malmo (click here or main (13)). The clinical details differ from study 259b. Citation: Kolkova Z, Bjurström MF, Länsberg JK, Svedas E, Hamer MA, Hansson SR, Herbst A, Zaigham M. Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report. Case Rep Womens Health. 2020 Jul 8;27:e00240. doi: 10.1016/j.crwh.2020.e00240. PMID: 32714844; PMCID: PMC7340590.

Study 587 – 0/67 tested pregnant women from South Africa

From Kalafong Provincial Tertiary Hospital in Atteridgeville, Pretoria. Abstract only (click here). Citation: N. Mopane F. Molokoane M. Mojela L. Seopela L.C. Snyman. First results of universal SARS-CoV-2 virus testing of asymptomatic pregnant patients presenting for antenatal care at the Kalafong Provincial Tertiary Hospital. Obstetrics and Gynaecology Forum Vol. 30, No. 2 Jan 2020

Study 586 – Case report from France

From Service de Gynécologie-Obstétrique, Centre Fédératif de Pelvi-Périnéologie, CHU de Nantes, Nantes (click here or main (12)). Citation: Smati S, Mahot P, Bourdiol A, Ploteau S, Hadjadj S, Cariou B. Euglycaemic ketoacidosis during gestational diabetes with concomitant COVID-19 infection. Diabetes Metab. 2020 Jul 29:S1262-3636(20)30100-2. doi: 10.1016/j.diabet.2020.07.008. Epub ahead of print. PMID: 32738403; PMCID: PMC7387919.

Study 585 – Case report from India

From Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra (click here or 2838-Article Text-7183-1-10-20200818 (1)). Citation: Priyanka Singh, Neema Acharya, & Neha Verma. (2020). Experience of managing covid-19 suspected case in labour in a green zone district tertiary care hospital. International Journal of Research in Pharmaceutical Sciences, 11(SPL1), 500-505. https://doi.org/10.26452/ijrps.v11iSPL1.2838

Study 584 – case report from Iran

From Imam Ali Hospital, Alborz University of Medical Sciences, Karaj (click here or main (11)). Citation: Motlagh AJ, Esmaelzadeh Saeieh S, Parhigar O, Salehi L. An asthmatic pregnant woman with COVID-19: A case report study. Respir Med Case Rep. 2020;31:101296. doi: 10.1016/j.rmcr.2020.101296. Epub 2020 Nov 19. PMID: 33240787; PMCID: PMC7676370.

Study 583 – case report from Spain

From Hospital Universitario 12 de Octubre, Madrid (click here or main (10)). Citation: López Pérez V, Cora Vicente J, Echevarría Granados C, Salcedo Vázquez ML, Estol F, Tebar Cuesta MY. Postpartum consciousness disturbance: can covid-19 cause posterior reversible encephalopathy syndrome? Rev Esp Anestesiol Reanim. 2020 Nov;67(9):511-515. English, Spanish. doi: 10.1016/j.redar.2020.06.008. Epub 2020 Jul 14. PMID: 33036761; PMCID: PMC7359790.

Study 582 – Case report from India

From Dr. RML Hospital, New Delhi, which has not previously reported cases  (click here or fmaa094). Citation: Bandyopadhyay T, Sharma A, Kumari P, Maria A, Choudhary R. Possible Early Vertical Transmission of COVID-19 from an Infected Pregnant Female to Her Neonate: A Case Report. J Trop Pediatr. 2020 Nov 22:fmaa094. doi: 10.1093/tropej/fmaa094. Epub ahead of print. PMID: 33221859; PMCID: PMC7717437.

29th January – studies 574 to 581 added

Study 581 – Placental analysis of 39 cases from USA

From Yale New Haven Hospital so probably overlap with studies 132, 155 and 314 (click here or 2021.01.25.21250452v1.full). Citation: Alice Lu-Culligan, Arun R. Chavan, Pavithra Vijayakumar, Lina Irshaid, Edward M. Courchaine, Kristin M. Milano, Zhonghua Tang, Scott D. Pope, Eric Song, Chantal B.F. Vogels, William J. Lu-Culligan, Katherine H. Campbell, Arnau Casanovas-Massana, Santos Bermejo, Jessica M. Toothaker, Hannah J. Lee, Feimei Liu, Wade Schulz, John Fournier, M. Catherine Muenker, Adam J. Moore, Yale IMPACT Team, Liza Konnikova, Karla M. Neugebauer, Aaron Ring, Nathan D. Grubaugh, Albert I. Ko, Raffaella Morotti, Seth Guller, Harvey J. Kliman, Akiko Iwasaki, Shelli F. Farhadian. SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. medRxiv 2021.01.25.21250452; doi: https://doi.org/10.1101/2021.01.25.21250452

Study 580 – 2,126 cases from Brazil

From the Brazilian Ministry of Health, “severe acute respiratory syndrome” tracking database (click here or 2021.01.22.21250346v1.full). For pregnancies see table 1. Likely overlap with studies 66, 138, 182, 194, 201, 213, 248, 249, 278, 309, 358, 426, 552, and 565. Citation: Eduardo Pietre, Gabriel P Amorim, Maria F F Bittencourt, Marcelo Ribeiro-Alves, Mariana Acquarone Prevalent comorbidities among young and underprivileged: Death portrait of COVID-19 among 235 555 hospitalized patients in Brazil. medRxiv 2021.01.22.21250346; doi: https://doi.org/10.1101/2021.01.22.21250346

Study 579 – 22 cases from USA

The authors are from Washington University in St. Louis, Missouri (click here or 1-s2.0-S2589933321000148-main). If the unnamed hospital was Barnes Jewish these cases may overlap with studies 69, 259 and 290. Citation: Megan C. OAKES MD , Annessa S. KERNBERG MD , Ebony B. CARTER MD MPH , Megan E. FOELLER MD , Arvind PALANISAMY MD FRCA , Nandini RAGHURAMAN MD MS , Jeannie C. KELLY MD MS , Pregnancy as a risk factor for severe coronavirus 2019 (COVID-19) disease using standardized clinical criteria, American Journal of Obstetrics & Gynecology MFM (2021), doi: https://doi.org/10.1016/j.ajogmf.2021.100319

Study 578 – serology of 88 cases from USA

From New York-Presbyterian Hospital, Weill Cornell, so probably overlapping with many previous studies (click here or 1-s2.0-S0002937821000533-main). Citation: Kubiak JM, Murphy EA, Yee J, Cagino K, Friedlander RL, Glynn SM, Matthews KC, Jurkiewicz M, Sukhu AC, Zhao Z, Prabhu M, Riley L, Yang YJ, SARS-CoV-2 serology levels in pregnant women and their neonates., American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.01.016.

Study 577 – Case report from Qatar

From Women’s Wellness and Research Center, Hamad Medical Corporation, Doha, which has not previously reported cases (click here or ccr3.3485). Probably included in studies 364 and 407. Citation: Yaqoub, S, Ahmad, S, Mansouri, Z, et al. Management of life‐threatening acute respiratory syndrome and severe pneumonia secondary to COVID‐19 in pregnancy: A case report and literature review. Clin Case Rep. 2021; 9: 137– 143. https://doi.org/10.1002/ccr3.3485

Study 576 – 9 ECMO cases from USA & Italy

From Houston, Iowa, New York, Boston and Bergamo (click here or Successful_Treatment_of_Pregnant_and_Postpartum.4). Citation: Barrantes JH, Ortoleva J, O’Neil ER, Suarez EE, Beth Larson S, Rali AS, Agerstrand C, Grazioli L, Chatterjee S, Anders M. Successful Treatment of Pregnant and Postpartum Women With Severe COVID-19 Associated Acute Respiratory Distress Syndrome With Extracorporeal Membrane Oxygenation. ASAIO J. 2021 Feb 1;67(2):132-136. doi: 10.1097/MAT.0000000000001357. PMID: 33229971.

Study 575 – 66 cases from Russia

Cared for at the National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation in Moscow which has not previously reported cases (click here or IJMF_0_1850683). Possible inclusion in study 278. Citation: Shmakov RG, Prikhodko A, Polushkina E, Shmakova E, Pyregov A, Bychenko V, Priputnevich TV, Dolgushin GO, Yarotskaya E, Pekarev O, Bolibok N, Degtyarev D, Sukhikh GT. Clinical course of novel COVID-19 infection in pregnant women. J Matern Fetal Neonatal Med. 2020 Nov 29:1-7. doi: 10.1080/14767058.2020.1850683. Epub ahead of print. PMID: 33249969; PMCID: PMC7711745.

Study 574 – Case report from Italy

From University Hospital, Modena, so probably included in studies 64, 117 and 252 (click here or R09Y9999N00A20113005). Citation: Sileo FG, Tramontano AL, Leone C, Meacci M, Gennari W, Ternelli G, La Marca A, Lugli L, Berardi A, Facchinetti F, Bertucci E. Pregnant woman infected by Coronavirus Disease (COVID-19) and calcifications of the fetal bowel and gallbladder: a case report. Minerva Ginecol. 2020 Nov 30. doi: 10.23736/S0026-4784.20.04717-6. Epub ahead of print. PMID: 33249821.

28th January – studies 570 to 573 added

Study 573 – 240 cases from USA

From 35 sites in Washington State (click here or 1-s2.0-S0002937821000338-main). These cases overlap with those in studies 83, 102, 139 and 389. Citation: Lokken EM, Huebner EM, Taylor GG, Hendrickson S, Vanderhoeven J,Kachikis A, Coler B, Walker CL, Sheng JS, al-Haddad BJS, McCartney SA, Kretzer NM, Resnick R,Barnhart N, Schulte V, Bergam B, Ma KK, Albright C, Larios V, Kelley L, Larios V, Emhoff S, Rah J,Retzlaff K, Thomas C, Paek BW, Hsu RJ, Erickson A, Chang A, Mitchell T, Hwang JK, Erickson S,Delaney S, Archabald K, Kline CR, LaCourse SM, Adams Waldorf KM, For the Washington StateCOVID-19 in Pregnancy Collaborative, Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State, American Journal ofObstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2020.12.1221.

Study 572 – Case report from Romania

From ‘Dr Carol Davila’ Central Military Emergency University Hospital, Bucharest, which has not previously reported cases (click here or etm_21_1_9524_PDF). Citation: Florea AA, Sirbu CA, Ghinescu MC, Plesa CF, Sirbu AM, Mitrica M and Ionita‑Radu F: SARS‑CoV‑2, multiple sclerosis, and focal deficit in a postpartum woman: A case report. Exp Ther Med 21: 92, 2021

Study 571 – serological testing in Spain

From Madrid (click here or pone.0243029). Overlap with study 458. Citation: Villalaı´n C, HerraizI, Luczkowiak J, Pe´rezRivilla A, Folgueira MD, Mejı´a I, et al. (2020) Seroprevalence analysis of SARS-CoV-2 in pregnant women along the first pandemic outbreak and perinatal outcome. PLoS ONE 15(11): e0243029. https://doi.org/10.1371/journal. pone.0243029

Study 570 – 1,120 cases from USA

Abstract reporting 1,129 pregnant cases from Los Angeles county (click here or 1-s2.0-S0027968420302765-main). Of those who have given birth no neonates tested positive. Citation: L. Khadijah Lang, Covid-19 Maternal-Neonate Vertical Transmission Rates in Los Angeles County, Journal of the National Medical Association, Volume 112, Issue 5, Supplement, 2020, Pages S36-S37, ISSN 0027-9684, https://doi.org/10.1016/j.jnma.2020.09.093. (http://www.sciencedirect.com/science/article/pii/S0027968420302765)

27th January – studies 567 to 569 added

Study 569 – 39 cases from Turkey

Cared for at Ankara City Hospital so probably overlap with studies 203, 223, 244, 399, 444 and 512 (click here or [16193997t). Citation: Erol Koç, E. M., Fındık, R. B., Akkaya, H., Karadağ, I., Tokalıoğlu, E. Ö., & Tekin, Ö. M. (2020). Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200403. doi: https://doi.org/10.1515/jpm-2020-0403

Study 568 – Case report from USA

Conference poster from Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY which has not previously reported cases (click here or ). Citation: Wander Praneet, He Qiu, Ceena Chandrabos, David Bernstein, Sanjaya Satapathy. P2162 (S2415). – COVID-19 Infection Presenting as Acute Hepatitis in a 22-Week Pregnant Woman. American Journal of Gastroenterology. Conference: 2020 Annual Scientific Meeting of the American College of Gastroenterology, ACG 2020. 115 (SUPPL) (pp S1282), 2020. Date of Publication: October 2020. AN: 633658549

Study 567 – Case report from USA

Cared for at Loyola University Medical Center, Chicago, Illinois, which has not previously reported cases (click here or S2301_COVID_19_and_Ulcerative_Colitis_in_Pregnancy.2301). Citation: Lewine, Eliza MD1; Trieu, Judy MD, MPH2; Asamoah, Nikiya MD2; Venu, Mukund MD, FACG2; Naik, Amar MD2 S2301 COVID-19 and Ulcerative Colitis in Pregnancy, The American Journal of Gastroenterology: October 2020 – Volume 115 – Issue – p S1217 doi: 10.14309/01.ajg.0000711252.28660.fc

26th January – studies 550 to 566 added

Study 566 – Two cases from Bangladesh

One pregnant woman with Covid-19 survived. The other died (click here or JSAFOG-12-258). They were both cared for at Chittagong Medical College Hospital, Chattogram, which has not previously reported cases. Citation: Rashid F, Shahnaz S, Sharmin R, et al. Pregnancy with COVID-19: Weal and Woe. J South Asian Feder Obst Gynae 2020;12(4):258–260.

Study 565 – Case report from Brazil

Cared for at Fundação Hospital de Clínicas Gaspar Vianna, Belém, Pará state, which has not previously reported cases (click here or en_1678-4170-abc-115-05-0936). Citation: HOLANDA, Lucianna Serfaty de et al. Infecção por COVID-19 em Gestante Cardiopata. Arq. Bras. Cardiol. [online]. 2020, vol.115, n.5 [cited 2021-01-26], pp.936-938. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2020001300936&lng=en&nrm=iso&gt;. Epub Dec 07, 2020. ISSN 1678-4170. http://dx.doi.org/10.36660/abc.20200517.

Study 564 – Case report from Iran

Cared for at Urmia University of Medical Sciences, Urmia, which has not previously reported cases (click here or archcid-15-5-104394). Citation: Zarrintan A, Boeoofeh B , Rabieipour M , Mohammadi A, Khademvatani K, et al. Pulmonary Thromboembolism in a Pregnant Patient with Severe COVID19: A Novel Case Report and Review of Literature, Arch Clin Infect Dis. 2020 ; 15(5):e104394. doi: 10.5812/archcid.104394.

Study 563 – Case report from USA

From School of Medicine and Public Health, University of Wisconsin, Madison, which has not previously reported cases (click here or 1-s2.0-S221491122030103X-main). Citation: Jennifer Jacobson, Kathleen Antony, Michael Beninati, William Alward, Kara K. Hoppe, Use of dexamethasone, remdesivir, convalescent plasma and prone positioning in the treatment of severe COVID-19 infection in pregnancy: A case report, Case Reports in Women’s Health, Volume 29, 2021, e00273, ISSN 2214-9112, https://doi.org/10.1016/j.crwh.2020.e00273. (http://www.sciencedirect.com/science/article/pii/S221491122030103X) 

Study 562 – Case report from India

From Lokmanya Tilak Muncipal General Hospital, Mumbai (click here or JSAFOG-12-243) so probably included in study 245. Citation: Mevada SA, Mehendale MA, Nayak AH, et al. Cardiomyopathy in Pregnancy with COVID-19: An Enigma. J South Asian Feder Obst Gynae 2020;12(4):243–244

Study 561- Case report from USA

A mother with Covid-19 gave birth to a baby with an ischaemic upper limb (click here or [21928959 – Case Reports in Perinatal Medicine] Neonate born with ischemic limb to a COVID-19 positive mother_ management and review of literature). The baby was cared for at Zucker School of Medicine at Hofstra, Northwell, New York. Citation: Perveen, S., Millington, K. A., Acharya, S., Grag, A., & Boyar, V. (2021). Neonate born with ischemic limb to a COVID-19 positive mother: management and review of literature, Case Reports in Perinatal Medicine, 10(1), 20200086. doi: https://doi.org/10.1515/crpm-2020-0086

Study 560 – 25 cases from France

Cared for at Cochin Hospital (Port-Royal Maternity) Paris (click here or 1-s2.0-S2468784720304177-main). Probably included in studies 150, 161 and 239. Citation: Tsatsaris V, Mariaggi AA, Launay O, Couffignal C, Rousseau J, Ancel PY, Marcault E, Ville Y, Cordier AG, Vivanti A, Carrara J, Luton D, Dommergues M, Borie C, Kayem G, Alessandrini V, Lecomte L, Meritet JF, Leruez-Ville M, Goffinet F, Dubois C, Picone O, Vauloup Fellous C. SARS-COV-2 IgG antibody response in pregnant women at delivery. J Gynecol Obstet Hum Reprod. 2020 Dec 10;50(7):102041. doi: 10.1016/j.jogoh.2020.102041. Epub ahead of print. PMID: 33310133.

Study 559 – 22 cases from China

Cared for at Tongji hospital, Wuhan (click here or 1-s2.0-S0924857920304805-main (1)). Previously reported many times. Citation: He Z, Fang Y, Zuo Q, Huang X, Lei Y, Ren X, Liu D. Vertical transmission and kidney damage in newborns whose mothers had coronavirus disease 2019 during pregnancy. Int J Antimicrob Agents. 2020 Dec 9:106260. doi: 10.1016/j.ijantimicag.2020.106260. Epub ahead of print. PMID: 33309765.

Study 558 – 19 cases from Uzbekistan

Abstract only (click here). Cared for in Kagan maternity hospital in Bukhara which has not previously reported cases. Citation: GULCHEKHRA A, IKHTIYAROVA, NIGORA K. DUSTOVA, MAVLYUDA A. KHASANOVA, GULRUKH S. SULEYMANOVA, SALIM S. DAVLATOV. Pathomorphological changes of the placenta in pregnant women infected with coronavirus covid-19 International Journal of Pharmaceutical Research ; 13(1):1935-1942, 2021.

Study 557 – case report from Kyrgyzstan

Cared for at City Maternity Hospital No. 2, 225 Moskva Street, Bishkek-720010, which has not previously reported cases (click here or 341-Article Text-592-1-10-20210107). Citation: Zhumabekova A, Tagaev T, Yethindra V, Zhumabaeva S, Ysabaeva D, Imankulova B. A case report of a pregnant woman with coronavirus disease 2019 (COVID-19) and her live-born infant. Biomedicine [Internet]. 2021Jan.1 [cited 2021Jan.26];40(4):551-3. Available from: https://biomedicineonline.org/index.php/home/article/view/341

Study 556 – case report from Iran

Cared for at Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, which has not previously reported cases (click here or Tanaffos-19-152). Citation: Pourdowlat G, Mikaeilvand A, Eftekhariyazdi M, Nematshahi M, Ebrahimi M, Kazemzadeh A. Prone-Position Ventilation in a Pregnant Woman with Severe COVID-19 Infection Associated with Acute Respiratory Distress Syndrome. Tanaffos. 2020;19(2):152-155.

Study 555 – 56 cases from Iran

Cared for at Nekouei-Hedayati-Forqani Hospital in Qom which has not previously reported cases (click here or 32025-Article Text-134703-5-10-20210108 (2)). Citation: Mirzaie M, Shafie H, Heidarifar R, Yousefi MS, Yousefi MS. Relationship between ABO Blood Group Type and COVID-19 Outcome in Pregnant Women. J Cell Mol Anesth [Internet]. 2020Sep.23 [cited 2021Jan.26];5(4):282-3. Available from: https://journals.sbmu.ac.ir/jcma/article/view/32025

Study 554 – 4 cases from Saudi Arabia

Cared for at King Saud University Medical City, Riyadh which has not previously reported cases (click here or JEGH-10-3-214). Citation: Barry M, AlMohaya A, AlHijji A, Akkielah L, AlRajhi A, Almajid F, Alsharidi A, Al-Shahrani FS, Alotaibi NH, Alanazi A, Ghonem L, Alhetheel A, Alsubaie S, Memish ZA. Clinical Characteristics and Outcome of Hospitalized COVID-19 Patients in a MERS-CoV Endemic Area. J Epidemiol Glob Health. 2020 Sep;10(3):214-221. doi: 10.2991/jegh.k.200806.002. PMID: 32954712; PMCID: PMC7509106.

Study 553 – 29 cases from USA

Screened at University of Illinois at Chicago which has not previously reported cases (click here or 10-1055-s-0040-1721416). Citation: Buhimschi CS, Elam GL, Locher SR, Norris-Stojak D, Aldasoqi H, Stephenson MD, Buhimschi IA. Prevalence and Neighborhood Geomapping of COVID-19 in an Underserved Chicago Pregnant Population. AJP Rep. 2020 Oct;10(4):e413-e416. doi: 10.1055/s-0040-1721416. Epub 2020 Dec 3. PMID: 33294287; PMCID: PMC7714615.

Study 552 – Case report from Brazil

Cared for at Hospital Universitário da Universidade Federal do Maranhão, São Luis, MA. which has not previously reported cases (click here or 1806-9282-ramb-66-12-1621). Citation: PESSOA, Fabrício Silva et al. Probable vertical transmission identified within six hours of life. Rev. Assoc. Med. Bras. [online]. 2020, vol.66, n.12 [cited 2021-01-26], pp.1621-1624. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001201621&lng=en&nrm=iso&gt;. Epub Dec 16, 2020. ISSN 1806-9282. https://doi.org/10.1590/1806-9282.66.12.1621.

Study 551 – Case report from USA

A maternal death from Covid-19 treated at St. Joseph’s University Medical Center, Paterson, New Jersey, which has not previously reported cases (click here or amjcaserep-21-e926591). Citation: Patel P, Kulkarni S, Guerrero M, Persaud C, Zuberi J, Rebein B. Emergency Cesarean Section at 38 Weeks of Gestation with COVID-19 Pneumonia: A Case Report. Am J Case Rep. 2020 Dec 19;21:e926591. doi: 10.12659/AJCR.926591. PMID: 33339814; PMCID: PMC7755590.

Study 550 – 67 cases from USA

From Massachusetts General Hospital, Boston (click here or ofaa524). Overlap with studies 142, 231, 262, 519, 531. Citation: M D Soffer, L L Shook, K James, M R Sawyer, A Ciaranello, R Mahrouk, S N Bernstein, A A Boatin, A G Edlow, C York-Best, A J Kaimal, I T Goldfarb, Protocol-Driven Intensive Outpatient Management of Pregnant Patients With Symptomatic Coronavirus Disease 2019, Open Forum Infectious Diseases, Volume 7, Issue 11, November 2020, ofaa524, https://doi.org/10.1093/ofid/ofaa524

24th January – studies 547 to 549 added

Study 549 – 32 cases from UK

These 32 women with Covid-19 in pregnancy were cared for at Newham University Hospital in London which has not previously reported cases (click here or 1753495×20985403). One woman died. They are included in the UKOSS reports. Citation: Milln J, Heard S, Gunganah K, Velauthar L, Saeed F. Clinical characteristics and pregnancy outcomes of women diagnosed with SARS-CoV-2 in London’s most ethnically diverse borough: A cross-sectional study. Obstetric Medicine. January 2021. doi:10.1177/1753495X20985403

Study 548 – 279 cases from Spain

Of 279 women with SARS-Cov-2 cared for in the 42 hospitals of the Spanish Obstetric Emergency Group, 174 were asymptomatic, and are reported in this paper (click here or Cruz-Lemini viruses-13-00112). They likely overlap with many of the previous studies from Spain. Citation: Cruz-Lemini, M.; Ferriols Perez, E.; de la Cruz Conty, M.L.; Caño Aguilar, A.; Encinas Pardilla, M.B.; Prats Rodríguez, P.; Muner Hernando, M.; Forcen Acebal, L.; Pintado Recarte, P.; Medina Mallen, M.d.C.; et al. Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women. Viruses 2021, 13, 112. https://doi.org/10.3390/v13010112

Study 547 – 879 cases from India

This paper from Nair Hospital, Mumbai reports on five pregnant women with Covid-19 (out of 879 treated in that hospital) who also had heart disease (click here or Tilve India EJOG in press). They probably overlap with those in studies 225, 283 & 520, but the clinical details suggest no overlap with studies 369 & 501. Citation: Tilve A, Mahajan NN, Pandey A, Jnanananda B, Gadekar S, Mahale SD, Gajbhiye RK, Impact of COVID-19 on pregnant women with Rheumatic heart disease or Peripartum cardiomyopathy, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2021), doi:  https://doi.org/10.1016/j.ejogrb.2021.01.024

19 January – studies 545 and 546 added

Study 546 – 55,154 cases from the US

The CDC tracking data up to Jan 11th 2021 includes 55,154 pregnant women with Covid-19, of whom 66 (0.12%) had died (click here). Citation: Centres for Disease Control. Weekly COVID-19 Pregnancy Data updated January 11 2021, Accessed 19 Jan 2021. [important]

Study 545 – 3,928 cases from the Netherlands

January 6 update of NETHOSS registry includes 3,928 women with Covid-19 in pregnancy and further details (click here). 26 women were treated in ITU, 10 ventilated and one woman died. There is also a graph showing the first and second waves. Available here. Accessed 19 Jan 2021. [important]

18 January – study 544 added

Study 544 – 6,380 cases from US

Among these 6,380 women with Covid-19, 86 required ventilation and nine died (click here or jamainternal_jering_2021_ld_200094_1610581352.25094). They were identified from a multi-hospital database covering about 20% of the United States, so will overlap with other series. Citation: Jering KS, Claggett BL, Cunningham JW, et al. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19. JAMA Intern Med. Published online January 15, 2021. doi:10.1001/jamainternmed.2020.9241

16 January – study 543 added

Study 543 – Case report from Ireland

A woman contracted COVID-19 at 36 weeks and was delivered by Caesarean (click here or 1-s2.0-S0143400421000205-main). Placental histology is described in detail. Mother and baby recovered. She was cared for at Cork University Maternity Hospital, which has not previously reported cases. Citation: Linehan L, O’Donoghue K, Dineen S, White J, Higgins JR, Fitzgerald B, SARS-CoV-2 Placentitis: An uncommon complication of maternal COVID-19, Placenta, https://doi.org/10.1016/j.placenta.2021.01.012.

14 January update – studies 540 to 542 added

Study 542 – 112 cases in ICU in UK

The 8 January ICNARC report includes 69 currently and 43 recently pregnant women in ICU with Covid-19 since 1 September 2020 (available here or ICNARC_COVID-19_Report_2021-01-08.pdf). 12 and 13 women respectively were ventilated. Citation: Intensive Care National Audit & Research Centre. ICNARC report on COVID-19 in critcal care: England, Wales and Northern Ireland 8 January 2021 Accessed 14 January 2021. https://www.icnarc.org/Our-Audit/Audits/Cmp/Reports&nbsp;

Study 541 – 73 cases from Spain

73 women with Covid-19 gave birth to 79 babies (click here or S1695403320305233). [Spanish. English abstract] No babies tested positive. From author affiliations they were probably cared for at Hospital General Universitario Gregorio Marañón, Madrid, so probably overlap with cases in studies 151 and 381. Citation: Gonzalo Solís-García, Ana Gutiérrez-Vélez, Isabel Pescador Chamorro, Elena Zamora-Flores, Sara Vigil-Vázquez, Elena Rodríguez-Corrales, Manuel Sánchez-Luna, Epidemiología, manejo y riesgo de transmisión de SARS-CoV-2 en una cohorte de hijos de madres afectas de COVID-19, Anales de Pediatría, 2020, ISSN 1695-4033, https://doi.org/10.1016/j.anpedi.2020.12.004. (http://www.sciencedirect.com/science/article/pii/S1695403320305233). Update 8 March For English language version (click here or SOlis Garcia Eng Ed An Pediatrica). English citation: Solís-García G, Gutiérrez-Vélez A, Pescador Chamorro I, Zamora-Flores E, Vigil-Vázquez S, Rodríguez-Corrales E, Sánchez-Luna M. Epidemiology, management and risk of SARS-CoV-2 transmission in a cohort of newborns born to mothers diagnosed with COVID-19 infection. An Pediatr (Engl Ed). 2021 Mar;94(3):173-178. doi: 10.1016/j.anpede.2020.12.006. Epub 2021 Jan 26. PMID: 33521167; PMCID: PMC7834971.

Study 540 – 9 cases from Israel

Of 1,326 asymptomatic pregnant women tested, 9 were positive for SARS-CoV-2 (click here or PIIS0002937821000259). No clinical details. From author affiliations they were probably cared for at Hadassah-Hebrew University Medical Center, Jerusalem, so may overlap with cases in study 330. Citation: Rottenstreich A, Zarbiv G, Kabiri D, Benenson S, Oster Y, Porat S, Sompolinsky Y, Reubinoff B, Rapid antigen detection testing for universal screening for SARS-CoV-2 in women admitted for delivery, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2021.01.002.

11 January update – studies 536 to 539 added

Study 539 -1,606 cases from UK and 2,398 from USA

This MedRxiv preprint describes 1,606 cases collected by the UK PanCovid registry and 2,398 from the US American Academy of Pediatrics Section on Neonatal Perinatal Medicine (AAP SONPM) National Perinatal COVID-19 Registry (click here or 2021.01.06.21249325v1.full). They likely overlap with other UK and US registries and reports. Citation: Edward Mullins, Mark Hudak, Jay Banerjee, Trace Getzlaff, Julia Townson, Kimberly Barnette, Rebecca Playle, Tom Bourne, Christoph Lees, PAN-COVID-investigators, National Perinatal COVID-19 Registry Study Group. Pregnancy and neonatal outcomes of COVID-19, co-reporting of common outcomes from the PAN-COVID and AAP SONPM registry. medRxiv 2021.01.06.21249325; doi: https://doi.org/10.1101/2021.01.06.21249325

23 Feb Update. Preprint in J Ultrasound Obstet Gynecol (click here or uog.23619). Cases reported from the AAP SONPM registry now 2,399. Two figures and four tables, referenced within, but missing from the MedRxiv preprint added. Citation: Mullins, E., Hudak, M.L., Banerjee, J., Getzlaff, T., Townson, J., Barnette, K., Playle, R., Bourne, T., Lees, C. on behalf of PAN‐COVID investigators and the National Perinatal COVID‐19 Registry Study Group (2021), Pregnancy and neonatal outcomes of COVID‐19: co‐reporting of common outcomes from PAN‐COVID and AAP SONPM registries. Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.23619

Study 538 – Case report from Iran

A woman who had recently delivered from a pregnancy complicated by pre-eclampsia contracted Covid-19 four days post-partum (click here or 1-s2.0-S2210778920301367-main). Despite intensive care and ventilation, she died on May 28th. She was cared for in Iranshahr University of Medical Sciences, Baluchestan, which has not previously reported cases. Citation: Fatemeh Azarkish, Firouzeh Sheikhi, Zohreh Mirkazehi, Saeed Kalkali, Paria Bameni Moghadam, Mahya Zahirniya, Preeclampsia and the crucial postpartum period for Covid-19 infected mothers: A case report, Pregnancy Hypertension, Volume 23, 2021, Pages 136-139, ISSN 2210-7789, https://doi.org/10.1016/j.preghy.2020.10.012. (http://www.sciencedirect.com/science/article/pii/S2210778920301367)

Study 537 – Case report of ECMO from USA

A woman with Covid-19 at 23 weeks gestation was treated with ECMO, and recovered (click here or mark ECMO pzaa189). From author affiliations she was likely treated at the University of Iowa Heart and Vascular Center, which has not previously reported pregnancy cases. However she may be included in study 535. Citation: Alex Mark, Jennifer P Crumley, Kristina L Rudolph, Kevin Doerschug, Anna Krupp, Maintaining Mobility in a Patient Who Is Pregnant and Has COVID-19 Requiring Extracorporeal Membrane Oxygenation: A Case Report, Physical Therapy, , pzaa189, https://doi.org/10.1093/ptj/pzaa189

Study 536 – 534 cases from Italy

This report, in Italian, includes 534 cases of Covid-19 in pregnancy, reported to the ITOSS registry between February 25th and July 10th 2020 (click here or itOSS 081-087_ART-Corsi (002)). There will be overlap with study 246. Citation: Edoardo Corsi, Alice Maraschini, Enrica Perrone, Michele Antonio Salvatore, Paola D’Aloja, Serena Donati, Gruppo di lavoro ItOSS COVID-194.  La preparedness dell’Italian obstetric surveillance system in occasione della pandemia da SARS-CoV-2: aspetti metodologici di uno studio di popolazione. (The preparedness of the Italian obstetric surveillance system in the response to the emergency of the SARS-CoV-2 pandemic: methodological aspects of a population-based study) Epidemiol Prev 2020; 44 (5-6) Suppl 2:81-87. doi: 10.19191/EP20.5-6.S2.089

8 January update – study 535 added

Study 535 – 22 pregnant women treated with ECMO

This series of people with Covid-19 treated with ECMO between Jan 16 and May 1, 2020, from 213 hospitals in 36 countries, includes 22 pregnant women (click here or PIIS0140673620320080). No separate outcome data. Citation: Barbaro, Ryan P, Alexander, Peta et al. Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry The Lancet, Volume 396, Issue 10257, 1071 – 1078.

7 January update – study 534 added

Study 534 – 145 cases from Italy

Of 145 pregnant women with SARS-CoV-2  infection, 116 were symptomatic (click here or DiGuardo2021_Article_PoorMaternalNeonatalOutcomesIn). Seven mothers and nine neonates died. They were cared for in two unnamed tertiary referral hospitals between March and July 2020. The authors are affiliated with one hospital in Calabria, in the south, two in Catania, Sicily and one in Vicenza in the North East. Ethics approval was from another hospital in Sicily. Assuming the two hospitals are in Sicily, these cases have probably not been reported. None of the author affiliations were with Palermo, study 355. Citation: Di Guardo F, Di Grazia FM, Di Gregorio LM, Zambrotta E, Carrara G, Gulino FA, Tuscano A, Palumbo M. Poor maternal-neonatal outcomes in pregnant patients with confirmed SARS-Cov-2 infection: analysis of 145 cases. Arch Gynecol Obstet. 2021 Jan 3:1–6. doi: 10.1007/s00404-020-05909-4. Epub ahead of print. PMID: 33389111; PMCID: PMC7778712.

6 January update – study 533 added

Study 533 – 1,148 cases from UK

This Medxiv preprint describes 1,148 pregnant women with SARS-CoV-2, 722 with symptoms. who were admitted to hospital (click here or UKOSS Preprint (002)).  Of 640 completed pregnancies, there were 16 pregnancy losses before 24 weeks, 5 stillbirths and 2 neonatal deaths. Eight mothers died. Collected from all 194 consultant-led obstetric units in the United Kingdom between 1st March and 31st August 2020, they therefore overlap with those reported in study 92. Citation: Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk, Marian Knight. The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: a national cohort study using the UK Obstetric Surveillance System (UKOSS). medRxiv 2021.01.04.21249195; doi: https://doi.org/10.1101/2021.01.04.21249195 [important] Update 16 May. Peer review published (click here or study) Citation: Vousden N, Bunch K, Morris E, Simpson N, Gale C, O’Brien P, et al. (2021) The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS). PLoS ONE 16(5): e0251123. https://doi.org/10.1371/journal.pone.0251123

3 January update – studies 529 to 532 added

Study 532 – zero pregnancy cases in a city in Japan

All 1475 pregnant women and 1343 partners tested for COVID-19 by PCR in saliva in all 12 maternity facilities in Himeji city between May 29 and September 5, 2020 were negative (click here or jog.14591). Over the same period 74 non-pregnant patients had Covid-19 in the same city. Citation: Okamura S, Akamatsu N, Kitajima T, Nakabayashi K, Fukumoto S, Katayama T, Mizutani Y, Kiyomoto H, Yamada H. Screening of COVID-19 polymerase chain reaction tests using saliva for pregnant women and their partners in Himeji city. J Obstet Gynaecol Res. 2020 Dec 22. doi: 10.1111/jog.14591. Epub ahead of print. PMID: 33354868.

Study 531 – 68 cases from USA

This preprint includes 68 pregnant women with suspected or confirmed COVID-19 (click here or 2907ed6a-c4cd-4147-b0bd-a5c41c5afec6). They were recruited through social media. Authors are mostly affilated with Harvard Medical School or Massachusetts General Hospital. Citation: Mayopoulos G, Ein-Dor T, Li K, Chan S, Dekel S. Giving birth under hospital visitor restrictions: Heightened acute stress in childbirth in COVID-19 positive women. Res Sq [Preprint]. 2020 Dec 9:rs.3.rs-112882. doi: 10.21203/rs.3.rs-112882/v1. PMID: 33330856; PMCID: PMC7743075.

Study 530 – 70 cases from Iran

Of 70 pregnant women with COVID-19 hospitalized from early March to late April 2020, two mothers died (click here or aim-23-856). 15/32 births were premature but no other baby outcomes are reported. The patients were cared for in various unnamed hospitals in Guilan province. Author affiliations suggest that these included Al-Zahra Hospital, in Rasht, which has not previously reported cases. Shared authors suggest the maternal deaths may overlap with those reported in study 67. Citation: Kazemi Aski S, Sharami SH, Hosseinzadeh F, Hesni E, Dalil Heirati SF, Ghalandari M, Mousavi A. Risk Factors, Clinical Symptoms, Laboratory Findings and Imaging of Pregnant Women Infected with COVID-19 in North of Iran. Arch Iran Med. 2020 Dec 1;23(12):856-863. doi: 10.34172/aim.2020.114. PMID: 33356344.

Study 529 – Case report from the Netherlands

A woman with Covid-19 was delivered by Caesarean at 31 weeks (click here or piaa153). There was evidence of SARS-CoV-2 in the placenta and the baby developed complications of both prematurity and birth asphyxia. However the baby tested negative. They were cared for in Erasmus University Medical Center, Rotterdam, which has not previously reported cases. The case was probably included in the NETHOSS registry. Citation: Schoenmakers S, Snijder P, Verdijk RM, Kuiken T, Kamphuis SSM, Koopman LP, Krasemann TB, Rousian M, Broekhuizen M, Steegers EAP, Koopmans MPG, Fraaij PLA, Reiss IKM. Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman. J Pediatric Infect Dis Soc. 2020 Dec 26:piaa153. doi: 10.1093/jpids/piaa153. Epub ahead of print. PMID: 33367801.

2 January update – studies 525-528 added

Study 528 – 16 cases from Singapore

16 pregnant women with COVID-19 cared for in 4 hospitals (abstract only click here). Citation: Mattar CN, Kalimuddin S, Sadarangani SP, Tagore S, Thain S, Thoon KC, Hong EY, Kanneganti A, Ku CW, Chan GM, Lee KZ, Yap JJ, Tan SS, Yan B, Young BE, Lye DC, Anderson DE, Yang L, Su LL, Somani J, Tan LK, Choolani MA, Chan JK. Pregnancy Outcomes in COVID-19: A Prospective Cohort Study in Singapore. Ann Acad Med Singap. 2020 Nov;49(11):857-869. PMID: 33381779.

Study 527 – 114 cases from Peru

114 pregnant women positive for SARS-CoV-2, between April 15 and May 10, 2020, who delivered in the National Perinatal Maternal Institute, Lima, which has not previously reported cases (English abstractonly click here). Three newborns died. Citation: Dávila-Aliaga C, Espínola-Sánchez M, Mendoza-Ibáñez E, Guevara-Ríos E, Torres-Marcos E, Hinojosa-Pérez R, Espinoza-Vivas Y, Álvarez-Carrasco R, Velásquez-Vásquez C, Meza-Santibáñez L, Gonzales-Carrillo O, Arango-Ochante P, Racchumí-Vela A, Saldaña-Díaz C. Resultados perinatales y serológicos en neonatos de gestantes seropositivas para SARS-CoV-2: estudio transversal descriptivo [Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study]. Medwave. 2020 Dec 21;20(11):e8084. Spanish. doi: 10.5867/medwave.2020.11.8084. PMID: 33382393.

Study 526 – 35 pregnant women from Switzerland

There were 35 pregnant women in this preprint hospital registry study up to August 31st, 2020 (click here or 2020.12.10.20246884v2.full). One went to ICU. No mothers died. No baby outcomes were reported. They were cared for 20 hospitals listed in the paper, and may overlap with cases in studies 72, 310 & 427. Citation: Amaury Thiabaud, Anne Iten, Carlo Balmelli, Laurence Senn, Nicolas Troillet, Andreas Widmer, Domenica Flury, Peter W. Schreiber, Miriam Vázquez, Lauro Damonti, Michael Buettcher, Danielle Vuichard-Gysin, Christoph Kuhm, Alexia Cusini, Thomas Riedel, Yvonne Nussbaumer, Roman Gaudenz, Ulrich Heininger, Christoph Berger, Franziska Zucol, Sara Bernhard-Stirnemann, Natascia Corti, Petra Zimmermann, Anita Uka, Anita Niederer-Loher, Céline Gardiol, Maroussia Roelens, Olivia Keiser. SARS-CoV-2/COVID-19 hospitalised patients in Switzerland: a prospective cohort profile. medRxiv 2020.12.10.20246884; doi: https://doi.org/10.1101/2020.12.10.20246884

Study 525 – 41 cases from Canada

Of 41 pregnant women testing positive for SARS-CoV-2, 30 had symptoms (click here or montreal). Two women required ventilation. There were no maternal deaths. No baby outcomes were reported. They were cared for in the Jewish General Hospital in Montreal, Quebec, which has not previously reported cases. Citation: Trahan, Marie-Julie et al.Screening and Testing Pregnant Patients for SARS-CoV-2: First-Wave Experience of a Designated COVID-19 Hospitalization Centre in Montreal J Obstet Gynaecol Can 2020;36(00):1−5. https://doi.org/10.1016/j.jogc.2020.11.001

1 January – study 254 added

Study 524 – 30 cases from Spain

13 pregnant and 17 postpartum women with Covid-19 in this series collected between 15th March and 15th October (click here or 2020.12.10.20246959v2.full). The authors suggest that pregnancy infection was more common in the second wave. Citation: Simona Iftimie, Ana F. López-Azcona, Immaculada Vallverdú, Salvador Hernàndez-Flix, Gabriel de Febrer, Sandra Parra, Anna Hernández-Aguilera, Francesc Riu, Jorge Joven, Jordi Camps, Antoni Castro, REUSCOVID Study Group. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. medRxiv 2020.12.10.20246959; doi: https://doi.org/10.1101/2020.12.10.20246959

31 December – study 523 added

Study 523 – seropositivity in pregnancy in Sweden

This preprint reports that about 15% of randomly sampled asymptomatic pregnant women from the Stockholm area had antibodies to SARS-CoV-2 by December 2020 (click here or 2020.12.24.20248821v1.full). 96% at levels that would be expected to confer immunity. Citation: Xaquin Castro Dopico, Sandra Muschiol, Murray Christian, Leo Hanke, Daniel J. Sheward, Nastasiya F. Grinberg, Gordana Bogdanovic, Gerald M. Mcinerney, Tobias Allander, Chris Wallace, Ben Murrell, Jan Albert, Gunilla B. Karlsson Hedestam. Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden. medRxiv 2020.12.24.20248821; doi: https://doi.org/10.1101/2020.12.24.20248821

29 December – studies 521 & 522 added.  Citation for study 313 updated.

Study 522 – Pancreatitis in a pregnant woman with Covid-19

A woman with severe Covid-19 at 33 weeks gestation also developed pancreatitis (click here or Acute_Pancreatitis_in_a_Pregnant_Patient_With.75). She went into preterm labour and delivered vaginally. Both mother and baby recovered. From author affiliations she was cared for at the Mayo Clinic, Rochester, Minnesota. USA, which has not previously reported cases. Citation: Narang K, Szymanski LM, Kane SV, Rose CH. Acute Pancreatitis in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020 Dec 22;Publish Ahead of Print. doi: 10.1097/AOG.0000000000004287. Epub ahead of print. PMID: 33355431.

Study 521 – 57 cases from India

Between May 5, and June 5, 2020, 348 pregnant women were tested and 57 positive for SARS-CoV-2 at Safdarjung Hospital, New Delhi (click here or PIIS170121632030829X). Three women died. Five babies tested positive but survived. Two test negative babies died. Likely overlap with study 441. Citation: Sumitra Bachani, Renu Arora, Anjali Dabral, Sheeba Marwah, Pratima Anand, K. Sravani Reddy, Nitesh Gupta, Balwinder Singh, Clinical Profile, Viral Load, MaternalFetal Outcomes of Pregnancy With COVID-19: 4-Week Retrospective, Tertiary Care Single-Centre Descriptive Study J Obstet Gynaecol Can 2020;000(000):1−9. https://doi.org/10.1016/j.jogc.2020.09.021

24 December – study 520 added

Study 520 – 879 cases from India

This series from Nair Hospital, Mumbai included 879 women with Covid-19 seen between April 4 and  September 10, 2020 (click here or ijgo.13508). They likely overlap with cases reported in studies 225, 283, 369 and 501. Citation: Mahajan, N.N., Ansari, M., Gaikwad, C., Jadhav, P., Tirkey, D., Pophalkar, M.P., Bhurke, A.V., Modi, D.N., Mahale, S.D. and Gajbhiye, R.K. (2020), Impact of SARS‐CoV‐2 on multiple gestation pregnancy. Int J Gynecol Obstet. https://doi.org/10.1002/ijgo.13508

23 December – studies 518 and 519 added

Study 519 – 127 cases from USA

A detailed analysis of viraemia, and placental transfer of virus and antibodies, in 127 pregnant women with SARS-CoV-2 (click here or edlow_2020_oi_200960_1607964328.94511). They were cared for in Massachusetts General, Brigham and Women’s Hospital, and Beth Israel Deaconess Medical Center, in Boston, Massachusetts between April 2 & June 13, 2020, and likely overlap with those in studies 129, 142, 231 and 232. Citation: Edlow AG, Li JZ, Collier AY, et al. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open. 2020;3(12):e2030455. doi:10.1001/jamanetworkopen.2020.30455

Study 518 – 7,028 cases from Mexico

7,028 pregnant with COVID-19  identified through the Mexican Public Health Network between February 1st and October 27th (click here or Martinez Portilla AJOG). 93 (1.3%) women died. They had been cared for 475 unnamed monitoring hospitals. A further analysis of the series reported in study 513, with additional cases. Citation: Martinez Portilla RJ, Smith ER, He S, Torres JT, Espino-Y-Sosa S, Solis-Paredes JM, Poon LC, Young pregnant women are also at an increased risk of mortality and severe illness due to COVID-19: Analysis of the Mexican National Surveillance Program, American Journal of Obstetrics and Gynecology (2021), doi: https://doi.org/10.1016/j.ajog.2020.12.1197. [important]

22 December – study 517 added

Study 517 – 47 screen positives in US

Of 126 women screened on admission in labour to Elmhurst Hospital, between March 29 and April 22, 45 tested positive for SARS-CoV-2 (click here or pone.0238409). They likely overlap with those in studies 160 and 236. Citation: Maru S, Patil U, Carroll-Bennett R, Baum A, Bohn-Hemmerdinger T, Ditchik A, et al. (2020) Universal screening for SARS-CoV-2 infection among pregnant women at Elmhurst Hospital Center, Queens, New York. PLoS ONE 15(12): e0238409. https://doi.org/10.1371/journal. pone.0238409

19 December – studies 513 to 516 added

Study 516 – 22 cases from China

22 neonates born to women with Covid-19 and admitted to Tongji Hospital, Wuhan, from January 1 to April 1, 2020 (click here or 1-s2.0-S0924857920304805-main). These cases have likely been reported before. Citation: Zheng He, Yinian Fang, Qin Zuo, Xiaoxing Huang, Yongfang Lei, Xiuhua Ren, Dong Liu, Vertical transmission and kidney damage in newborns from coronavirus disease 2019 infection pregnant mother, International Journal of Antimicrobial Agents (2020), doi: https://doi.org/10.1016/j.ijantimicag.2020.106260

Study 515 – 90 cases from Iran

45 symptomatic and 45 asymptomatic women with SARS-CoV-2 were compared (click here or Pregnancy outcomes among symptomatic and asymptomatic women infected with COVID 19 in the west of Iran a case control study). They were cared for in various hospitals of Hamadan Province from 1 September 2020 to 15 November 2020, and therefore should not overlap with study 375.  Citation: Ensiyeh Jenabi , Saeid Bashirian , Salman Khazaei , Seyedeh Zahra Masoumi , Samereh Ghelichkhani , Firoozeh Goodarzi & Mohammad Mirzaei (2020): Pregnancy outcomes among symptomatic and asymptomatic women infected with COVID-19 in the west of Iran: a case-control study, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1861599

Study 514 – 9 cases from Iran

A woman with Covid-19 gave birth at 37 weeks (click here or aaem-9-e5). The baby tested positive. The babies of 8 other affected women in the same hospital tested negative. They were cared for at Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, which has not previously reported cases. Citation: Parsa Y, Shokri N, Jahedbozorgan T, Naeiji Z, Zadehmodares S, Moridi A. Possible Vertical Transmission of COVID-19 to the Newborn; a Case Report: Vertical Transmission and The Coronavirus . Arch Acad Emerg Med [Internet]. 2020Nov.15 [cited 2020Dec.19];9(1):e5. Available from: https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/923

Study 513 – 5,183 cases in Mexico

5,183 pregnant women with Covid-19 identified throught the National Data Registry of Mexico from February 1st, to October 28th, 2020 (click here or uog.23575). 77 (1·5%) mothers died. They had been cared for in 475 unnamed monitoring hospitals, located in all 32 states. Citation: Martinez‐Portilla, R.J., Sotiriadis, A., Chatzakis, C., Torres‐Torres, J., Espino y Sosa, S., Sandoval‐Mandujano, K., Castro‐Bernabe, D.A., Medina‐Jimenez, V., Monarrez‐Martin, J.C., Figueras, F. and Poon, L.C. (2020), Pregnant women with SARS‐CoV‐2 infection are at higher risk of death and severe pneumonia: propensity score‐matched analysis of a nationwide prospective cohort study (COV19Mx). Ultrasound Obstet Gynecol. Accepted Author Manuscript. https://doi.org/10.1002/uog.23575

18 December – studies 511 (belatedly) and 512 added

Study 512 – 60 cases from Turkey

60 pregnant women with Covid-19 (click here or jmv.26725). Cared for in Ankara City Hospital between 26 June and 27 August 2020.  Probably overlapping with studies 31, 203, 223, 244, 399 & 444. Citation: Erol, S.A., Tanacan, A., Anuk, A.T., Tokalioglu, E.O., Biriken, D., Keskin, H.L., Tekin, O.M., Yazihan, N. and Sahin, D. (2020), Evaluation of Maternal Serum Afamin and Vitamin E Levels in Pregnant Women with COVID‐19 and Its Association with Composite Adverse Perinatal Outcomes. J Med Virol. Accepted Author Manuscript. https://doi.org/10.1002/jmv.26725

Study 511 – 9 cases from China

We were originally unable to source this early paper despite it being cited in a number of early reports (click here or 1007-9408-23-0004s). Patients were treated in the People’s Hospital of Wuhan University from January 22 to February 1, 2020, and therefore likely reported many times elsewhere. In Chinese. Citation: Lei Di, Wang Chen, Li Chunyan, et al. Clinical analysis of 9 cases of pregnancy with new coronavirus pneumonia[J]. Chinese Journal of Perinatal Medicine, 2020,23 (03): 225-231. DOI: 10.3760/cma. j.cn113903-20200216-00117

17 December – study 510 added

Study 510 – 1,584 cases in Canada

The first report of the Canadian Covid in pregnancy registry CanCovid (click here or CANCOVID-Preg-report-1-BC-AB-ON-data_02DEC2020).  As of November 23rd, 2020, 1,584 pregnant women with SARS-CoV-2 had been reported in Canada. 430 are reported here in detail. Eight were admitted to ITU. Nos. of events which affected <6 woman are not reported. Citation: Deborah Money. CANADIAN SURVEILLANCE OF COVID-19 IN PREGNANCY: EPIDEMIOLOGY, MATERNAL AND INFANT OUTCOMES Report #1: Released December 2nd, 2020 School of Population & Public Health, University of British Colombia [important]

15 December update – study 509 added

Study 509 – Case in China

A woman with Covid-19 at 36 weeks was delivered by Caesarean on 24 January (click here or PIIS0007091220301318). She was cared for at Wuhan Red Cross Hospital grid.507948.7, which has not previously reported cases. Citation: Xia H, Zhao S, Wu Z, Luo H, Zhou C, Chen X. Emergency Caesarean delivery in a patient with confirmed COVID-19 under spinal anaesthesia. Br J Anaesth. 2020 May;124(5):e216-e218. doi: 10.1016/j.bja.2020.02.016. Epub 2020 Mar 17. PMID: 32192711; PMCID: PMC7118662.

14 December update – studies 501 (HT Rahul Gajbhiye) to 508 added

Study 508 – Case in Iran

A woman with Covid-19 was delivered by Caesarean section at term and suffered a post-partum pulmonary embolus (click here or 20-1383). She was cared for [undated] at Shiraz University of Medical Sciences, Iran, which has not previously reported cases. Citation: Khodamoradi Z, Boogar SS, Shirazi FKH, Kouhi P. COVID-19 and Acute Pulmonary Embolism in Postpartum Patient. Emerg Infect Dis. 2020;26(8):1937-1939. doi:10.3201/eid2608.201383

Study 507 – 71 cases in USA

71 pregnant women with Covid-19 and their babies (click here or s-0040-1713416) were cared for [March 31, to May 5, 2020] in Morristown Medical Center, and at Overlook Medical Center, New Jersey, and therefore may overlap with those reported in study 159. Citation: Griffin I, Benarba F, Peters C, Oyelese Y, Murphy T, Contreras D, Gagliardo C, Nwaobasi-Iwuh E, DiPentima MC, Schenkman A. The Impact of COVID-19 Infection on Labor and Delivery, Newborn Nursery, and Neonatal Intensive Care Unit: Prospective Observational Data from a Single Hospital System. Am J Perinatol. 2020 Aug;37(10):1022-1030. doi: 10.1055/s-0040-1713416. Epub 2020 Jun 13. PMID: 32534458; PMCID: PMC7416206.

Study 506 – 37 cases in USA

37 pregnant women with Covid-19 were cared for at Flushing Hospital Medical Centre or Jamaica Hospital Medical Centre, New York, between March 20, and April 30, 2020 (click here or IDOG2020-8460672). Neither hospital has previously reported cases. Citation: Sindy C. Moreno, Justin To, Hajoon Chun, Ivan M. Ngai, “Vertical Transmission of COVID-19 to the Neonate”, Infectious Diseases in Obstetrics and Gynecology, vol. 2020, Article ID 8460672, 5 pages, 2020. https://doi.org/10.1155/2020/8460672

Study 505 – Case in USA

A woman with clinical Covid-19 (PCR negative but antibody positive) at 26 weeks gestation required 23 days ventilation (click here or CRIOG2020-8891787). She delivered vaginally at 39 weeks. The baby was healthy. From author affiliations she was cared for at Presbyterian-Brooklyn Methodist Hospital, New York, so may be included in study 230 and possibly other studies from the NY Presbyterian network. Citation: Farah Alsayyed, Victoria Hastings, Sanford Lederman, “Expectant Management of a Critically Ill Pregnant Patient with COVID-19 with Good Maternal and Neonatal Outcomes”, Case Reports in Obstetrics and Gynecology, vol. 2020, Article ID 8891787, 6 pages, 2020. https://doi.org/10.1155/2020/8891787

Study 504 – 4 mothers, 5 babies in Italy

Four women with Covid-19 had five babies who became infected (click here or olivini It J Ped 2020). From author affiliations the babies were cared for at Bambino Gesù Children’s Hospital, Rome. The paper has no OB authors so it is not clear which maternity hospital cared for the mothers. However, it is possible that some of them were included in studies 76, 78 and 464. Citation: Olivini, N., Calò Carducci, F.I., Santilli, V. et al. A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations. Ital J Pediatr 46, 180 (2020). https://doi.org/10.1186/s13052-020-00947-9

Study 503 – “Rooming in” in Italy

Of 61 mothers with Covid-19, and 62 neonates “roomed in”, only one baby got infected (click here or jamapediatrics_ronchi_2020_oi_200078_1605627156.62602). They were cared for in at 6
COVID-19 maternity centers, located in Lombardy, Northern Italy, between March 19 & May 2, 2020, and therefore probably overlap with those reported in the other Lombardy series. Citation: Ronchi A, Pietrasanta C, Zavattoni M, et al. Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy. JAMA Pediatr. Published online December 07, 2020. doi:10.1001/jamapediatrics.2020.5086

Study 502 – ICNARC 2nd wave, UK

The UK Intensive Care National Audit & Research Centre (ICNARC) is now reporting patients with Covid on ICU separately for the periods before and after 1 September 2020 (click here or ICNARC_COVID-19_Report_2020-12-11), For the period after 1 September, 13 currently pregnant and 12 recently pregnant women with Covid-19, had been admitted to ITU, of whom 8 and 10 respectively had been ventilated.

Study 501 – Case in India

A woman contracted Covid-19 at 30 weeks and developed delirium (click here or 1-s2.0-S1876201820306262-main). She recovered but the baby died. Three cases of post partum psychosis in women with Covid from the same hospital are mentioned. The hospital is Nair Hospital, Mumbai, so these cases may be included in studies 225, 283 & 369. Citation: Mahajan NN, Gajbhiye RK, Pednekar RR, Pophalkar MP, Kesarwani SN, Bhurke AV, Mahale SD, Delirium in a pregnant woman with SARS-CoV-2 infection in India, Asian Journal of Psychiatry (2020), doi: https://doi.org/10.1016/j.ajp.2020.10251

13 December update – studies 499 and 500 added

Study 500 – 7 cases in China

Seven pregnant women with Covid-19 (click here or 12098_2020_Article_3372). They were cared for in 5 provincial hospitals inHubei, namely Renmin Hospital of Wuhan University (n = 2) grid.412632.0, Huangshi Maternal and Child Health Hospital (n = 2) does not disambiguate, Jingzhou Maternal and Child Health Hospital (n = 1) grid.507996.4, Jingmen First Renmin Hospital (n = 1) does not disambiguate, and Zaoyang First Renmin Hospital (n = 1) which does not disambiguate. It is likely that the various Renmin hospital cases have been reported elsewhere. The Jingzhou case may not have been reported before. Citation: Nawsherwan, Khan S, Nabi G, Fan C, Wang S. Impact of COVID-19 Pneumonia on Neonatal Birth Outcomes. Indian J Pediatr. 2020;87(8):645-646. doi:10.1007/s12098-020-03372-2

Study 499 – 19 cases in China

17 mothers with Covid-19 and their babies (click here or 11684_2020_Article_772). They were cared for in Tongji Hospital in Wuhan, and therefore likely included in many previous reports. Citation: Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. Front Med. 2020;14(2):193-198. doi:10.1007/s11684-020-0772-y

12 December update – studies 493 to 498 added

Study 498 – Case in China

A 30-year-old woman with Covid-19 at 35-weeks was delivered by caesarean and became depressed and anxious after her baby was isolated (click here or JZUSB21-0394). From author affiliations she was cared for at the First Affiliated Hospital, Zhejiang University School of Medicine, grid.452661.2, Hangzhou, and may therefore the same case as in studies 4 and 9. Citation: Huang JW, Zhou XY, Lu SJ, et al. Dialectical behavior therapy-based psychological intervention for woman in late pregnancy and early postpartum suffering from COVID-19: a case report. J Zhejiang Univ Sci B. 2020;21(5):394-399. doi:10.1631/jzus.B2010012

Study 497 – Case in China

A woman contracted Covid-19 at 36 weeks (click here or 540_2020_Article_2796). She delivered by Caesarean at 37 weeks. Both mother and baby recovered. From author affiliatons she was cared for at the Second Affiliated Hospital of Xi’an Jiaotong University, grid.452672.0 Xi’an, Shaanxi, which has not previously reported cases. Citation: Du Y, Wang L, Wu G, Lei X, Li W, Lv J. Anesthesia and protection in an emergency cesarean section for pregnant woman infected with a novel coronavirus: case report and literature review. J Anesth. 2020;34(4):613-618. doi:10.1007/s00540-020-02796-6

Study 496 – Case in USA

A woman contracted Covid-19 and vulvovaginitis at 31 weeks (click here or s-0040-1713665). From author affiliations she was treated at the Hospital of the University of Pennsylvania, Philadelphia, so might be included in studies 86, 175, 302 & 350. Citation: Rubin ES, Sansone SA, Hirshberg A, Clement EG, Srinivas SK. Detection of COVID-19 in a Vulvar Lesion. Am J Perinatol. 2020 Sep;37(11):1183-1184. doi: 10.1055/s-0040-1713665. Epub 2020 Jul 2. PMID: 32615620; PMCID: PMC7516389.

Study 495 – 17 self-reported cases in Belgium

17 out of 6,470 self-selected pregnant or breast feeding women completing an internet survey, reported testing positive for SARS-CoV-2 (click here or ijerph-17-06766 (1)). Citation: Ceulemans M, Verbakel JY, Van Calsteren K, Eerdekens A, Allegaert K, Foulon V. SARS-CoV-2 Infections and Impact of the COVID-19 Pandemic in Pregnancy and Breastfeeding: Results from an Observational Study in Primary Care in Belgium. Int J Environ Res Public Health. 2020 Sep 17;17(18):6766. doi: 10.3390/ijerph17186766. PMID: 32957434; PMCID: PMC7559009. 

Study 494 – Case from Umbria, Italy

A woman with Covid-19 at 32 weeks gestation (click here or Lettera – Indraccolo). The pregnancy outcome was not reported. She was cared for at “Alto Tevere”, Hospital of Città di Castello, which has not previously reported cases.  Citation: Indraccolo U. A pregnant woman and the SARS-CoV-2 infection: how are barriers easily crossed? Recenti Prog Med. 2020 Apr;111(4):259-260. doi: 10.1701/3347.33190. PMID: 32319449.

Study 493 – Patient treated with ECMO in China

One of four patients treated with convalescent plasma was pregnant (click here or PIIS0012369220305717). She was aged 31, 35 weeks gestion, delivered by caesarean and following treatment with ECMO recovered. The baby died. She was initially treated at Xiaolan People’s Hospital of Zhongshan, and later transferred to the Second People’s Hospital of Zhongshan, neither of which disambiguates on GRID.ac but which must be the same as Zhongshan People’s Hospital grid.476868.3. This appears to be the sixth report of this woman, (studies 3, 57, 81, 192 & 433)  Citation: Zhang B, Liu S, Tan T, Huang W, Dong Y, Chen L, Chen Q, Zhang L, Zhong Q, Zhang X, Zou Y, Zhang S. Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Chest. 2020 Jul;158(1):e9-e13. doi: 10.1016/j.chest.2020.03.039. Epub 2020 Mar 31. PMID: 32243945; PMCID: PMC7195335.

11th December update – studies 491 and 492 added

Study 492 – 4 cases in Jordan

Four pregnant women with mild Covid-19 (click here or ijgo.13240). They were cared for in the King Abdullah University Hospital, Irbid, so may overlap with cases in studies 153, 435 & 463. Citation: Alsharaydeh I, Rawashdeh H, Saadeh N, Obeidat B, Obeidat N. Challenges and solutions for maternity and gynecology services during the COVID-19 crisis in Jordan. Int J Gynaecol Obstet. 2020 Aug;150(2):159-162. doi: 10.1002/ijgo.13240. Epub 2020 Jun 17. PMID: 32470178.

Study 491 – Abortion case in New York

An asymptomatic woman with sickle cell disease undergoing abortion by D&E at 15 weeks developed post operative pneumonia and tested positive for SARS-CoV-2 (click here or PIIS0010782420301530). From author affiliations she was cared for at Columbia University Irving Medical Center, previous reports from which (studies 14, 27, 136, & 271) have not included pregnancy termination cases. Citation: Fang NZ, Castaño PM, Davis A. A hospital-based COVID-19 abortion case in the early phase of the pandemic. Contraception. 2020;102(2):137-138. doi:10.1016/j.contraception.2020.05.005

8th December update – studies 478 to 490 added

Study 490 – Case in USA

A woman with Covid-19 was delivered by Caesarean at 35 weeks (click here or acc-14-e01303). She was cared for at Boston Medical Center, Boston, Massachusetts, so might be included in study 292. Citation: Norris MC, Kalustian A, Salavati S. Epidural Blood Patch for Postdural Puncture Headache in a Patient With Coronavirus Disease 2019: A Case Report. A&A Practice. 2020 Aug;14(10):e01303. DOI: 10.1213/xaa.0000000000001303.

Study 489 – Case in China

A woman contracted Covid-19 at 35 weeks, and was delivered by Caesarean (click here or BMJ-37-226). She recovered. From author affiliations she was cared for at Chongqing Three Gorges Central Hospital, grid.477128.f Chongqing. Other features also suggest this and study 252 describe the same woman. Citation: Liao X, Yang H, Kong J, Yang H. Chest CT Findings in a Pregnant Patient with 2019 Novel Coronavirus Disease. Balkan Med J. 2020;37(4):226-228. doi:10.4274/balkanmedj.galenos.2020.2020.3.89

Study 488 – 20 cases detected by screening in USA

Four hospitals associated with Mass General Brigham Health, Massachusetts, tested 757 women admitted in labour between April 18th & May 5th. 20 were positive for SARS-CoV-2 (click here or S0899823X2000255Xa). This organisation has not previously reported cases. Citation: Goldfarb IT, Diouf K, Barth WH, et al. Universal SARS-CoV-2 testing on admission to the labor and delivery unit: Low prevalence among asymptomatic obstetric patients. Infect Control Hosp Epidemiol. 2020;41(9):1095-1096. doi:10.1017/ice.2020.255

Study 487 – 5 cases in USA

There were 79/1,811 SARS-CoV-2 positive tests between April 27, and May 18, in a big hospital. Five were in pregnant women (click here or S0899823X2000358Xa). The hospital is unnamed, but probably affiliated with Virginia Commonwealth University, Richmond, Virginia,. Citation: : Sastry SR, et al. (2020). Universal screening for the SARS-CoV-2 virus on hospital admission in an area with low COVID-19 prevalence. Infection Control & Hospital Epidemiology, https://doi.org/10.1017/ice.2020.358

Study 486 – 37 cases in Chile

37/583 pregnant women had a positive test for SARS CoV-2 (click here or journal.pone.0239887). Two women required ventilation. None died. Two babies tested positive. One baby, who tested negative, died. The study was conducted in Clınica Davila, Santiago, which has not previously reported cases. Citation: Dı´az-Corvillo´n P, Mo¨nckeberg M, Barros A, Illanes SE, Soldati A, Nien J-K, et al. (2020) Routine screening for SARS CoV-2 in unselected pregnant women at delivery. PLoS ONE 15(9): e0239887. https://doi.org/10.1371/journal.pone.0239887

Study 485 – 3 cases in Spain

Three pregnant women with Covid-19 (click here or main (9) In Spanish). From author affiliations cared for at Hospital Universitario Materno-Infantil de Jaén, Jaén, so may overlap with study 158. Citation: Hijona Elósegui JJ, Carballo García AL, Fernández Risquez AC. New evidences that discard the possible vertical transmission of SARS-CoV-2 during pregnancy. Nuevas evidencias que descartan la posible transmisión vertical del SARS-CoV-2 durante la gestación. Med Clin (Barc). 2020;155(7):313-314. doi:10.1016/j.medcli.2020.05.021

Study 484 – Case report in Italy

A pregnant woman with Covid-19 also had a pulmonary embolus (click here or PIIS0049384820301389). She was cared for in Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, so probably included in the Lombardy series. Citation: Martinelli I, Ferrazzi E, Ciavarella A, Erra R, Iurlaro E, Ossola M, Lombardi A, Blasi F, Mosca F, Peyvandi F. Pulmonary embolism in a young pregnant woman with COVID-19. Thromb Res. 2020 Jul;191:36-37. doi: 10.1016/j.thromres.2020.04.022. Epub 2020 Apr 20. PMID: 32371163; PMCID: PMC7169886.

Study 483 – 21 cases in Italy

21 women with Covid-19 during pregnancy (click here or R02Y2020N11A1248). From author affiliations cared for at Spedali civili of Brescia, Brescia, so likely included in the various Lombardy series. Citation: Giannini A, Mantovani A, Vezzoli C, Franchini D, Finazzi P. Lung ultrasound for pregnant women admitted to ICU for COVID-19 pneumonia. Minerva Anestesiol. 2020 Nov;86(11):1248-1249. doi: 10.23736/S0375-9393.20.14726-6. Epub 2020 May 29. PMID: 32486608.

Study 482 – Case in Iraq

A pregnant woman with Covid-19 at 28 weeks went into preterm labour and delivered at 30 weeks (click here or AsianPacJReprod000-415713_113251). The baby was not infected. From author affiliations she was cared for at Al-Kadhemia Teaching Hospital, Baghdad. This is the first report from Iraq. Citation: Al-Kuraishy, H., Al-Maiahy, T., Al-Gareeb, A., Musa, R., & Ali, Z. (2020). COVID-19 pneumonia in an Iraqi pregnant woman with preterm delivery. Asian Pacific Journal of Reproduction, 9(3). https://doi.org/10.4103/2305-0500.282984

Study 481 – Puerperal skin manifestations of Covid-19

A woman with Covid-19 developed a skin rash 7 days post partum (click here or ijd.14919). She was cared for at San Raffaele Hospital, Milan, Italy, so may have been included in the various Lombardy series. Citation: Paolino, G., Canti, V., Mercuri, S.R., Rovere Querini, P., Candiani, M. and Pasi, F. (2020), Diffuse cutaneous manifestation in a new mother with COVID‐19 (SARS‐Cov‐2). Int J Dermatol, 59: 874-875. https://doi.org/10.1111/ijd.14919

Study 480 – Puerperal case in USA

A woman with puerperal Covid-19 (click here or 10-1055-s-0040-1712926). From author affiliations she was cared for at University of Alabama at Birmingham, Alabama, which has not previously reported cases. Citation: Sinkey RG, Rajapreyar I, Robbins LS, et al. Heart Failure with Preserved Ejection Fraction in a Postpartum Patient with Superimposed Preeclampsia and COVID-19. AJP Rep. 2020;10(2):e165-e168. doi:10.1055/s-0040-1712926

Study 479 – Patient in the Netherlands

A pregnant woman with systemic lupus erythematosus, using long-term corticosteroids, contracted Covid-19 (click here or bcr-2020-235581). She gave birth normally and the baby was unaffected. She was cared for at Reinier de Graaf Gasthuis, Delft, which has not previously reported cases. Citation: Grimminck K, Santegoets LAM, Siemens FC, et al. BMJ Case Rep 2020;13:e235581. doi:10.1136/bcr-2020-235581

Study 478 – Case report from Caracas, Venezuela

A woman tested postive for SARS-CoV-2 during the pregnancy, and had mild symptoms, but had recovered by the time she was delivered by Caesarean on March 31st (click here or main (8)). The baby tested negative. The birth hospital is not named. Citation: Forero-Peña DA, Rodríguez MI, Flora-Noda DM, et al. The first pregnant woman with COVID-19 in Venezuela: Pre-symptomatic transmission. Travel Med Infect Dis. 2020;36:101805. doi:10.1016/j.tmaid.2020.101805

7th December – studies 464 to 475 added

Study 475 – 308 cases from Mexico

Using open data from the Mexican Ministry of Health up to May 17th, 7/308 pregnant women with Covid-19 had died (click here or ijgo.13250). This report will overlap with study 340. Citation: Lumbreras‐Marquez, M.I., Campos‐Zamora, M., Lizaola‐Diaz de Leon, H. and Farber, M.K. (2020), Maternal mortality from COVID‐19 in Mexico. Int J Gynecol Obstet, 150: 266-67. https://doi.org/10.1002/ijgo.13250

Study 474 – 12 cases from Turkey

No SARS-CoV-2 was detected in vaginal fluid of 12 pregnant women with COVID-19 (click here or SARS CoV 2 is not present in the vaginal fluid of pregnant women with COVID 19 (1)). All had mild symptoms and none needed critical care. From author affiliations they were cared for at Sakarya Training and Research Hospital, Sakarya, Turkey, which has not previously reported cases. Citation: Mehmet Musa Aslan , Hilal Uslu Yuvacı , Osman Köse , Hande Toptan , Nermin Akdemir , Mehmet Köroğlu , Arif Serhan Cevrioğlu & Selçuk Özden (2020): SARS-CoV-2 is not present in the vaginal fluid of pregnant women with COVID-19, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1793318

Study 473 – Thrombocytopaenia & mild Covid-19

Three pregnant wowen with mild Covid-19 also had thrombocytopaenia (click here or main (7)). From author affiliations they were cared for at Antoine-Beclere Hospital, Paris, so may overlap with studies 217 and 326. Citation: Le Gouez A, Vivanti AJ, Benhamou D, Desconclois C, Mercier FJ. Thrombocytopenia in pregnant patients with mild COVID-19. Int J Obstet Anesth. 2020;44:13-15. doi:10.1016/j.ijoa.2020.05.010

Study 472 – 16 cases from China

These 16 pregnant women with COVID‐19 up until February 16, 2020 in Wuhan Union Hospital (click here or ijgo.13236) have probably been reported before. Citation: Zeng Y, Lin L, Yan Q, Wei W, Xiang Yang B, Huang R, He F, Chen D. Update on clinical outcomes of women with COVID-19 during pregnancy. Int J Gynaecol Obstet. 2020 Aug;150(2):264-266. doi: 10.1002/ijgo.13236. Epub 2020 Jun 9. PMID: 32438521.

Study 471 – 12 cases from China

12 pregnant women with Covid-19 (click here or 1-s2.0-S0890623820302677-main). They were cared for at Renmin Hospital of Wuhan University grid.412632.0 and the near hospitals in Wuhan City, Hubei Province, China. They have therefore probably already been reported. Citation: Cuifang Fan, No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-19. Letter. Reproductive Toxicology, https://doi.org/10.1016/j.reprotox.2020.11.008

Study 470 – Screening in Madrid, Spain

86 seropositive pregnant women were detected out of 759 tested between February 28th and May 10th (click here or pone.0243029). The hospital was Hospital Universitario 12 de Octubre, so they may overlap with those in studies 205 and 458. Citation: Villalaı´n C, Herraiz I, Luczkowiak J, Pe´rez-Rivilla A, Folgueira MD, Mejı´a I, et al. (2020) Seroprevalence analysis of SARS-CoV-2 in pregnant women along the first pandemic outbreak and perinatal outcome. PLoS ONE 15(11): e0243029. https://doi.org/10.1371/journal.pone.0243029

Study 469 – Case report from Turkey

An asymptomatic woman with SARS-CoV-2 delivered by Caesarean (click here or jog.14584). Cared for at Umraniye Training and Research Hospital Emergency Obstetrics Clinic, Istanbul, which has not previously reported cases. Citation: Palalioglu, R.M., Mahammadaliyeva, A., Erbiyik, H.I. and Muhcu, M. (2020), COVID‐19 in third trimester may not be as scary as you think, it can be innocent: Evaluating vertical transmission from a COVID‐19 positive asymptomatic pregnant woman with early membrane rupture. J. Obstet. Gynaecol. Res.. https://doi.org/10.1111/jog.14584

Study 468 – 4 patients from Canada

Four pregnant patients with SARS-CoV-2 were identified by screening (click here or birt.12520). It’s not possible to determine from author affiliations which centre in Toronto, cared for them, so some may have been included in studies 48 and 103. Citation: Mei-Dan, E, Satkunaratnam, A, Cahan, T, Leung, M, Katz, K, Aviram, A. Questionnaire‐based vs universal PCR testing for SARS‐CoV‐2 in women admitted for delivery. Birth. 2020; 00: 1– 8. https://doi.org/10.1111/birt.12520

Study 467 – 137 cases from West French Guiana

Of 137 pregnant women with SARS-CoV-2 infection, 3 required ITU admission but none died (click here or hcini ejog). There were 3 terminations and 7 stillbirths. Four babies were infected. Patients were cared for at West French Guiana Hospital Center (Centre Hospitalier de l’Ouest Guyanais), which has not previously reported cases. Citation: Hcini N, Maamri F, Picone O, Carod J-Francois, Lambert V, Mathieu M, Carles G, Pomar L, Maternal, fetal and neonatal outcomes of large series of SARS-CoV-2 positive pregnancies in peripartum period: a single-center prospective comparative study, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.11.068

Study 466 – Case report from USA

A woman with Covid-19 required ventilation (click here or Coronavirus_Disease_2019__COVID_19__Related.74). She survived. From author affiliations she was cared for in North Shore University Hospital, Manhasset, New York, which means she might be included in study 179. Citation: Gulersen, Moti MD, MSc; Staszewski, Cara MD; Grayver, Evelina MD; Tam Tam, Hima MD; Gottesman, Eric MD; Isseroff, Donnie MD; Rochelson, Burton MD; Bonanno, Clarissa MD Coronavirus Disease 2019 (COVID-19)–Related Multisystem Inflammatory Syndrome in a Pregnant Woman, Obstetrics & Gynecology: December 3, 2020 – Volume Latest Articles – Issue – 10.1097/AOG.0000000000004256 doi: 10.1097/AOG.0000000000004256 

Study 465 – Case report from China

A woman with Covid-19 at 34 weeks cared for at Renmin Hospital of Wuhan University (click here or ijgo.13232). Probably included in a multiple previous studies. Citation: Yu, Y., Fan, C., Bian, J. and YinShen, (2020), Severe COVID‐19 in a pregnant patient admitted to hospital in Wuhan. Int J Gynecol Obstet, 150: 262-263. https://doi.org/10.1002/ijgo.13232

Study 464 – Lung ultrasound in 4 cases

Four women with Covid-19 underwent lung ultrasound (click here or uog.22055). From author affiliations they were cared for at Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy, and may overlap with those in studies 76 and 78. Citation: Buonsenso, D., Raffaelli, F., Tamburrini, E., Biasucci, D.G., Salvi, S., Smargiassi, A., Inchingolo, R., Scambia, G., Lanzone, A., Testa, A.C. and Moro, F. (2020), Clinical role of lung ultrasound for diagnosis and monitoring of COVID‐19 pneumonia in pregnant women. Ultrasound Obstet Gynecol, 56: 106-109. https://doi.org/10.1002/uog.22055

6th December – studies 452 to 463 added

Study 463 – Case report from Jordan

A woman with Covid-19 (click here or 925512) was treated at King Abdullah University Hospital Irbid, Jordan, on March 28, 2020. She may therefore have been reported in studies 153 and 435. Citation: Bani Hani D.A. et al.: Successful anesthetic management in cesarean section for Pregnant Woman with COVID-19. Am J Case Rep, 2020; 21: e925512

Study 462 – Normal birth in Italy

A woman tested positive at 40 weeks gestation (click here or mjhid-12-1-e2020033). She gave birth normally. The baby tested negative. From author affiliations she gave birth at Santa Maria della Misericordia Hospital, Perugia, which has not previously reported cases. Citation: De Socio G.V., Malincarne L., Arena S., Troiani S., Benedetti S., Camilloni B., Epicoco G., Mencacci A., Francisci D. Delivery in asymptomatic italian woman with SARS-CoV-2 infection. Mediterr J Hematol Infect Dis 2020, 12(1): e2020033, DOI: http://dx.doi.org/10.4084/MJHID.2020.033&nbsp;

Study 461 – Maternal death in Iran

A woman contracted Covid-19 at 23 weeks with twins (click here or 29688-Article Text-117866-1-10-20200408). She died with the twins undelivered. She was cared for at Imam Hossein
Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, which has not previously reported cases. Citation: Shojaei S, Kouchek M, Miri MM, Salarian S, Sistanizad M, Ariana S, et al. Twin pregnant woman with COVID-19: a case report. J Cell Mol Anesth. 2020;5(1):43-6

Study 460 – Severe case from Italy

A woman with Covid-19 at 27 weeks required 15 days ventilation (click here or sv-YX051401). She recovered and the baby remained undelivered. She was cared for in Azienda Ospedaliera Santa Croce e Carle, Cuneo, which has not previously reported cases. Citation: Luigi Barile, Martina Cerrano, Alessandro Locatelli, Andrea Puppo, Anna F. Signorile, Nicoletta Barzaghi. Prone Ventilation in a 27 Week Pregnant Woman with COVID-19 Severe ARDS. Signa Vitae. 2020. 16(1);199-202.

Study 459 – 6 cases from China

6 pregnant women with Covid-19 (click here or PIIS0163445320302929). Three required ITU admission and ventilation, and one ECMO. They all survived. The patients were cared for in the First Affiliated Hospital of Jinan University grid.412601.0, Guangzhou, Guangdong. This suggests possible overlap with studies 3, 57 and 81, all of which also reported a pregnant woman treated with ECMO. Citation: Huang, Wenhui et al. Unfavorable outcomes in pregnant patients with COVID-19.Journal of Infection, Volume 81, Issue 2, e99 – e101

Study 458 – 2 cases from Spain

2/203 women screened on admission in labour at Hospital Universitario 12 de Octubre in Madrid, tested positive (click here or [16193997 – Journal of Perinatal Medicine] Universal screening for SARS-CoV-2 before labor admission during Covid-19 pandemic in Madrid). Citation: Herraiz, I., Folgueira, D., Villalaín, C., Forcén, L., Delgado, R., & Galindo, A. (2020). Universal screening for SARS-CoV-2 before labor admission during Covid-19 pandemic in Madrid, Journal of Perinatal Medicine, 48(9), 981-984. doi: https://doi.org/10.1515/jpm-2020-0236

Study 457 – 94 cases in USA

94 confirmed or suspected cases of Covid-19 in pregnancy (click here or s-0040-1712529). From author affiliations they were cared for at Icahn School of Medicine at Mount Sinai, so overlap with studies 86, 119, 131 and 455 is likely. Citation: Fox NS, Melka S. COVID-19 in Pregnant Women: Case Series from One Large New York City Obstetrical Practice. Am J Perinatol. 2020 Aug;37(10):1002-1004. doi: 10.1055/s-0040-1712529. Epub 2020 May 21. PMID: 32438425; PMCID: PMC7416214.

Study 456 – 9 cases from Senegal

Nine pregnant women with Covid-19 from March 2 to May 15, were identified (click here or 58). They all recovered. This is the first report from Senegal. Citation: Abdoul Aziz Diouf et al. Clinical characteristics and outcomes of COVID-19 infection in nine pregnant women: a report from a sub-Saharan African country, Senegal. Pan African Medical Journal. 2020;35(2):58. [doi: 10.11604/pamj.supp.2020.35.2.23736]

Study 455 – Case report from USA

A woman with Covid-19 at 30 weeks improved after Caesarean delivery (click here or e236290.full). From author affiliations she was cared for at Icahn School of Medicine at Mount Sinai, New York, so she might be included in studies 86, 119, and 131. Citation: Oliva M, Hsu K, Alsamarai S, et al. Clinical improvement of severe COVID-19 pneumonia in a pregnant patient after caesarean delivery. BMJ Case Reports CP 2020;13:e236290.

Study 454 – Follow up of four patients in Study 6

The four women who were undelivered at the time of reporting study 6 recovered, but their pregnancy outocmes are still not reported (Click here or ajr.20.23247). Citation: Lin Li, Dehan Liu, and Lian Yang. Follow-Up Information About the Four Pregnant Patients With Coronavirus Disease (COVID-19) Pneumonia Who Were Still in the Hospital at the End of Our Study. American Journal of Roentgenology 2020 215:1, W17-W18

Study 453 – Lung ultrasound in 2 pregnant women with Covid-19, Spain

The lung ultrasound appearances of two pregnant women with Covid-19 (click here or jum.15419). From author affiliations they were cared for in Hospital General Universitario de Alicante, which has not previously reported cases. Citation: Gil‐Rodrigo, A., Llorens‐Soriano, P. and Ramos‐Rincón, J.‐M. (2020), Ultrasound in Pregnant Women With Suspected COVID‐19 Infection. J Ultrasound Med. https://doi.org/10.1002/jum.15419

Study 452 – Maternal death in Turkey

A woman with Covid-19 at 31 weeks gestation died (click here or 202587-454095-1-PB). The baby, born by Caesarean also died. From author affiliations they were cared for in University Kocaeli Derince Training and Research Hospital, Kocaeli. The case may have been included in studies 244 and 382. Citation: K. Uzel, I. V. Lakhno A MORTAL CASE OF CORONAVIRUS DISEASE IN A PREGNANT DIABETIC WOMAN. CLINICAL CASE Reproductive Endocrinology, ISSN: 2411-1295, Vol: 0, Issue: 52, Page: 33-36

5th December – studies 438 to 451 added

Study 451 – 24 cases, 3 severe, from UK

Of 24 pregnant or immediately post-partum patients with COVID-19, three required prolonged admittion to ICU (click here or 1751143720947547). They were cared for at Chelsea and Westminster NHS Foundation Trust in London, which has not previously reported cases. However they were probably included in study 92. The three ICU cases were probabaly incuded in the various ICNARC reports. Citation: Morton S, Lamont H, Silvey N, et al. Adult intensive care unit admissions with severe COVID-19 infection following emergency Caesarean section deliveries: A case series. Journal of the Intensive Care Society. August 2020. doi:10.1177/1751143720947547

Study 450 – Case report from China

This woman with Covid-19 who delivered in Maternal and Child Health Hospital of Hubei Province on April 5, 2020 (click here or medi-99-e21335) must have been included in many of the Wuhan series.. Citation: Peng J, Li R, Yin H, et al. A case report of a pregnant woman infected with coronavirus disease 2019 pneumonia. Medicine (Baltimore). 2020;99(30):e21335. doi:10.1097/MD.0000000000021335

Study 449 – 11 cases from Israel

11 pregnant women with SARS-CoV-2 infection cared for at Sheba Medical Center, Tel-Hashomer, Ramat Gan, (click here or Mohr-Sasson2020_Article_LaboratoryCharacteristicsOfPre). They may overlap with cases in studies 278 and 330. Citation: Mohr-Sasson A, Chayo J, Bart Y, Meyer R, Sivan E, Mazaki-Tovi S, Yinon Y. Laboratory characteristics of pregnant compared to non-pregnant women infected with SARS-CoV-2. Arch Gynecol Obstet. 2020 Sep;302(3):629-634. doi: 10.1007/s00404-020-05655-7. Epub 2020 Jun 22. PMID: 32572616; PMCID: PMC7307945.

Study 448 – a case with polymorphic eruption of pregnancy

A woman who tested positive for SARS-CoV-2 at 39 weeks developed polymorphic eruption of pregnancy 10 days after giving birth (click here or dth.14117). The hospital is not named but from author affiliations is affiliated with Sapienza University of Rome, Italy. Citation: Proietti I, Bernardini N, Tolino E, Mambrin A, Balduzzi V, Marchesiello A, Michelini S, Skroza N, Potenza C. Polymorphic eruption of pregnancy as a possible COVID-19 manifestation. Dermatol Ther. 2020 Aug 1:e14117. doi: 10.1111/dth.14117. Epub ahead of print. PMID: 32737915; PMCID: PMC7436318.

Study 447 – 29 cases from China

29 women with Covid-19 delivered 30 babies (one set of twins) between January 30 and March 10 (click here or journal.pmed.1003195 (1)). They were cared for in Renmin Hospital, Wuhan University, grid.412793.a and Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology grid.412793.a. They likely overlap with many previous reports from Wuhan. Citation: Wu YT, Liu J, Xu JJ, Chen YF, Yang W, Chen Y, Li C, Wang Y, Liu H, Zhang C, Jiang L, Qian ZX, Kawai A, Mol BW, Dennis CL, Xiong GP, Cheng BH, Yang J, Huang HF. Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. PLoS Med. 2020 Jul 28;17(7):e1003195. doi: 10.1371/journal.pmed.1003195. PMID: 32722722; PMCID: PMC7386573.

Study 446 – A woman treated with ECMO in UK

A woman with severe Covid-19 was delivered by Caesarean at 39 weeks and required ventilation and ECMO (click here or demirjian2020). The baby tested positive and had clinical disease. Both eventually recovered. The birth took place at North Middlesex University Hospital NHS Trust, London, so although not cited, this is also case 1 in study 93. Citation: Demirjian A, Singh C, Tebruegge M, Herbert R, Draz N, Mirfenderesky M, Jones V, Hinstridge P, Seneviratne R, Myers R, Ellis J, Miah S, Meadows CI, Kenny J, Alonso A, Handforth J, Perkins S, Butler M, Blackburn F, Douthwaite S, Pillay D, Chand M, Zambon M. Probable Vertical Transmission of SARS-CoV-2 Infection. Pediatr Infect Dis J. 2020 Sep;39(9):e257-e260. doi: 10.1097/INF.0000000000002821. PMID: 32658096.

Study 445 – Miscarriage in Pakistan

A woman with Covid-19 miscarried at 11 weeks (click here or PIIS0163445320305879). She recovered. It is not possible to deduce which hospital cared for her from author affiliations. However, this is the first report from Islamabad. Citation: Rana MS, Usman M, Alam MM, Khalid A, Ikram A, Salman M, Zaidi SSZ, Faryal R, Qadir M, Umair M, Roohullah, Sufian MM. First trimester miscarriage in a pregnant woman infected with COVID-19 in Pakistan. J Infect. 2020 Sep 5:S0163-4453(20)30587-9. doi: 10.1016/j.jinf.2020.09.002. Epub ahead of print. PMID: 32896525.

Study 444 – SARS-CoV-2 detected in breast milk

A breast milk sample from an asymptomatic woman who tested positive for SARS-CoV-2 at birth, also tested positive (click here or 10.1089@bfm.2020.0161). The neonate tested negative and remained well. She was cared for Ankara City Hospital, Ankara, Turkey. The case may have been included in studies 95, 203 and 244. Citation: Bastug A, Hanifehnezhad A, Tayman C, Ozkul A, Ozbay O, Kazancioglu S, Bodur H. Virolactia in an Asymptomatic Mother with COVID-19. Breastfeed Med. 2020 Aug;15(8):488-491. doi: 10.1089/bfm.2020.0161. Epub 2020 Jul 1. PMID: 32614251.

Study 443 – No SARS-CoV-2 detected in colostrum

Seven women with SARS-CoV-2 positive tests at delivery gave samples of colostrum, which all tested negative (click here or bfm.2020.0183). From author affiliations the hospital was Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain, so they likely overlap with cases in studies 125, 151, 177, and 196. Citation: Marín Gabriel MÁ, Malalana Martínez AM, Marín Martínez ME, Anel Pedroche J. Negative Transmission of SARS-CoV-2 to Hand-Expressed Colostrum from SARS-CoV-2-Positive Mothers. Breastfeed Med. 2020 Aug;15(8):492-494. doi: 10.1089/bfm.2020.0183. Epub 2020 Jul 9. PMID: 32644841.

Study 442 – 30 cases from China

30 pregnant women with Covid-19 treated in th Central Hospital of Wuhan grid.440160.7, China, from December 8, 2019 to April 1, 2020 are reported (click here or ijgo.13265). They overlap with those in study 39 and many other Wuhan series. Citation: Wang Z, Wang Z, Xiong G. Clinical characteristics and laboratory results of pregnant women with COVID-19 in Wuhan, China. Int J Gynaecol Obstet. 2020 Sep;150(3):312-317. doi: 10.1002/ijgo.13265. Epub 2020 Jul 3. PMID: 32510581; PMCID: PMC7496890.

Study 441 – 69 cases from India

69 women with SARS-CoV-2 had one abortion and four stillbirths (click here or Anand2020_Article_ClinicalProfileViralLoadManage). Of 65 live births, 7 neonates tested positive. There were two neonatal deaths both of whom tested negative. Two mothers died. From author affiliations they were cared for at Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, which has not previously reported cases. Citation: Anand P, Yadav A, Debata P, Bachani S, Gupta N, Gera R. Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India. Eur J Pediatr. 2020 Sep 10:1–13. doi: 10.1007/s00431-020-03800-7. Epub ahead of print. PMID: 32910210; PMCID: PMC7482055.

Study 440 – Mother and obstetrician deaths in Nigeria

This predominantly opinion piece mentions a mother who died of Covid-19 in Lagos State University Teaching Hospital, who has not been reported elsewhere (click here or ijgo.13325). The article also refers to a newspaper report of an obstetrician who died of Covid-19 having been infected in his private clinic (added as report 274 here). Citation: Ijarotimi OA, Ubom AE, Olofinbiyi BA, Kuye-Kuku T, Orji EO, Ikimalo JI. COVID-19 and obstetric practice: A critical review of the Nigerian situation. Int J Gynaecol Obstet. 2020 Jul 22. doi: 10.1002/ijgo.13325. Epub ahead of print. PMID: 32698245.

Study 439 – One case from China

One pregnant woman in this series (click here or ijmsv17p2187). No further details. Hunan province is adjacent to Hubei province which contains the City of Wuhan. The authors are affiliated with hospitals in Changsha, Chenzhou, Loudi and Yiyang, all cities in Hunan. No previous cases have been reported from this province. Citation: Tao PY, Leng L, Liu K, Zhou RH, Hu YC, Wu SJ, Xiao YD, Liu J. Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients. Int J Med Sci. 2020 Aug 6;17(14):2187-2193. doi: 10.7150/ijms.47576. PMID: 32922180; PMCID: PMC7484673.

Study 438 – Maternal death in Turkey

A 22 year old woman died from Covid-19 at 32 weeks (click here or 42399_2020_Article_508). The baby, delivered by Caesarean, tested negative and survived. The mother had been treated with extra-corporal cytokine hemoadsorption therapy to remove inflammatory cytokines from the circulation. From author affliations she was cared for in Uşak Training and Research Hospital, Uşak,  which has not previously reported cases. Citation: Karabulut Keklik ES, Dal H, Bozok Ş. Cytokine Hemoadsorption in the Management of a Pregnant Woman with COVID-19 Pneumonia: Case Report [published online ahead of print, 2020 Sep 16]. SN Compr Clin Med. 2020;1-5. doi:10.1007/s42399-020-00508-5

4th December – studies 434 to 437 added

Study 437 – Case report from USA

A woman with Covid-19 at 34 weeks was delivered by emergency Caesarean for an abnormal CTG trace (click here or e625.full). The baby tested negative. From author affiliations the hospital was part of the NorthShore University Health System, Evanston, Illinois, which has not previously reported cases. Citation: Suresh SC, MacGregor CA, Ouyang DW. Urgent Cesarean Delivery Following Nonstress Test in a Patient with COVID-19 and Pregestational Diabetes. Neoreviews. 2020 Sep;21(9):e625-e630. doi: 10.1542/neo.21-9-e625. PMID: 32873658.

Study 436 – Case report from Korea

On March 6, 2020, a 28-year old woman with Covid-19 gave birth to a girl by Caesarean in Daegu Fatima Hospital at 37 weeks (click here or cep-2020-00850). This is probably the same patient as reported in study 22. Citation: Lee EK, Kim WD, Lee DW, Lee SA. Management of the first newborn delivered by a mother with COVID-19 in South Korea. Clin Exp Pediatr. 2020;63(9):373-375. doi:10.3345/cep.2020.00850

Study 435 – 2 patients delivered in a burns unit in Jordan

Two women with mild Covid-19 (but no burns) were delivered by caesarean section in a burns facility (click here or Altal2020_Article_PreparingTheBurnsUnitToAccommo). Neither baby was infected. All recovered. The hospital was King Abdullah University Hospital in Irbid, which may also be where the patient in study 153 delivered. The clinical features suggest that one of these cases is also that case.  Citation: Altal O, Bani Hani D, Aleshawi A, Alhowary AA, Obeidat B, Bani-Ata M. Preparing the Burns Unit to Accommodate Vaginal Delivery and Cesarean Section for Pregnant Women with COVID-19: A Successful Experience from Jordan. Adv Ther. 2020 Oct;37(10):4049-4053. doi: 10.1007/s12325-020-01457-0. Epub 2020 Aug 27. PMID: 32852673; PMCID: PMC7450677.

Study 434 – 242 women and 248 babies from Spain

This series from the Spanish Neo-COVID-19 Research Group seems to describe the same patients as those reported in study 390 (click here or Maternal,_Perinatal_and_Neonatal_Outcomes_With.2). There is also probably overlap with those in study 264b. Citation: Marín Gabriel MA, Reyne Vergeli M, Caserío Carbonero S, Sole L, Carrizosa Molina T, Rivero Calle I, Cuadrado Pérez I, Álvarez Fernández B, Forti Buratti A, Fernández-Cañadas Morillo A; Neo-COVID-19 Research Group. Maternal, Perinatal and Neonatal Outcomes With COVID-19: A Multicenter Study of 242 Pregnancies and Their 248 Infant Newborns During Their First Month of Life. Pediatr Infect Dis J. 2020 Dec;39(12):e393-e397. doi: 10.1097/INF.0000000000002902. PMID: 32947599.

3rd December – studies 428 to 433 added

Study 433 – pregnant woman with Covid-19 recovering after ECMO, China

A woman with Covid-19 at 35 weeks was ventilated, delivered by Caesarean, and treated with ECMO (click here or PIIS0147956320303599). She survived. The baby outcome is not reported in the present paper. She was cared for in Zhongshan People’s Hospital grid.476868.3, Zhongshan. It seems likely that this is the same case as reported in studies 3, 57, 81 and 192. In those papers the baby is reported to have died. The present paper cites none of those papers. Citation: Hou, Liusheng et al. First successful treatment of a COVID-19 pregnant woman with severe ARDS by combining early mechanical ventilation and ECMO. Heart & Lung: The Journal of Cardiopulmonary and Acute Care, Volume 0, Issue 0 https://doi.org/10.1016/j.hrtlng.2020.08.015 0147-9563

Study 432 – case report from Pakistan

A woman with Covid-19 was delivered by Caesarean (click here or JPAM_Vol_14_Issue2_p_1121-1123 (1)). The baby tested negative. Both recovered. She was cared for in Aziz Bhatti Shaheed Teaching Hospital in Gujrat, which has not previously reported cases. Citation: Tarar SH, Atta H, Khalid M, et al. A Case Report of Pregnant Lady having COVID-19 Delivered via Cesarean Section in Tertiary Care Hospital in Pakistan. J Pure Appl Microbiol. 2020;14(2):1121-1123. doi: 10.22207/JPAM.14.2.06

Study 431 – Case report from India

An asymptomatic woman who tested positive for SARS-CoV-2 was delivered by Caesarean at 38 weeks (click here or fmaa048). The asymptomatic baby was isolated and artificially fed, but tested positive at 48 hours. From author affiliations the hospital was S.N. Children Hospital, Prayagraj, Uttar Pradesh, which has not previously reported cases. Citation: Singh MV, Shrivastava A, Maurya M, Tripathi A, Sachan R, Siddiqui SA. Vertical Transmission of SARS-CoV-2 from an Asymptomatic Pregnant Woman in India. J Trop Pediatr. 2020 Sep 25:fmaa048. doi: 10.1093/tropej/fmaa048. Epub ahead of print. PMID: 32974677.

Study 430 – Screening in Italy

Of 333 pregnant women screened in four hospitals in Genoa, from April 1 to April 30, only one symptomatic patient (0.3%) and six asymptomatic ones (1.8%) tested positive (click here or JMV-9999-na). The hospitals were San Martino, G. Gaslini, Galliera and Villa Scassi – ASL3 Hospital, none of which have previously reported cases. Citation: Massarotti C, Adriano M, Cagnacci A, et al. Asymptomatic SARS-CoV-2 infections in pregnant patients in an Italian city during the complete lockdown [published online ahead of print, 2020 Aug 25]. J Med Virol. 2020;10.1002/jmv.26458. doi:10.1002/jmv.26458

Study 429 – Ovarian vein thrombosis and COVID‑19

A 26-year-old woman with Covid-19 at 8 weeks gestation also developed a right ovarian vein thrombosis  (click here or Mohammadi2020_Article_OvarianVeinThrombosisAfterCoro). The pregnancy outcome was not reported. She was cared for at Besat Hospital in Sanandaj, Iran, which has not previously reported cases. Citation: Mohammadi S, Abouzaripour M, Hesam Shariati N, Hesam Shariati MB. Ovarian vein thrombosis after coronavirus disease (COVID-19) infection in a pregnant woman: case report. J Thromb Thrombolysis. 2020 Oct;50(3):604-607. doi: 10.1007/s11239-020-02177-6. PMID: 32514763; PMCID: PMC7278233. 

Study 428 – Postnatal case from Italy

A 34-year-old pregnant woman gave birth on 9 August at the “Mater Dei” hospital, Bari, Apulia region, which has not previously reported cases (click here or main (6)). Both mother and baby contracted Covid-19 postnatally. Citation: Lenoci G, Galante D, Ceci E, et al. Sars-CoV-2 isolation from a 10-day-old newborn in Italy: A case report. IDCases. 2020;22:e00960. doi:10.1016/j.idcr.2020.e00960

2nd December – studies 419 to 427 added

Study 427 – 5 placentas from SARS-CoV-2 pregnancies

Five placentas from pregnancies positive for SARS-CoV-2 are described (click here or 511324). From author affiliations the pregnancies had been cared for at University Hospital Basel, Basel, Switzerland, which has not previously reported cases. Citation: Menter T, Mertz KD, Jiang S, Chen H, Monod C, Tzankov A, Waldvogel S, Schulzke SM, Hösli I, Bruder E. Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion. Pathobiology. 2020 Sep 18:1-9. doi: 10.1159/000511324. Epub ahead of print. PMID: 32950981; PMCID: PMC7573905.

Study 426 – Pregnancy, Covid-19 & sickle cell disease in Brazil

A pregnant woman with sickle cell disease contracted Covid-19 at 28 weeks gestation (click here or 2531-1379-htct-42-03-0212). She recovered and the pregnancy is ongoing. From author affiliations she was cared for in Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, which has not previously reported cases. Citation: JUSTINO, Caio Cesar et al. COVID-19 as a trigger of acute chest syndrome in a pregnant woman with sickle cell anemia. Hematol., Transfus. Cell Ther. [online]. 2020, vol.42, n.3 [cited 2020-12-02], pp.212-214. Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2531-13792020000300212&lng=en&nrm=iso&gt;. Epub Sep 18, 2020. ISSN 2531-1387. https://doi.org/10.1016/j.htct.2020.06.003.

Study 425 – Pregnant health care workers with Covid in Mexico

Of 11,226 health-care workers with Covid-19 living in Mexico city, 38 (0.34%) were pregnant, compared with 49/23,869 (0.21%) of HCWs without Covid-19 (click here or ciaa1487). Citation: Antonio-Villa NE, Bello-Chavolla OY, Vargas-Vázquez A, Fermín-Martínez CA, Márquez-Salinas A, Bahena-López JP. Health-care workers with COVID-19 living in Mexico City: clinical characterization and related outcomes. Clin Infect Dis. 2020 Sep 28:ciaa1487. doi: 10.1093/cid/ciaa1487. Epub ahead of print. PMID: 32986819; PMCID: PMC7543362.

Study 424 – Screening in Belgium

Of 221 pregnant women tested on admission to the obstetric ward, 10 (4.5%) were positive, of whom 4 had symptoms (click here or [16193997 – Journal of Perinatal Medicine] Testing of patients and coronavirus disease 2019 (COVID-19) infection before scheduled deliveries (1)). The hospital was Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. The cases may therefore overlap with those in studies 100 and 278, but likely not with those in studies 193 and 217. Citation: Yombi JC, De Greef J, Bernard P, Belkhir L. Testing of patients and coronavirus disease 2019 (COVID-19) infection before scheduled deliveries. J Perinat Med. 2020 Nov 26;48(9):995-996. doi: 10.1515/jpm-2020-0444. PMID: 32990649.

Study 423 – 111 cases from Wuhan, China

31 pregnant women admitted to Renmin Hospital of Wuhan University grid.412632.0 from January 15 to February 23 were compared with 80 non-pregnant women (click here or ofaa294). The cases may overlap with those in studies 6a, 10, 12, 36, 37, 40, 80, 183, 220 and 294. Citation: Biheng Cheng, Tao Jiang, Lu Zhang, Ruheng Hu, Jinhua Tian, Yan Jiang, Bo Huang, Jun Li, Min Wei, Jing Yang, Shengxiang Ren, Gaohua Wang, Clinical Characteristics of Pregnant Women With Coronavirus Disease 2019 in Wuhan, China, Open Forum Infectious Diseases, Volume 7, Issue 8, August 2020, ofaa294, https://doi.org/10.1093/ofid/ofaa294

Study 422 – Two mid-trimester cases from Wuhan, China

Two women contracted Covid-19 in the mid-trimester (click here or No evidence for vertical transmission of SARS CoV 2 in two neonates with mothers infected in the second trimester). The babies were unaffected. They were cared for in Wuhan No.1 Hospital grid.410609.a which appears to be separate from other Wuhan hospitals which have reported cases. Citation: Jing-yi Tang, Wen-qi Song, Hao Xu & Na Wang (2020) No evidence for vertical transmission of SARS-CoV-2 in two neonates with mothers infected in the second trimester, Infectious Diseases, 52:12, 913-916, DOI: 10.1080/23744235.2020.1798499

Study 421 – case report from Lima, Peru

An asymptomatic pregnant woman with SARS-CoV-2 antibodies, but PCR negative, delivered vaginally (click here or en_2304-5132-rgo-66-02-00008). From author affiliations the hospital was Delgado Clinic – AUNA, Lima, Peru, which has not previously reported cases.  Citation: Campodónico Olcese L, Paredes Salas JR, Campodónico Olcese D, Chang Vargas C, Acuña Barrueto L, Marchena Arias J. Management of eutocic delivery in a patient with COVID-19 in Lima, Peru. Rev Peru Ginecol Obstet: 2020;66(2) DOI: https://doi.org/10.31403/rpgo.v66i2251

Study 420 – 65 cases in Colombia

Of 946 pregnant women surveyed, between April 13 and May 18, in seven cities in Colombia, 65 had symptoms of Covid-19, 10 had required hospitalisation and 5 had tested positive. (click here or ijgo.13348). Citation: Parra‐Saavedra, M., Villa‐Villa, I., Pérez‐Olivo, J., Guzman‐Polania, L., Galvis‐Centurion, P., Cumplido‐Romero, Á., Santacruz‐Vargas, D., Rivera‐Moreno, E., Molina‐Giraldo, S., Guillen‐Burgos, H., Navarro, E., Flórez‐Lozano, K., Barrero‐Ortega, A., Sanz‐Cortes, M. and Miranda, J. (2020), Attitudes and collateral psychological effects of COVID‐19 in pregnant women in Colombia. Int J Gynecol Obstet, 151: 203-208. https://doi.org/10.1002/ijgo.13348

Study 419 – 31 cases from Pakistan

From 29th March to 9th May, 31/303  pregnant women tested positive for SARS-CoV-2 on admission in labour, of whom 29 had symptoms (click here or ANN_20_03_17). They were cared for in the Government Maternity Hospital, Gujrat, the Basic Health Unit, Fatehpur, Shaikh Zayed Hospital Lahore and DUHS Hospital Karachi, which have not previously reported cases.Citation: Ullah R, Memon FS, Anjum S. The alarming rate of COVID-19 among pregnant women in Pakistan. Anaesth. pain intensive care 2020;24(4):471-472. DOI: 10.35975/apic.v24i4.1325 

1st December update – studies 406 to 418 added

Study 418 – 86 cases from USA

Of 1,989 pregnant women screened for SARS-CoV-2, 86 (4.3%) tested positive (click here or An initiative to evaluate the safety of maternal bonding in patients with SARS CoV 2 infection). Rooming in, breastfeeding and neonatal infection are reported. The hospital was the University of Maryland School of Medicine, Baltimore. Apart from the single case in study 269 these are the first cases reported from that hospital. Citation: Liviu Cojocaru, Sarah Crimmins, Sripriya Sundararajan, Katherine Goetzinger, Emad Elsamadicy, Allison Lankford, Ozhan M. Turan & Sifa Turan (2020) An initiative to evaluate the safety of maternal bonding in patients with SARS-CoV-2 infection, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1828335. 

Study 417 – 8 pregnant women in ITU, Spain

Among 3,033 patients critically ill with Covid-19 in Vall dHebron University Hospital in Barcelona were eight pregnant women treated in intensive care (click here or 1-s2.0-S0213005X2030272X-main). All eight survived. They probably overlap with those in studies 140, 185 and 413. Citation: Ferrer R, Báguena M, Balcells J, Bañeras J, Biarnes A, de Nadal M, Gracia RM, Martinez J, Nuvials X, Riera J, Roca O, Ruiz-Rodriguez JC. Planning for the assistance of critically ill patients in a Pandemic Situation: The experience of Vall d’Hebron University Hospital. Enferm Infecc Microbiol Clin. 2020 Sep 8:S0213-005X(20)30272-X. English, Spanish. doi: 10.1016/j.eimc.2020.08.007. Epub ahead of print. PMID: 33010961.

Study 416 – Mother & newborn with Covid-19 from Mexico

A woman with severe Covid-19 at term required ventilation, and delivered a baby by Caesarean, who tested positive and had a clinical diagnosis of Covid-19 (click here or PIIS1201971220306846). Both mother and baby recovered. Both were treated at Hospital de Ginecología y Obstetricia, Instituto Materno Infantil del Estado de México, Toluca, which appears to be different from other hospitals reporting cases from that city in study 396, and has therefore probably not been previously reported. Citation: Hinojosa-Velasco A, de Oca PVB, García-Sosa LE, Mendoza-Durán JG, Pérez-Méndez MJ, Dávila-González E, Ramírez-Hernández DG, García-Mena J, Zárate-Segura P, Reyes-Ruiz JM, Bastida-González F. A case report of newborn infant with severe COVID-19 in Mexico: Detection of SARS-CoV-2 in human breast milk and stool. Int J Infect Dis. 2020 Nov;100:21-24. doi: 10.1016/j.ijid.2020.08.055. Epub 2020 Aug 27. PMID: 32860950; PMCID: PMC7449937.

Study 415 -388 pregnancies collected by WAPM

388 singleton pregnancies positive for Covid-19 from 73 centers in 22 countries collected by the World Association of Perinatal Medicine (click here or [16193997 – Journal of Perinatal Medicine] Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19)_ a secondary analysis of the WAPM study on COVID-19). These cases were also reported in studies 278 and 307. The centres are listed but not the number of cases per centre. Citation: Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med. 2020 Nov 26;48(9):950-958. doi: 10.1515/jpm-2020-0355. PMID: 32975205.

Study 414 – Low rate of symptomatic disease at birth

17/3,923 (0.43%) of pregnant women admitted to labor and delivery units in Kaiser Permanente Southern California (KPSC) hospitals between April 6 and May 11, who underwent SARSCoV-2 testing were positive (click here or s-0040-1714060). None had symptoms, although one woman developed a headache attributed to COVID-19 3 days postpartum. All babies tested negative. This is the first report from the Kaiser Permanante network. Citation: Fassett MJ, Lurvey LD, Yasumura L, Nguyen M, Colli JJ, Volodarskiy M, Gullett JC, Braun D, Fong A, Trivedi N, Bruxvoort K, Chiu V, Getahun D. Universal SARS-Cov-2 Screening in Women Admitted for Delivery in a Large Managed Care Organization. Am J Perinatol. 2020 Sep;37(11):1110-1114. doi: 10.1055/s-0040-1714060. Epub 2020 Jul 3. PMID: 32620022; PMCID: PMC7516390.

Study 413 – Two cases from Spain

Two women with severe Covid-19 requiring ventilation, one with twins, gave birth prematurely (click here or PIIS1875957220301455). All three babies tested negative and had an uneventful course. They were cared for in Vall d’Hebron University Hospital in Barcelona, so may overlap with studies 140, 185 and 196, as well as other Spanish registry studies. Citation: Fernandez-Garcia C, Montaner-Ramon A, Hernandez-Perez S, Camba-Longueira F, Ribes-Bautista C, Frick MA, Castillo-Salinas F. Severe COVID-19 during pregnancy and the subsequent premature delivery. Pediatr Neonatol. 2020 Sep 19:S1875-9572(20)30145-5. doi: 10.1016/j.pedneo.2020.09.005. Epub ahead of print. PMID: 33039313; PMCID: PMC7501516.

Study 412 – Abnormal bleeding at Caesarean in USA

A woman had abnormal bleeding at Caesarean, and subsequently tested positive for SARS-CoV-2 (click here or s12884-020-03140-2). From author affiliations she was cared for at Icahn School of Medicine at Mount Sinai West, New York, so might be included in studies 86, 119, and 131. Citation: Kinsey, K.E., Ganz, E., Khalil, S. et al. Intraoperative coagulopathy during cesarean section as an unsuspected initial presentation of COVID-19: a case report. BMC Pregnancy Childbirth 20, 481 (2020). https://doi.org/10.1186/s12884-020-03140-2

Study 411 – Eclampsia and Covid-19

A woman with eclampsia and cortical blindness at term who also tested positive for SARS-CoV-2 (click here or s12884-020-03275-2). She recovered. The baby outcome is not reported. She was cared for in the University Complex Hospital of Leon, which has not previously reported cases, but was included in other multicentre reports from Spain. Citation: Garcia Rodriguez A, Marcos Contreras S, Fernandez Manovel SM, Marcos Vidal JM, Diez Buron F, Fernandez Fernandez C, Riveira Gonzalez MDC. SARS-COV-2 infection during pregnancy, a risk factor for eclampsia or neurological manifestations of COVID-19? Case report. BMC Pregnancy Childbirth. 2020 Oct 6;20(1):587. doi: 10.1186/s12884-020-03275-2. PMID: 33023500; PMCID: PMC7538036.

Study 410 – Covid in a pregnant man with cystic fibrosis

A transgender man (genetically female, identifying as male) with cystic fibrosis contracted Covid-19 at 39 weeks gestation (click here or PIIS246804512030050X). The baby tested negative.  From author affiliations the patient was cared for in Sunshine Coast University Hospital, Queensland, Australia which has not previously reported cases. The case is likely to be the same as news report 220 (click here). Citation: Walczak A, Wilks K, Shakhovskoy R, Baird T, Schlebusch S, Taylor C, Reid D, Choong K. COVID-19 in a complex obstetric patient with cystic fibrosis. Infect Dis Health. 2020 Nov;25(4):239-241. doi: 10.1016/j.idh.2020.07.002. Epub 2020 Jul 23. PMID: 32763024; PMCID: PMC7379287.

Study 409 – Triplets from Iran

A woman with IVF triplets contracted Covid-19 and was delivered by Caesarean at 30 weeks (click here or IJN_Volume 11_Issue 3_Pages 120-122). She survived. The triplets all tested negative but two died of complications of prematurity. They were cared for in Arash Hospital, Tehran and appear to be the same triplets as case 5 in study 250. Citation: Farsi Z, Taheriderakhsh N, Bassirnia M, Ahmadi L, Shiva M, Yousefzadegan S. Coronavirus Disease-2019 Infection in Neonates of an Infected Pregnant Mother with Triplets. 2020 Sep: 11(3). DOI: 10.22038/ijn.2020.49218.1856

Study 408 – Post partum cardiomyopathy and Covid-19

A woman had experienced fever, cough, and altered sense of taste and smell a week before giving birth normally March 21(click here or echo.14873). On April 22 she developed cardiomyopathy and tested postive for SARS-CoV-2. She recovered. She was cared for in Luigi Sacco University Hospital, Milan, Italy, but it is not clear if she was included in the various Lombardy series. Citation: De Vita, S, Ippolito, S, Caracciolo, MM, Barosi, A. Peripartum cardiomyopathy in a COVID-19-infected woman: differential diagnosis with acute myocarditis—A case report from a Hub Institution during the COVID-19 outbreak. Echocardiography. 2020; 37: 1673– 1677. https://doi.org/10.1111/echo.14873

Study 407 – 26 cases from Quatar

There were 26 pregnant women with Covid-19 in this series (click here or s12879-020-05511-8). Two women miscarried, there were 10 live births and 14 pregnancies are ongoing. Cared for by Hamad Medical Corporation. Some cases are probably included in study 364. Citation: Omrani, A.S., Almaslamani, M.A., Daghfal, J. et al. The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study. BMC Infect Dis 20, 777 (2020). https://doi.org/10.1186/s12879-020-05511-8

Study 406 – 43 cases from China

These 43 cases from Tongji Hospital, grid.412793.a Wuhan, China, have surely been reported many times already (click here or pdf). Citation: Wei L, Gao X, Chen S, Zeng W, Wu J, Lin X, Zhang H, Mwamaka Sharifu L, Chen L, Feng L, Wang S. Clinical Characteristics and Outcomes of Childbearing-Age Women With COVID-19 in Wuhan: Retrospective, Single-Center Study. J Med Internet Res. 2020 Aug 24;22(8):e19642. doi: 10.2196/19642. PMID: 32750000; PMCID: PMC7446716.

30th November update – studies 397 to 405 added

Study 405 – 77 placentas from USA

The placental histology of 77 COVID-19 pregnancies are reported (click here or 1-s2.0-S0002937820311947-main). The patients were delivered at NYU Winthrop Hospital, New York so may have been included in studies 61 and 91. Citation: Patberg ET, Adams T, Rekawek P, Vahanian SA, Akerman M, Hernandez A, Rapkiewicz AV, Ragolia L, Sicuranza G, Chavez MR, Vintzileos AM, Khullar P. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol. 2020 Oct 19:S0002-9378(20)31194-7. doi: 10.1016/j.ajog.2020.10.020. Epub ahead of print. PMID: 33091406; PMCID: PMC7571377.

Study 404 – Case report from USA

A woman contracted Covid-19 at 38 weeks (click here or 9796-Article Text-55170-2-10-20200902). She had altered liver enzymes but recovered. The baby was not infected. From author affiliations she was probably cared for in St. John’s Episcopal Hospital, Far Rockaway, New York, which has not previously reported cases. Citation: Nkeih C, Sisti G, Schiattarella A. Elevated transaminases in a COVID-19 positive patient at term of gestation: a case report: Covid19 and pregnancy. Acta Bio Med [Internet]. 2020Sep.7 [cited 2020Nov.30];91(3):e2020002. https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9796

Study 402 – 9 cases from Nigeria

Nine pregnant women with COVID-19 gave birth at Lagos University Teaching Hospital (click here or ijgo.13436). Eight delivered by caesarean and there was one macerated stillbirth. This is the first series from this hospital although one case might be the same as in study 243. Citation: Banke‐Thomas, A., Makwe, C.C., Balogun, M., Afolabi, B.B., Alex‐Nwangwu, T.A. and Ameh, C.A. (2020), Utilization cost of maternity services for childbirth among pregnant women with coronavirus disease 2019 in Nigeria’s epicenter. Int J Gynecol Obstet. https://doi.org/10.1002/ijgo.13436

Study 401 – six cases from Mexico

Six women with Covid-19 underwent caesarean (click here or 1-s2.0-S2049080120303939-main). Two were admitted to ICU but no mothers or babies died. They were cared for in the General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City, so might be included in study 340. Citation: Dra Mariel González-Calatayud, Dr Benito Vargas-Ábrego, Dra Gabriela E. Gutiérrez-Uvalle, Dra Sandra C. López-Romero, Dr Luis Gabriel González-Pérez, Dr José Alberto Carranco-Martínez, Dr Jed Raful-Zacarías-Ezzat, Dr Noé I. Gracida-Mancilla. Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series, Annals of Medicine and Surgery, Volume 60, 2020, Pages 149-154, ISSN 2049-0801, https://doi.org/10.1016/j.amsu.2020.10.038.

Study 400 – six patients from Italy

Six women with Covid-19 and diabetes are reported (click here or ijgo.13434). They were cared for in Institution Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan,and therefore probably included in studies 64, 117, 163, 252, and 312. Citation: D’Ambrosi F, Rossi G, Soldavini CM, Maggi V, Cetera GE, Carbone IF, Di Martino D, Di Maso M, Ferrazzi E. Management of gestational diabetes in women with a concurrent Sars-Cov-2 infection, experience of a single center in Northern Italy. Int J Gynaecol Obstet. 2020 Oct 25. doi: 10.1002/ijgo.13434. Epub ahead of print. PMID: 33099770.

Study 399 – 95 cases from Turkey

95 pregnant women with Covid-19 (click here or jmv.26631). They were cared for at Turkish Ministry of Health Ankara City Hospital between May 11, and August 30, 2020.  They may have been included in studies 203, 223 and 244. Citation: Yazihan, N, Tanacan, A, Erol, SA, et al. Comparison of VEGF‐A values between pregnant women with COVID‐19 and healthy pregnancies and its association with composite adverse outcomes. J Med Virol. 2020; 1‐ 6. https://doi.org/10.1002/jmv.26631

Study 398 – Maternal death & twin pregnancy in Iran

A woman who had conceived twins via IVF, contracted Covid-19 at 28 weeks (click here or 30428-Article Text-131298-6-10-20201031). Mother and both twins died. She was cared for in Shohada-e-Tajrish Hospital, Tehran, which has not previously reported cases, and the clinical details differ from those in studies 23 and 218. Citation: Azizi FarsaniH, BehnazF, TeymourianH, MohseniG.Termination of Pregnancy in a Twin Pregnant Patient with COVID-19.J Cell Mol Anesth.2020;5(3):206-8.

Study 397 – Case Report from China

A woman with Covid-19 gave birth in Suzhou, by Caesarean at 30 weeks (click here or 13274-Article Text-114670-1-10-20201006). The baby was not infected. This may be the same case as study 257b. Citation: Xiaotong Wang, Zhiqiang Zhou, Jianping Zhang, Fengfeng Zhu, Yongyan Tang, Xinghua Shen, A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery, Clinical Infectious Diseases, Volume 71, Issue 15, 1 August 2020, Pages 844–846, https://doi.org/10.1093/cid/ciaa200

29th November update – studies 387 to 394 added

Study 396 – 20 pregnant women with Covid-19 from Mexico

Twenty pregnant or postnatal women with Covid-19 were treated at “Mónica Pretelini Sáenz” Maternal Perinatal Hospital, or “Dr. Nicolás San Juan” General Hospital, both in Toluca (click here or 13274-Article Text-114670-1-10-20201006). Two mothers died, and of the 15 pregnancies which had ended, there were three fetal loses due to: ectopic pregnancy, fetal death at 16 weeks of pregnancy and a postnatal death from prematurity complications. Neither of these hospitals has previously reported cases, although the maternal deaths may have been included in studies 66, 271 and 340.  Citation: Meneses Calderón J, Figueroa Flores M del R, Paniagua Coria L, Briones Garduño JC, Meneses Figueroa J, Vargas Contretas MJ, de la Cruz Ávila L, Díaz Meza S, Ramírez Chacón R, Padmanabhan S, Mendieta Zerón H (2020) Nitazoxanide against COVID-19 in three explorative scenarios. J Infect Dev Ctries 14:982-986. doi: 10.3855/jidc.13274

Study 395 – 48 cases from China

Maternal and neonatal details reported (click here or 10-1055-s-0040-1716505). The babies were cared for in Tongji Hospital grid.412793.a and HuangShi [?Huazhong] Maternal and Child Healthcare Hospital grid.412793.a, Wuhan, from January 17 to March 4, 2020 so the pregnancies have been reported before. Citation: Liu W, Cheng H, Wang J, et al. Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province. Am J Perinatol. 2020;37(13):1317-1323. doi:10.1055/s-0040-1716505

Study 394 – Infarction of a pituitary tumour and Covid-19 in pregnancy in USA

A woman with visual disturbance at 38 weeks tested positive for SARS-CoV-2 (click here or Chan2020_Article_PituitaryApoplexyAssociatedWit). She delivered vaginally and the baby tested negative. Two weeks later a presumed infarcted pituitary tumour was removed. From author affiliations she was cared for at Cedars-Sinai Medical Center, Los Angeles, and therefore might be included in study 121. Citation: Chan, J.L., Gregory, K.D., Smithson, S.S. et al. Pituitary apoplexy associated with acute COVID-19 infection and pregnancy. Pituitary 23, 716–720 (2020). https://doi.org/10.1007/s11102-020-01080-w

Study 393 – zero cases in pregnancy in a hospital in Slovenia

None of 202 pregnant women tested for SARS-CoV-2 in the Ljubljana Maternity Hospital between March 15 and May 16, 2020 were positive (click here or full text not available). Citation: Šterbenc, A., Premru Sršen, T., Lučovnik, M., Vidmar Šimic, M., Steblovnik, L., Fabjan Vodušek, V., Druškovič, M., Kavšek, G., Poljak, M., & Trojner Bregar, A. (2020). Usefulness of COVID-19 screen-and-test approach in pregnant women: an experience from a country with low COVID-19 burden, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200368. doi: https://doi.org/10.1515/jpm-2020-0368

Study 392 – two cases from USA

Two babies born to women with moderately severe Covid-19 are reported (click here or 10-1055-s-0040-1715180). From author affiliations the patients were cared for at Rutgers University, Robert Wood Johnson Medical School, New Brunswick, New Jersey. The mothers may therefore have been included in studies 86 and 285. Citation: Reddy A, Engelhardt K, Jain D. Air Leak Syndrome in Two Very Preterm Infants Born to Mothers with Coronavirus Disease 2019: An Association or a Coincidence?. AJP Rep. 2020;10(3):e266-e269. doi:10.1055/s-0040-1715180

Study 391 – 23 cases from USA

Of 23 pregnant women who tested positive for SARS-CoV-2, 13 had symptoms but none severe disease (click here or Dhuyvetter2020_Article_CoronavirusDisease2019InPregna). They were cared for at John H Stroger Hospital in Chicago, Illinois which has not previously reported cases. Citation: Dhuyvetter, A., Cejtin, H.E., Adam, M. et al. Coronavirus Disease 2019 in Pregnancy: The Experience at an Urban Safety Net Hospital. J Community Health (2020). https://doi.org/10.1007/s10900-020-00940-7

Study 390 – 248 infants from Spain

Breastfeeding rates among 242 mothers with Covid-19 and 248 live newborn infants (click here or PIIS0301211520306400). The infants were born in 15 Spanish hospitals, who were members of the Neo-COVID-19 research group, between 13 March and 31 May, and therefore probably overlap with those in studies 264b and 366. Citation: del Río R, Dip Pérez E, Marín Gabriel MÁ; the Neo-COVID-19 Research Group. Multi-centre study showed reduced compliance with the World Health Organization recommendations on exclusive breastfeeding during COVID-19. Acta Paediatr. 2020;00:1–2. https://doi.org/10.1111/apa.15642

Study 389 – Forceps birth in the ITU in USA

A woman with severe Covid-19 who had already required 5 days ventilation was induced and delivered vaginally by forceps at 33 weeks in the ITU (click here or Induction_of_Labor_in_an_Intubated_Patient_With.15). The perineum was intact. The baby tested negative. The mother required a further 4 days ventilation but recovered. From author affiliations she was cared for at Legacy Salmon Creek Hospital, Vancouver, Washington State, which has not previosly reported cases. Citation: Slayton-Milam, Suzanne MD; Sheffels, Samantha BS; Chan, Dominic PharmD, BCPS (AQ-ID); Alkinj, Bashar MD Induction of Labor in an Intubated Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: November 2020 – Volume 136 – Issue 5 – p 962-964 doi: 10.1097/AOG.0000000000004044

Study 388 – case report from USA

A woman with severe Covid-19 at 22 weeks (click here or Tocilizumab_and_Remdesivir_in_a_Pregnant_Patient.25). She recovered and the pregnancy is ongoing. From author affiliations she was cared for at Cedars Sinai Medical Center, Los Angeles, California, and therefore might be included in study 121. Citation: Naqvi, Mariam MD; Zakowski, Phillip MD; Glucksman, Lindsey MD; Smithson, Sarah DO, MS; Burwick, Richard M. MD, MPH Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: November 2020 – Volume 136 – Issue 5 – p 1025-1029 doi: 10.1097/AOG.0000000000004050

Study 387 – 22 cases from USA

Outpatient care of 22 pregnant women with Covid-19 (click here or main (5)). They were cared for at Beth Israel Deaconess Medical Center, Massachusetts, so may have been included in studies 129 and 231. Citation: Reforma LG, Duffy C, Collier AY, et al. A multidisciplinary telemedicine model for management of coronavirus disease 2019 (COVID-19) in obstetrical patients. Am J Obstet Gynecol MFM. 2020;2(4):100180. doi:10.1016/j.ajogmf.2020.100180

28th November update – studies 379 to 386 added

Study 386 – Case from Greece

A patient with mild Covid-19 at term gave birth by Caesarean (click here or JAnaesthClinPharmacol365121-6656644_182926). The authors state this was the first case in this country. From their affiliations the hospital was “Attikon” University Hospital, Athens. Citation: Batistaki C, Galarioti V, Vasiliadou S, Soulioti E, Kostopanagiotou G, Matsota P. Lessons learned from first case of Cesarean delivery in a COVID-19 positive parturient in Greek region. J Anaesthesiol Clin Pharmacol. 2020;36(Suppl 1):S121-S124. doi:10.4103/joacp.JOACP_157_20

Study 385 – Case from India

A pregnant woman had mild Covid-19 at 37 weeks (click here or JAnaesthClinPharmacol36577-6694834_183548). She was delivered by Caesarean under spinal anaesthesia. The baby tested negative. From author affiliations the hospital was Gian Sagar Medical College and Hospital, Banur, Patiala. Citation: Bajwa SJS, Gupta R, Wahi A, Goraya SPS. Exploring the unknown territories in the new normal world of COVID. J Anaesthesiol Clin Pharmacol. 2020;36(Suppl 1):S77-S80. doi:10.4103/joacp.JOACP_350_20

Study 384 – Seroconversion among maternity workers in London

In two London hospitals 29/200 (15%) of obstetric healthcare professionals seroconverted between 11 May 2020 and 5 June 2020 (click here or anae.15229). From author affiliations the hospitals were probably University College London Hospitals NHS Foundation Trust, and Northwick Park Hospital. Citation: Bampoe, S., Lucas, D.N., Neall, G., Sceales, P., Aggarwal, R., Caulfield, K., Siassakos, D. and Odor, P.M. (2020), A cross‐sectional study of immune seroconversion to SARS‐CoV‐2 in frontline maternity health professionals. Anaesthesia, 75: 1614-1619. https://doi.org/10.1111/anae.15229

Study 383 – Follow up of 138 cases from China

This important study reports three month follow-up of 72/138 pregnant women with Covid-19 collected by the National Epidemic Reporting System (NERS) in China (click here or s12916-020-01825-1). All 13 first trimester cases were aborted. In supplementary table 1 (click here or 12916_2020_1825_MOESM1_ESM) it appears that one of the 138 original mothers died; the first report of a maternal death from Covid-19 in China. The cases overlap with those in study 55 and other Chinese reports. Citation: Wang, Y., Chen, L., Wu, T. et al. Impact of Covid-19 in pregnancy on mother’s psychological status and infant’s neurobehavioral development: a longitudinal cohort study in China. BMC Med18, 347 (2020). https://doi.org/10.1186/s12916-020-01825-1

Study 382 – 64 cases from Turkey

Of 64 pregnant women with suspected Covid-19, 33 tested positive (click here or PCR positivity and D-dimer levels in pregnant women with COVID-19). Limited clinical information is presented, but one woman underwent thoracotomy. From author affiliation they were cared for in Kocaeli Derince Training and Research Hospital, Kocaeli, so some may have been included in study 244. Citation: K. Uzel, I. Lakhno. PCR positivity and D-dimer levels in pregnant women with COVID-19. Clin. Exp. Obstet. Gynecol. - ISSN: 0390-6663 XLVII, n. 5, 2020. doi: 10.31083/j.ceog.2020.05.2229

Study 381 – 111 patients with suspected COVID-19 in Spain

In this paper 68 pregnant women who tested positive were compared with 43 who tested negative (click here or jcm-09-03552-v2). The negative group included nine women with both symptoms and radiological findings of pneumonia, one of whom later developed anti SARS-CoV-2 antibodies. The women were cared for in University Hospital Gregorio Marañón, Madrid. They probably overlap with those reported in study 151 and possibly 196. Citation: Cuñarro-López, Y.; Cano-Valderrama, Ó.; Pintado-Recarte, P.; Cueto-Hernández, I.; González-Garzón, B.; García-Tizón, S.; Bujan, J.; Asúnsolo, Á.; Ortega, M.A.; De León-Luis, J.A. Maternal and Perinatal Outcomes in Patients with Suspected COVID-19 and Their Relationship with a Negative RT-PCR Result. J. Clin. Med. 2020, 9, 3552.

Study 380 – 66 cases from Pakistan

66 women who tested positive for SARS-CoV-2 in pregnancy between 27th April and 16th June 2020, were mostly asymptomatic (click here or Bulletin_pdf). No babies were infected. From author affililiations they were cared for at the Indus Hospital, Karachi, which has not previously reported cases. These may be the first reported cases from this country. Citation: Khan M.A., Kumar V., Ali S.R. Vertical Transmission of Novel Coronavirus (COVID-19) from Mother to Newborn: Experience from a Maternity Unit, The Indus Hospital, Karachi. Journal of the College of Physicians and Surgeons–Pakistan : JCPSP. 30 (10) (pp 136), 2020. Date of Publication: 01 Oct 2020.

Study 379 – 34 cases from China

These 34 cases (click here or ofaa283) cared for in Union Hospital Wuhan (grid.412839.5) between January 15 & March 15, 2020, likely overlap with those in  studies 2a, 2b, 2c, 5*, and 6). Citation: Xu S, Shao F, Bao B, et al. Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. Open Forum Infect Dis. 2020;7(7):ofaa283. Published 2020 Jul 5. doi:10.1093/ofid/ofaa283

27th November update – studies 373 to 378 added

Study 378 – Zero pregnancy cases in one prefecture, Japan

805 pregnant women (half of all women giving birth in the region) were tested for SARS-CoV-2 in Fukui prefecture, Japan between April 24 to July 25, 2020 (click here or jog.14567). All tested negative, and later checking against case notifications of COVID‐19, revealed no missed cases. Fukui had a SARS-CoV-2 prevalence of 16.5/100.000 during this period. Citation: Orisaka, M., Kawamura, H. and Yoshida, Y. (2020), COVID‐19 testing of pregnant women in Japan. J. Obstet. Gynaecol. Res.. https://doi.org/10.1111/jog.14567

Study 377 – Co-infection with rhinovirus & SARS-CoV-2 in pregnancy

A woman was infected with both SARS-CoV-2 and Rhinovirus/Enterovirus at 31 weeks gestation (click here or 21928959 – Case Reports in Perinatal Medicine] A case report of co-infection with rhinovirus and SARS-CoV-2 in pregnancy). She had mild symptoms but recovered and the pregnancy is ongoing. The authors are affiliatated with Renaissance School of Medicine Stony Brook University, Stony Brook, New York, USA, which has not previously reported cases. Citation: Heiselman, C. J., Iovino, N., & Herrera, K. M. (2020). A case report of co-infection with rhinovirus and SARS-CoV-2 in pregnancy, Case Reports in Perinatal Medicine, 9(1), 20200028. doi: https://doi.org/10.1515/crpm-2020-0028

Study 376 – Infected baby from USA

A woman contracted Covid-19 at 36 weeks and was delivered by Caesarean (click here or piaa109). The baby was asymptomatic but tested positive. The baby was born at Presbyterian Brooklyn Methodist Hospital in New York and therefore may be included in study 230. Citation: Ihab Alamar, Mohammad H Abu-Arja, Taryn Heyman, Drucilla J Roberts, Niyati Desai, Pramod Narula, Beata Dygulska, A Possible Case of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Newborn With Positive Placental In Situ Hybridization of SARS-CoV-2 RNA, Journal of the Pediatric Infectious Diseases Society, Volume 9, Issue 5, November 2020, Pages 636–639, https://doi.org/10.1093/jpids/piaa109

Study 375 – 50 cases from Iran

Of 50 pregnant women hospitalised with Covid-19 in Hamadan (alt. spelling Hamedan) Province, 2 mothers died, 7 babies were infected and 26 women remain undelivered (click here or jrhs-20-e00488). The recruitment period was January 6, 2020 to June 21, 2020. The hospitals are unnamed and cannot be guessed at from author affliliations. Hamadan province is remote from Tehran, Ilam, Tabriz, and Sari from which most Iranian reports of maternal disease have come. However, study 250 included some infected babies from Hamadan province, and the two maternal deaths may have been included in studies 23 and 67. Citation: Sattari M, Bashirian S, Masoumi SZ, Shayan A, Jenabi E, Ghelichkhani S, Ali Shirzadeh A, Jalili E, Alimohammadi S. Evaluating Clinical Course and Risk Factors of Infection and Demographic Characteristics of Pregnant Women with COVID-19 in Hamadan Province, West of Iran. J Res Health Sci. 2020; 20(3): e00488.

Study 374 – 44 advice calls to a teratology service in Italy

This report describes 44 advice calls to a teratology service in Bergamo in Lombardy concerning drug prescription to 16 pregnant or lactating women with suspected, and 28 with confirmed, Covid-19 (click here or [16193997 – Journal of Perinatal Medicine] Medications prescriptions in COVID-19 pregnant and lactating women_ the Bergamo Teratology Information Service experience during COVID-19 outbreak in Italy). Citation: Giampreti, A., Eleftheriou, G., Gallo, M., Butera, R., Contessa, G., Faraoni, L., Sangiovanni, A., Negri, G., Falchi, G., & Bacis, G. (2020). Medications prescriptions in COVID-19 pregnant and lactating women: the Bergamo Teratology Information Service experience during COVID-19 outbreak in Italy, Journal of Perinatal Medicine, 48(9), 1001-1007. doi: https://doi.org/10.1515/jpm-2020-0339

Study 373 – Case report from the Netherlands

A woman contracted severe Covid-19 at 23 weeks requiring prolonged ventilation and Caesarean delivery at 28 weeks (click here or main (2)). The mother survived. The baby suffered complications of prematurity but was not infected and survived. From author affiliations she was cared for at Leiden University Medical Center. Apart from NethOSS reports, the case has not been previously reported. The centre and clinical features differ from the case in study 263. Citation: du Fossé NA, Bronsgeest K, Arbous MS, et al. Detailed immune monitoring of a pregnant woman with critical Covid-19 [published online ahead of print, 2020 Oct 29]. J Reprod Immunol. 2020;143:103243. doi:10.1016/j.jri.2020.103243

26th November update – studies 368 to 372 added

Study 372 – A case of thyroiditis following post-partum Covid-19 in Japan

A woman contracted Covid-19, 103 days after giving birth, and 33 days later was diagnosed with thyroiditis (click here or advpub_EJ20-0553). From author affililiations the thyroiditis was treated at Wakayama Medical University, Wakayama. Citation: Mizuno S, Inaba H, Kobayashi KI, Kubo K, Ito S, Hirobata T, Inoue G, Akamizu T, Komiya N. A case of postpartum thyroiditis following SARS-CoV-2 infection. Endocr J. 2020 Nov 12. doi: 10.1507/endocrj.EJ20-0553. Epub ahead of print. PMID: 33177251.

Study 371 – 40 cases in USA

Of 40 pregnant women with SARS-CoV-2 cared for in the Nuvance healthcare system, 3/4 had symptoms and 25 delivered (click here or full text not accessed). Of 20 neonates tested for SARS-CoV-2 all were negative. Nuvance maternity hospitals include Vassar Brothers, and Norwalk hospitals, in New York State and Connecticut, neither of which have previously reported cases. Citation: Ogamba, I., Kliss, A., Rainville, N., Chuang, L., Panarelli, E., Petrini, J., & Zilberman, D. (2020). Initial review of pregnancy and neonatal outcomes of pregnant women with COVID-19 infection, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200446. doi: https://doi.org/10.1515/jpm-2020-0446

Study 370 – A postnatal woman treated with ECMO in Japan

A woman with Covid-19 at 36 weeks gestation was delivered by Caesarean (click here or amjcaserep-21-e927521). The baby tested negative but the mother’s condition deteriorated, necessitating ventilation and later ECMO. She recovered. She was delivered in an unnamed general hospital in Tokyo, and from author affiliations the postnatal intensive care probably took place at Tokyo Medical and Dental University Hospital, Tokyo. These, and the clinical features, suggest she has not been included in previous series from Japan. Citation: Takayama W, Endo A, Yoshii J, et al. Severe COVID-19 Pneumonia in a 30-Year-Old Woman in the 36th Week of Pregnancy Treated with Postpartum Extracorporeal Membrane Oxygenation. Am J Case Rep. 2020;21:e927521. Published 2020 Oct 28. doi:10.12659/AJCR.927521

Study 369 – 3 pregnant women with Covid-19 & malaria, and one with dengue from India

All four survived although one of the women with malaria experienced an intrauterine fetal death at 24 weeks (click here or ijgo.13415). They were cared for in Nair hospital in Mumbai, so may have been included in studies 225 & 283. Citation: Mahajan, N.N., Kesarwani, S.N., Shinde, S.S., Nayak, A., Modi, D.N., Mahale, S.D. and Gajbhiye, R.K. (2020), Co‐infection of malaria and dengue in pregnant women with SARS‐CoV‐2. Int. J. Gynecol. Obstet., 151: 459-462. https://doi.org/10.1002/ijgo.13415

Study 368 – Covid-19 in a pregnant renal transplant recipient

A woman who was 30 weeks pregnant with a renal transplant contracted Covid-19 (click here or 40620_2020_Article_897). She recovered and gave birth normally at term. The baby was not tested. From author affiliations she was probably cared for at Queen Charlottes & Chelsea Hospital in London, UK, which has not previously reported cases.  Citation: Gleeson S, Noori M, Lightstone L, Webster P. Lesson for the clinical nephrologist: Kidney transplant, COVID-19 and pregnancy [published online ahead of print, 2020 Nov 12]. J Nephrol. 2020;1-3. doi:10.1007/s40620-020-00897-9

25 November update – studies 362 to 367 added

Study 367 – Two cases from Italy

Santo Stefano Hospital in Prato, in Tuscany treated two cases of Covid-19 in pregnancy (click here or Cavaliere) and has not previously reported cases. Citation: A. F. Cavaliere, P. L. Vasarri, E. Scatena, A. Vidiri, M. S. Santicchia, I. Bordoni Vicini, M. Gardelli, F. Bressan, D. Matarrese, F. Perelli. SARS-CoV2 containment during pregnancy: single Center experience and the unique Chinese reality in Prato. Italian Journal of Gynæcology & Obstetrics September 2020 – Vol.32 – N. 3 – Quarterly – ISSN 2385 – 0868 

Study 366 – 403 cases from Spain

These 403 cases of Covid-19 in pregnancy were divided into 231 with early cord clamping and 172 with delayed (click here or 1471-0528.16597). Two and three infants respectively tested positive. The cases were selected from the Spanish Registry of COVID-19 which collects cases from 100 Spanish hospitals. Citation: Mejía Jiménez, I., Salvador López, R., García Rosas, E., de la Torre, I.R., Montes García, J., de la Cruz Conty, M.L., Martínez Pérez, O. and (2020), Umbilical cord clamping and skin‐to‐skin contact in deliveries from women positive for SARS‐CoV‐2: a prospective observational study. BJOG: An International Journal of Obstetrics & Gynaecology. Accepted Author Manuscript. https://doi.org/10.1111/1471-0528.16597

Study 365 – 3 cases from UK

Three pregnant women were included in this series from Southampton General Hospital, UK (click here or 1-s2.0-S0163445320306381-main). No further details are given. Citation: N.J. Brendish, S. Poole, V.V. Naidu et al., Clinical characteristics, symptoms and outcomes of 1054 adults presenting to hospital with suspected COVID-19: A comparison of patients with and without SARS-CoV-2 infection, Journal of Infection, https://doi.org/10.1016/j.jinf.2020.09.033

Study 364 – 678 cases from Qatar

There were 678 pregnant women testing positive for SARS-CoV-2 in this preprint (click here or main (1)). These are the first pregnant cases reported from Quatar. Citation: Ehab Hamed, Ahmed Sameer Alnuaimi, Mohamed Ahmed Syed, Mohamed Abd Elhamid , Saad Thamer Sedeeq , Bayan Alemrayat , Amina Ali Mohamed Muktar, AlAnoud Saleh AlFehaidi , Hamda Abdulla A/Qotba, Clinical characteristics of 51815 patients presenting with positive and negative SARS-CoV-2 swab results in primary health care settings, Journal of Infection (2020), doi: https://doi.org/10.1016/j.jinf.2020.11.014. Final published version(click here or PIIS016344532030709X)

Study 363 – A maternal death from Birmingham UK

A woman with Covid-19 in pregnancy was ventilated and transferred elsewhere for ECMO but died (click here). Full text not available, so it is not yet clear if the case has been reported elsewhere. Citation: Stout A, Crichton R, Tahmasebi F. Maternal death secondary to COVID-19 infection: A case report and review of the literature. Obstetric Medicine. November 2020. doi:10.1177/1753495X20970816

Study 362 – Case report from USA

A case of severe COVID-19 pneumonia in a periviable pregnancy treated with concurrent combination of remdesivir, corticosteroids, and convalescent plasma therapy, leading to rapid maternal pulmonary improvement (click here or ). Full text not yet obtained. From author affiliation cared for at St. Mary’s Hospital-St. Louis, Missouri, which has not previously reported cases. Citation: Lam H., Lacasse A.  Combination of remdesivir, corticosteroid, and convalescent plasma for severe COVID-19 in periviable pregnancy. Infectious Diseases in Clinical Practice. 28 (6) (pp e21-e23), 2020. Date of Publication: 01 Nov 2020.

24th November update – studies 359 to 361 added

Study 361 – 252 cases from Texas

252 pregnant women who tested positive for SARS-CoV-2 were compared with 3,122 who tested negative (click here or adhikari_2020_oi_200933_1605126584.8159). There was no difference in a primary composite outcome of birth <37 weeks, severe pre-eclampsia, or cesarean for abnormal fetal heart rate. There were no maternal deaths in either group. No babies died in the SARS-CoV-2 group. Women were cared for at Parkland Health and Hospital System, Dallas. Citation: Adhikari EH, Moreno W, Zofkie AC, et al. Pregnancy Outcomes Among Women With and Without Severe Acute Respiratory Syndrome Coronavirus 2 Infection. JAMA Netw Open. 2020;3(11):e2029256. doi:10.1001/jamanetworkopen.2020.29256

Study 360 – 21 cases from Israel

21 women with Covid-19 all gave birth to healthy babies, one of whom tested positive (click here or Lopian PedNeo). They were cared for in Mayanei Hayeshua Medical Center in Bnei Brak, between March 23, 2020, and May 8, 2020. This centre has not previously reported cases. Citation: Lopian M et al., Safety of vaginal delivery in women infected with COVID-19, Pediatrics and Neonatology, https://doi.org/10.1016/j.pedneo.2020.10.010

Study 359 – 39 severe cases from US 

In this case control study, 39 pregnant women with severe or critical Covid-19 were compared with 94 non-pregnant women (click here or DeBolt AJOG). They were cared for in four academic medical centers in New York and one in Philadelphia. Some or all of the pregnant women have probably been previously reported in studies 85, 86, 91, 98, 152, 160, 175 and 350. Citation: DeBolt CA, Bianco A, Limaye MA, Silverstein J, Penfield CA, Roman AS, Rosenberg HM, Ferrara L, Lambert C, Khoury R, Bernstein PS, Burd J, Berghella V, Kaplowitz E, Overbey JR, Stone J, Pregnant women with severe or critical COVID-19 have increased composite morbidity compared to non-pregnant matched controls, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.11.022.

23rd November update – studies 357 and 358 added

Study 358 – A case from Brazil

A woman contracted severe Covid-19 at 27 weeks gestation, the fetus died in utero, was delivered by Caesarean section and tested positive (click here). The mother required ventilation but recovered. From author affiliations she was cared for in Hospital de Clínicas da Universidade Federal do Paraná, Parana. Citation: Stonoga ETS, Lanzoni LA, Rebutini PZ, Olveira ALP, Chiste JA, Fugaça CA, et al. Intrauterine transmission of SARS-CoV-2. Emerg Infect Dis. 2021 Feb [date cited]. https://doi.org/10.3201/eid2702.203824

Study 357 – A case from China

Among 67 cases of COVID-19 in Wenzhou, one was in a pregnant woman (click here or s12879-020-05528-z). No details are given of her, but all patients survived. They were cared for in Ruian People’s Hospital grid.452885.6 which has not previously reported cases. Citation: Hong, L., Ye, E., Sun, G. et al. Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, China. BMC Infect Dis 20, 841 (2020). https://doi.org/10.1186/s12879-020-05528-z

22nd November update – studies 353 to 356 added

Study 356 – 15 women from Italy

Among 15 pregnant women with SARS-CoV-2 none delivered infected infants (click here or fped-08-565522). They were cared for at City Hospital in Piacenza from late February through May 15, 2020. Although just outside Lombardy they have probably been reported in studies 32, 64 and 117. Citation: Biasucci G, Cannalire G, Raymond A, Capra ME, Benenati B, Vadacca G, Schiavo R, Pavesi C, Bonini R. Safe Perinatal Management of Neonates Born to SARS-CoV-2 Positive Mothers at the Epicenter of the Italian Epidemic. Front Pediatr. 2020 Oct 29;8:565522. doi: 10.3389/fped.2020.565522. PMID: 33194893; PMCID: PMC7658585.

Study 355 – Two cases from Northwestern China

Among 617 COVID-19 patients in this region, over 1,000km from Wuhan, two were pregnant, and one gave birth to a healthy baby at term. The outcome of the other was not reported. The exact location of neither was reported. Citation: Zhu J, Zhang Q, Jia C, et al. Epidemiological Characteristics and Clinical Outcomes of Coronavirus Disease Patients in Northwest China: High-Volume Research From Low Population Density Regions. Front Med (Lausanne). 2020;7:564250. Published 2020 Oct 30. doi:10.3389/fmed.2020.564250

Study 354 –  First trimester case from France

A woman with an ivf pregnancy contracted Covid-19 at 7 weeks (click here or s12879-020-05551-0). Prior to the diagnosis she had been treated with estradiol, progesterone, corticosteroids, chloroquine, aspirin & heparin. Liver enzymes were raised. She recovered. The pregnancy was ongoing at the time of the report. From author affiliations she was cared for at Hôpital Privé de Parly 2, Le Chesnay, Paris. Citation: Lamazou, F., Oger, P., Dieli-crimi, R. et al. COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report. BMC Infect Dis 20, 845 (2020). https://doi.org/10.1186/s12879-020-05551-0

Study 353 – Anaphylaxis after convalescent plasma therapy

A woman with Covid-19 at 31 weeks gestation experienced an anaphylactic reaction after treatment with convalescent plasma (click here or 1-s2.0-S0012369220330798-main). She required delivery. Neither mode of birth nor outcome for mother or baby was reported. The hospital was unnamed and no author affiliations are given. Citation: MARGARET MALLARI SREEJA SOMPALLI SHAISTA NOORMOHAMMAD ISHITA MALIK AND SIVASHANKAR SIVARAMAN. ANAPHYLACTIC SHOCK IN A PREGNANT PATIENT WITH COVID-19 IN THE SETTING OF CONVALESCENT PLASMA TRANSFUSION. CHEST, Volume 158, Issue 4, A959

15 November update – study 352 added

Study 352 – infected stillbirth in Portugal

An asymptomatic woman gave birth to a hydropic stillborn fetus at 34 weeks (click here or PIIS0301211520307533). Both mother and fetus tested positive for SARS-CoV-2. From author affiliations she was cared for at Hospital Prof. Doutor Fernando Fonseca, Amadora, which has not previously reported cases. Citation: Rodrigues ML, Gasparinho G, Sepulveda F, Matos T, Signs suggestive of congenital SARS-CoV-2 infection with intrauterine fetal death: a case report, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.11.042

11 November update – study 351 added

Study 351 – SARS-CoV-2 seroprevalence in antenatal samples in Australia

This anonymised seroprevalence study on samples collected between April & June 2020 in Sydney, included 560 samples from women undergoing antenatal screening. 0.79% were positive for SARS-CoV-2 IgG (click here or Gidding mja20.01971 – 11 November 2020_0). Citation: Heather F Gidding, Dorothy A Machalek, Alexandra J Hendry, Helen E Quinn, Kaitlyn Vette, Frank H Beard, Hannah Shilling, Rena Hirani, Iain B Gosbell, David O Irving, Linda Hueston, Marnie Downes, John B Carlin, Matthew NV O’Sullivan, Dominic E Dwyer, John M Kaldor and Kristine Macartney. Seroprevalence of SARS-CoV-2-specific antibodies in Sydney, Australia following the first epidemic wave in 2020 Med J Aust. Published online: 11 November 2020

10 November update – studies 349 and 350 added

Study 350 – 8 pregnant women detected by screening in USA

Of 318 pregnant women screened between April 13th & 26th, 2020, eight tested positive for Sars-CoV-2 (click here or Bender AJOG MFM main). The women were screened in the Hospital of the University of Pennsylvania and Pennsylvania Hospital, and may overlap with some reported in studies 65, 86, 175, and 202.  Citation: Bender WR, Hirshberg A, Coutifaris P, et al. Universal testing for severe acute respiratory syndrome coronavirus 2 in 2 Philadelphia hospitals: carrier prevalence and symptom development over 2 weeks. Am J Obstet Gynecol MFM 2020;2:100226.
https://doi.org/10.1016/j.ajogmf.2020.100226

Study 349 – 66 babies with neonatal SARS-CoV-2 infection in UK

Of 66 neonates with confirmed SARS-CoV-2 infection, 28 (42%) had severe disease,16 (24%) were born preterm and one died of an unrelated cause (click here or Gale Lancet PIIS2352464220303424). However, only two babies (3%) were considered to have possible vertically acquired infection (SARS-CoV-2-positive sample within 12 h of birth where the mother was also positive). Citation: Gale, Chris et al. Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. The Lancet Child & Adolescent Health, Volume 0, Issue 0 DOI: https://doi.org/10.1016/S2352-4642(20)30342-4&nbsp; [important]

9th November update – study 342 (update of 203) and 343 to 348 added

Study 348 – 33 patients from USA

Of 33 women with Covid-19, two required ventilation and one died (click here or Curi AJOG MFM). The were two intrauterine fetal deaths. Patients were cared for at Lincoln Hospital Medical and Mental Health Center, South Bronx, which has not previously reported cases. Citation: Berenice Curi, Alexander Sabre, Israel Benjamin, Lisa Serventi, Dilfuza Nuritdinova. Coronavirus infection in a high-risk obstetrical population of the South Bronx, New York, American Journal of Obstetrics & Gynecology MFM, Volume 2, Issue 4, Supplement, 2020, 100203, ISSN 2589-9333, https://doi.org/10.1016/j.ajogmf.2020.100203. (http://www.sciencedirect.com/science/article/pii/S2589933320301725)

Study 347 – Case report from Monterrey, Mexico

A woman contracted severe Covid-19 at 27 weeks (click here or ijgo.13467). She required four days ventilation and was also treated with enoxaparin, azithromycin, ceftaroline, lopinavir/ritonavir, methylprednisolone and convalescent plasma. She recovered and delivered a growth restricted baby (birth weight not reported) at 39 weeks. The hospital was San José Tec Salud which has not previously reported cases. However, she may be included in study 340. Citation: Magallanes‐Garza, G.I., Valdez‐Alatorre, C., Dávila‐González, D., Martínez‐Reséndez, M.F., Sánchez‐Salazar, S.S., Castilleja‐Leal, F. and Cardona‐Huerta, S. (2020), Rapid improvement of a critically ill obstetric patient with SARS‐CoV‐2 infection after administration of convalescent plasma. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript. https://doi.org/10.1002/ijgo.13467

Study 346 – 4 cases from France

Two women with Covid-19 delivered infected babies (click here or hascoet fped-08-568979). Two others delivered uninfected babies. From author affiliations they were likely cared for at Maternite Regionale CHRU Nancy, and therefore probably included in study 150.  Citation: Hascoët Jean-Michel, Jellimann Jean-Marc, Hartard Cedric, Wittwer Apolline, Jeulin Hélène, Franck Patricia, Morel Olivier. Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2. Frontiers in Pediatrics VOLUME=8. 2020. P 632. URL=https://www.frontiersin.org/article/10.3389/fped.2020.568979. DOI=10.3389/fped.2020.568979

Study 345 – 15 maternal deaths from Covid-19 in Iran

Of 32 women who tested positive at Firoozgar General Hospital, Tehran, 15 died (click here or Moghadam ijgo.13461). Although this hospital has not previously reported cases, overlap with cases in studies 23, 67 & 218 cannot be excluded. Citation: Moghadam, S.A., Dini, P., Nassiri, S., Motavaselian, M., Hajibaba, M. and Sohrabi, M. (2020), Clinical features of pregnant women in Iran who died due to COVID‐19. Int J Gynecol Obstet. Accepted Author Manuscript. https://doi.org/10.1002/ijgo.13461

Study 344 – Case report from USA

A woman with Covid-10 was delivered by Caesarean on 3 April (click here or 2050313×20945536). She and the baby were fine. The patient was treated in Lehigh Valley Hospital, Stroudsburg, Pennsylvania, which has not previously reported cases.  Citation: Krupa Daniel, Kiran Goli, Anita Sargent. Repeat cesarean section in a COVID-19 positive mother in the United States. SAGE Open Medical Case Reports Volume 8: 1–3. 2020.  DOI: 10.1177/2050313X20945536

Study 343 – 32 cases from Jodhpur, India

32 women with Covid-19 during prepgnany were seen over 5 months from April to August 2020 (click here or ijgo.13457). Few details given. The paper is largely concerned with indirect effects of the pandemic. Citation: Goyal, M., Singh, P., Singh, K., Shekhar, S., Agrawal, N. and Misra, S. (2020), The effect of the COVID‐19 pandemic on maternal health due to delay in seeking health care: Experience from a tertiary center. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript. https://doi.org/10.1002/ijgo.13457

Study 342 – an update of study 203 from Turkey

The 100 cases in study 203 have been expanded to 533 cases (click here or ijgo.13460). Two women died. There were 131 births and all neonatwes tested negative. Citation: Sahin, D., Tanacan, A., Erol, S.A., Anuk, A.T., Yetiskin, F.D., Keskin, H.L., Ozcan, N., Ozgu‐Erdinc, A.S., Eyi, E.G., Yucel, A., Tayman, C., Unlu, S., Dinc, B., Sari, E., Surel, A.A. and Moraloglu, O.T. (2020), Updated experience of a tertiary pandemic center on 533 pregnant women with COVID‐19 infection: A prospective cohort study from Turkey. Int J Gynecol Obstet. Accepted Author Manuscript. https://doi.org/10.1002/ijgo.13460

5th November update – studies 340 and 341 added

Study 341 – 18 pregnant women with antibodies from Denmark

18/1019 (1.8%) women with stored first trimester serum taken for Down’s screening at Copenhagen University Hospital Hvidovre between Feb 17 & Apr 23 2020, had SARS-CoV-2 antibodies (click here or deaa311). Half had had symptoms. None were hospitalised. One miscarried. Of 36 women who miscarried before Down’s screening, none had antibodies. The positive antibody women may overlap with those in study 299. Citation: la Cour Freiesleben N, Egerup P, Vauvert Römmelmayer Hviid K, Rosenbek Severinsen E, Kolte AM, Westergaard D, Fich Olsen L, Prætorius L, Zedeler A, Hellerung Christiansen AM, Reinhardt Nielsen J, Bang D, Berntsen S, Ollé-López J, Ingham A, Bello-Rodríguez J, Marie Storm D, Ethelberg-Findsen J, Hoffmann ER, Wilken-Jensen C, Stener Jørgensen F, Westh H, Løvendahl Jørgensen H, Nielsen HS. SARS-CoV-2 in first trimester pregnancy: a cohort study. Hum Reprod. 2020 Nov 4:deaa311. doi: 10.1093/humrep/deaa311. Epub ahead of print. PMID: 33145598.

Study 340 – 448 cases from Mexico

448 women in the open national database of COVID-19 from the Ministry of Health between February 28 & May 25, 2020, were pregnant (click here or jogh-10-020512). 137 were hospitalised, 14 admitted to ICU, 7 ventilated and 10 died. Some cases may overlap with those in studies 66 & 271. Citation: Ríos-Silva M, Murillo-Zamora E, Mendoza-Cano O, Trujillo X, Huerta M. COVID-19 mortality among pregnant women in Mexico: A retrospective cohort study. J Glob Health. 2020 Dec;10(2):020512. doi: 10.7189/jogh.10.020512. PMID: 33110595; PMCID: PMC7567444. [important]

4th November update – study 339 added

Study 339 – 65 cases from China

Using the Maternal and Child Health Information Management System of Wuhan, 65 women with Covid-19 delivering between Jan 13 & March 18 were identified and compared with 11,013 women without, or not tested for, Covid-19 (click here or s12916-020-01798-1). The paper was first submitted on 14 May. Despite six revisions the authors fail to make clear, and the referees & editors failed to notice, that most, if not all, of these cases will have been included in studies 1, 2, 6a, 8, 10, 11, 12, 13, 15, 34, 36, 39, 54, 55, 57, 59, 73, 75, 80, 108, 179, 183, 211, 220, 262b, 268, 280, 294, 305, & 329. Citation: Yang, R., Mei, H., Zheng, T. et al. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med 18, 330 (2020). https://doi.org/10.1186/s12916-020-01798-1

3rd November update – studies 336 to 338 added

Study 338 – birth outcomes among 4,442 pregnancies from the US

5,252 women with laboratory-confirmed SARS-CoV-2 infection were reported from 16 jurisdictions within the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET), during March 29–October 14, 2020 (click here or mm6944e2-H). 309 pregnancies were presumed ongoing, and 501 had missing outcomes. Among 4,442 women with known pregnancy outcomes there were 3,912 live births with known gestational age, 12.9% were preterm (<37 weeks).  Among 4,527 babies (incl. 79 twins and one set of triplets) 12 (0.3%) pregnancies miscarried before 20 weeks and there was 20 stillbirths (0.4%) after 20 weeks. Among 610 infants with reported SARS-CoV-2 test results, 16 were positive.  Citation: Woodworth KR, Olsen EO, Neelam V, et al. Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29–October 14, 2020. MMWR Morb Mortal Wkly Rep. ePub: 2 November 2020. DOI: http://dx.doi.org/10.15585/mmwr.mm6944e2external icon [important]

Study 337 – 30,415 maternal outcomes from the US

Compared with nonpregnant women of the same age, pregnant women were more frequently admitted to ICU (10.5 versus 3.9 per 1,000 cases), ventilated (2.9 versus 1.1 per 1,000 cases), treated with ECMO (0.7 versus 0.3 per 1,000 cases) (click here or mm6944e3-H). 34/23,434 (1.5 per 1,000) symptomatic pregnant women died, compared with 447/386,028 (1.2 per 1,000) nonpregnant women. Citation: Zambrano LD, Ellington S, Strid P, et al. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–October 3, 2020. MMWR Morb Mortal Wkly Rep. ePub: 2 November 2020. DOI: http://dx.doi.org/10.15585/mmwr.mm6944e3external icon [important]

Study 336 – 5 women from Israel,

Vaginal swabs were tested from 35 women, aged 21-93 years with Covid-19 (click here or 1471-0528.16556). Two were positive. Five of the tested women were in the 3rd trimester of pregnancy, but none of them had a postive vaginal swab. From author affilitions the women were cared for in Lis Maternity Hospital, Tel Aviv, and may therefore be included in study 330. Citation: Schwartz, A., Yogev, Y., Zilberman, A., Alpern, S., Many, A., Yousovich, R. and Gamzu, R. (2020), Detection of SARS‐CoV‐2 in vaginal swabs of women with acute SARS‐CoV‐2 infection: a prospective study.. BJOG: An International Journal of Obstetrics & Gynaecology. Accepted Author Manuscript. doi:10.1111/1471-0528.16556 . 

1st November update – studies 329 to 335 added

Study 335 – Case report from Italy

A woman with Covid-19 at 27 weeks required mechanical ventilation for over 4 weeks, latterly via tracheostomy, and was delivered by Caesarean section at 30 weeks (click here or ccr3.3426). She survived. The baby tested negative and survived. Both were cared for at Ospedali Riuniti Villa Sofia-Cervello, Palermo which has not previously reported cases. Citation: Donzelli, M, Ippolito, M, Catalisano, G, et al. Prone positioning and convalescent plasma therapy in a critically ill pregnant woman with COVID‐19. Clin Case Rep. 2020; 00: 1– 7. https://doi.org/10.1002/ccr3.3426

Study 334 – seroprevalaence among pregnant women, UK

53/1000 (5.3%) of antenatal blood samples, in the Oxford region, between 14 April and 15 June 2020 were positive for SARS-CoV-2 IgG (click here or Lumley eurosurv-25-42-4). Citation: Lumley Sheila F , Eyre David W , McNaughton Anna L , Howarth Alison , Hoosdally Sarah , Hatch Stephanie B , Kavanagh James , Chau Kevin K , Downs Louise O , Cox Stuart , Dunn Laura , Justice Anita , Wareing Susan , Dingle Kate , Rudkin Justine , Auckland Kathryn , Fyfe Alexander , Bolton Jai , Paton Robert , Mentzer Alexander J, Jeffery Katie , Andersson Monique I , James Tim , Peto Tim E A , Marsden Brian D , Screaton Gavin , Cornall Richard J , Klenerman Paul , Ebner Daniel , Stuart David I , Crook Derrick W , Stoesser Nicole , Kennedy Stephen H , Thompson Craig , Gupta Sunetra , Matthews Philippa C ORCID icon. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. Euro Surveill. 2020;25(42):pii=2001721. https://doi.org/10.2807/1560-
7917.ES.2020.25.41.2001721 

Study 333 – 250 cases from Italy

In this updated series from Lombardy, of 250 pregnant women with either asymptomatic, non-severe, or severe SARS-CoV-2 up to June 18, 2020, nine were admitted to ICU but there were no maternal deaths (click here or ijgo.13435). Some cases were included in studies 32, 64, 114, 180, 188, 197 & 252. Citation: Di Martino, D., Chiaffarino, F., Patanè, L., Prefumo, F., Vergani, P., Ornaghi, S., Savasi, V., Spinillo, A., Cromi, A., D’Ambrosi, F., Tassis, B., Iurlaro, E., Parazzini, F. and Ferrazzi, E. (2020), Assessing risk factors for severe forms of COVID‐19 in a pregnant population: A clinical series from Lombardy, Italy. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13435

Study 332 – Case report from Granada, West Indies

A woman with Covid-19 gave birth to an infected neonate (click here or Majachani AMCaseRep 925766). The mother had a past history of HIV infection. Both recovered. From author affiliations the unnamed hospital was probably St. George’s University General Hospital, which has not previously reported cases. Citation: Nicole Majachani, Jean Luc M. Francois, Ashen K. Fernando, Jamshed Zuberi. A Case of a Newborn Baby Girl Infected with SARS-CoV-2 Due to Transplacental Viral Transmission. Am J Case Rep 2020; 21:e925766 DOI: 10.12659/AJCR.925766. Available online: 2020-09-17

Study 331 – 180 cases from USA

Of these 180 women with Covid-19 in pregnancy, 7 required intensive care (click here or Janssen AJOG MFM). Three babies tested positive but none had illness consistent with COVID-19. The patients were probably cared for in the Northwell system hospitals in New York, so some have probably been reported in studies 162, 179, 289 & 315.  Citation: Janssen O, Thompson M, Milburn S, Green R, Wagner B, Bianco A, Stroustrup A, The Impact of Perinatal SARS-CoV2 Infection During the Peripartum Period, American Journal of Obstetrics & Gynecology MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100267.&nbsp;

Study 330 – 52 cases from 7 hospitals in Israel

Of 52 women with Covid-19 in pregnancy, one was critically ill, but no babies were infected (click here or Rottenstreich2020_Article_VaginalDeliveryInSARS-CoV-2-in). The seven hospitals are unnamed, but from author affiliations probably include Hadassah-Hebrew University Medical Center, Jerusalem: Sheba Medical Center, Tel-Aviv University, Tel-Hashomer; Mayenei Hayeshua Medical Center, Tel-Aviv University, Ramat Gan; Lis Maternity Hospital, Tel-Aviv; Meir Medical Center, Tel-Aviv University, Kfar Saba; and Ziv Medical Center, Safed. None of these hospitals have reported cases. Citation: Rottenstreich, A., Tsur, A., Braverman, N. et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in Israel: a multicenter prospective analysis. Arch Gynecol Obstet (2020). https://doi.org/10.1007/s00404-020-05854-2

Study 329 – 60 cases from China

These cases (click here or fcimb-10-560899) delivered between January 24 & March 14, 2020 in the Maternity and Child Health Hospital in Wuhan, Hubei province have probabaly been reported many times. The MCH hospital is part of Huazhong University of Science and Technology Hospital grid.488485.d. Studies 8, 17, 30, 38, 54, 55 & 262b. Citation: Sun G, Zhang Y, Liao Q and Cheng Y (2020) Blood Test Results of Pregnant COVID-19 Patients: An Updated Case-Control Study. Front. Cell. Infect. Microbiol. 10:560899. doi: 10.3389/fcimb.2020.560899

31st October update – study 328 added

Study 328 – 154 cases from the Dominican Republic

Of 154 women with Covid-19, 15 developed cardiac injury (click here or Mercedes AJOG PIIS0002937820312060). Two died. The hospital is “an obstetric tertiary level hospital in Santo Domingo”. However none of the authors report an affiliation from that city, which contains more than one large maternity hospital.  Citation: Mercedes BR, Serwat A, Naffaa L, Ramirez N, Khalid F, Steward SB, Caro Feliz OG, Kassab M, Karout L, New-Onset myocardial injury in COVID-19 Pregnant Patients: A Case Series of 15 Patients, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.10.031

28th October – study 327 added

Study 327 – 40 cases of neonatal SARS-CoV-2 from a Spanish registry

A National Registry supported by the Spanish Society of Neonatology identified 40 neonates who tested positive for SARS-CoV-2 between 3 April & 18 May 2020 (click here or fped-08-580584) Citation: Fernández Colomer Belén, Sánchez-Luna Manuel, de Alba Romero Concepción, Alarcón Ana, Baña Souto Ana, Camba Longueira Fátima, Cernada María, Galve Pradell Zenaida, González López María, López Herrera M. Cruz, Ribes Bautista Carmen, Sánchez García Laura, Zamora Flores Elena, Pellicer Adelina, Alonso Díaz Clara, Herraiz Perea Cristina, Romero Ramírez Dolores Sabina, de las Cuevas Terán Isabel, Pescador Chamorro Isabel, Fernández Trisac José Luis, Arruza Gómez Luis, Cardo Fernández Luis Miguel, García García Mª Jesús, Nicolás López Marta, Hortelano López Miryam, Riaza Gómez Mónica, Hernández González Natalio, González Sánchez Raquel, Zambudio Sert Sílvia, Larrosa Capacés Susana, Matías del Pozo Vanesa. Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain. Frontiers in Pediatrics. VOL 8. 2020. p 670. https://www.frontiersin.org/article/10.3389/fped.2020.580584. DOI 10.3389/fped.2020.580584

25th October – study 326 added

Study 326 – seroprevalence in Paris, France

Of women admitted to the delivery room at Antoine Be´clère Hospital maternity ward from 4th to 31st May, 20/249 (8%) were SARS-CoV-2 IgG positive (click here or journal.pone.0240782). 1/190 tested for nasopharyngeal SARS-CoV-2 RT-PCR was positive. She was asymptomatic and her baby tested negative. The period covered the final week of, and first three weeks post, lockdown. Citation: Mattern J, Vauloup-Fellous C, Zakaria H, Benachi A, Carrara J, Letourneau A, et al. (2020) Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France. PLoS ONE 15(10): e0240782. https://doi.org/10.1371/journal.pone.0240782.

24 October update – studies 319 to 325 added

Study 325 – Screening in Portugal

Click here. 11/184 (6.0%) of pregnant women screened for SARS-CoV-2 on admission in labour between 19th March and 4th May were positive. Two reported symptoms (click here or ). From author affiliations the hospital was Centro Hospitalar Universitário de São João, Porto. Citation: Figueiredo R, Tavares S, Moucho M, Ramalho C. Systematic screening for SARS-CoV-2 in pregnant women admitted for delivery in a Portuguese maternity. J Perinat Med. 2020 Oct 21:/j/jpme.ahead-of-print/jpm-2020-0387/jpm-2020-0387.xml. doi: 10.1515/jpm-2020-0387. Epub ahead of print. PMID: 33085639.

Study 324 – A case of neonatal SARS in Portugal

Full text not yet available (click here or ). From author affililations this was Hospital de São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon. Citation: Correia, Cátia R. MD*; Marçal, Mónica MD*; Vieira, Filipa MD*; Santos, Edmundo MD*; Novais, Cristina MD*; Maria, Ana Teresa MD*; Malveiro, Duarte MD*; Prior, Ana Rita MD*; Aguiar, Marta MD*; Salazar, Anabela MD*; Gouvêa Pinto, Constança MD*; Carvalho Rodrigues, Luís MD†; Pessanha, Maria Ana PhD†; Borges, Vítor PhD‡; Isidro, Joana MSc‡; Gomes, João Paulo PhD‡; Duarte, Sílvia MSc§; Vieira, Luís MSc§; Costa, Inês MSc¶; Alves, Maria João PhD‖; Calhau, Conceição PhD**; Guiomar, Raquel MSc¶; Tuna, Madalena Lopo MD* Congenital SARS-CoV-2 Infection in a Neonate With Severe Acute Respiratory Syndrome, The Pediatric Infectious Disease Journal: October 22, 2020 – Volume Online First – Issue –
doi: 10.1097/INF.0000000000002941 

Study 323 – Two mothers treated with ECMO in USA

Two women with Covid-19 required treatment with ECMO (click here or s-0040-1718694). Both mothers and babies survived. From author affiliations they were cared for in the University of California, Los Angeles. The hospital is not named.  Citation: K. Marie Douglass, Katie M. Strobel, Michael Richley, Thalia Mok  , Annabelle de St Maurice, Viviana Fajardo, Andrew T. Young, Rashmi Rao, Lydia Lee, Peyman Benharash, Alison Chu, Yalda Afshar. Maternal-Neonatal Dyad Outcomes of Maternal COVID-19 Requiring Extracorporeal Membrane Support: A Case Series Am J Perinatol. DOI: 10.1055/s-0040-1718694

Study 322 – 60 cases from Oman

Sixty women with Covid-19 were cared for at The Royal Hospital, Muscat, from March 24 to July 31, 2020 (click here or ijgo.13427). Seven required ITU care of whom one was critically ill. No mothers died. There were four miscarriages, one stillbirth and eight pregnancies ongoing. The remainder of the babies survived. All four tested neonates were negative. Citation: Santhosh, J., Al Salmani, M., Khamis, F., Al Ubaidani, S.A. and Al‐Zakwani, I. (2020), Clinical characteristics of COVID‐19 in pregnant women: A retrospective descriptive single‐center study from a tertiary hospital in Muscat, Oman. International Journal of Gynecology & Obstetrics. Accepted Author Manuscript. doi:10.1002/ijgo.13427

Study 321 – Four cases from Iran

Four pregnant women contracted Covid -19 (click here or Iran case series). All four recovered. One was postnatal, one delivered vaginally and two remained undelivered. They were cared for in Shahid Mostafa Khomeini Hospital in Ilam which has not previously reported cases. Citation: Gheysarzadeh A, Sadeghifard N, Safari M, Rashidian T, Mohammadyari E, Tavan H, Report of four pregnant women getting COVID-19 in Ilam, Iran: Case Series, New Microbes and New Infections, https://doi.org/10.1016/j.nmni.2020.100783.&nbsp;

Study 320 – Case report from USA

A woman with Covid-19 at 36 weeks required 6 days ventilation and delivery by Caesarean (click here or 8889487). She survived, but at the time of the report remained in an inpatient rehabilitation facility. The baby tested negative. From author affiliations she was likely cared for in the Einstein Medical Center, Philadelphia which has not previously reported cases. Citation: Jerald Pelayo ,Gabriella Pugliese, Grace Salacup, Eduardo Quintero, Adeeb Khalifeh, David Jaspan, and Bhavna Sharma. Severe COVID-19 in Third Trimester Pregnancy: Multidisciplinary Approach. Case reports in Critical Care. Volume 2020 |Article ID 8889487 | https://doi.org/10.1155/2020/8889487

Study 319 – No cases in 3 hospitals in Australia

No positive test results among 350 pregnant women from three hospitals in Melbourne over the two-week period 6th to 19th May 2020 (click here or Rolnik 1-s2.0-S1871519220303553-main). This period was after the first wave had subsided. Citation: D.L. Rolnik, T.M. Korman, A. Rindt et al., Coronavirus testing in women attending antenatal care, Women Birth, https://doi.org/10.1016/j.wombi.2020.09.024&nbsp;

20th October update – study 318 added

Study 318 – Case report from Chizhou, Anhui Province, China

A woman contracted Covid-19 on Jan 6th, six months after delivery while still breastfeeding ((click here or 15010_2020_Article_1532). Breastfeeding was stopped and the infant artificially fed at home. The infant’s infection status and outcome were not reported. The mother recovered. Citation: Liu X, Zhou L, Zhu Y. Report on a lactating patient with COVID-19 [published online ahead of print, 2020 Oct 9]. Infection. 2020;1-5. doi:10.1007/s15010-020-01532-2

19th October update – study 317 added

Study 317 – 101 neonates from USA

Of 101 neonates born to 100 mothers positive for SARS-CoV-2 from March 13 to April 24, 2020, two had borderline results and the rest tested negative. No baby had clinical disease (click here or jamapediatrics_dumitriu_2020_oi_200070_1601920765.25034). From author affiliations Columbia University Irving Medical Center. Fourteen babies were reported in study 27. Citation: Dumitriu D, Emeruwa UN, Hanft E, et al. Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City. JAMA Pediatr. Published online October 12, 2020. doi:10.1001/jamapediatrics.2020.4298

18th October update – studies 315 and 316 added

Study 316  – Case report from Japan.

A woman with Covid-19 was delivered by caesarean section on April 2nd (click here or jog.14393). This was the first birth to a woman with Covid-19 in Japan. Mother and baby survived. The baby was not infected. They were cared for in the Center for Perinatal, Pediatric and Developmental Medicine, Kitasato University Hospital which has not previously reported cases. Citation: Mochizuki, J., Nakamura, M., Iwahata, S., Nishijima, J., Ito, T., Wada, T., Takayama, Y. and Unno, N. (2020), First report in Japan of a delivery of a woman with the 2019 novel coronavirus disease. J. Obstet. Gynaecol. Res.. doi:10.1111/jog.14393

Study 315 – 31 severe cases from New York

Of 31 pregnant women with severe or critical disease, four had abnormal cardiac biomarkers, of whom two died (click here or PIIS0002937820311881). The women were cared for in the Northwell health system so may have been included in studies 162, 179 and 289. Citation: PACHTMAN SHETTY SL, MEIROWITZ N, BLITZ MJ, GADOMSKI T, WEINBERG CR, Myocardial injury associated with coronavirus disease 2019 in pregnancy, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.10.014. &nbsp;

17 October update – studies 311 to 314 added

Study 314 – 141 cases from USA

Of 141 women with Covid-19 in pregnancy, one died (click here or PIIS2589933320302147 (1)). Of 76 live births, no babies were affected. They were cared for in Yale New Haven, Bridgeport, and Greenwich hospitals. One woman, who had a 22 week termination for severe pre-eclampsia, was reported in study 155. Some may also have been included in study 132. Citation: GRECHUKHINA O, GREENBERG V, LUNDSBERG LS, DESHMUKH U, CATE J, LIPKIND HS, CAMPBELL KH, PETTKER CM, KOHARI KS, REDDY UM, Coronavirus Disease 2019 (COVID-19) pregnancy outcomes in a racially and ethnically diverse population, American Journal of Obstetrics & Gynecology MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100246.

Study 313 – Case report from Mumbai, India

In this MedRxiv preprint, an asymptomatic woman tested positive for SARS-CoV-2 at 8 weeks gestation. At 13 weeks the fetus had died (click here or 2020.08.18.20177121v1.full). The authors detected virus in the placenta and argue the fetal demise was due to congenital transmission of SARS-CoV-2. Citation: Prajakta Shende, Pradip Gaikwad, Manisha Gandhewar, Pawankumar Ukey, Anshul Bhide, Vainav Patel, Sharad Bhagat, Vikrant Bhor, Smita Mahale, Rahul Gajbhiye, Deepak Modi Persistence of SARS-CoV-2 in the first trimester placenta leading to vertical transmission and fetal demise from an asymptomatic mother. medRxiv 2020.08.18.20177121; doi: https://doi.org/10.1101/2020.08.18.20177121. 29 December update. Published in Human Reproduction (click here). Citation: Shende P, Gaikwad P, Gandhewar M, Ukey P, Bhide A, Patel V, Bhagat S, Bhor V, Mahale S, Gajbhiye R, Modi D. Persistence of SARS-CoV-2 in the first trimester placenta leading to transplacental transmission and fetal demise from an asymptomatic mother. Hum Reprod. 2020 Dec 21:deaa367. doi: 10.1093/humrep/deaa367. Epub ahead of print. PMID: 33346816.

Study 312 – analysis of a range of specimens from 31 affected pregnancies in Italy

31 pregnancies with SARS-CoV-2 (click here or s41467-020-18933-4). From author affiliations the patients were probably cared for in Milan. Citation: Fenizia, C., Biasin, M., Cetin, I. et al. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nat Commun 11, 5128 (2020). https://doi.org/10.1038/s41467-020-18933-4

Study 311 – 21 placentas from St Louis, USA

No differences were seen between 21 placentas from SARS-CoV-2 positive pregnancies and 20 control ones (click here or Histopathology of Third Trimester Placenta from SARS CoV 2 Positive Women). The hospitals are not reported. Citation: Mai He, Priya Skaria, Kasey Kreutz, Ling Chen, Ian S. Hagemann, Ebony B. Carter, Indira U. Mysorekar, D. Michael Nelson, John Pfeifer & Louis P. Dehner (2020) Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women, Fetal and Pediatric Pathology, DOI: 10.1080/15513815.2020.1828517

13 October update – studies 309 and 310 added

Study 310 – 86 pregnant women treated with remdesivir

Of the first 86 pregnant, or recently pregnant, women with severe Covid-19 (O2 satuation <=94%), treated with compassionate use remdesivir (all outside a trial) between March 21, & April 22nd 2020, 63 were admitted to ICU, 45 required ventilation and one ECMO (click here or ciaa1466). One woman died. At 28-day follow-up seven women were still being ventilated (appendix Fig 2 ciaa1466_suppl_supplementary_materials_1 (1)).  Among 45 deliveries there was one 17 weeks miscarriage but otherwise no babies died. Four women were treated in Spain, two in Switzerland and one each in Italy and the UK. The rest were from the United States. Many have presumably been included in other reports. Citation: Richard M Burwick, Sigal Yawetz, Kathryn E Stephenson, Ai-Ris Y Collier, Pritha Sen, Brian G Blackburn, E Milunka Kojic, Adi Hirshberg, Jose F Suarez, Magdalena E Sobieszczyk, Kristen M Marks, Shawn Mazur, Cecilia Big, Oriol Manuel, Gregory Morlin, Suzanne J Rose, Mariam Naqvi, Ilona T Goldfarb, Adam DeZure, Laura Telep, Susanna K Tan, Yang Zhao, Tom Hahambis, Jason Hindman, Anand P Chokkalingam, Christoph Carter, Moupali Das, Anu O Osinusi, Diana M Brainard, Tilly A Varughese, Olga Kovalenko, Matthew D Sims, Samit Desai, Geeta Swamy, Jeanne S Sheffield, Rebecca Zash, William R Short, Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19, Clinical Infectious Diseases, , ciaa1466, https://doi.org/10.1093/cid/ciaa1466

Study 309 – 2,475 pregnant women with Covid-19 from Brazil

Among 2,475 women identified through an acute respiratory distress register, 494 were admitted to ITU, 242 underwent invasive ventilation and 204 died (click here or ijgo.13407). Among the women who died, 8 (6%) had not reached hospital, 81 (40%) had not been admitted to intensive care, and 52 (26%) had no access to any respiratory support before dying. These are updated figures from studies 182, 248 & 249. Citation: Menezes, M.O., Takemoto, M.L., Nakamura‐Pereira, M., Katz, L., Amorim, M.M., Salgado, H.O., Melo, A., Diniz, C.S., de Sousa, L.A., Magalhaes, C.G., Knobel, R., Andreucci, C.B. and (2020), Risk factors for adverse outcomes among pregnant and postpartum women with acute respiratory distress syndrome due to COVID‐19 in Brazil. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13407  [important]

12 October update – studies 303 to 308 added.  Study 167 publication updated.

Study 308 – Case report from Korea

One case report of Covid-19 in pregnancy plus 12 further cases mentioned in the final pragraph (click here or ogs-20106). All cared for at Daegu Fatima Hospital or Daegu Dongsan Hospital and likely overlap with those in studies 22 & 143.  Citation: Jin-Gon Bae , Jin-Kyeong Ha, Myoung Kwon, Hak-Youle Park, Won-Joon Seong, Seong-Yeon Hong. A case of delivery of a pregnant woman with COVID-19 infection in Daegu, Korea. Obstet Gynecol Sci > Epub ahead of print  Case Report DOI: https://doi.org/10.5468/ogs.20106 [Epub ahead of print] Published online October 5, 2020.

Study 307 – 257 cases from Europe and other continents

These cases (click here or PIIS0301211520306400) probably overlap considerably with those reported in study 278. Citation: Di Mascio D, D’Antonio F, Perinatal mortality and morbidity of SARS-COV-2 infection during pregnancy in European countries: findings from an international study, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.10.009

Study 306 – Neonatal death in Ilam province, Iran

The mother had Covid-19 (click here or 13256_2020_Article_2519). The baby, delivered by elective caesarean at 39 weeks, had normal Apgar scores but collapsed soon after birth and died. Maternal SARS-CoV-2 swabs were positive, and baby swabs negative. The birth was at Zagros Hospital and the baby was later transferred to Ayatollah Taleghani Hospital, both in Ivan City, and neither of which have previously reported caes. Citation: Rashidian, T., Sharifi, N., Fathnezhad-Kazemi, A. et al. Death of a neonate with suspected coronavirus disease 2019 born to a mother with coronavirus disease 2019 in Iran: a case report. J Med Case Reports 14, 186 (2020). https://doi.org/10.1186/s13256-020-02519-1

Study 305 – Two cases from Wuhan, China

These two women with Covid-19 in pregnancy have probably been reported already (click here or s12884-020-03281-4). Citation: Cao, D., Chen, M., Peng, M. et al. Vaginal delivery in women with COVID-19: report of two cases. BMC Pregnancy Childbirth 20, 580 (2020). https://doi.org/10.1186/s12884-020-03281-4

Study 304 – 32 pregnant women admitted to ITU in the USA

Thirty two pregnant women with Covid-19 were admitted to ITU in multiple US hospitals (click here or rccm.202006-2182le). Citation: Sarah Rae Easter, Shruti Gupta, Samantha K. Brenner, David E. Leaf Outcomes of Critically Ill Pregnant Women with COVID-19 in the United States. American Journal of Respiratory and Critical Care Medicine Published Online: October 07, 2020 https://doi.org/10.1164/rccm.202006-2182LE

Study 303 – Case report from Turkey

This case report from (judging by author affiliations) Recep Tayyip Erdoğan University School of Medicine, Rize (click here or 354-356) may have been reported in studies 244 and 277.  Citation: Özçelik N, Özdemir S, Gürlek B, Yıldız İE. COVID-19 Pregnant Patient Management with a Case of COVID-19 Patient with An Uncomplicated Delivery. Turk Thorac J. 2020 Sep;21(5):354-356. doi: 10.5152/TurkThoracJ.2020.20135. Epub 2020 Sep 1. PMID: 33031729.

11 October update – study 302 added

Study 302 – Two cases of repeat SARS-CoV-2 positivity in pregnancy from Italy

A pregnant women who had recovered from mild Covid-19 in March 2020 at 24 weeks, retested positive when she gave birth in July at 41 weeks. Another asymptomatic women with SARS-CoV-2 in April at 32 weeks gestation, who had later tested negative, tested positive again at birth in June (click here or 1471-0528.16362). From author affiliations both cases were probably cared for in Brescia which means they were likely included in studies 32, 64 & 252. Citation: Zanardini, C., Saccani, B., Franceschetti, l., Zatti, S., Sartori, E. and Prefumo, F. (2020), Retest positive for SARS‐CoV‐2 RNA of recovered pregnant women with COVID‐19. Ultrasound Obstet Gynecol. Accepted Author Manuscript. doi:10.1002/uog.23144

10 October update – study 301 added

Study 301 – 736 women in the US PRIORITY study

The clinical features of 736 pregnant women with Covid-19 (594 SARS-CoV-2 positive), recruited through social media in the PRIORITY study, are reported (click here or 1471-0528.16362). They will overlap with study 281 and many other US reports. Citation: Afshar, Yalda MD, PhD; Gaw, Stephanie L. MD, PhD; Flaherman, Valerie J. MD; Chambers, Brittany D. PhD, MPH; Krakow, Deborah MD; Berghella, Vincenzo MD; Shamshirsaz, Alireza A. MD; Boatin, Adeline A. MD, MPH; Aldrovandi, Grace MD; Greiner, Andrea MD; Riley, Laura MD; Boscardin, W. John PhD; Jamieson, Denise J. MD; Jacoby, Vanessa L. MD, MAS, on behalf of the Pregnancy CoRonavIrus Outcomes RegIsTrY (PRIORITY) Study Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People, Obstetrics & Gynecology: October 07, 2020 – Volume Latest Articles – Issue – 10.1097/AOG.0000000000004178 doi: 10.1097/AOG.0000000000004178

9 October update – study 300 added

Study 300 – 26 cases from Dublin, Ireland

26 women had SARS-CoV-2 detected during pregnancy by PCR in the Rotunda Hospital between 1st March & 1st July 2020 (click here or Infants-Born-to-Mothers-with-COVID-19-During-Pregnancy-The-First-Four-Months-of-the-Pandemic). Maternal survival was not reported but, by implication, was good. All infants survived and none were infected. These case are probably included in study 284. Citation: C. Murphy, D. O’Reilly, N. McCallion, R. Drew, W. Ferguson. Infants Born to Mothers with COVID-19 During Pregnancy: The First Four Months of the Pandemic Ir Med J; Vol 113; No. 9; P193

8 October update – study 299 added

Study 299 – 29 women with anti SARS-CoV-2 antibodies from Denmark

Of the 29 women reported in this Medxiv preprint, 15 had previously had Covid-19 symptoms, but none had a positive swab (click here or 2020.09.14.20191106v1.full). They were cared for at Copenhagen University Hospital, Hvidovre, which has not previously reported cases. Citation; Pia Egerup, Line Fich Olsen, Ann-Marie Hellerung Christiansen, David Westergaard, Elin Rosenbek Severinsen, Kathrine Vauvert Roemmelmayer Hviid, Astrid Marie Kolte, Amalie Dyhrberg Boje, Marie-Louise Mathilde Friis Bertelsen, Lisbeth Praetorius, Anne Zedeler, Josefine Reinhardt Nielsen, Didi Bang, Sine Berntsen, Jeppe Ethelberg-Findsen, Ditte Marie Storm, Judith Bello-Rodriguez, Andreas Ingham, Joaquim Olle-Lopez, Eva Hoffmann, Charlotte Wilken-Jensen, Lone Krebs, Finn Stener Joergensen, Henrik Torkil Westh, Henrik Lovendahl Jorgensen, Nina la Cour Freiesleben, Henriette Svarre Nielsen medRxiv 2020.09.14.20191106; doi: https://doi.org/10.1101/2020.09.14.20191106

5 October update – studies 292 to 298 added

Study 298 – 67 cases from Sweden

The authors claim that these 67 pregnant women with SARS-CoV-2 comprise all those cared for in the Stockholm region between March 19 & April 26, 2020 (click here or aogs.14006). Four women were admitted to intensive care but none died. Three babies were infected. Two babies died. From author affliliations the unnamed hospitals probably include Karolinska, Södersjukhuset (Southern), Danderyd, and Södertälje hospitals. The series likely includes some women reported in studies 20, 88, and 282. Study 282 reported 156 women with SARS-Cov-2 admitted in labour to the Karolinska alone, albeit over a longer time period March 25 to July 24 (study 282). Citation: Remaeus, K., Savchenko, J., Brismar Wendel, S., Gidlöf, S.B., Graner, S., Jones, E., Molin, J., Saltvedt, S., Wallström, T. and Pettersson, K. (2020), Characteristics and short‐term obstetric outcomes in a case series of 67 women tested positive for SARS‐CoV‐2 in Stockholm, Sweden. Acta Obstet Gynecol Scand. Accepted Author Manuscript. doi:10.1111/aogs.14006

Study 297 – anti SARS-CoV-2 IgA in breastmilk within 72 hr of birth

A woman with a clinical diagnosis of Covid-19, but with negative PCR tests, delivered by Caesarean at 37 weeks (click here or 0890334420960433). Anti SARS-CoV-2 IgA was detected in breast milk soon after birth. The baby was not infected. From author affiliations the hospital was probably Municipal Universitário de São Bernardo do Campo, Brazil, which has not previously reported cases. Citation: Lebrão CW, Cruz MN, Silva MH da, et al. Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection. Journal of Human Lactation. September 2020. doi:10.1177/0890334420960433

Study 296 – Case report from USA

A woman wih Covid-19 developed pre-eclampsia at 34 weeks (click here or main). Both her and the baby recovered. From author affiliations the hospital was probably Maine Medical Center, Portland, Maine, which has not previously reported cases. Citation: J.N. Hansen, J. Hine and T.D. Strout, COVID-19 and preeclampsia with severe features at 34-weeks gestation, American Journal of Emergency Medicine, https://doi.org/10.1016/j.ajem.2020.06.052

Study 295 – Takotsubo cardiomyopathy in pregnancy & SARS-CoV-2

The first report of Takotsubo cardiomyopathy in pregnancy in association with SARS-CoV-2 infection (click here or e239104.full). The mother was delivered by caesarean and recovered. Baby outcomes were not reported. The hospital was probably Gauhati Medical College and Hospital, Guwahati, India, which has not previously reported cases. Citation: Bhattacharyya PJ, Attri PK, Farooqui W. Takotsubo cardiomyopathy in early term pregnancy: a rare cardiac complication of SARS-CoV-2 infection. BMJ Case Reports CP 2020;13:e239104.

Study 294 – 16 women with SARS-CoV-2 infection from China

16 pregnant women with SARS-CoV-2 infection (click here or Zhou2020_Article_TheMetabolicAndImmunologicalCh). From author affiliations and ethics committee review the hospital was probably Renmin Hospital of Wuhan University grid.412632.0, which means the cases probably overlap with those in studies 6a, 10, 12, 36, 37, and 40. Citation: Zhou, J., Wang, Y., Zhao, J. et al. The metabolic and immunological characteristics of pregnant women with COVID-19 and their neonates. Eur J Clin Microbiol Infect Dis (2020). https://doi.org/10.1007/s10096-020-04033-0

Study 293 – Infected triplets from Oman

All three triplets born by Caesarean at 32 weeks to a woman with Covid-19 were infected (click here or IS_VERTICAL_TRANSMISSION_OF_SARS_CoV_2_INFECTION.96038). They all thrived. The woman was cared for at Khoula Hospital, Muscat, which has not previously reported cases. Citation: Alwardi, Talal Hamood; Ramdas, Vidya; Al Yahmadi, Mohammed; Al Aisari, Salima; Bhandari, Satish; Saif Al Hashami, Hilal; Al Jabri, Amal; Manikoth, Prakash; Malviya, Manoj. IS VERTICAL TRANSMISSION OF SARS-CoV-2 INFECTION POSSIBLE IN PRETERM TRIPLET PREGNANCY? A CASE SERIES, The Pediatric Infectious Disease Journal: September 25, 2020 – Volume Online First – Issue – doi: 10.1097/INF.0000000000002926 

Study 292 – Blood loss at birth among 53 women in USA

The blood loss at birth among 53 women with Covid 19 was no different from women without the disease (click here or s-0040-1718403). Women were cared for in Boston Medical Center which has not previously reported cases. Citation: Wang MJ, Schapero M, Iverson R, Yarrington CD. Obstetric Hemorrhage Risk Associated with Novel COVID-19 Diagnosis from a Single-Institution Cohort in the United States. Am J Perinatol. 2020 Sep 29. doi: 10.1055/s-0040-1718403. Epub ahead of print. PMID: 32992351.

28 September update – study 291 added

Study 291 – Spanish registry of Covid-19 screening in asymptomatic pregnant women

By May 31st 2020, of 16,308 pregnant women screened, 338 (2.1%) had tested positive (click here or RS94C_202009092). Testing was done in 100 maternity hospitals listed in Table 2. This is a different registry from study 264b, which only covered 45 hospitals. However the hospitals, time period and presumably cases overlap.  Spanish with English abstract. Citation: Encinas Pardilla MB, Caño Aguilar Á, Marcos Puig B, Sanz Lorenzana A, Rodríguez de la Torre I, Hernando López de la Manzanara P, Fernández Bernardo A, Martínez Pérez Ó. Registro español de cribado de Covid-19 en gestantes asintomáticas. Rev Esp Salud Pública. 2020; 94: 18 de septiembre e202009092

27 September update – studies 284-290 added. I’ve also noticed ten duplicate numbers, studies 257 to 266 & renumbered the later ones as 257b to 266b

Study 290 – 25 symptomatic women in USA

25/532 (4.7%) women admitted for an obstetric procedure were asymptomatic but positive for SARS-CoV-2 at Barnes-Jewish Hospital in St Louis, Missouri from May 28 – July 22 (click here or PIIS0002937820311029). This series will not include the severely ill woman in study 69, but probably includes some in study 259. Citation: KELLY JC, RAGHURAMAN N, PALANISAMY A, STOUT MJ, CARTER EB, Pre-procedural asymptomatic COVID-19 in obstetric and surgical units, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.09.023.

Study 289 – seroprevalence during labour in New York State

269/1671 (16%) women were seropositive in labour (click here or Haizler-Cohen PIIS0002937820311017). They delivered in 7 hospitals in the Northwell Health system so probably were included in studies 162 and 179. Citation: HAIZLER-COHEN L, DAVIDOV A, BLITZ MJ, FRUHMAN G, SARS-CoV-2 Antibodies in Pregnant Women Admitted to Labor and Delivery, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.09.022.

Study 288 – serological testing among pregnant women in Estonia

The SARS-CoV-2 seroprevalemce was reported to be nearly five time higher than the rate of PCR positivity, and also 10 times lower than the rate of seropositivity in the general population of Spain (sic) (click here or aogs.13995) Citation: Veerus, P., Salumets, A., Naaber, P., Krjutškov, K., Tilk, K., Laanpere, M. and Uusküla, A. (2020), Seroprevalence of SARS‐CoV‐2 antibodies among pregnant women in Estonia: a call for epidemiological studies. Acta Obstetricia et Gynecologica Scandinavica. Accepted Author Manuscript. doi:10.1111/aogs.13995

Study 287 – 2 cases from Iran

A woman with severe Covid-19 at 31 weeks was delivered by Caesarean and died in Shariati hospital, Tehran. Her baby was seriously ill with complications of prematurity and neonatal Covid-19. He recovered, albeit with hydrocephalus (click here or s13052-020-00897-2). A second women had milder disease diagnosed clinically. Her baby also had complications of prematurity and neonatal Covid-19 and recoverd. The mothers may have been included in studies 66, 67 and 218. The babies may have been reported in study 250. Citation: Sagheb, S., Lamsehchi, A., Jafary, M. et al. Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report. Ital J Pediatr 46, 137 (2020). https://doi.org/10.1186/s13052-020-00897-2

Study 286 – 52 cases from Turkey

27 women with Covid-99 in pregnancy confirmed on PCR, and 25 diagnosed clinically (click here or Alay jog.14493 (1)). From author affiliations the unnamed tertiary referral hospital is probably Dr. Sadi Konuk Education and Training Hospital, Istanbul, which has not previously reported cases on its own behalf. They may be included in other Istanbul series such as study 244. It also appears to be a different hospital from Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital which is nearby, and reported cases in studies 144 and 210. Citation: Alay, I., Yildiz, S., Kaya, C., Yasar, K.K., Aydin, O.A., Karaosmanoglu, H.K., Aydeniz, B., Salihoglu, O., Yaşar, L. and Ekin, M. (2020), The clinical findings and outcomes of symptomatic pregnant women diagnosed with or suspected of having coronavirus disease 2019 in a tertiary pandemic hospital in Istanbul, Turkey. J. Obstet. Gynaecol. Res.. doi:10.1111/jog.14493

Study 285 – 61 cases from New Jersey, USA

A case control study including 61 women with confirmed COVID-19 in pregnancy (click here or Brandt PIIS0002937820311340). The women were cared for at the Robert Wood Johnson University Hospital, in New Brunswick, which also reported cases in study 86. Citation: BRANDT JS, HILL J, REDDY A, SCHUSTER M, PATRICK HS, ROSEN T, SAUER MV, BOYLE C, ANANTH CV, Epidemiology of COVID-19 in Pregnancy: Risk Factors and Associations with Adverse Maternal and Neonatal Outcomes American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.09.043.

Study 284 – 70 cases from the Republic of Ireland’s Covid-19 register

70 women tested positive for SARS-CoV-2 during pregnancy in March and April 2020 (click here). There were no maternal deaths (pers comm Keelin O’Donoghue). The first report from the Republic of Ireland. Citation: ROI COVID-19 Study https://www.ucc.ie/en/npec/roicovid-19study/ Accessed 27 Sept 2020

24th September update – study 283 added

Study 283 – 321 cases from India

This first report from the Indian PregCOVID registry reports 141 pregnant women testing positive for SARS-CoV-2 in 15 hospitals in Maharashtra state (click here or PIIS0301211520306084). To these are added a further 180 cases from Topiwala National Medical College & BYL Nair Charitable Hospital, grid.413161.0, a dedicated Covid-19 hospital in Mumbai. The registry hospitals are listed and appear to have not previously reported cases. Note Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, in Mumbai grid.415652.1, study 245, does not appear to be part of the registry. The Nair hospital cases may overlap with those in study 225. Citation: Waghmare R, Gajbhiye R, Mahajan N, Modi D, Mukherjee S, Mahale S, Universal screening identifies asymptomatic carriers of SARS-CoV-2 among pregnant women in India, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.09.030

23 September update – study 282 added

Study 282 – 156 cases from Sweden

Of 156 pregant women seen at the Karolinska Hospital in Stockoholm who tested positive for SARS-CoV-2, 65% were asymptomatic (click here or  jama_ahlberg_2020_ld_200101_1600871779.60882). There was one stillbirth. Maternal deaths were not reported. Compared with a control group matched on various factors there was an increase in pre-eclampsia but no increase in preterm birth. This is the first report from this hospital. The cases don’t overlap with those reported in studies 20 or 259, but likely overlap with some in study 88. Citation: Ahlberg M, Neovius M, Saltvedt S, et al. Association of SARS-CoV-2 Test Status and Pregnancy Outcomes. JAMA. Published online September 23, 2020. doi:10.1001/jama.2020.19124

21 September update – study 281 added

Study 281 – First report from the US PRIORITY Study 

The PRIORITY study collected self-reported cases of Covid-19 in pregnancy. In this report they describe the outcomes of 179 infants born to mothers who had tested positive and 84 who tested negative. 82% of the former group and 63% of the latter had symptoms (click here or ciaa1411). 44 babies were admitted to NICU, and two were infected. Although not explicitly stated there appear to have been no stillbirths or neonatal deaths. Births occurred at over 100 hospitals across the US so it is likely that many will have been included in other US reports. Citation: Valerie J Flaherman, MD, MPH, Yalda Afshar, MD, PHD, John Boscardin, PHD, Roberta L Keller, MD, Anne Mardy, MD, Mary K Prahl, MD, Carolyn Phillips, MD, Ifeyinwa V Asiodu, RN, PHD, W Vincenzo Berghella, MD, Brittany D Chambers, PHD, Joia Crear-Perry, MD, Denise J Jamieson, MD, MPH, Vanessa L Jacoby, MD, MAS, Stephanie L Gaw, MD, PHD, Infant Outcomes Following Maternal Infection with SARS-CoV-2: First Report from the PRIORITY Study, Clinical Infectious Diseases, ciaa1411, https://doi.org/10.1093/cid/ciaa1411

20 September update – study 274 belatedly added (we’d missed it on 8 June). Studies 275 to 280 also added

Study 280 – Case report from China

A woman with Covid-19 gave birth on March 6th. The baby was not infected (click here or 5f3fc192e7305c00087df995). The hospital was Wuhan Central Hospital grid.440160.7 which presumably reported this case in study 39. Citation: Gao W, Deng Z, Zeng L, Yang Y, Gong H, Liu J, Xiao H. A newborn with normal IgM and elevated IgG antibodies born to an asymptomatic infection mother with COVID-19. Aging (Albany NY). 2020; 12:16672-16674. https://doi.org/10.18632/aging.103346

Study 279 – The first case of Covid-19 in pregnancy in the USA

A woman with Covid-19 presented to New York City Health and Hospitals/Lincoln on March 12, 2020 (click here or 9795-IN PRESS-52450-5-10-20200908). She had mild disease, was treated as an outpatient and recovered. She was delivered by Caesarean at 37 weeks and the baby was not infected. The authors claim this was the first case of Covid-19 in pregnancy in the US. They may be correct. However the paper title is misleading because it was not a case of intrauterine transmission. Citation: Elkafrawi D, Joseph J, Schiattarella A, Rodriguez B, Sisti G. Intrauterine transmission of COVID-19 in Pregnancy: case report and review of literature. Acta Bio Med [Internet]. 2020Sep.7 [cited 2020Sep.20];91(3):e2020041. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9795

Study 278 – 388 mothers testing positive for SARS-COV-2 from 22 countries.

The World Association of Perinatal Medicine Covid-19 working group has collected 388 women, pregnant with singletons, and diagnosed with SARS-CoV-19 between February 1 and April 30, 2020, from 73 centers in 22 countries (Argentina, Australia, Belgium, Brazil, Colombia, Czech Republic, Finland, Germany, Greece, Israel, Italy, North Macedonia, Peru, Portugal, Republic of
Kosovo, Romania, Russia, Serbia, Slovenia, Spain, Turkey, and United States (click here or uog.23107). Three mothers died. Of 266 completed pregnancies there were 6 miscarriages, 3 pregnancy terminations, and 6 stillbirths. Of 251 livebirths, 5 neonates died. The centres are listed in the supplement here uog23107-sup-0001-supinfo and many appear to have not previously reported cases. However the number of cases per centre is not reported and there is no explicit statement about previous reports. Citation: Di Mascio, D. and the WAPM (The World Association of Perinatal Medicine) working group on COVID‐19 (2020), Maternal and Perinatal Outcomes of Pregnant Women with SARS‐COV‐2 infection. Ultrasound Obstet Gynecol. Accepted Author Manuscript. doi:10.1002/uog.23107

Study 277 – 37 Neonates with community acquired Covid-19 in Turkey

This series of 37 neonates with Covid-91 acquired in the community were collected from 24 neonatal intensive care units around Turkey (click here or A_Multicentered_Study_on_Epidemiologic_and.2). Those born to mothers with SARS-CoV-2 during pregnancy were excluded. One with Down’s syndrome died. Citation: Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Akin, Ilke Mungan; Can, Emrah; Demir, Nihat; Arayici, Sema; Baser, Demet Orhan; Caner, Ibrahim; Memisoglu, Asli; Uygun, Saime Sundus; Akar, Selahattin; Akin, Mustafa Ali; Ataoglu, Emel; Bezirganoglu, Handan; Bilgin, Leyla; Bozdag, Senol; Comert, Serdar; Gurpinar, Resat; Imamoglu, Ebru Yalin; Imdadoglu, Timucin; Narter, Fatma; Ozdemir, Ramazan; Toptan, Handan Hakyemez; Yalinbas, Emine Esin; Yaman, Akan; Erdeve, Omer; Koc, Esin. A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19, The Pediatric Infectious Disease Journal: October 2020 – Volume 39 – Issue 10 – p e297-e302
doi: 10.1097/INF.0000000000002862 

Study 276 – a case treated with Remdesivir from USA

A woman with severe Covid-19 requiring supplemental oxygen but not invasive ventilation was treated with hydroxychloroquine and remdesivir (click here or ofaa345). She recovered and later gave birth vaginally. She was a health care worker caring for COVID-19 patients. From author affiliations this was NewYork-Presbyterian Hospital, Weill Cornell Medical Center, so she may have been included in studies 99, 230, 234 and 270 and possibly other series.  Citation: Grace A Maldarelli, MD, PhD, Megan Savage, MD, Shawn Mazur, PharmD, Corrina Oxford-Horrey, MD, Mirella Salvatore, MD, Kristen M Marks, MD, Remdesivir treatment for severe COVID-19 in third-trimester pregnancy: Case report and management discussion, Open Forum Infectious Diseases, , ofaa345, https://doi.org/10.1093/ofid/ofaa345

Study 275 – 20 women infected with SARS-CoV-2 and pre-eclampsia from Peru

20 women with SARS-CoV-2 also developed pre-eclampsia (click here or PIIS0301211520305959). Two babies died. One baby tested positive. One woman require hysterectomy for placenta accreata. Patients were cared for at Hospital Nacional Edgardo Rebagliati Martins, Lima, and, as acknowledged by the authors, they overlap with those reported in study 274. Citation: Coronado-Arroyo JC, Concepcion-Zavaleta MJ, Zavaleta-Gutierrez FE, Concepcion-Urteaga LA, Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.09.020&nbsp;

Study 274 – 41 patients from Peru

Of 41 women with Covid-19 in pregnancy, treated  between March 24 & May 7, 2020, none died although two required non invasive ventilation. Report in Spanish (click here). English translation (available here or 2245-6876-2-PB). From author affiliations the patients were cared for in Edgardo Rebagliati Martins National Hospital, Lima. One baby was infected. This is a different hospital from the case in study 51. Citation: Huerta Saenz IH, Elías Estrada JC, Campos Del Castillo K, Muñoz Taya R, Cristina Coronado J. Maternal and perinatal characteristics of pregnant women with COVID-19 in a national hospital in Lima, Peru. Rev Peru Ginecol Obstet. 2020;66(2). DOI: https://doi.org/10.31403/rpgo.v66i2245&nbsp;

16 September update – studies 272 & 273 added.

Study 273 – 598 cases from US COVID-NET hospitals

598 hospitalized women with COVID-19, cared for in the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) were pregnant (click here or mm6938e1-H). 44 mothers were admitted to ICU, 23 required invasive mechanical ventilation, and two died. COVID-NET covers 99 counties in 14 US states, which amounts to about 10% of the US population. The cases likely overlap with those in previous COVID-NET reports, studies 171 and 173. Citation: Delahoy MJ, Whitaker M, O’Halloran A, et al. Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 — COVID-NET, 13 States, March 1–August 22, 2020. MMWR Morb Mortal Wkly Rep. ePub: 16 September 2020. DOI: http://dx.doi.org/10.15585/mmwr.mm6938e1

Study 272 – 105 cases from eight US hospitals participating in vaccine surveillance

Among 105 pregnant women admitted with SARS-CoV-2 infection to eight hospitals participating in a Vaccine Safety Datalink (VSD) surveillance project, over half were admitted for obstetric reasons (click here or mm6938e2-H). The participating hospitals are listed here. Citation: Panagiotakopoulos L, Myers TR, Gee J, et al. SARS-CoV-2 Infection Among Hospitalized Pregnant Women: Reasons for Admission and Pregnancy Characteristics — Eight U.S. Health Care Centers, March 1–May 30, 2020. MMWR Morb Mortal Wkly Rep. ePub: 16 September 2020. DOI: http://dx.doi.org/10.15585/mmwr.mm6938e2external icon

14 September update – study 270 added

Study 271 – 86 “extra” maternal deaths during pandemic in Mexico

These authors used publicly available goverment statisitics (click here) to estimate the excess maternal deaths from Covid-19 in Mexico in 2020 (click here or Excess_Maternal_Deaths_Associated_With_Coronavirus.97254). The predicted maternal mortality ratio was 29.5 per 100,000 live births, and so far in 2020 the actual ratio is 42.4. The excess was entirely confined to respiratory disease. Overall 86 “extra” deaths have ocurred. In comparison the 168 deaths officially reported as due to respiratory disease are made up of 109 deaths due to confirmed COVID-19, 34 for which COVID-19 needs to be confirmed, and 25 due to other respiratory diseases. Citation: Lumbreras-Marquez, Mario I. MBBS, MMSc; Campos-Zamora, Melissa MBBS, MMSc; Seifert, Sara M. MD; Kim, Jimin MD, MSc; Lumbreras-Marquez, Jesus MBBS; Vazquez-Alaniz, Fernando PhD; Fields, Kara G. MS; Farber, Michaela K. MD, MS Excess Maternal Deaths Associated With Coronavirus Disease 2019 (COVID-19) in Mexico, Obstetrics & Gynecology: September 09, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004140 [important]

13 September update – studies 267-270 added

Study 270 – more from USA

Not clear from abstract if this includes original data (click here or [16193997 – Journal of Perinatal Medicine] COVID-19 in obstetrics 2020). Citation: Dayal, A. K., Razavi, A. S., Jaffer, A. K., Prasad, N., & Skupski, D. W. (2020). COVID-19 in obstetrics 2020: the experience at a New York City medical center, Journal of Perinatal Medicine (published online ahead of print 2020), 000010151520200365. doi: https://doi.org/10.1515/jpm-2020-0365

Study 269 – Case report from USA

A woman with Covid-19 ruptured her membranes at 19 weeks, and delivered vaginally at 29 weeks (click here or Haiti 8847859 (1)). The baby tested negative but suffered complications of prematurity and remains on ICU. From author affiliations the hospital was probably University of Maryland Medical Center, Baltimore, which has not previously repoted cases. Citation: Mary E. Burgoyne, Emad A. Elsamadicy, Liviu Cojocaru, Andrea Desai, “COVID-19 Barriers to Care for Pregnant Patients in Prolonged Isolation”, Case Reports in Obstetrics and Gynecology, vol. 2020, Article ID 8847859, 4 pages, 2020. https://doi.org/10.1155/2020/8847859

Study 268 – 14 cases from China

Further details on 14 cases from Tongi, Wuhan, which have probably been described before (click here or 1-s2.0-S2052297520301049-main). Citation: Gao X, Wang S, Zeng W, Chen S, Wu J, Lin X, Liu Y, Sun Z, Feng L, Clinical and immunological features among COVID-19 affected mother-infant pairs: antibodies to SARS- CoV- 2 detected in breast milk, New Microbes and New Infections,  https://doi.org/10.1016/j.nmni.2020.100752.

Study 267 – Case from Turkey

Mild Covid-19 delivered by Caesarean, both well (click here or ozer pdf_TPD_1941). From Dokuz Eylul University Hospital, Izmir, which has not previously reported cases. Citation: Ozer E, Cagliyan E, Yuzuguldu RI, Cevizci MC, Duman N. Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19 [published online ahead of print, 2020 Sep 8]. Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19 [published online ahead of print, 2020 Sep 8]. Turk Patoloji Derg. 2020;10.5146/tjpath.2020.01506. doi:10.5146/tjpath.2020.01506

11 September update – study 266 added

Study 266b – USA, Centres for Disease Control update

The latest CDC tracking data, updated 10th September, shows 20,798 pregnant women with Covid-19 in the United States, of whom 44 (0.21%) have died (click here). Among those for which data were available 205/5,339 (4.7%) were admitted to ICU, and 77/4,674 (1.6%) required mechanical ventialtion. Citation: Centres for Disease Control. Weekly COVID-19 Pregnancy Data updated September 10, 2020, Accessed 11 Sept 2020.

10th September update – studies 264 & 265 added

Study 265b – 71 cases from USA

The authors report 71 women who tested positive for SARS-CoV-2 at delivery, four who had tested positive earlier in the pregnancy and two postnatally (click here or PIIS0301211520305807). One mother with severe disease recovered. Another required ECMO and remains on ventilatory support at a tertiary centre three months following delivery at 30 weeks. All neonates were isolated, and one tested positive but was asymptomatic. No babies died. All authors were affiliated with McGovern Medical School at The University of Texas. Houston but the acknowledgment suggests that the unnamed community hospital was Memorial Hermann Southwest Hospital. There have been no previous reports from Houston. Citation: Pineles BL, Alamo IC, Farooq N, Green J, Blackwell SC, Sibai BM, Parchem JG, Racial-Ethnic Disparities and Pregnancy Outcomes in SARS-CoV-2 Infection in a Universally-Tested Cohort in Houston, Texas, European Journal of Obstetrics & Gynecology & Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.09.012

Study 264b – 246 cases from Spain

246 women with SARS-CoV-2 and 763 control women are reported in this Medxiv preprint (click here or 2020.09.05.20188458v1.full). Five women were admitted to ICU, but none died. Three babies were stillborn. This is the first report from the Spanish “Obs Covid registry” which includes 77 hospitals. The patients are therefore likely to include some from previous Spanish series, namely studies 53, 125, 151, 158, 165, 185, 191, 196, 235, and 266. Note that study 196, authored by the Neo-COVID-19 Research Group, which includes 14 hospitals, reported 42 cases and included one maternal death, so presumably does not completely overlap. Citation: SPANISH OBSTETRIC EMERGENCY GROUP, Oscar Martinez Perez, et al. The association between COVID-19 and preterm delivery: A cohort study with a multivariate analysis. medRxiv 2020.09.05.20188458; doi: https://doi.org/10.1101/2020.09.05.20188458

8 September update – studies 261-263 added

Study 263b – 66 cases (plus one maternal death) from Tehran, Iran

Of 66 women with Covid-19 treated between March 1 to Sep 1, 2020, four were admitted to ICU but none required ventilation (click here or taaa158). Two women aborted, 43 delivered, and 21 pregnancies are ongoing. No baby outcomes are reported directly, although one baby tested positive. No women in the series died. However in the discusssion section it is mentioned that in February 2020, a 22-year-old pregnant woman with COVID-19 at 37 weeks had died in the same hospital. It is not clear if she had been included in studies 23, 66 or 67. The women were cared for in Arash Women’s Hospital, which has also reported a set of triplets of which one was infected with SARS-CoV-2 and survived, and the other two who were negative died, (case 5 in study 250). Those triplets seem not to be included in the present series although it is not clear why. Citation: Pirjani R, Hosseini R, Soori T, et al. Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study [published online ahead of print, 2020 Sep 5]. J Travel Med. 2020;taaa158. doi:10.1093/jtm/taaa158

Study 262b – case report from China

A woman with Covid-19 gave birth normally on Feb 22nd at 38 weeks gestation (click here or Antibodies in the breast milk of a maternal woman with COVID 19). Her baby was isolated and tested negative. IgG and IgA were both detected in breast milk, but no virus. The hospital of birth is unnamed but the mother was later transferred Guanggu Branch of Hubei Maternal and Child Health Hospital, a designated hospital for COVID-19 treatment in Wuhan city. This is not listed on GRID.ac but has reported cases many times. The case has probably been included in studies 8, 17, 30, 38, 54, and 55, and perhaps others. Citation: Yunzhu Dong, Xiangyang Chi, Huang Hai, Liangliang Sun, Mengyao Zhang, Wei-Fen Xie & Wei Chen (2020) Antibodies in the breast milk of a maternal woman with COVID-19, Emerging Microbes & Infections, 9:1, 1467-1469, DOI: 10.1080/22221751.2020.1780952 

Study 261b – Case report from  Saudi Arabia

A woman with mild Covid-19 from Al Ahssa, was delivered by Caesarean at 38 weeks and the baby isolated from the mother (click here or cureus-0012-00000010035). The baby did not become infected although 1/29 health care workers involved contracted SARS-CoV-2. This is the first reported case from this country. Citation: AlOmran A, Almatawah Y, Al Sharit B, Alsadah Z, Mousa O. Infection Prevention and Control Challenges With First Pregnant Woman Diagnosed With COVID-19: A Case Report in Al Ahssa, Saudi Arabia. Cureus. 2020;12(8):e10035. Published 2020 Aug 26. doi:10.7759/cureus.10035

7 September update – studies 258-260 added

Study 260b – Case report from UK

A woman with Covid-19 at 28 weeks recovered and delivered at term (click here or e237007.full). The baby was unaffected. From author affiliations the hospital was part of University Hospitals of Leicester NHS Trust, which runs two maternity hospitals, Leicester Royal Infirmary and Leicester General Hospital. Neither has previously reported cases, although the patient was probably included in the UKOSS report, Study 92. Citation: Anness A, Siddiqui F. COVID-19 complicated by hepatic dysfunction in a 28-week pregnant woman. BMJ Case Reports CP 2020;13:e237007.

Study 259b – Case report from Sweden

A woman with severe Covid-19 and coagulopathy at 32 weeks required Caesarean delivery (click here or s12884-020-03172-8). Mother and baby recovered. The baby tested negative. The hospital was Skåne University Hospital in Malmö which has not previously reported cases. Citation: Ronnje, L., Länsberg, J., Vikhareva, O. et al. Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery. BMC Pregnancy Childbirth 20, 511 (2020). https://doi.org/10.1186/s12884-020-03172-8

Study 258b – Case of successful ECMO from France

A woman with Covid 19 required ventilation and Caesarean at 31 weeks. Following delivery her condition worsened and she was treated with ECMO for 7 days (click here or PIIS105307702030793X (002)). She recovered with moderate residual shortness of breath. The baby tested negtive and also recovered. From author affiliations the unnamed ECMO hospital was probably Hôpital Henri-Mondor in Creteil, a southeastern suburb of Paris. The patient may have been previously included in studies 150 & 184. Citation: Fiore A, Piscitelli M, Adodo DK, et al. Successful use of Extracorporeal Membrane Oxygenation (ECMO) in postpartum as rescue therapy in a woman with Covid-19: ECMO postpartum in COVID-19 patient [published online ahead of print, 2020 Aug 6]. J Cardiothorac Vasc Anesth. 2020;doi:10.1053/j.jvca.2020.07.088

3rd September update

Study 257b – Case report from China

A woman with Covid-19 was delivered by Caesarean on February 6, 2020 (click here or main (1)). The baby and other placental/amniotic samples tested negative. Both mother and baby survived. She was cared for in the 5th People’s Hospital of Suzhou grid.490559.4 (click here) which has not previously reported cases. Citation: Lv Y, Gu B, Chen Y, et al. No intrauterine vertical transmission in pregnancy with COVID-19: A case report [published online ahead of print, 2020 Aug 5]. J Infect Chemother. 2020;S1341-321X(20)30266-X. doi:10.1016/j.jiac.2020.07.015

Study 266 – Two cases from Spain

Two pregnant woman with Covid-19 at 12 and 20 weeks respectively had amniocenteis negative for SARS-CoV-2 (click here or 10.1080@14767058.2020.1811669). From author affiliations the unnamed hospital was probably Hospital La Mancha Centro, in Alcazar de San Juan, which has not previously reported cases. Citation: Ana M. Rubio Lorente, Maria Pola Guillén, Nuria López Jimenez, Maria Moreno-Cid Garcia-Suelto, Eduardo Rodriguez Rodriguez & Ana Pascual Pedreño (2020) Study of amniotic fluid in pregnant women infected with SARS-CoV-2 in first and second trimester. Is there evidence of vertical transmission?, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1811669

2nd September update

Study 265 – Pregnant v non-pregnant disease severity using smartphone apps

The authors of this Medxiv preprint (click here or 2020.08.17.20161760v1.full) used a smartphone app (400K women – click here) and the Facebook/Carnegie Mellon COVID-19 survey (1.8M women – click here) to record Covid-19 symptoms and outcomes prospectively. Pregnant women with SARS-CoV-2 infection had the same disease severity as the non-pregnant. Citation: Erika Molteni, Christina M Astley, Wenjie Ma, Carole Helene Sudre, Laura A Magee, Benjamin Murray, Tove Fall, Maria F Gomez, Neli Tsereteli, Paul W Franks, John S Brownstein, Richard Davies, Jonathan Wolf, Timothy Spector, Sebastien Ourselin, Claire Steves, Andrew T Chan, Marc Modat SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology. medRxiv 2020.08.17.20161760; doi: https://doi.org/10.1101/2020.08.17.20161760

1st September update – studies 257 to 264 added

Study 264 – SARS-CoV-2 cell entry gene expression in placenta

Placental expression of the SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2 in pre-pandemic stored samples from the Research Centre for Women’s and Infants’ Health BioBank, and the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, both in Toronto, Ontario (click here or Bloise AJOG 1-s2.0-S000293782030884X-main). Citation: Bloise E, Zhang J, Nakpu J, Hamada H, Dunk CE, Li S, Imperio GE, Nadeem L, Kibschull M, Lye P, Matthews SG, Lye SJ, Expression of SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.08.055.

Study 263 – Case report from The Netherlands

A pregnant woman with Covid-19 developed coagulopathy at 31 weeks, and CTG abnormalities at 32 weeks, necessitating Caesarean birth (click here or Mongula uog.22189). From author affiliations the unnamed hospital was probably Máxima Medical Centre, in Einthoven. Apart from NethOSS reports, the case has not been previously reported. Citation: Mongula, J.E., Frenken, M.W.E., van Lijnschoten, G., Arents, N.L.A., de Wit‐Zuurendonk, L.D., Schimmel‐de Kok, A.P.A., van Runnard Heimel, P.J., Porath, M.M. and Goossens, S.M.T.A. (2020), COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy. Ultrasound Obstet Gynecol. Accepted Author Manuscript. doi:10.1002/uog.22189

Study 262 – COVID-19 perinatal biorepository in Massachusetts

100 women and 78 newborns enrolled in the Massachussets General Hospital COVID-19 biorepository (click here or s12874-020-01102-y). No clinical outcomes reported. Citation: Shook, L.L., Shui, J.E., Boatin, A.A. et al. Rapid establishment of a COVID-19 perinatal biorepository: early lessons from the first 100 women enrolled. BMC Med Res Methodol 20, 215 (2020). https://doi.org/10.1186/s12874-020-01102-y

Study 261- Cardiac abnomalities with, but not caused by, SARS-CoV-2. USA

Six babies with congenital heart disease and one with congenital diaphragmatic hernia born to women with SARS-CoV-2, and cared for in the cardiac unit of New York Presbyterian’s Morgan Stanley Children’s Hospital and Columbia University Irving Medical Center (click here or Goldshtrom 2150135120950256). No babies had symptoms and none tested positive. Four babies were inborn, & two transferred in. Some of the pregnancies and births have probably been described elsewhere. Citation: Goldshtrom, N., Vargas, D., Vasquez, A., Kim, F., Desai, K., Turner, M. E., … Krishnamurthy, G. (2020). Neonates With Complex Cardiac Malformation and Congenital Diaphragmatic Hernia Born to SARS-CoV-2 Positive Women—A Single Center Experience. World Journal for Pediatric and Congenital Heart Surgery. https://doi.org/10.1177/2150135120950256

Study 260 – 2 patients from Italy

Two women with positive SARS-CoV-2 serology also had anti SARS-CoV-2 IgG antibodies in their baby’s cord blood (click here or vendola EJOG PIIS0301211520305352). One birth was vaginal and one by Caesarean. From author affilitations the unnamed hospital was probably Ospedale Sant’Andrea in Vercelli in Piedmont, which has not previously reported caes. Both mothers and babies were healthy.  Citation: Vendola Nicoletta, Stampini Viviana, Amadori, Roberta, Gerbino Martina, Curatolo Annalisa, Surico Daniela, et al. Vertical transmission of antibodies in infants born from mothers with positive serology to COVID-19 pneumonia’ European Journal of Obstetrics & Gynecology & Reproductive Biology, Accepted article online.

Study 259 – Test uptake during hospital birth in USA

Of 270 women offered SARS-CoV-2 testing on admission in labour, 13 had symptomatic disease, 3 had tested positive earlier in the pregnancy, and 223 accepted testing. Uptake rose after a range of methods to encourage testing (click here or Kernberg Universal_SARS.97256). Time period May 28th to June 25th No clinical details or test results reported. Barnes Jewish Hospital in St. Louis, Missouri has not previously reported cases. However the case reported in study 69 may have been cared for in the same hospital. Citation: Kernberg A, Kelly J, Nazeer S, et al. Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Testing Uptake in the Labor and Delivery Unit: Implications for Health Equity [published online ahead of print, 2020 Aug 26]. Obstet Gynecol. 2020;10.1097/AOG.0000000000004127

Study 258 – Environmental sampling during 4 births in Oregon, USA

A range of samples were collected from the room during two vaginal and two Ceasarean births of asymptomatic women with SARS-CoV-2 (click here or Hermesch SARSCoronavirus_2.97258). No other clinical details. The unnamed university hospital is difficult to identify from author affiliations. Citation: Hermesch, Amy C. MD, PhD; Horve, Patrick F. BS; Edelman, Alison MD, MPH; Dietz, Leslie PhD; Constant, David PhD; Fretz, Mark DDS, MArch; Messer, William B. MD, PhD; Martindale, Robert MD; Van Den Wymelenberg, Kevin PhD Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Environmental Contamination and Childbirth, Obstetrics & Gynecology: August 19, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004112

Study 257 – 6 cases treated with nitric oxide from USA

Six pregnant women with severe Covid-19 were treated with nitric oxide (click here or FAKHR High_Concentrations_of_Nitric_Oxide_Inhalation.97257). Three women delivered four babies, and three pregnancies are ongoing. No mothers or babies died. The patients were treated at Massachusetts General Hospital from April to June 2020, and probably overlap with those reported in studies 142 & 231. Citation: Safaee Fakhr B, Wiegand SB, Pinciroli R, et al. High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) [published online ahead of print, 2020 Aug 26]. Obstet Gynecol. 2020; 10.1097/AOG.0000000000004128. 

21st August update – studies 255 & 256 added

Study 256 – Case report from Norway

In Norweigan. Following from Google translate. A woman with twins developed mild Covid-19 during the process of labour induction at 38 weeks (click here or 59551-fødende-risikopasient-med-covid-19). Both babies were delivered vaginally. She recovered and the twins were healthy. Baby test results not reported. 14 hospital employees were quarantined due to patient contact, but none diagnosed with infection. From author affiliations the unnamed hospital was Sørlandet Hospital, Kristiansand, which has not previously reported cases.  Citation: Ane Cecilie Munk, Linda Reme Sagedal, Turid Stavseth Krogedal, Ida McFadzean, Hanna Oommen. Fødende risikopasient med covid-19 (Maternity risk patient with covid-19) Tidsskrift for Den norske legeforening. Published: July 16, 2020 Issue 11, August 18, 2020 Tidsskr Nor Legeforen 2020 doi: 10.4045 / tidsskr.20.0425

Study 255 – 16 maternal deaths in the UK

Ten women died with SARS-CoV-2 between 01/03/2020 and 31/05/2020, seven directly due to Covid-19, one cause not determined, and two due to unrelated causes (click here or Ref.-201-MBRRACE-UK-maternal-COVID-19-Report-FINAL (002)).  Six further women died by suicide or domestic violence, conceivably related to lockdown, over the same period. They overlap with those in studies 29, 52, 68, 92, 107, 126 & 200. Citation: Knight M, Bunch K, Cairns A, Cantwell R, Cox P, Kenyon S, Kotnis R, Lucas DN, Lucas S, Marshall L, Nelson-Piercy C, Page L, Rodger A, Shakespeare J, Tuffnell D, Kurinczuk JJ on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care Rapid Report: Learning from SARS-CoV-2-related and associated maternal deaths in the UK March – May 2020 Oxford: National Perinatal Epidemiology Unit, University of Oxford 2020.

20 August update – study 254 added

Study 254 – Breast milk testing in 18 affected women from the USA

Eighteen women with SARS-CoV-2, 17 symptomatic, had multiple breast milk samples tested (click here or jama_chambers_2020_ld_200087_1597789061.40481). One sample had detectable SARS-CoV-2 RNA, but no replication-competent virus was detectable in any sample, including the sample that tested positive for viral RNA. The samples were collected from woman anywhere in the United States so may include cases previously reported. Citation: Chambers C, Krogstad P, Bertrand K, et al. Evaluation for SARS-CoV-2 in Breast Milk From 18 Infected Women. JAMA. Published online August 19, 2020. doi:10.1001/jama.2020.15580 [important]

19 August update – Studies 251 to 253 added.

Study 253 – Case report from China

A woman with Covid-19 was delivered at 35 weeks gestation by caesarean section (click here or 1-s2.0-S1876034120304391-main). The baby was not infected. From author affiliations the unnamed hospital was probably Chongqing Three Gorges Central Hospital (grid.477128.f) which has not previously reported cases. Citation: Zhoujie Peng, Jianhui Wang, Yunbo Mo, Wei Duan, Guangjun Xiang, Ming Yi, Lei Bao, Yuan Shi. Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report. Journal of Infection and Public Health, Volume 13, Issue 5, 2020, Pages 818-820, ISSN 1876-0341, https://doi.org/10.1016/j.jiph.2020.04.004.

Study 252a – Case report from Italy

An asymptomatic woman with SARS-CoV-2 underwent Caesarean for breech at 38 weeks gestation (click here or medicina-56-00306-v2). The baby was asymptomatic and tested negative. Swabs from the amniotic surface of the placenta were positive. The hospital was IRCCS Ospedale Policlinico San Martino, Genoa, which has not previously reported cases. Citation: Ferraiolo, A.; Barra, F.; Kratochwila, C.; Paudice, M.; Vellone, V.G.; Godano, E.; Varesano, S.; Noberasco, G.; Ferrero, S.; Arioni, C. Report of Positive Placental Swabs for SARS-CoV-2 in an Asymptomatic Pregnant Woman with COVID-19. Medicina 2020, 56, 306.

Study 252 – 49 new cases from Italy

These 49 women with SARS-CoV-2 in pregnancy were collected between 10–26 April (click here or 10.1080@14767058.2020.1788532).  No outcomes reported. The unnamed hospitals in Milan and the six provinces of Lombardy (Brescia, Como, Lecco, Monza, Pavia, and Sondrio) were probably Sacco (Milan), Mangiagalli (Milan), S. Gerardo MBBM Foundation (Monza), Papa Giovanni XXIII (Bergamo), and San Matteo (Pavia) and the hospitals of Padua, Florence, Lecco, Trento, Modena, Seriate and Piacenza. However the recruitment period was later than that in studies 33, 64 & 117, so these patients have not been previously reported. Citation: Enrico Ferrazzi, Paolo Beretta, Stefano Bianchi, Irene Cetin, Paolo Guarnerio, Anna Locatelli, Anna Maria Marconi, Mario Giuseppe Meroni, Giulia Pavone, Armando Pintucci, Federico Prefumo, Valeria Savasi, Arsenio Spinillo, Beatrice Tassis, Patrizia Vergani, Michele Vignali, Fabio Parazzini & Carlo La Vecchia. (2020): SARS-CoV-2 infection testing at delivery: a clinical and epidemiological priority. Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1788532

Study 251 – 101 cases from USA

Risk factors for 101 pregnant women testing positive for SARS-CoV-2 were compared with 1,317 controls (click here or 1-s2.0-S2589933320301543-main). No outcome data. The women were cared for at Northwestern Memorial Hospital, Chicago March 19 to May 31 2020. They likely include cases in studies 116 & 124.  Citation: SAKOWICZ A, AYALA AE, UKEJE CC, WITTING CS, GROBMAN WA, MILLER ES, Risk Factors for SARS-CoV2 Infection in Pregnant Women, American Journal of Obstetrics & Gynecology MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100198.

18 August update – belated addition of study 246, ItOSS registry, (HT Aris Papageorghiou), & studies 247 to 250.

Study 250 – 19 infected babies from Iran

19 newborns (incl. one set of triplets) infected with SARS-CoV-2 (click here or 10.1080@14767058.2020.1797672). One mother and four babies died. Dates of birth preceded paper receptin 20 June. The hospitals were Imam Khomeini Hospital, Orumiyeh, West Azerbaijan Province; Shariati Hospital, Tehran (the mother of this case died); Torbat-e Jām Hospital in Torbat-e Jām, Razavi Khorasan Province; Taleghani Hospital in Tehran, Arash Women’s Hospital in Tehran (triplets – 2 died, 1 survived); Boo-Ali Sina Hospital in Sari, Mazandaran Province; Qods Hospital in Qazvin; Ayatollah Mousavi Hospital in Zanjan; Mustafa Khomeini Hospital in Ilam; Allameh Bohluli Hospital in Gonabad, Razavi Khorasan Province; Imam Reza Hospital in Mashhad, Khorasan-e Razavi Province; Imam Sajad Hospital in Shahriar, Tehran Province; Day General Hospital in Tehran; Taleghani Hospital in Gorgan, Golestan Province (baby died); Hakim Jorjani Hospital in Gorgan, Golestan Province (baby died); and Hamedan Besat Hospital in Hamedan. The cases may overlap with those in studies 66, 67 & 218. They probably differ from those reported in studies 23 & 70. Citation: David A. Schwartz, Parisa Mohagheghi, Babak Beigi, Nazanin Zafaranloo, Fereshteh Moshfegh, Anita Yazdani. Spectrum of neonatal COVID-19 in Iran: 19 infants with SARS-CoV-2 perinatal infections with varying test results, clinical findings and outcomes. J Mat Fetal & Neonatal Med 2020, AHEAD-OF-PRINT, 1-10 https://doi.org/10.1080/14767058.2020.1797672

Study 249 – 669 cases with respiratory problems from Brazil

Another report of women with Covid-19 in pregnancy identified through the Brazilian Acute Respiratory Distress Syndrome Surveillance System (click here or oup-accepted-manuscript-2020). Overlap with studies 66, 138, 282, 194, 201, 203 & 248. Citation: Debora de Souza Santos, RN, PhD, Mariane de Oliveira Menezes, CM, MSc, Carla Betina Andreucci, MD, PhD, Marcos Nakamura-Pereira, MD, PhD, Roxana Knobel, MD, PhD, Leila Katz, MD, PhD, Heloisa de Oliveira Salgado, MSc, PhD, Melania Maria Ramos de Amorim, MD, PhD, Maira L S Takemoto, CNM, PhD, Disproportionate impact of COVID-19 among pregnant and postpartum Black Women in Brazil through structural racism lens, Clinical Infectious Diseases, , ciaa1066, https://doi.org/10.1093/cid/ciaa1066

Study 248 – 978 cases with respiratory problems from Brazil

Of 978 pregnant or postpartum women with COVID-19 and Acute Respiratory Distress Syndrome (ARDS), 124 died (click here or 1471-0528.16470). These appear to be the same cases as reported in study 182, albeit in more detail. They probably also overlap with studies 66, 138, 194, 201, & 203. Citation: Takemoto, M.L., Menezes, M.O., Andreucci, C.B., Knobel, R., Sousa, L.A., Katz, L., Fonseca, E.B., Nakamura‐Pereira, M., Magalhães, C.G., Diniz, C.S., Melo, A.S., Amorim, M.M. and Menezes, M.O. (2020), Clinical characteristics and risk factors for mortality in obstetric patients with severe COVID‐19 in Brazil: a surveillance database analysis. BJOG: Int J Obstet Gy. Accepted Author Manuscript. doi:10.1111/1471-0528.16470

Study 247 – 6 placentas from 5 women, Italy

This preprint reports the histology of 6 placentas from 5 pregnancies (one set of twins) complicated by Covid-19 (click here or Placenta in SARS-CoV-2 Bertero). All mothers and babies survived and all babies tested negative. They were cared for in S. Anna Hospital, Turin from March 22, to April 23, 2020, so are probably included in study 246. Citation: Luca Bertero, Fulvio Borella, Giovanni Botta, Andrea Carosso, Stefano Cosma, Marialuisa Bovetti, Marco Carosso, Giancarlo Abbona, Mauro Papotti, Paola Cassoni. Placenta in SARS-CoV-2 infection: a new target for inflammatory and thrombotic events. Research Square. Maternal Fetal Medicine. 2020. DOI: 10.21203/rs.3.rs-30412/v1

Study 246 – 146 cases from Italy (ItOSS)

This Medxiv preprint (not yet published as a peer reviewed paper) reports 146 women with Covid-19 in pregnancy up to April 22nd and collected by the Italian Obstetric Surveillance System, ItOSS (click here or 2020.06.11.20128652v1.full). 142 were positive for SARS-CoV-2 and 4 diagnosed clinically via CXR. Seven mothers were admitted to ITU, and 2 intubated, but none died. Two babies were stillborn and five tested positive. There were no neonatal deaths. These patients likely overlap with those in studies 32, 64, 76, 79, 109, 114, 188 and 197. They probably do not overlap with those in study 195. Citation: Alice Maraschini, Edoardo Corsi, Michele Antonio Salvatore, Serena Donati. Coronavirus and birth in Italy: results of a national population-based cohort study. medRxiv 2020.06.11.20128652; doi: https://doi.org/10.1101/2020.06.11.20128652 For published version click here or ANN_20_03_17. Citation: Maraschini A, Corsi E, Salvatore MA, Donati S; ItOSS COVID-19 Working Group. Coronavirus and birth in Italy: results of a national population-based cohort study. Ann Ist Super Sanita. 2020 Jul-Sep;56(3):378-389. doi: 10.4415/ANN_20_03_17. PMID: 32959805.

17th August update – studies 238 to 245 added

Study 245 – 141 cases from India

Out of 141 women with Covid-19 in pregnancy there were 3 abortions, one ectopic pregnancy and 3 maternal deaths (click here or Nayak 13224_2020_Article_1335). There were 3 stillbirths and 3 babies tested positive. From the description and author affiliations, the unnamed hospital is almost certainly Lokmanya Tilak Municipal General Hospital, grid.415652.1, Mumbai, which has not previously reported cases. Citation: Nayak, A.H., Kapote, D.S., Fonseca, M. et al. Impact of the Coronavirus Infection in Pregnancy: A Preliminary Study of 141 Patients. J Obstet Gynecol India 70, 256–261 (2020). https://doi.org/10.1007/s13224-020-01335-3

Study 244 – 125 cases from Turkey

Of 125 pregnant women with Covid-19 (click here or Oncel2020_Article), 7 mothers required ventilation and 5 died. Four babies tested positive and one (who tested negative) died. The babies were cared for in 34 unnamed neonatal intensive care units. From author affiliations these probably include İzmir (3 centres), İstanbul (6 centres), Rize (1 centre), Ankara (4 centres) and Kocaeli (1 centre). Some of these cases probably overlap with those reported in studies 31, 145, 146, 203, 210 & 223. Citation: Oncel, M.Y., Akın, I.M., Kanburoglu, M.K. et al. A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society. Eur J Pediatr (2020). https://doi.org/10.1007/s00431-020-03767-5

Studies 238 to 243 – 6 case reports, from Portugal, France, US, India, UK & Nigeria

S 238 (facial palsy) from Porto, Portugal (click here or figuerdo), Citation: Figueiredo R, Falcão V, Pinto MJ, et al. BMJ Case Rep 2020;13:e237146. doi:10.1136/bcr-2020-237146. S 239 (severe case) from Paris (click here or federici). Citation: Federici L, Picone O, Dreyfuss D, et al. BMJ Case Rep 2020;13:e237511. doi:10.1136/bcr-2020-237511. S 240 (serial cord antibody levels) from Mount Sinai, New York (click here or Toner). Citation: Toner et al. Passive Immunity in COVID Positive Pregnant Patient. Am J Perinatol. 21 July 2020. https://doi.org/10.1055/s-0040-1715643. &nbsp;S 241 (mild case) from New Delhi, (click here or Chhabra IndianJAnaesth6414141-6060246_165002). Citation: Chhabra A, Rao TN, Kumar M, Singh Y, Subramaniam R. Anaesthetic management of a COVID‑19 parturient for caesarean section ‑ Case report and lessons learnt. Indian J Anaesth 2020;64:S141-3. S 242 (HELLP) from Birmingham, UK (click here or Ahmed e237521.full) Citation: Ahmed I, Eltaweel N, Antoun L, et al. BMJ Case Rep 2020;13:e237521. doi:10.1136/bcr-2020-237521.  S 243 (Caesarean) from Lagos (click here or Makwe). Citation: Christian Chigozie Makwe et al. Caesarean delivery of first prediagnosed COVID-19 pregnancy in Nigeria. Pan African Medical Journal. 2020;36:100. [doi: 10.11604/pamj.2020.36.100.23892]

13 August update – studies 236 & 237 added

Study 237 – Effect of lockdown on hospital births in Nepal

Birth numbers halved, stillbirths increased by 50% and neonatal mortality nearly fourfold, during lockdown in nine Nepal hospitals (click here PIIS2214109X20303454). No women or babies were tested for Covid-19. Citation: Ashish KC, Rejina Gurung, Mary V Kinney, Avinash K Sunny, Md Moinuddin, Omkar Basnet, Prajwal Paudel, Pratiksha Bhattarai, Kalpana Subedi, Mahendra Prasad Shrestha, Joy E Lawn, Mats Målqvist. Effect of the COVID-19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: a prospective observational study. Lancet Global Health. August 10, 2020 DOI: https://doi.org/10.1016/S2214-109X(20)30345-4 [important]

Study 236 – 45 cases from USA

45 babies were born to SARS-CoV-2 positive mothers, 30 were vaginal births, 33 co-located with their mothers and 31 were breast fed (click here or s41372-020-0765-30). 27 of the mothers were asymptomatic. No other maternal details were reported. All 45 newborns were tested & 3 were positive. The patients were cared for at Elmhurst Hospital Center in New York which has not previously reported cases.  Citation: Patil, U.P., Maru, S., Krishnan, P. et al. Newborns of COVID-19 mothers: short-term outcomes of colocating and breastfeeding from the pandemic’s epicenter. J Perinatol (2020). https://doi.org/10.1038/s41372-020-0765-3

11 August update – study 235 added

Study 235 – 125 anti-SARS-CoV-2 sero-positive women from Spain

Of 874 pregnant women attending first trimester screening (n=372) or delivery (n=502) from April 14 to May 5, 2020, 125 were positive for anti-SARS-CoV-2 IgG, IgM, or IgA. 54/372 in first trimester, and 71/502 in 3rd trimester (click here or PIIS0140673620317141 & supplementary material mmc1). Three women required oxygen therapy, but none critical care. No baby outcomes reported. Women were cared for in Hospital Sant Joan de Déu, Hospital Clínic, and Sant Pau all in Barcelona. They probably overlap with cases reported in studies 185 and 191, but probably not with those in studies 53, 125, 151, 158, 165, or 196. Citation: Francesca Crovetto, Fàtima Crispi, Elisa Llurba, Francesc Figueras, María Dolores Gómez-Roig, Eduard Gratacós. Seroprevalence and presentation of SARS-CoV-2 in pregnancy.  Lancet. Published Online August 6, 2020 https://doi.org/10.1016/S0140-6736(20)31714-1

10 August update – study 234 added

Study 234 – 70 cases from US

Of 675 pregnant women admitted for delivery and tested for SARS-CoV-2, 70 were positive, of whom 55 were asymptomatic on presentation (click here or 1471-0528.16403). Three mothers were hypoxic, one was admitted to ITU but none required ventilation. No mothers died. There was one stillbirth to a mother with asymptomatic Covid-19 and other pathology. 73 babies were born, 71 were tested and all were negative. The three hospitals, were Weill Cornell Medical Center, Queens, and Lower Manhattan Hospital. The cases may therefore also have been included in studies 160, 216 and 230. However, they were probably not included in the other NY Presbyterian series namely studies 14, 27, 41, 95, 96 and 136. Citation: Prabhu, M., Cagino, K., Matthews, K.C., Friedlander, R.L., Glynn, S.M., Kubiak, J.M., Yang, Y.J., Zhao, Z., Baergen, R.N., DiPace, J.I., Razavi, A.S., Skupski, D.W., Snyder, J.R., Singh, H.K., Kalish, R.B., Oxford, C.M. and Riley, L.E. (2020), Pregnancy and postpartum outcomes in a universally tested population for SARS‐CoV‐2 in New York City: A prospective cohort study. BJOG: Int J Obstet Gy. Accepted Author Manuscript. doi:10.1111/1471-0528.16403. 

9 August update – studies 230 to 233 added

Study 233 – case report from Morocco

A woman contracted Covid-19 at 31 weeks gestation, required oxygen therapy and went into premature labour. A Caesarean was performed for fetal distress (click here or 8852816). The mother recovered. The baby tested negative but had severe birth asphyxia and died age 5 days. The mother was cared for at University Hospital of Mohammed VI, Marrakech, which has not previously reported cases. This is the first report from Morocco. Citation: Yassamine Abourida, Houssam Rebahi, Imane Oussayeh, Hajar Chichou, Bouchra Fakhir, Abderraouf Soummani, Hicham Jalal, Fatiha Bennaoui, Nadia El Idrissi Slitine, Fadl Mrabih Rabou Maoulainine, Ahmed Rhassane El Adib, and Mohamed Abdenacer Samkaoui. Management of Severe COVID-19 in Pregnancy. Case Reports in Obstetrics and Gynecology Volume 2020, Article ID 8852816, 5 pages https://doi.org/10.1155/2020/8852816

Study 232 – 44 cases from US

Of 44 pregnant or recently postpartum women with COVID-19, 5 had severe disease and 2 required ventilation (click here or ijgo.13333). All mothers survived. Of 11 babies born, 9 tested negative and 2 declined testing. All survived. 31 pregnancies are ongoing. The majority of patients belonged to racial [sic] or ethnic minority groups. From author affiliations the unnamed hospital was probably Brigham and Women’s Hospital, Boston. Some cases may therefore have been reported in study 231, but probably differ from those in studies 129 & 142. Citation: Onwuzurike, C., Diouf, K., Meadows, A.R. and Nour, N.M. (2020), Racial and ethnic disparities in severity of COVID‐19 disease in pregnancy in the United States. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13333

Study 231 – 19 placentas from USA

2/19 placentas of affected pregnancies tested positive for SARS-CoV-2 by in-situ hybrization (click here or s41379-020-0639-4). There were no specific pathologic features compared with 262 control placentas. One fetus was stillborn at 22 weeks and not tested. There were two sets of twins. All liveborn babies survived, and only one tested positive. From the case codes in Table 2 it appears that 10 pregnancies had been cared for at Massachusetts General Hospital, 4 at Brigham and Women’s Hospital & 5 at Beth Israel Deaconess Medical Center, Boston. Some have therefore probably been reported in studies 129 & 142. Citation: Hecht, J.L., Quade, B., Deshpande, V. et al. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Mod Pathol (2020). https://doi.org/10.1038/s41379-020-0639-4

Study 230 – Placental features of 74 cases from USA

2/53 placentas from affected pregnancies contained a SARS-CoV-2 viral signal by in-situ hybridization (click here or Zhang, Placenta, AJOGMFM). One baby tested positive, the other negative. Both were asymptomatic. There were no specific histological differences between 74 placentas from SARS-CoV-2 positive pregnancies and 290 controls. The authors are affiliated with the New York Presbyterian, Brooklyn Methodist, Weill Cornell group of hospitals so the clinical aspects of the cases have probably been reported before.  Citation: Zhang P, Heyman T, Salafia C, Dygulska B, Lederman S, Detection of SARS-CoV-2 in placentas with pathology and vertical transmission, American Journal of Obstetrics & Gynecology MFM (2020), doi:  https://doi.org/10.1016/j.ajogmf.2020.100197.

8 August update – studies 225 to 229 added

Study 229 – Some assisted reproduction pregnancies during the pandemic in France.

The authors report 88, or possibly 104, women (numbers are unclear) who conceived by assisted reproduction between December 2019 & March 2020, and were still pregnant after the first reported case of Covid-19 in France on 12th February. Ten had symptoms related to Covid-19, none severe or requiring intensive care (click here or PIIS0301211520304929). Five of the ten were tested and two were positive. 15 women miscarried although their Covid-19 status was not reported. From author affiliations the unnamed centre was probably the Reproductive Biology Unit,  Antoine Béclère Hospital, Clamart. These cases may therefore feature in studies 150, 157, 184 & 217. The pregnancies were unlikely to have been sufficiently far advanced to have featured in studies 48 & 187. Citation: Mayeur A, Binois O, Gallot V, Hesters L, Benoit A, Oppenheimer A, Presse M, Zeghari F, Benguigi J, Grynberg M, Frydman N, Sonigo C, First follow-up of art pregnancies in the context of the COVID-19 outbreak, European Journal of Obstetrics & Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.050

Study 228 – case report from USA

A pregnant woman contracted severe Covid-19 requiring ventilation at 32 weeks (click here or Ching Case Rep RespMed). She was delivered by Caesarean section for suspected placenta praevia and recovered. The baby required intubation and ventilation for 48 hours but tested negative. The ultimate baby outcome is not reported. The hospital is unnamed but the authors’ affiliation with San Joaquin Critical Care Medical Group, suggests that it was San Joaquin General Hospital in Stockton, California which has not previously reported cases. Citation: Josebelo Chong, Siraj Ahmed, Kyle Hill. Acute Respiratory Distress Syndrome in a pregnant patient with COVID-19 improved after delivery: A case report and brief review. Respiratory Medicine Case Reports. Volume 31, 2020, 101171, ISSN 2213-0071, https://doi.org/10.1016/j.rmcr.2020.101171.

Study 227 – case report from USA

A woman with mild Covid-19 gave birth to a male infant vaginally at term (click here or HSU jmv.26386). She recovered. The baby breast fed, tested negative and was fine. The virus was demonstrated in the placenta by immuno-histochemistry using a  SARS-CoV-2 nucleocapsid-specific monoclonal antibody. Mother and baby were cared for at University of Missouri Women and Children’s Hospital Columbia, Missouri, which has not previously reported cases. The clinical details of case 69 differ. Citation: Hsu, A.L., Guan, M., Johannesen, E., Stephens, A.J., Khaleel, N., Kagan, N., Tuhlei, B.C. and Wan, X.‐F. (2020), Placental SARS‐CoV‐2 in a Pregnant Woman with Mild COVID‐19 Disease. J Med Virol. Accepted Author Manuscript. doi:10.1002/jmv.26386

Study 226 – 3 cases treated with remdesivir from USA

Three pregnant women with Covid-19 were treated with remdesivir outside a clinical trial (click here or PIIS0002937820308292). One developed “transaminitis” – I think the authors mean raised liver transaminase. The pre-print is missing a table – which the authors attributed to the remdesivir. That woman later developed intrahepatic cholestasis of pregnancy and delivered normally. The other pregnancies are ongoing. The acknowledgements suggest that the unnamed hospital is Lucile Packard Children’s Hospital at Stanford, California. Although one author is shared with study 115 from another unnamed Stanford hospital, the clinical details differ. These cases have probably not previously been reported. Citation: Igbinosa I, Miller S, Bianco K, Nelson J, Kappagoda S, Blackburn BG, Grant P, Subramanian A, Lyell D, El-Sayed Y, Aziz N, Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.08.001.

Study 225 – over 600 cases (412 births) in India

Nair hospital, Mumbai, a dedicated Covid-19 facility, has cared for over 600 pregnant women with the disease (click here or ijgo.13338). There have been 412 births including seven pairs of twins and one set of triplets. No mothers died of Covid-19 directly, although four died of other causes. No baby outcomes reported. The first two cases had originally been cared for elsewhere, and also previously denied admission at four private hospitals, the latter a feature of news reports from India (click here). Two health care workers contracted COVID-19. Nair Hospital has not previously reported cases. The case reported in study 58 was from New Delhi. Citation: Mahajan, N.N., Pednekar, R., Patil, S.R., Subramanyam, A.A., Rathi, S., Malik, S., Mohite, S.C., Shinde, G., Joshi, M., Kumbhar, P., Tilve, A., Lokhande, P.D. and Srivastava, S.A. (2020), Preparedness, administrative challenges for establishing obstetric services, and experience of delivering over 400 women at a tertiary care COVID‐19 hospital in India. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13338 [important]

31 July update – studies 221 to 224 added

Study 224 – 6 cases from Sri lanka

This paper primarily reports the mental health of pregnant women without Covid-19 during the pandemic in Sri Lanka (click here or ijgo.13335). The authors mention six cases of COVID-19 positive pregnant women in the country. Although no further details are given, and the link given (ref 8) to the Live Situational Analysis Dashboard of Sri Lanka (click here) does not cite pregnancy cases, this is the first scientific report of Covid-19 in pregnancy from Sri Lanka. Citation: Patabendige, M., Gamage, M.M., Weerasinghe, M. and Jayawardane, A. (2020), Psychological impact of the COVID‐19 pandemic among pregnant women in Sri Lanka. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13335

Study 223 – 3 cases from Turkey

Three pregnant women tested postive for SARS-CoV-2 in Ankara City Hospital (click here or PIIS0301211520304930). All three had co-morbidities but mild disease and were delivered by Caesarean. Baby outcomes not reported. Citation: Tanacan A, Erol SA, Turgay B, Anuk AT, Secen EI, Yegin GF, Ozyer S, Kirca F, Dinc B, Unlu S, Yapar Eyi EG, Keskin HL, Sahin D, Surel AA, Tekin OM, The Rate of SARS-CoV-2 Positivity in Asymptomatic Pregnant Women Admitted to Hospital for Delivery: Experience of A Pandemic Center in Turkey, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.051

Study 222 – Case report from USA

A 22-year-old woman with placenta previa and a past medical history of tuberous sclerosis and multiple associated comorbidities contracted Covid-19 at 23 weeks + 6 days gestation (click here or 2324709620946621). She required intubation and ventilation and was delivered by caesarean at 25+5. The baby tested negative. Both mother and baby survived. The hospital is unnamed but from author affiliations is probably Los Angeles County+USC Medical Center, California,which has not previously reported cases. Citation: Easterlin, M. C., De Beritto, T., Yeh, A. M., Wertheimer, F. B., & Ramanathan, R. (2020). Extremely Preterm Infant Born to a Mother With Severe COVID-19 Pneumonia. Journal of Investigative Medicine High Impact Case Reports. https://doi.org/10.1177/2324709620946621

Study 221 – SARS-CoV-2 serological testing of 1,293 parturient women, USA

1,293 parturient women tested for SARS-CoV-2 antibodies in two hospitals in Philadelphia, 80 were positive (click here or eabd5709.full), Percentages in results table 1 are given by row rather than column making comparisons difficult. The hospitals are unnamed. A preprint of this paper in MedXiv was study 202. Citation: D. D. Flannery et al., Sci. Immunol. 10.1126/sciimmunol.abd5709 (2020)

30 July update – study 220 added

Study 220 – 29 cases from China

29 women with Covid-19 between January 30 and March 10, 2020, gave birth to 30 neonates (1 set of twins) (click here or journal.pmed.1003195). The hospitals were Renmin Hospital, Wuhan University, and Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology. These cases have surely been published before. Citation: Wu Y-T, Liu J, Xu J-J, Chen Y-F, Yang W, Chen Y, et al. (2020) Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. PLoS Med 17(7): e1003195. https://doi.org/10.1371/journal.pmed.1003195

28 July update – studies 217 to 219 added

Study 219 – 3 cases from New Jersey, USA

Three women with Covid-19 in pregnancy required ventilation and delivery by Caesarean (click here or Douedi AM J Cas Rep NJ). All three mothers and babies survived, and all babies tested negative. The hospital is unnamed, but from author affiliations is probably Jersey Shore University Medical Center. The cases were probably therefore also reported in study 149. Citation: Steven Douedi, Asseel Albayati, Nasam Alfraji, Usman Mazahir, Eric Costanzo Steven Douedi, Asseel Albayati, Nasam Alfraji, Usman Mazahir, Eric Costanzo. Am J Case Rep 2020; 21:e925513 DOI: 10.12659/AJCR.925513

Study 218 – Case report from Iran

A 30 year old woman contracted Covid-19 at 21 weeks gestion (click here or Soleimani JMFM). She received methyprednisolone, Lopinivir, Azithromycin, Hydrocortisone and immune plasma and survived. The pregnancy is ongoing. The hospital is unnamed and only identifiable as being in Tehran from author affiliations. The case in study 101 was from a different city, and the details differ from those of the two survivors is study 67. Citation: Zahra Soleimani & Azam Soleimani (2020): ADRS due to COVID-19 in midterm pregnancy: successful management with plasma transfusion and corticosteroids, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1797669

Study 217 – 83 cases from France & Belgium

83 pregnant women with Covid-19 were compared with a group of non-pregnant affected control women (click here or Badr AJOG PIIS0002937820307766). No raw data and no pregnancy outcomes provided. The hospitals were Antoine Béclère, Clamart, Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, Centre Hospitalier Sud Francilien, Corbeil-Essones, and University Hospital Brugmann, Brussels. These cases have probably been already reported. Citation: Badr DA, Mattern J, Carlin A, Cordier A-G, Maillart E, El Hachem L, El Kenz H, Andronikof M, De Bels D, Damoisel C, Preseau T, Vignes D, Cannie MM, Vauloup-Fellous C, Fils J-F, Benachi A, Jani JC, Vivanti AJ, Are clinical outcomes worse for pregnant women ≥ 20 weeks’ gestation infected with COVID-19? A multicenter case-control study with propensity score matching, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.07.045.

27 July update – study 216 added

Study 216 – 120 babies born to SARS-CoV-2 positive mothers from USA

120 neonates born to 116 mothers who had tested positive for SARS-CoV-2 in pregnancy, were were tested at 24 hours of life. Of them, 79 were also tested at 5-7 days, and 72 at 14 days. All tested negative at all time points and none had symptoms of COVID-19 (click here or  1-s2.0-S2352464220302352-main). From author affiliations they were probably cared for at Weill Cornell Presbyterian Komansky, Presbyterian Queens, and Presbyterian Lower Manhattan hospitals all in New York. Citation: Christine M Salvatore, Jin-Young Han, Karen P Acker, Priyanka Tiwari, Jenny Jin, Michael Brandler, Carla Cangemi, Laurie Gordon, Aimee Parow, Jennifer DiPace, Patricia DeLaMora. Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study, The Lancet Child & Adolescent Health, 2020, ISSN 2352-4642, https://doi.org/10.1016/S2352-4642(20)30235-2.

25 July update – studies 212 to 215 added

Study 215 – Case report from USA

A woman with Covid-19 in pregnancy continued to test positive for SARS-CoV-2 for 100 days (click here or Prolonged_Detection_of_Severe_Acute_Respiratory.97292). Mother and baby survived. All viral tests on baby, placenta and breast milk were negative. The cord blood was positive for IgG antibodies to SARS-CoV-2. From author affiliations the hospital was MultiCare Tacoma General Hospital, Tacoma, Washington State, which has not previously reported cases. Citation: Molina, Loren P. MD; Chow, Siu-Kei PhD; Nickel, Adam DO; Love, Jason E. MD Prolonged Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in an Obstetric Patient With Antibody Seroconversion, Obstetrics & Gynecology: July 21, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004086

Study 214 – 100 cases from USA

The authors report the Race [sic] and Ethnicity of 100 cases of Covid-19 in pregnancy from New York (click here or Influence_of_Race_and_Ethnicity_on_Severe_Acute.97290). These cases have likely been reported before. Citation: Emeruwa, Ukachi N. MD, MPH; Spiegelman, Jessica MD; Ona, Samsiya MD; Kahe, Ka MD, ScD; Miller, Russell S. MD; Fuchs, Karin M. MD, MHA; Aubey, Janice J. MD, MPH; Booker, Whitney MD; D’Alton, Mary E. MD; Friedman, Alexander M. MD, MPH; Aziz, Aleha MD, MPH; Sutton, Desmond MD; Purisch, Stephanie E. MD; Goffman, Dena MD; Melamed, Alexander MD, MPH; Gyamfi-Bannerman, Cynthia MD, MSc Influence of Race and Ethnicity on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Rates and Clinical Outcomes in Pregnancy, Obstetrics & Gynecology: July 21, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004088

Study 213 – 89 cases from Brazil

Of 89 women with Covid-19 cared for in a single institution between March 12 & May 25, 2020, the details of five who experienced a fetal death are reported (click here or 1-s2.0-S2214911220300734-main). No details of the other cases, and no explicit maternal outcomes are reported, but enough details are given for it to be implied that the mothers survived. From author affiliations the unnamed hospital is probably Hospital e Maternidade Santa Joana, São Paulo. Apart from study 194 which was from a different city, all previous reports of Covid-19 in pregnancy from Brazil (studies 66, 138, 182 & 201) have been of maternal deaths. These cases have therefore probably not previously been reported. Citation: Rosana Richtmann, Maria Regina Torloni, Andre Ricardo Oyamada Otani, Jose Eduardo Levi, Mariana Crema Tobara, Camila de Almeida Silva, Lívio Dias, Lisia Miglioli-Galvão, Pollyanna Martins Silva, Mario Macoto Kondo, Fetal deaths in pregnancies with SARS-CoV-2 infection in Brazil: A case series, Case Reports in Women’s Health,  Volume 27, 2020, e00243, ISSN 2214-9112,
https://doi.org/10.1016/j.crwh.2020.e00243.

Study 212 – 2 cases from China

There were only two pregnant women with Covid-19 in Yichang city between January 20 & April 9, 2020 (click here or Coronavirus_disease_2019__COVID_19__in_pregnancy_.126). Both mothers and both babies survived. Neither baby was infected. The hospital was Yichang Central People’s Hospital. On GRID.ac this disambiguates as Peking University People’s Hospital grid.411634.5 which is probably an error. Yichang city is in Western Hubei province about 200 km west of Wuhan, and about 1000 km south of Peking/Beijing. Yichang city was a centre in study 57, so these two cases were probably included in that series, Citation: Zheng, Tingting; Guo, Jianqiang; He, Wencong; Wang, Hao; Yu, Huiling; Ye, Hong. Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China, Medicine: July 17, 2020 – Volume 99 – Issue 29 – p e21334 doi: 10.1097/MD.0000000000021334

24 July update – studies 208 to 211 added

Study 211 – 21 cases from China

21 term pregnancies with Covid-19 (click here or Chen-Bai2020_Article_MaternalAndInfantOutcomesOfFul). No mothers or babies died. All babies tested negative. The patients were cared for in Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology. They probably overlap with those in studies 2, 8, 11, 15, 39, 55, 57, 59, 73, and 108. Citation: Chen, Y., Bai, J. Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series. Arch Gynecol Obstet (2020). https://doi.org/10.1007/s00404-020-05573-8

Study 210 – 23 cases from Turkey

23/296 pregnant women tested positive for SARS-CoV-2 infection during one month’s screening from 27 April, in a “Coronavirus Pandemic Hospital” in Istanbul (click here or 10.1080@14767058.2020.1798398). Another 15 referral cases were treated over the same period. No pregnancy outcomes were reported. From author affiliations the unnamed hospital is probably Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital. If so, these cases probably include those reported in study 146. Citation: Murat Yassa, Cihangir Yirmibes, Gul Cavusoglu, Hazal Eksi, Cevdet Dogu, Canberk Usta, Memis Ali Mutlu, Pinar Birol, Cagri Gulumser & Niyazi Tug. (2020). Outcomes of universal SARS-CoV-2 testing program in pregnant women admitted to hospital and the adjuvant role of lung ultrasound in screening: A prospective cohort study. The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1798398

Study 209 – 51 placentas from infected pregnancies in New York, USA

All 51 placentas from SARS-CoV-2 affected pregnancies were negative for SARS-Cov-2 by in situ hybridization and immunohistochemistry (click here or his.14215), Citation: Smithgall, M.C., Liu‐Jarin, X., Hamele‐Bena, D., Cimic, A., Mourad, M., Debelenko, L. and Chen, X. (2020), Third Trimester Placentas of SARS‐CoV‐2‐Positive Women: Histomorphology, including Viral Immunohistochemistry and in Situ Hybridization. Histopathology. Accepted Author Manuscript. doi:10.1111/his.14215

Study 208 – Ten cases from Portugal

Ten pregnant women with Covid-19 were cared for at Centro Hospitalar Universitario, Sao Joao, Porto (click here or Perinatal management of SARS CoV 2 infection in a level III University Hospital). One women was admitted to intensive care but all mothers and babies survived. No babies tested positive. This hospital has not previously reported cases. Citation: Susana Pissarra, Marta Rosário, Marina Moucho & Henrique Soares (2020) Perinatal management of SARS-CoV-2 infection in a level III University Hospital, The Journal of Maternal-Fetal & Neonatal Medicine. DOI: 10.1080/14767058.2020.1786526

2 July update – studies 205 to 207 added

Study 207 – Mental health of 14 cases from London, UK

Fourteen women with Covid-19 in pregnancy recorded their levels of anxiety & depression (click here or PIIS0301211520304796). No clinical outcomes reported. The hospital is not named but the authors note that this is an extension of the series in study 206 so must be North Middlesex. The patients are therefore also included in study 93. Citation: Kotabagi P, Nauta M, Fortune L, Yoong W, COVID-19 positive mothers are not more anxious or depressed than non COVID pregnant women during the pandemic: a pilot case-control comparison. European Journal of Obstetrics and Gynecology and Reproductive Biology (2020). doi: https://doi.org/10.1016/j.ejogrb.2020.07.037

Study 206 – Mental health of 11 cases from London, UK

Eleven women with Covid-19 in pregnancy recorded their levels of anxiety & depression (click here or aogs.13928). No clinical outcomes reported. The authors note that these patients were treated at North Middlesex Hospital and included those in study 93. Citation: Kotabagi, P., Fortune, L., Essien, S., Nauta, M. and Yoong, W. (2020), Anxiety and depression levels among pregnant women with COVID‐19. Acta Obstet Gynecol Scand, 99: 953-954. doi:10.1111/aogs.13928

Study 205 – 91 cases from Madrid, Spain

Of 91 pregnant women with Covid-19 treated in Hospital Universitario “12 de Octubre”, 4 required ventilation, but none died (click here or 10.1080@14767058.2020.1793320). 38 babies delivered, all testing negative immediately after birth, although one developed mild Covid-19 and tested positive at 6 days. These cases likely overlap with those in studies 151, 165 & 196. Citation: Patricia Barbero, Laura Mugüerza, Ignacio Herraiz, Antonio García Burguillo, Rafael San Juan, Laura Forcén, Inmaculada Mejía, Emma Batllori, María Dolores Montañez, Paloma Vallejo, Olga Villar, Diana García Alcazar & Alberto Galindo (2020) SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19. The Journal of Maternal-Fetal & Neonatal Medicine. DOI: 10.1080/14767058.2020.1793320

21 July update – study 204 added

Study 204 – 7 screen positives from UK

Seven pregnant women tested positive for SARS-CoV-2 out of 189 screened over a two week period 22nd April to 5th May, 2020 at Newham University Hospital in East London (click here or PIIS0301211520304772). Only one was symptomatic. No outcomes reported. Citation: Abeysuriya S, Wasif S, Counihan C, Shah N, Iliodromiti S, Cutino-Moguel M-Teresa, Saeed F, Velauthar L, Universal Screening for SARS-CoV-2 in Pregnant Women at Term Admitted to an East London Maternity Unit, European Journal of Obstetrics & Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.035

19 July update – study 203 added.

Study 203 – 37 cases from Turkey

Of 100 pregnant women with possible Covid-19, 29 had the diagnosis confirmed by RT‐PCR, and a further eight were clinically high suspicious (click here or ijgo.13318). None died or were admitted to ITU. No babies died or tested positive. Patients were cared for at the Ministry of Health Ankara City Hospital which has not previously reported cases. The only previous Ankara case (study 31) was from a different hospital and the clinical details differ. Citation: Sahin, D., Tanacan, A., Erol, S.A., Anuk, A.T., Eyi, E.G., Ozgu‐ Erdinc, A.S., Yucel, A., Keskin, H.L., Tayman, C., Unlu, S., Kirca, F., Dinc, B., San, I., Parpucu, Ü.M., Surel, A.A. and Moraloglu, O.T. (2020). A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13318 

18 July update – studies 198 to 202 added

Study 202 – 80 cases from Pennsylvania, USA

Twenty COVID-19 related maternal deaths were identified from the Brazilian Ministry of Health surveillance system (click here or Takemoto Maternal mortality and COVID 19). Ten were in the Northeast region, and nine in the Southeast (5 in São Paulo). They probably overlap with those in studies 138, 182 & 194. Citation: Maira L. S. Takemoto , Mariane O. Menezes , Carla B. Andreucci , Roxana Knobel , Liduína A. R. Sousa , Leila Katz , Eduardo B. Fonseca , Claudia G. Magalhães, Wanderson K. Oliveira , Jorge Rezende-Filho , Adriana S. O. Melo & Melania M. R. Amorim (2020): Maternal mortality and COVID-19, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1786056

Study 200 – 23 cases from UK

Of 23 pregnant women with COVID-19, four were admitted to ITU and one died from basilar artery thrombosis, pulmonary embolism, and diabetic ketoacidosis (click here or Antoun EJOG 1-s2.0-S0301211520304486-main). 20 babies were delivered, incl. one set of twins. All survived. Seven babies were tested for SARS-CoV-2 and all were negative. The hospital is unnamed but from its size and author affiliations is likely to be Birmingham Women’s Hospital which has not previously reported cases. However, they will have been included in the UKOSS report study 92. The clinical details of the maternal death suggest this is the same patient as reported in study 107 as having been delivered at Birmingham Heartlands Hospital. Citation: Antoun L, Taweel NE, Ahmed I, Patni S, Honest H, Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome A prospective cohort study, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.008

Study 199 – case report of a miscarriage from France

A woman with Covid-19 miscarried at 20 weeks (click here or Hachem EJOG 1-s2.0-S0301211520304668-main). The hospital is unnamed but from author affiliation is René Dubos Hospital, Cergy-Pontoise, a northern suburb of Paris. No authors with this affiliation were included in the GROG series, study 150, so this case has probably not been reported before. Citation: Hachem R, Markou G, Veluppillai C, Poncelet C, Late miscarriage as a presenting manifestation of COVID-19, European Journal of Obstetrics and Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.07.024

Study 198 – 10 cases from USA

Ten pregnant women tested positive for SARS-CoV-2, of whom three were symptomatic (click here or Berkowitz AJOG PIIS0002937820307298). None required medical treatment beyond standard obstetric care. They were cared for at various hospitals managed by the Cleveland Clinic Foundation in Ohio, which appear to be all based around the town of Cleveland itself. If so they have not previously been reported. Citation: Berkowitz KM, Goje O, Eaton J. Implementation of universal testing for SARS-CoV-2 in pregnant women with intended admission for delivery. American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.07.011.

17 July update – studies 192 to 196 added

Study 197 – A case report from Italy

A pregnant woman with Covid-19 at 24 weeks gestation was treated with convalescent plasma (click here or Grisolia AJOG MFM 1-s2.0-S258993332030118X-main). The following day her condition worsened, and she was transferred to ICU where she received non-invasive ventilation. After a 2nd dose of convalescent plasma she recovered. The pregnancy is ongoing.  The hospital is not named but from author affiliations was Carlo Poma Hospital, Mantova. Mantova is in Lombardy so this case was probably included in studies 32 & 64. Citation: Grisolia G, Franchini M, Glingani C, Inglese F, Garuti M, Beccaria M, Capuzzo M, Pinto A, Pavan G, Righetto L, Perotti C, Zampriolo P, De Donno G, Convalescent plasma for COVID-19 in pregnancy: a case report and review, American Journal of Obstetrics & Gynecology MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100174.

Study 196 – 42 cases from Spain

42 women with COVID-19 in the third trimester of pregnancy from 14 hospitals delivered 42 babies (click here or Gabriel apa.15474). One mother died. 3/37 babies tested positive. No babies died. The authors wrote on behalf of the Neo-COVID-19 Research Group. The hospitals were, 12 de Octubre, Clínico San Carlos, Fuenlabrada, Fundación Jiménez Díaz, Getafe, Josep Trueta, La Paz, Hospitales-Madrid Group, Príncipe de Asturias, Puerta de Hierro-Majadahonda, Rey Juan Carlos, Río Hortega, Santiago de Compostela, Sant Joan, Severo Ochoa Leganés, Vall d’Hebrón and the European Institute of Perinatal Mental Health. The cases probably overlap with those in studies 151, 158, 165, 185 &  191. Citation: Marín Gabriel, M.A., Cuadrado, I., Álvarez Fernández, B., González Carrasco, E., Alonso Díaz, C., Llana Martín, I., Sánchez, L., Olivas, C., de las Heras, S., Criado, E. and (2020), Multi‐centre Spanish study found no incidences of viral transmission in infants born to mothers with COVID‐19. Acta Paediatr. Accepted Author Manuscript. doi:10.1111/apa.15474

Study 195 – 14 first trimester cases from Italy

14 women tested positive for SARS-CoV-2 in the first trimester (click here or cosma turin jmv.26267). No outcomes reported. They were cared for at Sant’ Anna Hospital, Turin, so are likely included in the 23 first trimester cases in study 167. Citation: Cosma, S., Borella, F., Carosso, A., Sciarrone, A., Cusato, J., Corcione, S., Mengozzi, G., Preti, M., Katsaros, D., Di Perri, G. and Benedetto, C. (2020), The “scar” of a pandemic: cumulative incidence of COVID‐19 during the first trimester of pregnancy. J Med Virol. Accepted Author Manuscript. doi:10.1002/jmv.26267

Study 194 – Three cases from Vitoria, Espirito Santo State, Brazil.

Two women with severe Covid-19 in pregnancy, and one with severe disease postnatally, required prolonged ICU admission and ventilation (click here or dos Reis Case Rep Brazil). One mother died. All three babies tested negative and survived. This is the first scientific report from this city. However, the woman who died may be included in studies 66, 138 & 182. Citation: Reis Helena Lucia Barroso dos, Boldrini Neide Aparecida Tosato, Caldas João Victor Jacomele, Paz Ana Paula Calazans da, Ferrugini Carolina Loyola Prest, Miranda Angelica Espinosa. Severe coronavirus infection in pregnancy: challenging cases report. Rev. Inst. Med. trop. S. Paulo [Internet]. 2020 [cited 2020 July 17] ; 62: e49. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100513&lng=en. Epub July 13, 2020. https://doi.org/10.1590/s1678-9946202062049.

Study 193 – Case report from Belgium

A pregnant woman with twins developed mild Covid-19 at 22 weeks gestation (click here or Pulinx 10096_2020_Article_3964). She was nursed at home, but at 24 weeks went into spontaneous labour. One twin was stillborn and the other died soon after birth. Amniotic fluid and placental tissue tested positive for SARS-CoV-2. From author affiliations this was probably Sint-Trudo Hospital in Sint-Truiden, which has not previous reported cases. Citation: Pulinx, B., Kieffer, D., Michiels, I. et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Clin Microbiol Infect Dis (2020). https://doi.org/10.1007/s10096-020-03964-y

Study 192 – Case report from Zhongshan, in Guangdong Province, China.

A mother with Covid-19 at 35 weeks gestation suffered from a cytokine storm, and required both ventilation and ECMO (click here or Wang 1-s2.0-S0002937820307286-main). She survived, but the baby died. As the authors note this case was included in Study 3. The hospital, mother’s age, gestational age and baby outcome all suggest she is also the same woman as in studies 57 and 81. Citation:  Wang X, Wang D, He S, The role of a cytokine storm in severe COVID-19 disease in pregnancy, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.07.010.

16 July update – studies 188 – 191 added

Study 191 – 27 cases from Spain

This preprint reports 27 pregnant women with COVID-19 of whom seven developed some features of HELLP syndrome (click here or 2020.07.10.20133801v1.full). The details are difficult to interpret but I think 12 delivered, 5 by Caesarean, and no mothers or babies died. The patients were cared for in two unnamed hospitals which from author affiliations were probably Hospital de la Santa Creu i Sant Pau and Hospital Sant Joan de Deu, both in Barcelona. These hospitals have not previously reported cases under their own names. However, the patients may have been included in the Spanish Covi-Preg registry study 151. Citation: Francesc Figueras, Elisa LLurba, Raigam Martinez-Portilla, Josefina Mora, Fatima Crispi, Eduard Gratacos. COVID-19 causing HELLP-like syndrome in pregnancy and role of angiogenic factors for differential diagnosis. medRxiv 2020.07.10.20133801; doi: https://doi.org/10.1101/2020.07.10.20133801

Study 190 – Two cases from Italy

Two pregant women with diabetes contracted Covid -19. Clinical details are given for only one who recovered (click here or ijgo.13306). Both were cared for in Papa Giovanni XXIII Hospital in Bergamo between Feb 22 & May 17, 2020 so have probably been reported in studies 32, 64, 114 & 117. Citation: Dodesini, A.R., Galliani, S., Ciriello, E., Bellante, R. and Trevisan, R. (2020), Pre‐gestational diabetes during the COVID‐19 pandemic in Bergamo, Italy. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13306

Study 189 – 185 cases from Kuwait

This preprint reports 185 pregnant women with Covid-19 treated in New-Jahra Hospital, where all pregnant women with Covid-19 in Kuwait are treated, between March 15th & May 31st 2020 (click here or 2020.07.10.20150623v1.full). No mothers died or required ECMO, although two required ventilation. Three women miscarried, and 41 babies delivered. Two babies tested positive but none died.  Citation: Amal Ayed, Alia Embaireeg, Asmaa Benawadth, Wadha Al-Fouzan, Majeda Hammoud, Monif Alhathal, Abeer Alzaydai, Mariam Ayed. Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. medRxiv 2020.07.10.20150623; doi: https://doi.org/10.1101/2020.07.10.20150623 For published verion (click here).

Study 188 – Four, possibly five, cases from Italy

Four pregnant women with Covid-19 and a further woman who had possible pneumonia one day after delivering twins and two months later had SARS-CoV-2 IgG antibodies, are reported (click here or 10.1080@14767058.2020.1791817) All mothers and babies survived although one of the four definite Covid-19 mothers developed Guillain-Barré syndrome and remains in hospital. All patients were cared for Bolognini Hospital which is a “spoke center” for COVID 19 in pregnancy in Seriate, Bergamo in Lombardy. It is thus likely that they were included in studies 32, 64 & 117. Citation: Paola Algeri, Valentina Stagnati, Maria Donata Spazzini, Cristina Bellan, Alessandro Montanelli, Gianluigi Patelli & Massimo Ciammella (2020) Considerations on COVID-19 pregnancy: a cases series during outbreak in Bergamo Province, North Italy, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2020.1791817

15 July update – study 187 added

Study 187 – Case report of neonatal infection from France

A woman contracted Covid-19 at 35 weeks, required Caesarean for fetal distress, and recovered with supportive treatment (click here or s41467-020-17436-6). The baby was initially well but developed neurological symptoms on day 3. Maternal nasopharynx (NP), blood, placental, vaginal and amniotic samples were all positive for SARS-CoV-2. Baby blood and rectal samples, as well as NP samples on days 1, 3 and 18, were also positive. The baby recovered with supportive treatment. From author affiliations the hospital was Antoine Béclère, Paris. Although not cited, this is case two in study 48. The papers share two authors, Alexandra J Vivanti & Alexandra Benachi, from the same hospital, and all reported maternal and baby characteristics, as well as all the mother’s blood values on the day of birth, are identical. Citation: Vivanti, A.J., Vauloup-Fellous, C., Prevot, S. et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun 11, 3572 (2020). https://doi.org/10.1038/s41467-020-17436-6

13 July update – study 186 added

Study 186 – Case report from USA

A woman with Covid-19 gave birth vaginally at 34 weeks (click here or INTRAUTERINE_TRANSMISSION_OF_SARS_COV_2_INFECTION.96099). Despite isolation from the mother, the baby was infected SARS-CoV-2. Mother and baby were cared for at Parkland Health & Hospital System, Dallas, Texas which has not previously reported cases. Citation: Sisman, Julide; Jaleel, Mambarambath A; Moreno, Wilmer; Rajaram, Veena; Collins, Rebecca R.J; Savani, Rashmin; Rakheja, Dinesh; Evans, Amanda S. INTRAUTERINE TRANSMISSION OF SARS-COV-2 INFECTION IN A PRETERM INFANT, The Pediatric Infectious Disease Journal: July 10, 2020 – Volume Online First – Issue – doi: 10.1097/INF.0000000000002815

12 July update – studies 183 to 185 added

Study 185 – Two cases from Spain

The fetuses of two pregnant women with Covid-19 developed transient skin oedema at 21 and 25 weeks gestation (click here or Fetal_Transient_Skin_Edema_in_Two_Pregnant_Women.97307). One mother, cared for at Vall d’Hebron University Hospital in Barcelona, had severe disease requiring ventilation. The other, hospital not stated, had mild disease only. Amniotic fluid was negative for SARS-CoV-2 in both cases. Both resolved and the pregnancies are ongoing. The Barcelona case at least was probably included in study 140. Citation: Garcia-Manau P, Garcia-Ruiz I, Rodo C, et al. Fetal Transient Skin Edema in Two Pregnant Women With Coronavirus Disease 2019 (COVID-19) [published online ahead of print, 2020 Jul 7]. Obstet Gynecol. 2020;10.1097/AOG.0000000000004059. doi:10.1097/AOG.0000000000004059

Study 184 – 100 cases from France

One hundred pregnant women with Covid-19 were treated in four Paris hospitals between March 12 & April 13, 2020 (click here). Ten were admitted to ICU of whom 9 required intubation. There were no stillbirths or miscarriages, but one neonatal death due to prematurity. All neonates were tested for SARS-CoV-2. One was positive but did not show signs of respiratory illness. The hospitals were Antoine Béclère, Clamart; Bicêtre Hospital, Le Kremlin Bicêtre; Louis-Mourier, Colombes; and Centre Hospitalier Sud Francilien, Evry. They therefore include one of the cases in study 48, are included in study 150 and probably also overlap with those in study 157. Citation: Vivanti AJ, Mattern J, Vauloup-Fellous C, Jani J, Rigonnot L, El Hachem L, Le Gouez A, Desconclois C, Ben M’Barek I, Sibiude J, Benachi A, Picone O, Cordier AG. Retrospective Description of Pregnant Women Infected with Severe Acute Respiratory Syndrome Coronavirus 2, France. Emerg Infect Dis. 2020 Jul 6;26(9). doi: 10.3201/eid2609.202144. Online ahead of print.

Study 183 – 18 cases from China

Between Jan 30, & Mar 1, 2020, 10 clinically diagnosed and 8 swab positive pregnant women with COVID-19 were treated at Renmin Hospital of Wuhan University (click here or s12884-020-03026-3). These cases probably overlap with studies 10, 36, 37, 40, and 80. They are also likely to be included in studies 55 & 57. Citation: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. Zhang L, Dong L, Ming L, Wei M, Li J, Hu R, Yang J. BMC Pregnancy Childbirth. 2020 Jul 8;20(1):394. doi: 10.1186/s12884-020-03026-3.

11 July update study 181 & 182  added. Latter HT Fred Peret.

Study 182 – 124 maternal deaths from Covid-19 in Brazil

Between Feb 26 & June 18, 978 pregnant and postpartum women with COVID-19 were registered with the Brazilian Ministry of Health’s Acute Respiratory Distress Syndrome (ARDS) Surveillance System, of whom 124 died (click here or IJOGfinal (1)). They probably include five cases from study 66.  Citation: Takemoto, M.L.S., Menezes, M.O., Andreucci, C.B., Nakamura‐Pereira, M., Amorim, M.M.R., Katz, L. and Knobel, R. (2020), The tragedy of COVID‐19 in Brazil: 124 maternal deaths and counting. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13300

Study 181 – Rise in stillbirths during pandemic in UK capital

Nineteen women with Covid-19 were cared for at St Georges Hospital in London during the period February 1 to June 14, 2020. None experienced stillbirth. However the overall stillbirth rate in the hospital was significantly higher than in the pre-pandemic period (click here or jama_khalil_2020_ld_200076). Included in study 92. Citation: Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P, Magee L. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic. JAMA. Published online July 10, 2020. doi:10.1001/jama.2020.12746

4th July update – studies 178 -180 added.

Study 180 – case report of postnatal Covid-19 from Italy

A mother developed pyrexia on day two after a normal birth, and both her and her baby tested positive (click here or e20201121.full). The baby was cared for in Fondazione Monza e Brianza per il Bambino e la sua Mamma and Azienda Socio Sanitaria Territoriale-Monza. Monza is in Lombardy so this case may be included in studies 32, 64, 109 & 114. However as a postnatal case it may not. We’re keeping an open mind.  Citation: Sinelli M, Paterlini G, Citterio M, et al. Early Neonatal SARS-CoV-2 Infection Manifesting With Hypoxemia Requiring Respiratory Support. Pediatrics. 2020;146(1):e20201121

Study 179 – 67 cases from USA

67 women with SARS-CoV-2 infection from March 13 to April 24, (click here or s-0040-1713851). Patients cared for in seven hospitals within the Northwell Health system in New York: North Shore University Hospital, Long Island Jewish Medical Center, Long Island Jewish Forest Hills, Huntington Hospital, Southside Hospital, Lenox Hill Hospital, and Staten Island University Hospital. The patients probably overlap with those reported in studies 49, 83, 113,118,134 & 162. Citation: Moti Gulersen, Matthew J. Blitz, Burton Rochelson, Michael Nimaroff, Weiwei Shan, Eran Bornstein Clinical Implications of SARS-CoV-2 Infection in the Viable Preterm Period. Am J Perinatol DOI: 10.1055/s-0040-1713851

Study 178 – Ten cases from China

Ten pregnant women with COVID-19, treated in the Zhongnan Hospital of Wuhan University (grid.413247.7) from Jan 20 to Feb 6 (click here or 10.1371@journal.pone.0235134). These women are probably also included in studies 1, 13, 55 & 57, and may also overlap with study 75. Citation: Gong X, Song L, Li H, Li L, Jin W, Yu K, et al. (2020) CT characteristics and diagnostic value of COVID-19 in pregnancy. PLoS ONE 15(7): e0235134. https://doi.org/10.1371/journal.pone.0235134

3rd July update – study 177 added. Study 176 removed. Duplicate of study 89.  Jim’s mistake. HT Keelin.

Study 177 – CTG changes in 12 Covid-19 pregnancies, Spain

Intrapartum electronic fetal cardiotocograms (CTGs) from 11 women with Covid-19 and one antepartum CTG at 28 weeks, were evaluated using a physiological system (click here or PIIS0301211520304243). All eleven delivered babies had normal Apgar scores and cord pH. No details of maternal severity, mode of delivery or other baby details were given. Some patients had been cared for in Puerta de Hierro hospital, Madrid, which also included cases in studies 125 and 151.  Others came from Germans Trias i Pujol Hospital, Badalona, a northern suberb of Barcelona, which has not previously reported cases. Citation: Gracia-Perez-Bonfils A, Martinez-Perez O, Llurba E, Chandraharan E, Fetal heart rate changes on the cardiotocograph trace secondary to maternal COVID-19 infection, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.06.049

1 July update – study 176 added.

Study 176 – Case report from San Francisco. Deleted 3 July duplicate of study 89

A 34 year old woman contracted Covid-19 at 28 weeks gestation (click here or Acute_Respiratory_Distress_Syndrome_in_a_Preterm.11). She required ventilation and was delivered by Caesarean section. The baby tested negative. Both recovered. The hospital is not named but authors are all affiliated with University of California, San Francisco. Citation: Blauvelt, Christine A. MD; Chiu, Catherine MD; Donovan, Anne L. MD; Prahl, Mary MD; Shimotake, Thomas K. MD; George, Ronald B. MD, FRCPC; Schwartz, Brian S. MD; Farooqi, Naghma A. MD; Ali, Syed S. MD; Cassidy, Arianna MD; Gonzalez, Juan M. MD, PhD; Gaw, Stephanie L. MD, PhD Acute Respiratory Distress Syndrome in a Preterm Pregnant Patient With Coronavirus Disease 2019 (COVID-19), Obstetrics & Gynecology: July 2020 – Volume 136 – Issue 1 – p 46-51 doi: 10.1097/AOG.0000000000003949

30 June update – study 175 added

Study 175 – 5 cases from Philadelphia, Pennsylvania, USA

Five pregnant women with Covid-19 were treated with remdesivir (click here or mccoy remdesevir ajogmfm). Three were ventilated, four delivered and all recovered. One pregnancy is ongoing.  All neonates tested negative. From author affiliations these cases may overlap with studies 65 and 86. Citation: Mccoy JA, Short WR, Srinivas SK, Levine LD, Hirshberg A, Compassionate use remdesivir for treatment of severe COVID-19 in pregnant women at a United States academic center, American Journal of Obstetrics & Gynecology MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100164.

26 June update –  study 174 added

Study 174 – US CDC Covid-19 & pregnancy weekly tracking data

The US Centers for Disease Control (CDC) are now publishing weekly COVID-19 in pregnancy tracking data. The June 25th update (click here) duplicates that in study 172. Citation: US CDC Weekly COVID-19 Pregnancy Data; Pregnant women with COVID-19, United States [January 22-June 23, 2020] https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/special-populations/pregnancy-data-on-covid-19.html Accessed 26 June 2020.

25 June update – studies 171 to 173 added. (Study 173 belatedly). Study 43 withdrawn

Study 173 – 33 cases from Covid-Net

An April 6th MMWR, which we had previously missed, of SARS-CoV-2 hospitalisations reported to COVID-NET, a network of hospitals representing about 10% of the United States, included 33 pregnant women of whom 3 (9%) had been hospitalised (click here or mm6915e3-H). These cases overlap with studies 171 and 172. Citation: Garg S, Kim L, Whitaker M, et al. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:458–464. DOI: http://dx.doi.org/10.15585/mmwr.mm6915e3external icon

Study 172 – 8,207 pregnant woman with SARS-CoV-2 from CDC

Of 8,207 pregnant women who tested positive for SARS-CoV-2 and were reported to the US Centers For Disease Control by 7th June, 2,587 (31.5%) were hospitalised, 120 (1.5%) admitted to ICU, 42 (0.5%) ventilated, and 16 (0.2%) died. Comparative figures for 83,205 non-pregnant women in the same age group were; 4,840 (5.8) hospitalised, 757 (0.9%) admitted to ICU, 225 (0.3%) ventilated, 208 (0.2%) died (click here or mm6925a1-H). Citation: Ellington S, Strid P, Tong VT, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–June 7, 2020. MMWR Morb Mortal Wkly Rep 2020;69:769–775. DOI: http://dx.doi.org/10.15585/mmwr.mm6925a1external icon

Study 171 – 36 cases from Covid-Net 

In this MedRxiv preprint, of 2,491 adults hospitalised with Covid-19, in the US Covid-Net database (154 acute hospitals in 13 states), 26 were pregnant. This represent 12.9% of the 279 women of childbearing age (15–49 years) in the cohort (click here or 2020.05.18.20103390v1.full). [Comment – see table 1. The percentage seems to be wrong.] Citation: Lindsay Kim, Shikha Garg, Alissa O’Halloran, Michael Whitaker, Huong Pham, Evan J. Anderson, Isaac Armistead, Nancy M. Bennett, Laurie Billing, Kathryn Como-Sabetti, Mary Hill, Sue Kim, Maya L. Monroe, Alison Muse, Arthur Reingold, William Schaffner, Melissa Sutton, H. Keipp Talbot, Salina M. Torres, Kimberly Yousey-Hindes, Rachel A Holstein, Charisse Cummings, Lynette Brammer, Aron Hall, Alicia Fry, Gayle E. Langley. Interim Analysis of Risk Factors for Severe Outcomes among a Cohort of Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET) medRxiv 2020.05.18.20103390; doi: https://doi.org/10.1101/2020.05.18.20103390

24 June update – studies 165 to 170 added

Study 170 – 241 cases from the Netherlands

The 19th June update of NethOSS (click here), accessed 24 June 2020, contains the following. 6/224 women with brief additional details were admitted to intensive care. One mother died. 69 women have given birth, 26 by Caesarean. 152 pregnancies are ongoing. No baby has died. No babies were infected. Citation: See Studies 42, 46, 120, 141, & 147. Available here. Accessed 24 June 2020.

Study 169 – 19 June ICNARC report

The 19th June ICNARC update (click here or ICNARC COVID-19 report 2020-06-19.pdf) contains 26 currently, and 37 recently, pregnant women critically ill with Covid-19.  Of these 10 are currently, and 24 have in the past,  received advanced respiratory support. NOTE – ICNARC has recently started reporting pregnancy data subdivided by white/non white ethnicity.

Study 168 – The PRIORITY study 24 June 2020

The PRIORITY (Pregnancy Coronavirus Outcomes Registry) study (click here) has issued no formal reports yet. However the dashboard (click here accessed 24 June 2020) shows 882 participants, by age group, gestational age band, ethnic group and US state of residence. Citation: University of California San Francisco. PRIORITY Study dashboard https://priority.ucsf.edu/dashboard. Accessed 24 June 2020.

Study 167 – 23 women in the first trimester from Italy

Of 23 women in this preprint from Medxiv, testing positive for SARS-Cov2 in the first trimester, 11 miscarried and 12 had ongoing pregnancies (click here or 2020.06.19.20135749v1.full). 12 October update. Published in AJOG here or PIIS0002937820311777). This was a case control study comparing SARS-Cov2 rates between women experiencing miscarriage and matched women with ongoing pregnancy. The rates did not differ significantly. The patients were cared for at S. Anna Hospital, Turin, which has not previously reported cases in the first trimester. Citation: Stefano Cosma, Andrea Carosso, Jessica Cusato, Fulvio Borella, Marco Carosso, Marialuisa Bovetti, Claudia Filippini, Antonio D’Avolio, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto. COVID-19 and first trimester spontaneous abortion: a case-control study of 225 pregnant patients. medRxiv 2020.06.19.20135749; doi: https://doi.org/10.1101/2020.06.19.20135749&nbsp;

12 October update. Published in AJOG (here or PIIS0002937820311777). AJOG citation: Stefano COSMA, Andrea R. CAROSSO, Jessica CUSATO, Fulvio BORELLA, Marco CAROSSO, Marialuisa BOVETTI, Claudia FILIPPINI, Antonio D’AVOLIO, Valeria GHISETTI, Giovanni DI PERRI, Chiara BENEDETTO, COVID-19 and first trimester spontaneous abortion: a case-control study of 225 pregnant patients, American Journal of Obstetrics and Gynecology, 2020, ISSN 0002-9378, https://doi.org/10.1016/j.ajog.2020.10.005.

Study 166 – 3 cases from China

Three pregnant woman with Covid-19 were all delivered by Caesarean (click here or E603.full).  The babies all tested negative. The mothers came from a cohort of 166 pregnant women testing positive for SARS-Cov19 in a predefined administrative region containing 12 hospitals, including the Xiangyang First People’s Hospital in Hubei, China. This hospital is not found on GRID.ac. Citation: Peng An, Bradford J. Wood, Wei Li, Min Zhang, Yingjian Ye. Postpartum exacerbation of antenatal COVID-19 pneumonia in 3 women. CMAJ Jun 2020, 192 (22) E603-E606; DOI: 10.1503/cmaj.200553

Study 165 – 65 cases from Madrid

Of 65 women with Covid-19, 13 were diagnosed postnatally. Of the 52 antenatal cases, 32 developed pneumonia and two required ICU admission (click here or PIIS2589537020301516. No mother died.  6/32 women with pneumonia had delivered and no babies were infected. Patients were cared for at University Hospital “12 de Octubre”. They therefore probably overlap with those reported in study 151 but differ from those in study 125. Citation: R. San-Juan et al., Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain, EClinicalMedicine (2020), https://doi.org/10.1016/j.eclinm.2020.100407

23 June update – studies 163 & 164 added

Study 164 – Two cases from USA

One woman with severe Covid-19 miscarried at 22 weeks. At the time of writing she remained ventilated. Another woman required Caesarean birth at 29 weeks and recovered. Her baby required intubation and tested positive for SARS-Cov2 at 6 days (click here or Futterman NY s-0040-1712978).  The hospital is not named. Author affiliations are Dept. OBGYN, New York Medical College, Valhalla, which is affiliated with multiple clinical sites. These cases may therefor have been previously reported. Citation: Itamar Futterman, Miriam Toaff, Liel Navi, Camille A. Clare. COVID-19 and HELLP: Overlapping Clinical Pictures in Two Gravid Patients. Am J Perinatol Rep 2020;10:e179–e182.

Study 163 – 9 cases with placental histology from Italy

Of 9 women with SARS-CoV2 infection delivered between March and April 2020 at Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico (Milan), all mothers recovered and all babies tested negative (click here or Cribiu Eur JOG IIS0301211520304164). Placental histology is reported. Although the hospital name differs these cases are probably included in studies 32 & 64. Citation: Cribi `u FM, Croci GA, Gobbo AD, Rizzuti T, Iurlaro E, Tondo M, Viscardi A, Bosari S, Ferrero S, HISTOLOGICAL CHARACTERIZATION OF PLACENTA IN COVID19 PREGNANT WOMEN, European Journal of Obstetrics and amp; Gynecology and Reproductive Biology (2020), doi: https://doi.org/10.1016/j.ejogrb.2020.06.041

21 June update – studies 161 & 162 added

Study 162 – 462 cases (70 severe) from New York, USA

Of 462 pregnant women with Covid-19, 70 had severe disease, 14 were admitted to ICU, and two died (click here or PIIS0002937820306360). The patients were cared for in the Northwell Hospital network which includes Maimonides Medical Centre. The paper includes a statement about severe case overlap with studies 113, 118 & 134. Shared authorship suggests overlap with studies 49 and 83 as well. Citation: Blitz MJ, Rochelson B, Minkoff H, Meirowitz N, Prasannan L, London V, Rafael TJ, Chakravarthy S, Bracero LA, Wasden SW, Pachtman Shetty SL, Santandreu O, Chervenak FA, Schwartz BM, Nimaroff M, Maternal Mortality Among Women with COVID-19 Admitted to the Intensive Care Unit, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.06.020.

Study 161 – 54 cases from France

Of 54 pregnant women with confirmed (n=38) or suspected (n=16) COVID-19 in pregnancy treated at Strasbourg University Hospital from March 1 to April 3, there was one miscarriage, 21 live births (12 vaginal, 9 cesarean), and 32 ongoing pregnancies (click here or PIIS0002937820306396). Five women were admitted to ICU, three required mechanical ventilation and one ECMO. No mothers died, although at the time of writing the woman on ECMO remained on it. All babies tested negative & none died. Strasbourg doctors co-authored the GROG report, so these cases are probably included in study 150. Citation: Sentilhes L, De Marcillac F, Jouffrieau C, Kuhn P, Thuet V, Hansmann Y, Ruch Y, Fafi-Kremer S, Deruelle P, COVID-19 in pregnancy was associated with maternal morbidity and preterm birth, American Journal of Obstetrics and Gynecology (2020), doi: https://doi.org/10.1016/j.ajog.2020.06.022.

18 June update – studies 157-160 added

Study 160 – 241 cases from USA

Of 241 pregnant women with laboratory-confirmed SARSCoV-2 infection who gave birth between March 13 & April 12, there were 245 live births to 241 women (6 sets of twins), & 2 stillbirths (click here or Characteristics_and_Outcomes_of_241_Births_to.97310). 17 women were admitted to ITU and 9 intubated. No mothers died, although one woman remained intubated at time of writing. 27% of neonates were admitted to NICU. Of liveborns with SARS-CoV-2 test results 236/230 tested negative. No further neonatal outcomes reported. The five hospitals were “Montefiore Medical Center; Mount Sinai Health System, including Mount Sinai Hospital and Mount Sinai West; its affiliate, NYC Health and Hospitals- Elmhurst Hospital; NY-Presbyterian Hospital- Columbia University; and NY University Langone Health, including NYU Langone Hospitals, Manhattan campus, and NYU Langone Hospitals-Brooklyn”. These cases therefore likely overlap with studies 14, 27, 41, 49, 83, 85, 86, 95, 95, 119, 135, 136, & 152. They probably do not overlap with women in studies 61, 113, 118, 122 & 134, which included women cared for in different centres. Women in Study 99 are unclear. Citation: Khoury, Rasha MD, MPH; Bernstein, Peter S. MD; Debolt, Chelsea MD; Stone, Joanne MD; Sutton, Desmond M. MD; Simpson, Lynn L. MD; Limaye, Meghana A. MD; Roman, Ashley S. MD; Fazzari, Melissa PhD; Penfield, Christina A. MD; Ferrara, Lauren MD; Lambert, Calvin MD; Nathan, Lisa MD; Wright, Rodney MD; Bianco, Angela MD; Wagner, Brian MD; Goffman, Dena MD; Gyamfi-Bannerman, Cynthia MD; Schweizer, William E. MD; Avila, Karina MPH; Khaksari, Bijan MPH; Proehl, Meghan MPH; Heitor, Fabiano MD; Monro, Johanna BS; Keefe, David L. MD; D’Alton, Mary E. MD; Brodman, Michael MD; Makhija, Sharmila K. MD; Dolan, Siobhan M. MD Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers, Obstetrics & Gynecology: June 16, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004025

Study 159 – Three severe cases from USA

Three pregnant women with Covid-19 required ventilation (click here or s-0040-1713664). All three recovered and their pregnancies are ongoing. They were cared for in Morristown Medical Center and St. Peter’s University Medical Center in central New Jersey, neither of which have previously reported cases. Citation: Lucarelli E, Behn C, Lashley S, Smok D, Benito C, Oyelese Y. Mechanical Ventilation in Pregnancy Due to COVID-19: A Cohort of Three Cases [published online ahead of print, 2020 Jun 16]. Am J Perinatol. 2020;10.1055/s-0040-1713664. doi:10.1055/s-0040-1713664

Study 158 – Four patients undergoing amniocentesis from Spain.

Four pregnant women with Covid-19 underwent midtrimester amniocentesis for prenatal diagnosis of other conditions (click here or 1-s2.0-S0014256520301569-main). No amniotic samples tested positive. The hospital is not named but from author affiliations is probably Hospital Universitario Maternal-Infantil de Jaén, Jaén. This hospital has not previously reported cases, but these cases may be included in study 151 which included registry cases. Citation: Hijona Elósegui JJ, et al. ¿Existe transmisión materno-fetal del SARS-CoV-2 durante la gestación? Rev Clin Esp. 2020. https://doi.org/10.1016/j.rce.2020.06.001

Study 157 – 88 cases from France

Eighty eight pregnant women with Covid-19 responded to an anonymous internet survey hosted by the French television pregnancy show “la Maison des Maternelles” (click here or PIIS030121152030364X). 6 had been sufficiently severe to require oxygen. 14 had delivered, 5 by Caesarean. Many are probably included in study 150. Citation: J. Cohen, et al., Covid-19 in pregnant women: General data from a French National Survey, Eur J Obstet Gynecol (2020), https://doi.org/10.1016/j.ejogrb.2020.06.002

16 June update study 156 added

Study 156 – Case report of Covid-19, pregnancy & pancreatitis, USA

A 36-year-old woman contracted Covid-19 at 33 weeks (click here or 1-s2.0-S2214911220300588-main). Pancreatitis was diagnosed on the basis of raised lipase, despite normal amylase. She recovered and was later delivered by Caesarean. Both mother & baby discharged  in stable condition. Author affiliations Saint Joseph Hospital, Denver, Colorado. Citation: Sarah R. Rabice, Paulina C. Altshuler, Claire Bovet, Cathlyn Sullivan, Amy J. Gagnon. COVID-19 infection presenting as pancreatitis in a pregnant woman: A case report. Case Reports in Women’s Health. Volume 27, 2020, e00228, ISSN 2214-9112, https://doi.org/10.1016/j.crwh.2020.e00228.

15 June update study 155 added

Study 155 – Case report of placental infection from USA

This MedRxiv preprint (click here or SARS-CoV-2 infection of the placenta (002)) (click here for published peer reviewed version update 24 June) reports a 35-year-old woman who contracted Covid-19 at 22 weeks gestation. She had coagulopathy and hypertension, and was offered and accepted pregnancy termination, which was performed under GA with extubation on day 1.  SARS-CoV-2 RNA was present at high levels in the placenta, and virions were visible on electron microscopy. The hospital is not named but author affiliations are Yale School of Medicine. The case is therefore probably included in study 132.  Citation: Hillary Hosier, Shelli Farhadian, Raffaella Morotti, Uma Deshmukh, Alice Lu-Culligan, Katherine Campbell, Yuki Yasumoto, Chantal Vogels, Arnau Casanovas-Massana, Pavithra Vijayakumar, Bertie Geng, Camila Odio, John Fournier, Anderson Brito, Joseph Fauver, Feimei Liu, Tara Alpert, Reshef Tal, Klara Szigeti-Buck, Sudhir Perincheri, Christopher Larsen, Aileen Gariepy, Gabriela Aguilar, Kristen Fardelmann, Malini Harigopal, Hugh Taylor, Christian Pettker, Anne Wyllie, Charles Dela Cruz, Aaron Ring, Nathan Grubaugh, Albert Ko, Tamas Horvath, Akiko Iwasaki, Uma Reddy, Heather Lipkind.  SARS-CoV-2 Infection of the Placenta. medRxiv 2020.04.30.20083907; doi: https://doi.org/10.1101/2020.04.30.20083907

Update 24 June. Peer reviewed citation, [online ahead of print, 2020 Jun 23]. J Clin Invest. 2020;139569. doi:10.1172/JCI139569

11 June update studies 154 & 154 added

Study 154 – Case report from Northwick Park Hospital, London, UK

A 34-year woman with immunologic thrombocytopaenia developed a cough, fever, petechiae and gum bleeding at 20 weeks gestation (click here or Nesr BJH case bjh.16928). She had a low platelet count, swabbed positive for SARS-CoV-2 and recovered. Pregnancy outcome not reported, but by implication ongoing. Case presumably included in study 92.  Citation: Nesr, G., Garnett, C., Bailey, C. and Arami, S. (2020), ITP flare with mild COVID‐19 infection in pregnancy: A case report. Br J Haematol. Accepted Author Manuscript. doi:10.1111/bjh.16928

Study 153 – Case report from Jordan

A 30-year-old woman, contracted mild Covid-19 at 36 weeks gestation (click here or Al Zaghal Case Rep Jordan 1-s2.0-S2214911220300424-main). She delivered by Caesarean. The baby tested negative. Both recovered. The first report from this country. Citation: Laila A. AlZaghal, Najwa AlZaghal, Safwan O. Alomari, Nail Obeidat, Basil Obeidat, Wail A. Hayajneh. Multidisciplinary team management and cesarean delivery for a Jordanian woman infected with SARS-COV-2: A case report. Case Reports in Women’s Health 27 (2020) https://doi.org/10.1016/j.crwh.2020.e00212

9 June update – studies 151 & 152 added.

Study 152 – 2 severe cases from New York, USA

Two women with Covid-19 required ventilation and caesarean delivery (click here or Silverstein AmJPerinatol Rep s-0040-1712925). Both neonates tested negative. Both mothers recovered. The hospital(s) are not named but author affiliations suggest either Langone Medical Center or Bellevue Hospital Center. The cases are therefore probably included in studies 85 & 86, and possibly also in studies 49 & 83. Citation: Jenna S. Silverstein, Meghana A. Limaye, Sara G. Brubaker, Ashley S. Roman, Judita Bautista, Judith Chervenak, Adam J. Ratner, Philip M. Sommer, Nicole M. Roselli, Charlisa D. Gibson, David Ellenberg, Christina A. Penfield. Acute Respiratory Decompensation Requiring Intubation in Pregnant Women with SARS-CoV-2 (COVID-19) Am J Perinatol Rep 2020;10:e169–e175.

Study 151 – 82 cases from Spain

Of 82 women with singleton pregnancies and Covid-19, who delivered within 14 days of disease onset, collected from from 96 maternity hospitals, 9 were admitted to ICU and 7 ventilated (click here or jama_martnezperez_2020_ld_200062). Five babies tested positive. No mothers or babies died. The hospitals are not named but author affiliations include Puerta de Hierro University Hospital, 12 Octubre University Hospital, & Gregorio Marañon University Hospital, all three from Madrid. Three other authors are associated with the Covi-Preg registry in Switzerland (click here). The cases probably overlap with those in studies 53 & 125. Citation: Martínez-Perez O, Vouga M, Cruz Melguizo S, et al. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain. JAMA. Published online June 08, 2020. doi:10.1001/jama.2020.10125

8 June update – study 150 added.

Study 150 – 617 cases from France

Thirty three maternity units from the “Groupe de Recherche en Obstétrique et Gynécologie (GROG)” treated 617 pregnant women with COVID-19 between March 1 & April 14 (click here or GIlles France JOG HR). Eighty three women required nasal oxygen, a further 10 non-invasive ventilation, a further 29 mechanical ventilation and a further six, ECMO.  One woman died. There were 5 miscarriages and 7 stillbirths among the 181 pregnancies which had ended. Among the 190 live births (7 twins & 1 set of triplets) there was one neonatal death. Two babies tested positive. The 33 maternity units (including 24 tertiary referral centers) are not named, although 19 can be guessed from the author affiliations. Citation: Kayem G, Alessandrini V, Azria E, Blanc J, Bohec C, Bornes M, Bretelle F, Ceccaldi P-Franc¸ois, Chalet Y, Chauleur C, Cordier A-Gael, Deruelle P, Desbri`ere R, Doret M, Dreyfus M, Driessen M, Fermaut M, Gallot D, Garab´edian C, Huissoud C, Lecarpentier E, Luton D, Morel O, Perrotin F, Picone O, Rozenberg P, Schmitz T, Sentilhes L, Sroussi J, Vayssi`ere C, Verspyck E, Vivanti AJ, Winer N, A snapshot of the Covid-19 pandemic among pregnant women in France, Journal of Gynecology Obstetrics and Human Reproduction (2020), doi: https://doi.org/10.1016/j.jogoh.2020.101826 [important]

6 June update – study 149 added

Study 149 – 73 cases, 8 severe, from USA

Of 73 pregnant women with COVID-19, 31 were admitted, of whom 8 visited ICU. Of these 6 needed intubation, and 1 ECMO (click here or 1-s2.0-S2589933320300951-main). 7 of the 8 ICU cases were delivered by Caesarean and one remains undelivered.  All babies were isolated and fed artificial or donor milk. All tested negative. All mothers were discharged from intensive care. No babies died but four remain in hospital. No details given of the non ICU cases. The “network’s two largest hospitals” in which the patients were treated are not named. The authors are affiliated with three large hospitals in New Jersey  Hackensack University Medical Center, University Hospital (Newark, New Jersey) and Hackensack Meridian Jersey Shore University Medical Center. The patients are therefore probably different from those reported in Studies 86, and 111. Citation: Romagano MP, Guerrero K, Spillane N, Kayaalp E, Smilen SW, Alvarez M, Alvarez-Perez J, Francis Kim A, Aschner J, Al-Khan A, Perinatal outcomes in critically ill pregnant women with COVID-19, American Journal of Obstetrics & Gynecology MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100151.

5 June update – studies 143 to 148 added.

Study 148 – 29th May ICNARC report

The 29th May ICNARC update (click here or ICNARC COVID-19 report 2020-05-29.pdf) contains 23 currently, and 34 recently, pregnant women critically ill with Covid-19. Of these 10 and 20 respectively had received advanced respiratory support.

Study 147 – 223 cases from the Netherlands

The 5th June  update of NethOSS (click here), accessed 4 June 2020, contains the following. 6/210 women with brief additional details were admitted to intensive care. One mother died. 66 women have given birth, 25 by Caesarean. 142 pregnancies are ongoing. No baby has died. No babies were infected. Citation: See Studies 42, 46, 120, & 141. Available here. Accessed 5 June 2020.

Study 146 – 8 cases from Turkey

Two pregnant women with Covid-19 were delivered by Caesarean at term, one miscarried at 7 weeks and five pregnancies are ongoing (click here or jum.15367).  One delivered baby tested negative. No details are reported of the other. All mothers recovered. The tertiary hospital is not named, but from author affiliations is probably Sehit Prof Dr Ilhan Varank Sancaktepe Training & Research Hospital, Istanbul. These case are therefore unlikely to overlap with those in Studies 31 and 145. Citation: Yassa M, Birol P, Mutlu AM, Tekin AB, Sandal K, Tug N. Lung Ultrasound Can Influence the Clinical Treatment of Pregnant Women With COVID-19 [published online ahead of print, 2020 Jun 1]. J Ultrasound Med. 2020;10.1002/jum.15367. doi:10.1002/jum.15367

Study 145 – Case report from Turkey

A 25 year old woman with Covid-19 was delivered by Caesarean at 38 weeks (click here or 1-s2.0-S0952818020308953-main). The mother recovered and the baby tested negative. The hospital is not named but from author affiliations is likely Necmettin Erbakan University, Meram Faculty of Medicine, Konya. The patient is different from the one in study 31.  Citation: Resul Yilmaz, FatmaKiliç, Şule Arican, Gülçin Hacibeyoğlu, Halime Süslü, Mustafa Koyuncu, Sema Tuncer Uzun. Anesthetic management for cesarean birth in pregnancy with the novel coronavirus (COVID-19). Journal of Clinical Anesthesia. Available online 27 May 2020. https://doi.org/10.1016/j.jclinane.2020.109921

Study 144 – 2 (or 3) cases from Japan

Of 52 asymptomatic pregnant women screened for SARS-CoV-2 between April 6 and April 27, two tested positive and one, whose partner had Covid-19, was treated as if she was infected despite a negative test (click here or ijgo.13252). All three were delivered by Caesarean section, and their babies isolated. No babies were infected. Patients were cared for in Keio University Hospital, Tokyo. These are the first cases of Sars-Cov2 from this country. Citation: Ochiai, D., Kasuga, Y., Iida, M., Ikenoue, S. and Tanaka, M. (2020), Universal screening for SARS‐CoV‐2 in asymptomatic obstetric patients in Tokyo, Japan. Int J Gynecol Obstet. Accepted Author Manuscript. doi:10.1002/ijgo.13252

Study 143 – 12 cases from Korea

Twelve women with COVID-19 were admitted for delivery between February 26th & to April 3rd 2020 (click here or kja-20204). Four birthed vaginally and 8 by Caesarean. Two babies were stillborn. All patients were cared for at Daegu Fatimal Hospital, (see Study 22 cited in paper). Although there is no explicit statement about whether the patient in Study 22 was included, the clinical details (age and gestation) differ, so it is likely that all 12  have not previously been reported.  Citation: Jeongmin Oh, Eunju Kim, Hyunkyum Kim, Sang-Ah Lee, Kyeong Hee Lee, Mi Hyae Yu, Jihyun An. Infection control of operating room and anesthesia for cesarean section during pandemic Coronavirus disease-19 (COVID-19) outbreak in Daegu, the republic of Korea – 8 cases report. Korean J Anesthesiol DOI: https://doi.org/10.4097/kja.20204 [Epub ahead of print]. Published online June 5, 2020.

4th June update – studies 141 and 142 added

Study 142 – 61 cases from USA

Of these 61 women with Covid-19 in pregnancy, cared for at a single academic medical centre, 21 were admitted to hospital, of whom 6 went to intensive care, of whom four were intubated (click here or Prevalence_and_Severity_of_Coronavirus_Disease.97338). No mothers died. The hospital is not named, but from author affiliations is likely Massachusetts General Hospital, Boston, Mass. If so, these women probably differ from those reported in Study 129, and have not previously been reported. Citation: Goldfarb, Ilona Telefus MD, MPH; Clapp, Mark A. MD, MPH; Soffer, Marti D. MD, MPH; Shook, Lydia L. MD; Rushfirth, Katherine CNM, MSN; Edlow, Andrea G. MD, MSc; Boatin, Adeline A. MD, MPH; Kaimal, Anjali J. MD, MAS; Barth, William H. Jr MD; Bryant, Allison S. MD, MPH Prevalence and Severity of Coronavirus Disease 2019 (COVID-19) Illness in Symptomatic Pregnant and Postpartum Women Stratified by Hispanic Ethnicity, Obstetrics & Gynecology: June 02, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000004005

Study 141 – 201 women from the Netherlands Covid in pregnancy registry

The 22nd May update of NethOSS (click here), accessed 4 June 2020, contains the following. 7/176 women with brief additional details were admitted to intensive care. One mother died after prolonged admission and intubation as a result of pulmonary infection with multiple pulmonary emboli. 49 women have given birth, 16 by Caesarean. 124 pregnancies are ongoing. No baby has died. No babies were infected. Citation: See Studies 42, 46 & 120. Available here. Accessed 4 June 2020. Update 9 September – Professor Kitty Bloemenkamp @kBloemenkamp, chair Birth Centre, Wilhelmina’s Children Hospital, University Medical Centre, Utrecht, and senior author of study 826 assures me that to date there have been no maternal deaths from Covid in the Netherlands.

2nd June update – study 140 added

Study 140 – 42 cases from Spain

Forty two pregnant women with Covid-19 between March 13 & April 10 (click here or 1471-0528.16339). Eight required admission to ICU of whom 6 developed some features of pre-eclampsia, 4 requiring Caesarean, one of which was due to HELLP syndrome. No maternal or baby outcomes are reported but it is implied “after recovery from severe pneumonia, hypertensive therapy was no longer required in all cases” that all women recovered. The “tertiary care” hospital is not named but from author affiliations is likely to be Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona. If so, these cases have not been previously reported. Citation: Mendoza, M., Garcia‐Ruiz, I., Maiz, N., Rodo, C., Garcia‐Manau, P., Serrano, B., Lopez‐Martinez, R.M., Balcells, J., Fernandez‐Hidalgo, N., Carreras, E. and Suy, A. (2020). Preeclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study. BJOG. doi:10.1111/1471-0528.16339

1st June update – Studies 138 (HT Frederico Amedee Peret) & 139 added. Study 137 removed.

Study 139 – 13 cases in USA

Twelve women with Covid-19 were detected through targeted testing, and one by universal screening (click here or ciaa675). No separate clinical details given for the SARS-Cov2 positive women.  Patients were treated at the University of Washington Montlake Labor and Delivery Unit and Northwest Birth Center. They therefore likely overlap with Study 102. Citation: Sylvia M LaCourse, Alisa Kachikis, Michela Blain, LaVone E Simmons, James A Mays, Amber D Pattison, Carol C Salerno, Stephen A McCartney, Nicole M Kretzer, Rebecca Resnick, Rosemary L Shay, Leah M Savitsky, Anna C Curtin, Emily M Huebner, Kimberly K Ma, Shani Delaney, Carlos Delgado, Adrienne Schippers, Jeff Munson, Paul S Pottinger, Seth Cohen, Santiago Neme, Lori Bourassa, Andrew Bryan, Alex Greninger, Keith R Jerome, Alison C Roxby, Erica Lokken, Edith Cheng, Kristina M Adams Waldorf, Jane Hitti. Low prevalence of SARS-CoV-2 among pregnant and postpartum patients with universal screening in Seattle, Washington. Clinical Infectious Diseases ciaa675, https://doi.org/10.1093/cid/ciaa675

Study 138 – 36 deaths among 484 pregnant women with Covid-19 in Brazil

Bulletin no 17 from the Brazilian Ministry of Health contains a special section on pregnant women with Covid-19 (click here or 2020-05-25—BEE17—Boletim-do-COE). The report is in Portugese. I’ve prepared an English translation of the pregnancy section using google translate Brazil MoH Covid 19 Bulletin 17 translation of pregnancy section. Citation: Ministério da Saúde, Secretaria de Vigilância em Saúde. Boletim Epidemiológico Especial da COVID-19 no Brasil. Número do boletim 17.  25 May 2020.

31 May update – study 137 added.

Study 137 – A patient with Covid-19 & an ectopic pregnancy

A 37-year-old woman tested positive for SARS-Cov2 and presented two days later with an ectopic pregnancy (click here or Ectopic_Pregnancy_During_Coronavirus_Disease_2019.97340). The authors discuss treatment options but give no further clinical details. Although the report is ambiguous, it is conventional in educational medical reports to present real cases unless stated otherwise. From author affiliations the patient was likely cared for in South Dakota or Texas. Citation: Hansen, Keith A; Stovall, Dale W. Ectopic Pregnancy During Coronavirus Disease 2019 (COVID-19), Obstet Gynecol: May 27, 2020 doi: 10.1097/AOG.0000000000003995 Removed 1 June 2020 because the peer review correspondence available here or aog_136_2_2020_05_18_hansen_20-1079_sdc1 makes clear that the case is hypothetical.

30 May update – study 136 added.

Study 136 – 158 cases from USA

Of 158 pregnant women with Covid-19, 34 had moderate or severe disease, 9 received ICU or step down care and 1 required intubation. There were no deaths (click here or Andrikopoulou Green Symptoms_and_Critical_Illness_Among_Obstetric.97341). No baby outcomes reported. Patients were cared for at NY Presbyterian/Columbia University Irving Medical Center, and at
New York-Presbyterian/Allen Hospital. Cases presumably overlap with those in studies 14, 27, 41 & 95. Citation: Andrikopoulou, Maria; Madden, Nigel; Wen, Timothy; Aubey, Janice J; Aziz, Aleha; Baptiste, Caitlin D;  Breslin, Noelle; D’Alton, Mary E; Fuchs, Karin; Goffman Dena; Gyamfi-Bannerman, Cynthia; Matseoane-Peterssen, Dara N; Miller, Russell S; Sheen, Jean-Ju; Simpson, Lynn L; Sutton, Desmond; Zork, Noelia; Friedman, Alexander M. Symptoms and Critical Illness Among Obstetric Patients With Coronavirus Disease 2019 (COVID-19) Infection, Obstet Gynecol May 27, 2020 – doi: 10.1097/AOG.0000000000003996

28 May update – studies 133 to 135 added

Study 135 –  50 cases from USA

Among 307 asymptomatic women tested on admission in labour, 50 were SARS CoV-2 positive (click here or Buckley Mount Sinai AJOGMFM). The women were tested between April 4 & 15, 2020, at two institutions within Mount Sinai Health System in New York. They therefore probably overlap with those in Study 119. Citation: Buckley A, Bianco A, Stone J, Universal testing of patients and their support persons for COVID-19 when presenting for admission to Labor and Delivery within the Mount Sinai Health System, Am J Obstet Gynecol MFM (2020), doi: https://doi.org/10.1016/j.ajogmf.2020.100147.

Study 134 – 125 cases from USA

These authors report further details on 12 pregnant women with severe Covid 19, out of 125 in total (click here or McLaren AJOG PIIS0002937820305676). 7 were delivered by Caesarean, 2 vaginally, and 3 remain undelivered. No mothers died, although one remains in hospital. This is an update on study 113, and again the hospital is presumably Maimonides Medical Center, Brooklyn, New York. Citation: MCLAREN Jr. RA, LONDON V, ATALLAH F, MCCALLA S, HABERMAN S, FISHER N, STEIN JL, MINKOFF HL, Delivery For Respiratory Compromise Among Pregnant Women With COVID-19, Am J Obstet Gynecol (2020), doi: https://doi.org/10.1016/j.ajog.2020.05.035.

Study 133 – 3 cases identified by screening in Italy

By screening 533 women admitted for delivery for SARS-CoV2 between March 26th & April 1st in North Tuscany and Liguria, these authors identified 3 positives, who all gave birth without clinical problems (click here or PIIS0002937820305421). The women birthed in all the 6 hospitals of Azienda USL “Toscana Nord Ovest” (Tuscany), and Gaslini Children’s Hospital (Genoa, Liguria). They have therefore probably not previously been reported. Citation: Gagliardi L, Danieli R, Suriano G, Vaccaro A, Tripodi G, Rusconi F, Ramenghi LA, Universal SARS-CoV-2 testing of pregnant women admitted for delivery in two Italian regions. Am J Obstet Gynecol (2020), doi: https://doi.org/10.1016/j.ajog.2020.05.017.

27 May update – study 132 added (HT @janevandis)

Study 132 – 42 cases from USA

Of 782 women presenting for childbirth between April 2nd & 29th, 2020, 12 had already been diagnosed with Covid-19. Of the remainder 30/770 screened positive, 22 of whom were asymptomatic (click here orjama_campbell_2020_ld_200052). No clinical outcomes reported. No health care workers infected. Patients were cared for in 3 Yale New Haven Health hospitals in southern Connecticut. Citation: Katherine H. Campbell, Jean M. Tornatore, Kirsten E. Lawrence, Jessica L. Illuzzi, L. Scott Sussman, Heather S. Lipkind, Christian M. Pettker. Prevalence of SARS-CoV-2 Among Patients Admitted for Childbirth in Southern Connecticut. JAMA. Published online May 26, 2020. doi:10.1001/jama.2020.8904

26 May update – studies 129 to 131 added.

Study 131 – Anti-SARS-Cov2 IgA antibodies in breast milk of recovering women.

The authors of this not yet peer-reviewed preprint report anti SARS-Cov2 IgA antibodies in breast milk samples from 15 women previously infected with SARS-Cov2 (click here or 2020.05.04.20089995v1.full). No clinical details. The authors, mainly from Icahn School of Medicine at Mount Sinai, New York, report that they have recruited over 350 lactating women who have recovered from COVID-19.  Citation: Alisa Fox, Jessica Marino, Fatima Amanat, Florian Krammer, Jennifer Hahn-Holbrook, Susan Zolla-Pazner, Rebecca L Powell.  Evidence of a significant secretory-IgA-dominant SARS-CoV-2 immune response in human milk following recovery from COVID-19 doi: https://doi.org/10.1101/2020.05.04.20089995

Study 130 – Case report from Amsterdam Medical Centre, the Netherlands

A woman developed Covid-19 at 41 weeks gestation (Click here or ajh.25877). She also developed autoimmune throbocytopaenia. The baby was delivered by Caesarean. Citation: Man Wai Tang, Erfan Nur, Bart J. Biemond. Immune Thrombocytopenia during Pregnancy due to COVID-19. Am J Haematol. First published:23 May 2020 https://doi.org/10.1002/ajh.25877

Study 129 – 15 patients from USA

Of 213 admitted pregnant women screened by differential white blood count, 15 had Sars-Cov2 (click here or Duffy Green Lymphopenia_and_Severe_Acute_Respiratory_Syndrome.97345 (002)). Three required critical care for hypoxia. No other clinical details. From author affiliations patients were probably cared for in Beth Israel Deaconess Med Center, Harvard Med School, Boston, Mass. Citation: Duffy, Cassandra R. MD, MPH; Hart, Jessica M. MD; Modest, Anna M. PhD; Hacker, Michele R. ScD; Golen, Toni MD; Li, Yunping MD, MSc; Zera, Chloe MD, MPH; Shainker, Scott A. DO, MS; Mehrotra, Preeti MD, MPH; Zash, Rebecca MD; Wylie, Blair J. MD, MPH Lymphopenia and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Hospitalized Obstetric Patients, Obstetrics & Gynecology: May 19, 2020 – Volume Publish Ahead of Print – Issue – doi: 10.1097/AOG.0000000000003984

25 May update – studies 127-8 added.

Study 128 – 13 patients from North East Flanders, Belgium

Of 470 pregnant women screened, 13 tested positive for SARS-Cov2, 8 were asymptomatic 4 had mild upper airway symptoms, and one respiratory symptoms. None developed severe disease (click here or Ceulemans Flanders uog.22099 (1)) The hospitals caring for the four patients are unnamed but shown on a map. Citation: Ceulemans, D., Thijs, I., Schreurs, A., Vercammen, J., Lannoo, L., Deprest, J., Richter, J., De Catte, L. and Devlieger, R. (2020), Screening for COVID ‐19 at childbirth: does it deliver?. Ultrasound Obstet Gynecol. Accepted Author Manuscript. doi:10.1002/uog.22099

Study 127 – SARS-CoV-2 in human breastmilk

Breast milk from two nursing mothers infected with SARS-CoV-2 was tested. Samples from one woman were positive (click here or PIIS0140673620311818). Where the patients were cared for, was not reported. The authors came from Ulm in Germany. Citation: Rüdiger Groß, Carina Conzelmann, Janis A Müller, Steffen Stenger, Karin Steinhart, Frank Kirchhoff, Jan Münch. Detection of SARS-CoV-2 in human breastmilk. Lancet. Published online May 21, 2020 https://doi.org/10.1016/S0140-6736(20)31181-8

24 May update

Study 126 – The ISARIC report in the BMJ

Among 20,133 patients admitted to hospital with covid-19 in the UK, 100/1033 (10%) women of childbearing age, were reported as being pregnant (click here or bmj.m1985.full). This is similar to the estimated proportion of pregnant women in the community. Pregnancy was not associated with mortality. This is an update of study 68. Citation: Docherty Annemarie B, Harrison Ewen M, Green Christopher A, Hardwick Hayley E, Pius Riinu, Norman Lisa et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 2020; 369 :m1985

23 May update – studies 121-125 added

Study 125 – 60 cases from Spain

Of 60 pregnant women with COVID-19 (click here or aogs.13921), 18 had pneumonia, 2 severely. One woman was admitted to ICU. No mothers died. Of 23 women delivered, 5 were by cesarean and 18 vaginally. Two delivered preterm. All 23 babies tested negative, and 21 were breast fed. Two babies were admitted to NICU for other reasons. No babies died. The patients were all were treated at Puerta de Hierro University Hospital Madrid, from March 14th to April 14th, 2020. Citation: Pereira, A., Cruz‐Melguizo, S., Adrien, M., Fuentes, L., Marin, E. and Perez‐Medina, T. (2020), Clinical course of Coronavirus Disease‐2019 (COVID‐19) in pregnancy. Acta Obstet Gynecol Scand. Accepted Author Manuscript. doi:10.1111/aogs.13921

Study 124 – 16 cases from USA

Fourteen patients delivered at term, 1 at 34 weeks, & 1 at 16-weeks (click here or aqaa089). No mothers admitted to ITU. No mother or baby deaths. No baby infections. The cases were ide